| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Oncology, Markers, Clinical Correlates |
Departments of Thoracic/Head and Neck Medical Oncology [L. W., J-C. S., L. M., F. R. K.], Pathology [B. L. K.], and Biostatistics [D. D. L.], The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030
Activation of telomerase plays a critical role in unlimitedproliferation and immortalization of cells. The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase catalytic subunit (hTERT) as a prognostic marker.
The expression of hTERT in a large population of 153 patients with stage I non-small cell lung cancer was analyzed using the in situ hybridization technique.
We found that diffuse and clear hTERT expression was present in 51 (33%) of 153 patients. Kaplan-Meier analysis showed that hTERT expression was associated with shorter overall survival (P = 0.04), shorter disease-specific survival (P = 0.03), and shorter disease-free survival (P = 0.02). Multivariate analysis confirmed this independent prognostic value of hTERT expression.
Our results indicated that hTERT mRNA expression is associated with malignant tumor progression and poor outcome. hTERT may serve as a useful marker to identify patients with poor prognosis and to select patients with early-stage non-small cell lung cancer who might benefit from adjuvant treatment.
This article has been cited by other articles:
|
|
 |
|
  Y. Wang, Z. Hu, J. Liang, Z. Wang, J. Tang, S. Wang, X. Wang, J. Qin, X. Wang, and H. Shen A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women Carcinogenesis, June 1, 2008; 29(6): 1197 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mavrogiannou, A. Strati, A. Stathopoulou, E. G. Tsaroucha, L. Kaklamanis, and E. S. Lianidou Real-Time RT-PCR Quantification of Human Telomerase Reverse Transcriptase Splice Variants in Tumor Cell Lines and Non-Small Cell Lung Cancer Clin. Chem., January 1, 2007; 53(1): 53 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, Q. Wei, L.-E Wang, K. D. Aldape, Y. Cao, M. F. Okcu, K. R. Hess, R. El-Zein, M. R. Gilbert, S. Y. Woo, et al. Survival Prediction in Patients With Glioblastoma Multiforme by Human Telomerase Genetic Variation J. Clin. Oncol., April 1, 2006; 24(10): 1627 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brachner, S. Sasgary, C. Pirker, C. Rodgarkia, M. Mikula, W. Mikulits, H. Bergmeister, U. Setinek, M. Wieser, S.-F. Chin, et al. Telomerase- and Alternative Telomere Lengthening-Independent Telomere Stabilization in a Metastasis-Derived Human Non-Small Cell Lung Cancer Cell Line: Effect of Ectopic hTERT. Cancer Res., April 1, 2006; 66(7): 3584 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Dome, C. A. Bockhold, S. M. Li, S. D. Baker, D. M. Green, E. J. Perlman, D. A. Hill, and N. E. Breslow High Telomerase RNA Expression Level Is an Adverse Prognostic Factor for Favorable-Histology Wilms' Tumor J. Clin. Oncol., December 20, 2005; 23(36): 9138 - 9145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fan, Z. Liu, X. Fang, Z. Ge, N. Ge, Y. Jia, P. Sun, F. Lou, M. Bjorkholm, A. Gruber, et al. Differential Expression of Full-length Telomerase Reverse Transcriptase mRNA and Telomerase Activity between Normal and Malignant Renal Tissues Clin. Cancer Res., June 15, 2005; 11(12): 4331 - 4337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lu, J.-C. Soria, X. Tang, X.-C. Xu, L. Wang, L. Mao, R. Lotan, B. Kemp, B. N. Bekele, L. Feng, et al. Prognostic Factors in Resected Stage I Non-Small-Cell Lung Cancer: A Multivariate Analysis of Six Molecular Markers J. Clin. Oncol., November 15, 2004; 22(22): 4575 - 4583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tchirkov, C. Chaleteix, C. Magnac, Y. Vasconcelos, F. Davi, A. Michel, F. Kwiatkowski, O. Tournilhac, G. Dighiero, and P. Travade hTERT expression and prognosis in B-chronic lymphocytic leukemia Ann. Onc., October 1, 2004; 15(10): 1476 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Tsao, E. S. Kim, and W. K. Hong Chemoprevention of Cancer CA Cancer J Clin, May 1, 2004; 54(3): 150 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Smith, J.-C. Soria, L. Morat, Q. Yang, L. Sabatier, D. D. Liu, R. A. Nemr, A. Rashid, and J.-N. Vauthey Human Telomerase Reverse Transcriptase (hTERT) and Ki-67 are Better Predictors of Survival than Established Clinical Indicators in Patients Undergoing Curative Hepatic Resection for Colorectal Metastases Ann. Surg. Oncol., January 1, 2004; 11(1): 45 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sozzi, D. Conte, M. Leon, R. Cirincione, L. Roz, C. Ratcliffe, E. Roz, N. Cirenei, M. Bellomi, G. Pelosi, et al. Quantification of Free Circulating DNA As a Diagnostic Marker in Lung Cancer J. Clin. Oncol., November 1, 2003; 21(21): 3902 - 3908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Massion and D. P. Carbone From Clinical and Pathologic to Molecular Staging of Lung Cancer Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1587 - 1588. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Moghissi and J. Greenman Editorial Comment Eur. J. Cardiothorac. Surg., February 1, 2003; 23(2): 199 - 200. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
