Clinical Cancer Research Meeting Calendar Advances in Breast Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, L.
Right arrow Articles by Coukos, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, L.
Right arrow Articles by Coukos, G.
Clinical Cancer Research Vol. 9, 264-272, January 2003
© 2003 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

Expression of Endocrine Gland-derived Vascular Endothelial Growth Factor in Ovarian Carcinoma1

Lin Zhang, Nuo Yang, Jose-Ramon Conejo-Garcia, Dionyssios Katsaros, Alisha Mohamed-Hadley, Stefano Fracchioli, Katia Schlienger, Alanna Toll, Bruce Levine, Stephen C. Rubin and George Coukos2

Center for Research on Reproduction and Women’s Health [L. Z., J-R. C-G., A. M-H., G. C.], Abramson Family Cancer Research Institute [K. S., A. T., B. L., G. C.], Division of Gynecologic Oncology, Department of Obstetrics and Gynecology [S. C. R., G. C.], and Cell and Molecular Biology Program [N. Y.], University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Department of Obstetrics and Gynecology, University of Turin, Turin, Italy [D. K., S. F.]

The first tissue-specific angiogenic molecule, endocrine gland-derived vascular endothelial growth factor (EG-VEGF), was identified recently in human ovary, raising hopes of developing tumor type-specific angiogenesis inhibitors. In the present study, we analyzed the expression of EG-VEGF mRNA in normal human tissues and ovarian neoplasms by quantitative real-time reverse transcription-PCR. EG-VEGF mRNA was expressed in all ovarian neoplasms examined. No significant difference was identified among benign, low malignant potential neoplasms or stage I ovarian cancer, all of which exhibited 2-fold lower mRNA levels compared with normal premenopausal ovaries. EG-VEGF mRNA levels further decreased in late stage compared with early stage carcinomas (P < 0.05) and were consistently lower in laser capture microdissected tumor islets compared with surrounding stroma. EG-VEGF was undetectable by reverse transcription-PCR in 17 established epithelial ovarian cancer cell lines or in cultured human ovarian surface epithelial cells, whereas it was detected in peripheral blood as well as tumor-infiltrating T lymphocytes. Finally, in contrast to VEGF, EG-VEGF mRNA levels did not correlate with clinical outcome in advanced ovarian carcinoma. These results suggest that EG-VEGF is most likely derived from nonepithelial components of ovarian carcinomas and may play a marginal role in promoting angiogenesis in advanced ovarian carcinoma. We postulate that EG-VEGF-targeted antiangiogenic therapy may prove useful in early stage but not in advanced stage ovarian carcinoma.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
A. Morales, S. Morimoto, L. Diaz, G. Robles, and V. Diaz-Sanchez
Endocrine gland-derived vascular endothelial growth factor in rat pancreas: genetic expression and testosterone regulation
J. Endocrinol., May 1, 2008; 197(2): 309 - 314.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Keramidas, C. Faudot, A. Cibiel, J.-J. Feige, and M. Thomas
Mitogenic functions of endocrine gland-derived vascular endothelial growth factor and Bombina variegata 8 on steroidogenic adrenocortical cells
J. Endocrinol., March 1, 2008; 196(3): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
Q.-Y. Zhou
The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES
Mol. Interv., December 1, 2006; 6(6): 330 - 338.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Pasquali, V. Rossi, S. Staibano, G. De Rosa, P. Chieffi, D. Prezioso, V. Mirone, M. Mascolo, D. Tramontano, A. Bellastella, et al.
The Endocrine-Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF)/Prokineticin 1 and 2 and Receptor Expression in Human Prostate: Up-Regulation of EG-VEGF/Prokineticin 1 with Malignancy
Endocrinology, September 1, 2006; 147(9): 4245 - 4251.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, J. Huang, N. Yang, S. Liang, A. Barchetti, A. Giannakakis, M. G. Cadungog, A. O'Brien-Jenkins, M. Massobrio, K. F. Roby, et al.
Integrative Genomic Analysis of Protein Kinase C (PKC) Family Identifies PKC{iota} as a Biomarker and Potential Oncogene in Ovarian Carcinoma.
Cancer Res., May 1, 2006; 66(9): 4627 - 4635.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. S. W. Ngan, K. Y. Lee, W. S. B. Yeung, H. Y. S. Ngan, E. H. Y. Ng, and P. C. Ho
Endocrine Gland-Derived Vascular Endothelial Growth Factor Is Expressed in Human Peri-implantation Endometrium, But Not in Endometrial Carcinoma
Endocrinology, January 1, 2006; 147(1): 88 - 95.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Chimenti, M. Pieroni, A. Russo, P. Sale, M. A. Russo, A. Maseri, and A. Frustaci
Laser Microdissection in Clinical Cardiovascular Research
Chest, October 1, 2005; 128(4): 2876 - 2881.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, N. Yang, J. Huang, R. J. Buckanovich, S. Liang, A. Barchetti, C. Vezzani, A. O'Brien-Jenkins, J. Wang, M. R. Ward, et al.
Transcriptional Coactivator Drosophila Eyes Absent Homologue 2 Is Up-Regulated in Epithelial Ovarian Cancer and Promotes Tumor Growth
Cancer Res., February 1, 2005; 65(3): 925 - 932.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. M. Fraser, J. Bell, H. Wilson, P. D. Taylor, K. Morgan, R. A. Anderson, and W. C. Duncan
Localization and Quantification of Cyclic Changes in the Expression of Endocrine Gland Vascular Endothelial Growth Factor in the Human Corpus Luteum
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 427 - 434.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Chimenti, A. Russo, M. Pieroni, F. Calabrese, R. Verardo, G. Thiene, M. A. Russo, A. Maseri, and A. Frustaci
Intramyocyte Detection of Epstein-Barr Virus Genome by Laser Capture Microdissection in Patients With Inflammatory Cardiomyopathy
Circulation, December 7, 2004; 110(23): 3534 - 3539.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, N. Yang, D. Katsaros, W. Huang, J.-W. Park, S. Fracchioli, C. Vezzani, I. A. Rigault de la Longrais, W. Yao, S. C. Rubin, et al.
The Oncogene Phosphatidylinositol 3'-Kinase Catalytic Subunit {alpha} Promotes Angiogenesis via Vascular Endothelial Growth Factor in Ovarian Carcinoma
Cancer Res., July 15, 2003; 63(14): 4225 - 4231.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, N. Yang, J.-W. Park, D. Katsaros, S. Fracchioli, G. Cao, A. O'Brien-Jenkins, T. C. Randall, S. C. Rubin, and G. Coukos
Tumor-derived Vascular Endothelial Growth Factor Up-Regulates Angiopoietin-2 in Host Endothelium and Destabilizes Host Vasculature, Supporting Angiogenesis in Ovarian Cancer
Cancer Res., June 15, 2003; 63(12): 3403 - 3412.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.