Clinical Cancer Research Landon Prizes for Basic and Translational Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention
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Clinical Cancer Research Vol. 9, 4914-4925, October 15, 2003
© 2003 American Association for Cancer Research

Molecular Oncology, Markers, Clinical Correlates

Elevated Expression of Inhibitor of Apoptosis Proteins in Prostate Cancer

Maryla Krajewska1, Stan Krajewski1, Steven Banares, Xianshu Huang, Bruce Turner, Lukas Bubendorf, Olli-P. Kallioniemi, Ahmed Shabaik, Antonella Vitiello, Donna Peehl, Guo-Jian Gao and John C. Reed2

The Burnham Institute, La Jolla, California 92037 [M. K., S. K., S. B., X. H., J. C. R.]; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 [B. T.]; Institute of Pathology, University of Basel, Switzerland [L. B.]; Laboratory of Cancer Genetics, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892-4470 [O-P. K.]; Department of Pathology, University of California, San Diego, San Diego, California 92103 [A. S.]; The R. W. Johnson Pharmaceutical Research Institute, San Diego, California [A. V.]; Department of Urology, Stanford University, Stanford, California 94305 [D. P.]; and BD Biosciences Pharmingen, San Diego, California 92121 [G-J. G.]

Purpose: Inhibitor of apoptosis (IAP) family proteins are suppressors of apoptosis that have been implicated in apoptosis resistance in some cancers. Their expression and relevance to the prognosis of prostate cancer were investigated.

Experimental Design: The expression of four members of the IAP family (cellular inhibitor of apoptosis protein 1, cellular inhibitor of apoptosis protein 2, X chromosome-linked IAP, and survivin) was examined by immunohistochemistry and immunoblotting in human prostate cancers and in prostate tissues from transgenic mice expressing SV40 large T antigen under control of a probasin promoter.

Results: Tumor-associated elevations in the levels of all four IAP family members were common in prostate cancers of both humans and mice, suggesting concomitant up-regulation of multiple IAP family proteins. Compared with normal prostatic epithelium, increased IAP expression was often evident even in prostatic intraepithelial neoplasia lesions (carcinoma in situ), suggesting that deregulation of IAP expression occurs early in the pathogenesis of prostate cancer. IAP expression did not correlate with Gleason grade or prostate-specific antigen levels.

Conclusions: The findings demonstrate that tumor- associated elevations in the expression of several IAP family proteins occur as a frequent and early event in the etiology of prostate cancer.




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Copyright © 2003 by the American Association for Cancer Research.