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HER-2-Targeted Therapy

Lessons Learned and Future Directions

Departments of Breast Medical Oncology [R. N., F. J. E.] and Molecular and Cellular Oncology [F. J. E.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas

ABSTRACT

HER-2 is overexpressed in 20–25% of invasive breast cancers and is associated with an aggressive tumor phenotype and reduced survival rates. The HER-2 status of a tumor is the critical determinant of response to the HER-2-targeted antibody trastuzumab. Thus, accurate assessment of HER-2 expression levels is essential for identifying breast cancer patients who will benefit from HER-2-targeted therapy. Trastuzumab combined with chemotherapy increases response rates, time to progression, and survival. However, the majority of cancers that initially respond to trastuzumab begin to progress again within 1 year. This minireview describes HER-2 targeting strategies currently in use or in stages of development for the treatment of breast cancer.

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