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Clinical Cancer Research Vol. 9, 5442-5453, November 15, 2003
© 2003 American Association for Cancer Research


Meeting Summary

Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development

Meeting Summary

Richard Gorlick1, Peter Anderson2, Irene Andrulis3, Carola Arndt2, G. Peter Beardsley4, Mark Bernstein5, Julia Bridge6, Nai-Kong Cheung1, Jeffrey S. Dome7, David Ebb8, Thomas Gardner9, Mark Gebhardt8, Holcombe Grier10, Marc Hansen11, John Healey1, Lee Helman12, Janet Hock9, Janet Houghton7, Peter Houghton7, Andrew Huvos1, Chand Khanna12, Mark Kieran10, Eugenie Kleinerman13, Marc Ladanyi1, Ching Lau14, David Malkin15, Neyssa Marina16, Paul Meltzer1, Paul Meyers1, Deborah Schofield17, Cindy Schwartz18, Malcolm A. Smith22, Jeffrey Toretsky19, Maria Tsokos12, Leonard Wexler1, Jon Wigginton12, Stephen Withrow20, Mason Schoenfeldt21 and Barry Anderson22

1 Memorial Sloan-Kettering Cancer Center, New York, New York;
2 Mayo Clinic, Rochester, Minnesota;
3 Mount Sinai Hospital and Research Institute, Toronto, Ontario, Canada;
4 Yale University School of Medicine, New Haven, Connecticut;
5 Hopital Sainte-Justine, Montreal, Quebec, Canada;
6 University of Nebraska Medical Center, Omaha, Nebraska;
7 St. Jude Children’s Research Hospital, Memphis, Tennessee;
8 Massachusetts General Hospital, Boston, Massachusetts;
9 Indiana University Medical Center, Indianapolis, Indiana;
10 Dana-Farber Cancer Institute and Children’s Hospital, Boston, Massachusetts;
11 Health Sciences Center, University of Connecticut, Farmington, Connecticut;
12 Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland;
13 M. D. Anderson Cancer Center, Houston, Texas;
14 Texas Children’s Cancer Center at Baylor College of Medicine, Houston, Texas;
15 Hospital for Sick Children, Toronto, Ontario, Canada;
16 Stanford University Medical Center, Stanford, California;
17 Children’s Hospital Los Angeles, Los Angeles, California;
18 Johns Hopkins Hospital, Baltimore, Maryland;
19 Georgetown University Medical Center, Washington, DC;
20 College of Veterinary Medicine and Biological Sciences, Colorado State University, Ft. Collins, Colorado;
21 EMMES Corporation, Rockville, Maryland; and
22 Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, Maryland

ABSTRACT

Childhood osteogenic sarcoma (OS) is a rare bone cancer occurring primarily in adolescents. The North American pediatric cooperative groups have performed a series of clinical treatment trials in this disease over the past several decades, and biology studies of tumor tissue have been an important study component. A meeting was held in Bethesda, Maryland on November 29–30, 2001, sponsored by the NIH Office of Rare Diseases, the Children’s Oncology Group, and the National Cancer Institute-Cancer Therapy Evaluation Program with the general objectives: (a) to review the current state of knowledge regarding OS biology; (b) to identify, prioritize, and support the development of biology studies of potential clinical relevance in OS; and (c) to discuss the available tissue resources and the appropriate methods for analysis of OS samples for the conduct of biology studies. This report summarizes the information presented and discussed by the meeting participants.




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Cancer Research Clinical Cancer Research
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Copyright © 2003 by the American Association for Cancer Research.