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Clinical Trials |
1 Dana Farber Cancer Institute, Brigham and Women’s Hospital and Massachusetts General Hospital, Boston, Massachusetts;
2 Universitaets-Klinikum, Mainz, Germany;
3 Glasgow Royal Infirmary, Glasgow, United Kingdom;
4 Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia;
5 Novartis Oncology, East Hanover, New Jersey and Basel, Switzerland; and
6 Institut Gustave Roussy, Villejuif, France
Purpose: The purpose of our study was to assess the objective response to imatinib administered to patients with small cell lung cancer (SCLC).
Experimental Design: Eligible patients were those with SCLC who either had chemotherapy-naive extensive-stage or had SCLC in a sensitive relapse. Patients enrolled on the trial were treated with 600 mg of imatinib daily. The response was assessed using Southwest Oncology Group (SWOG) criteria after 3 and 6 weeks. Tumor specimens were examined by immunohistochemistry for the KIT receptor.
Results: Nineteen patients with SCLC entered on the study, including 16 men and 3 women. Nine patients had previously untreated extensive-stage disease and 10 patients had sensitive relapse. A central pathology review confirmed SCLC in only 14 of the 19 patients. There were no objective responses; however, one patient with sensitive-relapse disease had prolonged stabilization of disease (>3 months) while on imatinib therapy. The median time to progression was 0.8 months (range, 0.6–1.3 months) and 1.2 months (range, 0.2–4.1 months) in the previously untreated and sensitive-relapse groups, respectively. Tumor tissue samples from 4 (21%) of the 19 patients had the KIT receptor (CD117).
Conclusions: There was no observed antitumor activity in this limited Phase II trial of patients with SCLC, of which only a few tumors showed expression of the imatinib target. The results of this trial are, thus, inconclusive about the antitumor activity of imatinib against SCLC with the targeted KIT receptor (CD117). Further testing of imatinib in patients with SCLC will focus on demonstration of KIT expression in the setting of confirmed SCLC histology.
Commentary
Clin. Cancer Res. 2003 9: 5825-5828.
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