| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Oncology, Markers, Clinical Correlates |
Departments of Surgery [C. B. B., K. W. S., B. Z., D. Y. G., T. J. F.] and Pathology [G. G.], New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York 10021; and Johns Hopkins University School of Medicine, Baltimore, Maryland [M. A. Z.]; and Strang Cancer Prevention Center, New York, New York [T. J. F.]
Purpose: Thyroid nodules are common, with a lifetime risk of developing a clinically significant thyroid nodule of 10% or higher. Preoperative diagnosis was greatly enhanced by the introduction of fine needle aspiration in the 1970s, but there has been little advancement since that time. Discrimination between benign and malignant follicular neoplasms is currently not possible by fine needle aspiration and can even be difficult after full pathologic review. The purpose of these studies is to identify genes expressed in follicular adenomas and carcinomas of the thyroid that will permit molecular differentiation of these neoplasms.
Experimental Design: Gene expression patterns of 17 thyroid follicular tumors were analyzed by oligonucleotide array analysis. Gene profiles for follicular adenomas and carcinomas were identified, and the two groups were compared for differences in expression levels. The differentially expressed genes were used to perform a hierarchical clustering analysis training set. Five follicular tumors with diagnosis undisclosed to the investigators and 2 minimally invasive carcinomas were entered into the cluster analysis as a test set to determine whether diagnosis by gene profile correlated with that obtained by pathologic evaluation.
Results: Thyroid follicular adenomas and carcinomas showed strikingly distinct gene expression patterns. The expression patterns of 105 genes were found to be significantly different between follicular adenoma and carcinoma. Many uncharacterized genes contributed to the distinction between tumor types. For five follicular tumors for which the final diagnosis was undisclosed, the clustering algorithm gave the correct diagnosis in all 5 cases.
Conclusions: Gene profiling is a useful tool to predict the molecular diagnosis of follicular thyroid tumors. Genes were identified that reliably differentiate follicular thyroid carcinoma from adenoma. This study provides insight into genes that may be important in the molecular pathogenesis of follicular thyroid tumors, as well candidates for preoperative diagnosis of follicular thyroid carcinoma.
This article has been cited by other articles:
|
|
 |
|
  M. Eszlinger, K. Krohn, S. Hauptmann, H. Dralle, T. J. Giordano, and R. Paschke Perspectives for Improved and More Accurate Classification of Thyroid Epithelial Tumors J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3286 - 3294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Bryson, C. G. Shores, C. Hart, L. Thorne, M. R. Patel, L. Richey, A. Farag, and A. M. Zanation Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas Arch Otolaryngol Head Neck Surg, June 1, 2008; 134(6): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. B. Prasad, H. Somervell, R. P. Tufano, A. P.B. Dackiw, M. R. Marohn, J. A. Califano, Y. Wang, W. H. Westra, D. P. Clark, C. B. Umbricht, et al. Identification of Genes Differentially Expressed in Benign versus Malignant Thyroid Tumors Clin. Cancer Res., June 1, 2008; 14(11): 3327 - 3337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Durand, C. Ferraro-Peyret, S. Selmi-Ruby, C. Paulin, M. El Atifi, F. Berger, N. Berger-Dutrieux, M. Decaussin, J.-L. Peix, C. Bournaud, et al. Evaluation of Gene Expression Profiles in Thyroid Nodule Biopsy Material to Diagnose Thyroid Cancer J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1195 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Riesco-Eizaguirre and P. Santisteban New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy Endocr. Relat. Cancer, December 1, 2007; 14(4): 957 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujarewicz, M. Jarzab, M. Eszlinger, K. Krohn, R. Paschke, M. Oczko-Wojciechowska, M. Wiench, A. Kukulska, B. Jarzab, and A. Swierniak A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping Endocr. Relat. Cancer, September 1, 2007; 14(3): 809 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Foukakis, A. Gusnanto, A. Y. Au, A. Hoog, W.-O. Lui, C. Larsson, G. Wallin, and J. Zedenius A PCR-based expression signature of malignancy in follicular thyroid tumors Endocr. Relat. Cancer, June 1, 2007; 14(2): 381 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Eszlinger, K. Krohn, A. Kukulska, B. Jarzab, and R. Paschke Perspectives and Limitations of Microarray-Based Gene Expression Profiling of Thyroid Tumors Endocr. Rev., May 1, 2007; 28(3): 322 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. W Baloch and V. A LiVolsi Our approach to follicular-patterned lesions of the thyroid J. Clin. Pathol., March 1, 2007; 60(3): 244 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Chia, M. Milas, S. K. Reddy, A. Siperstein, M. Skugor, J. Brainard, and M. K. Gupta Thyroid-Stimulating Hormone Receptor Messenger Ribonucleic Acid Measurement in Blood as a Marker for Circulating Thyroid Cancer Cells and Its Role in the Preoperative Diagnosis of Thyroid Cancer J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 468 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. L. Griffith, A. Melck, S. J.M. Jones, and S. M. Wiseman Meta-Analysis and Meta-Review of Thyroid Cancer Gene Expression Profiling Studies Identifies Important Diagnostic Biomarkers J. Clin. Oncol., November 1, 2006; 24(31): 5043 - 5051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Lubitz, S. K. Ugras, J. J. Kazam, B. Zhu, T. Scognamiglio, Y.-T. Chen, and T. J. Fahey III Microarray Analysis of Thyroid Nodule Fine-Needle Aspirates Accurately Classifies Benign and Malignant Lesions J. Mol. Diagn., September 1, 2006; 8(4): 490 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cerutti, F. R.M. Latini, C. Nakabashi, R. Delcelo, V. P. Andrade, M. J. Amadei, R. M.B. Maciel, F. C. Hojaij, D. Hollis, J. Shoemaker, et al. Diagnosis of Suspicious Thyroid Nodules Using Four Protein Biomarkers. Clin. Cancer Res., June 1, 2006; 12(11): 3311 - 3318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eszlinger, M. Wiench, B. Jarzab, K. Krohn, M. Beck, J. Lauter, E. Gubala, K. Fujarewicz, A. Swierniak, and R. Paschke Meta- and Reanalysis of Gene Expression Profiles of Hot and Cold Thyroid Nodules and Papillary Thyroid Carcinoma for Gene Groups J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1934 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lacroix, V. Lazar, S. Michiels, H. Ripoche, P. Dessen, M. Talbot, B. Caillou, J.-P. Levillain, M. Schlumberger, and J.-M. Bidart Follicular Thyroid Tumors with the PAX8-PPAR{gamma}1 Rearrangement Display Characteristic Genetic Alterations Am. J. Pathol., July 1, 2005; 167(1): 223 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Krohn, D. Fuhrer, Y. Bayer, M. Eszlinger, V. Brauer, S. Neumann, and R. Paschke Molecular Pathogenesis of Euthyroid and Toxic Multinodular Goiter Endocr. Rev., June 1, 2005; 26(4): 504 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Weber, L. Shen, M. A. Aldred, C. D. Morrison, A. Frilling, M. Saji, F. Schuppert, C. E. Broelsch, M. D. Ringel, and C. Eng Genetic Classification of Benign and Malignant Thyroid Follicular Neoplasia Based on a Three-Gene Combination J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2512 - 2521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jarzab, M. Wiench, K. Fujarewicz, K. Simek, M. Jarzab, M. Oczko-Wojciechowska, J. Wloch, A. Czarniecka, E. Chmielik, D. Lange, et al. Gene Expression Profile of Papillary Thyroid Cancer: Sources of Variability and Diagnostic Implications Cancer Res., February 15, 2005; 65(4): 1587 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zou, K. S. Famulski, R. S. Parhar, E. Baitei, F. A. Al-Mohanna, N. R. Farid, and Y. Shi Microarray Analysis of Metastasis-Associated Gene Expression Profiling in a Murine Model of Thyroid Carcinoma Pulmonary Metastasis: Identification of S100A4 (Mts1) Gene Overexpression as a Poor Prognostic Marker for Thyroid Carcinoma J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6146 - 6154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chevillard, N. Ugolin, P. Vielh, K. Ory, C. Levalois, D. Elliott, G. L. Clayman, and A. K. El-Naggar Gene Expression Profiling of Differentiated Thyroid Neoplasms: Diagnostic and Clinical Implications Clin. Cancer Res., October 1, 2004; 10(19): 6586 - 6597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Morrison, W. Farrar, J. Kneile, N. Williams, Y. Liu-Stratton, A. Bakaletz, M. A. Aldred, and C. Eng Molecular Classification of Parathyroid Neoplasia by Gene Expression Profiling Am. J. Pathol., August 1, 2004; 165(2): 565 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Finley, N. Arora, B. Zhu, L. Gallagher, and T. J. Fahey III Molecular Profiling Distinguishes Papillary Carcinoma from Benign Thyroid Nodules J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3214 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mazzanti, M. A. Zeiger, N. Costourous, C. Umbricht, W. H Westra, D. Smith, H. Somervell, G. Bevilacqua, H. R. Alexander, and S. K. Libutti Using Gene Expression Profiling to Differentiate Benign versus Malignant Thyroid Tumors Cancer Res., April 15, 2004; 64(8): 2898 - 2903. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
