This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Emberley, E. D. Articles by Watson, P. H. Search for Related Content PubMed PubMed Citation Articles by Emberley, E. D. Articles by Watson, P. H.

Psoriasin (S100A7) Expression Is Associated with Poor Outcome in Estrogen Receptor-negative Invasive Breast Cancer¹

Departments of Pathology [Y. N., P. H. W.], Biochemistry and Medical Genetics [E. D. E., L. C. M.], and Community Health Sciences [E. V. K.], University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada, and Department of Preventive Oncology and Epidemiology, CancerCare Manitoba [C. N., E. V. K.], and Epidemiology Unit Manitoba Health [E. V. K.], Winnipeg, Manitoba, R3E OW3 Canada

Purpose: Psoriasin (S100A7) is highly expressed in preinvasive ductal carcinoma in situ of the breast and persistent expression occurs in some invasive carcinomas. This study explores the clinical significance of psoriasin in relation to patient survival in invasive breast cancer.

Experimental Design: We examined psoriasin expression by immunohistochemistry in a cohort of 122 estrogen receptor-negative invasive ductal carcinomas.

Results: Psoriasin expression was observed in 64 of 122 cases (52%) but was not correlated with other prognostic factors (including progesterone receptor, stage, size, grade, and nodal status) within this cohort. However, in univariate analysis, psoriasin expression (nuclear and cytoplasmic) was associated with a shorter time to progression (P < 0.04) and poor survival (P < 0.03). In multivariate analysis, cytoplasmic psoriasin also emerged as independent indicator of time to progression (hazard ratio, 1.86; 95% confidence interval, 1.02–3.39; P = 0.044) and survival (hazard ratio, 2.12; 95% confidence interval, 1.06–4.23; P = 0.033).

Conclusions: These results suggest that psoriasin expression may be associated with a worse prognosis in estrogen receptor-negative invasive ductal carcinomas and raise the possibility that psoriasin expression may also be an indicator of risk of progression in ductal carcinoma in situ.

This article has been cited by other articles:

				H Zhang, Q Zhao, Y Chen, Y Wang, S Gao, Y Mao, M Li, A Peng, D He, and X Xiao Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas Thorax, April 1, 2008; 63(4): 352 - 359. [Abstract] [Full Text] [PDF]

				I. Krop, A. Marz, H. Carlsson, X. Li, N. Bloushtain-Qimron, M. Hu, R. Gelman, M. S. Sabel, S. Schnitt, S. Ramaswamy, et al. A Putative Role for Psoriasin in Breast Tumor Progression Cancer Res., December 15, 2005; 65(24): 11326 - 11334. [Abstract] [Full Text] [PDF]

				R. D. Kennedy, J. J. Gorski, J. E. Quinn, G. E. Stewart, C. R. James, S. Moore, K. Mulligan, E. D. Emberley, T. F. Lioe, P. J. Morrison, et al. BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage-Inducible Gene Cancer Res., November 15, 2005; 65(22): 10265 - 10272. [Abstract] [Full Text] [PDF]

				E. D. Emberley, Y. Niu, L. Curtis, S. Troup, S. K. Mandal, J. N. Myers, S. B. Gibson, L. C. Murphy, and P. H. Watson The S100A7-c-Jun Activation Domain Binding Protein 1 Pathway Enhances Prosurvival Pathways in Breast Cancer Cancer Res., July 1, 2005; 65(13): 5696 - 5702. [Abstract] [Full Text] [PDF]

				A. G. Banerjee, I. Bhattacharyya, and J. K. Vishwanatha Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia Mol. Cancer Ther., June 1, 2005; 4(6): 865 - 875. [Abstract] [Full Text] [PDF]

				D. Vimalachandran, W. Greenhalf, C. Thompson, J. Luttges, W. Prime, F. Campbell, A. Dodson, R. Watson, T. Crnogorac-Jurcevic, N. Lemoine, et al. High Nuclear S100A6 (Calcyclin) Is Significantly Associated with Poor Survival in Pancreatic Cancer Patients Cancer Res., April 15, 2005; 65(8): 3218 - 3225. [Abstract] [Full Text] [PDF]