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Auckland Cancer Society Research Centre The Faculty of Medical and Health Sciences The University of Auckland Auckland, New Zealand

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Dr. Zhou has raised the question of whether our observation, that hydroxylated metabolites of thalidomide are found in urine of mice but not in that of multiple myeloma patients, is related to the administered dose. We have analyzed urinary thalidomide metabolites of mice treated with the same dose as that used for cancer patients and found them to be present still in proportions comparable with those found at higher doses.

Thank you for the opportunity to respond.

Received 6/15/03; accepted 7/17/03.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ching, L.-M. Articles by Lu, J. Search for Related Content PubMed Articles by Ching, L.-M. Articles by Lu, J.