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Innovations and Challenges in Renal Cancer

Reversal of Tumor-Mediated Immunosuppression

Johannes Vieweg, Zhen Su, Philipp Dahm and Sergei Kusmartsev
Johannes Vieweg
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Zhen Su
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Philipp Dahm
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Sergei Kusmartsev
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DOI: 10.1158/1078-0432.CCR-06-1924 Published January 2007
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Tables

  • Table 1.

    Human myeloid immunosuppressive cell populations reported in current literature

    PhenotypeMechanismTumor system/model
    CD15+ (48)H2O2Metastatic adenocarcinomas of the pancreas, colon, and breast
    CD15+, CD11b+, CD14− (50)ARG1RCC
    Lin−, DR− (46)N/AHNSCC, non–small cell lung carcinoma, and breast cancer
    DR−, Lin−CD33+1*ROS/NORCC
    • Abbreviations: H2O2, hydrogen peroxide; HNSCC, squamous cell carcinoma of the head and neck; N/A, not applicable; ROS, reactive oxygen species.

    • ↵* Dannull J, Su Z, Kuebler H, et al. Abrogation of immature myeloid cell induced immunosuppression, in preparation.

  • Table 2.

    Murine myeloid immunosuppressive cell populations reported in current literature

    PhenotypeMechanismTumor system/model
    Gr-1+, CD11b+ (40)ROS/NOMetastatic colon carcinoma
    Gr+, CD11b+ (56)ARG1 + iNOSColon carcinoma, lymphoma
    Gr-1+, CD11b+ (57)ARG1T-cell lymphoma
    Gr-1+, CD11b+ (58)TGF-βFibrosarcoma
    Gr+, CD11b+ (45)ARG1 STAT6Metastatic mammary carcinoma
    Tumor-infiltrated CD11b+ (44)ARG1Lewis lung carcinoma (3LL)
    Tumor-associated F4/80+ (59)TNF-α, iNOS3-Methylcholanthrene-38 (MCA-38)3 induced sarcoma
    Tumor-associated F4/80+ (41)ARG1 + iNOS, STAT1Colon carcinoma, T-cell lymphoma, fibrosarcoma, and sarcoma
    Gr-1+, CD115+ (60)N/A (induction of Treg)Colon carcinoma
    • Abbreviations: STAT, signal transducer and activator of transcription; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α.

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Clinical Cancer Research: 13 (2)
January 2007
Volume 13, Issue 2
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Reversal of Tumor-Mediated Immunosuppression
Johannes Vieweg, Zhen Su, Philipp Dahm and Sergei Kusmartsev
Clin Cancer Res January 15 2007 (13) (2) 727s-732s; DOI: 10.1158/1078-0432.CCR-06-1924

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Reversal of Tumor-Mediated Immunosuppression
Johannes Vieweg, Zhen Su, Philipp Dahm and Sergei Kusmartsev
Clin Cancer Res January 15 2007 (13) (2) 727s-732s; DOI: 10.1158/1078-0432.CCR-06-1924
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Clinical Cancer Research
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