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Tables
- Table 1.
Human myeloid immunosuppressive cell populations reported in current literature
Phenotype Mechanism Tumor system/model CD15+ (48) H2O2 Metastatic adenocarcinomas of the pancreas, colon, and breast CD15+, CD11b+, CD14− (50) ARG1 RCC Lin−, DR− (46) N/A HNSCC, non–small cell lung carcinoma, and breast cancer DR−, Lin−CD33+1* ROS/NO RCC Abbreviations: H2O2, hydrogen peroxide; HNSCC, squamous cell carcinoma of the head and neck; N/A, not applicable; ROS, reactive oxygen species.
↵* Dannull J, Su Z, Kuebler H, et al. Abrogation of immature myeloid cell induced immunosuppression, in preparation.
- Table 2.
Murine myeloid immunosuppressive cell populations reported in current literature
Phenotype Mechanism Tumor system/model Gr-1+, CD11b+ (40) ROS/NO Metastatic colon carcinoma Gr+, CD11b+ (56) ARG1 + iNOS Colon carcinoma, lymphoma Gr-1+, CD11b+ (57) ARG1 T-cell lymphoma Gr-1+, CD11b+ (58) TGF-β Fibrosarcoma Gr+, CD11b+ (45) ARG1 STAT6 Metastatic mammary carcinoma Tumor-infiltrated CD11b+ (44) ARG1 Lewis lung carcinoma (3LL) Tumor-associated F4/80+ (59) TNF-α, iNOS 3-Methylcholanthrene-38 (MCA-38)3 induced sarcoma Tumor-associated F4/80+ (41) ARG1 + iNOS, STAT1 Colon carcinoma, T-cell lymphoma, fibrosarcoma, and sarcoma Gr-1+, CD115+ (60) N/A (induction of Treg) Colon carcinoma Abbreviations: STAT, signal transducer and activator of transcription; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α.
January 2007
Volume 13, Issue 2
Volume 13, Issue 2
Reversal of Tumor-Mediated Immunosuppression
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