RB200 is an Fc-mediated heterodimer of native HER1 and HER3 ligand binding domains. RB200 can sequester most growth factors that activate the human EGF receptor family members. It inhibits cancer cell proliferation in vitro, and suppresses tumor growth and metastases in mouse xenograft models. Thus, RB200 becomes the first pan-specific therapeutic protein that downregulates EGF receptor family.
- American Association for Cancer Research