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Clinical Cancer Research

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Table of Contents

Editorial

  • Editorial
    BRCA-1 in Sporadic Epithelial Ovarian Cancer: Lessons Learned from the Genetics of Hereditary Disease
    Stephen A. Cannistra
    Clin Cancer Res December 15 2007 13 (24) 7225-7227; DOI:10.1158/1078-0432.CCR-07-2222

The Clinical Connection

  • The Clinical Connection
    The Requirements for CTL-Mediated Rejection of Cancer in Humans: NKG2D and Its Role in the Immune Responsiveness of Melanoma
    Ena Wang, Silvia Selleri and Francesco M. Marincola
    Clin Cancer Res December 15 2007 13 (24) 7228-7231; DOI:10.1158/1078-0432.CCR-07-2150

CCR Practice of Translational Oncology

  • CCR Practice of Translational Oncology
    Src Continues Aging: Current and Future Clinical Directions
    Scott Kopetz, Ami N. Shah and Gary E. Gallick
    Clin Cancer Res December 15 2007 13 (24) 7232-7236; DOI:10.1158/1078-0432.CCR-07-1902

Molecular Pathways

  • Molecular Pathways
    Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications
    Valeria R. Fantin and Victoria M. Richon
    Clin Cancer Res December 15 2007 13 (24) 7237-7242; DOI:10.1158/1078-0432.CCR-07-2114

  • Molecular Pathways
    Delta-like 4/Notch Signaling and Its Therapeutic Implications
    Minhong Yan and Greg D. Plowman
    Clin Cancer Res December 15 2007 13 (24) 7243-7246; DOI:10.1158/1078-0432.CCR-07-1393

CCR Focus

  • CCR Focus
    From the Editor
    Susan E. Bates
    Clin Cancer Res December 15 2007 13 (24) 7247-7247; DOI:10.1158/1078-0432.CCR-13-24-INT

  • CCR Focus
    Dedication
    Edward J. Benz Jr. and David G. Nathan
    Clin Cancer Res December 15 2007 13 (24) 7248-7249; DOI:10.1158/1078-0432.CCR-07-2227

  • CCR Focus
    Targeting the Cell Death-Survival Equation
    Edward J. Benz Jr., David G. Nathan, Ravi K. Amaravadi and Nika N. Danial
    Clin Cancer Res December 15 2007 13 (24) 7250-7253; DOI:10.1158/1078-0432.CCR-07-2221

  • CCR Focus
    BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death
    Nika N. Danial
    Clin Cancer Res December 15 2007 13 (24) 7254-7263; DOI:10.1158/1078-0432.CCR-07-1598

  • CCR Focus
    The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members
    Gregory L. Verdine and Loren D. Walensky
    Clin Cancer Res December 15 2007 13 (24) 7264-7270; DOI:10.1158/1078-0432.CCR-07-2184

  • CCR Focus
    The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
    Ravi K. Amaravadi and Craig B. Thompson
    Clin Cancer Res December 15 2007 13 (24) 7271-7279; DOI:10.1158/1078-0432.CCR-07-1595

  • CCR Focus
    Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient?
    Olivier Rixe and Tito Fojo
    Clin Cancer Res December 15 2007 13 (24) 7280-7287; DOI:10.1158/1078-0432.CCR-07-2141

Review

  • Review
    Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications
    Karène Mahtouk, Dirk Hose, John De Vos, Jérôme Moreaux, Michel Jourdan, Jean François Rossi, Thierry Rème, Harmut Goldschmidt and Bernard Klein
    Clin Cancer Res December 15 2007 13 (24) 7289-7295; DOI:10.1158/1078-0432.CCR-07-1758

Human Cancer Biology

  • Human Cancer Biology
    A Novel Set of DNA Methylation Markers in Urine Sediments for Sensitive/Specific Detection of Bladder Cancer
    Jian Yu, Tongyu Zhu, Zhirou Wang, Hongyu Zhang, Ziliang Qian, Huili Xu, Baomei Gao, Wei Wang, Lianping Gu, Jun Meng, Jina Wang, Xu Feng, Yixue Li, Xuebiao Yao and Jingde Zhu
    Clin Cancer Res December 15 2007 13 (24) 7296-7304; DOI:10.1158/1078-0432.CCR-07-0861

  • Human Cancer Biology
    Estrogen Receptor Status Could Modulate the Genomic Pattern in Familial and Sporadic Breast Cancer
    Lorenzo Melchor, Emiliano Honrado, Jia Huang, Sara Álvarez, Tara L. Naylor, María J. García, Ana Osorio, David Blesa, Michael R. Stratton, Barbara L. Weber, Juan C. Cigudosa, Nazneen Rahman, Katherine L. Nathanson and Javier Benítez
    Clin Cancer Res December 15 2007 13 (24) 7305-7313; DOI:10.1158/1078-0432.CCR-07-0711

  • Human Cancer Biology
    Angiogenesis-Promoting Gene Patterns in Alveolar Soft Part Sarcoma
    Alexander J.F. Lazar, Parimal Das, Daniel Tuvin, Borys Korchin, Quansheng Zhu, Zeming Jin, Carla L. Warneke, Peter S. Zhang, Vivian Hernandez, Dolores Lopez-Terrada, Peter W. Pisters, Raphael E. Pollock and Dina Lev
    Clin Cancer Res December 15 2007 13 (24) 7314-7321; DOI:10.1158/1078-0432.CCR-07-0174

  • Human Cancer Biology
    EWSR1-CREB1 and EWSR1-ATF1 Fusion Genes in Angiomatoid Fibrous Histiocytoma
    Sabrina Rossi, Kàroly Szuhai, Marije Ijszenga, Hans J. Tanke, Lucia Zanatta, Raf Sciot, Christopher D.M. Fletcher, Angelo P. Dei Tos and Pancras C.W. Hogendoorn
    Clin Cancer Res December 15 2007 13 (24) 7322-7328; DOI:10.1158/1078-0432.CCR-07-1744

  • Human Cancer Biology
    HLA Tetramer–Based Artificial Antigen-Presenting Cells Efficiently Stimulate CTLs Specific for Malignant Glioma
    Xiaobing Jiang, Xiaoling Lu, Ruen Liu, Fangcheng Zhang and Hongyang Zhao
    Clin Cancer Res December 15 2007 13 (24) 7329-7334; DOI:10.1158/1078-0432.CCR-07-1025

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Mitochondrial Resequencing Arrays Detect Tumor-Specific Mutations in Salivary Rinses of Patients with Head and Neck Cancer
    Suhail K. Mithani, Ian M. Smith, Shaoyu Zhou, Andrew Gray, Wayne M. Koch, Anirban Maitra and Joseph A. Califano
    Clin Cancer Res December 15 2007 13 (24) 7335-7340; DOI:10.1158/1078-0432.CCR-07-0220

  • Imaging, Diagnosis, Prognosis
    Gene Expression-Based Molecular Diagnostic System for Malignant Gliomas Is Superior to Histological Diagnosis
    Mitsuaki Shirahata, Kyoko Iwao-Koizumi, Sakae Saito, Noriko Ueno, Masashi Oda, Nobuo Hashimoto, Jun A. Takahashi and Kikuya Kato
    Clin Cancer Res December 15 2007 13 (24) 7341-7356; DOI:10.1158/1078-0432.CCR-06-2789

  • Imaging, Diagnosis, Prognosis
    BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials
    Madeleine M.A. Tilanus-Linthorst, Inge-Marie Obdeijn, Wim C.J. Hop, Petrina A. Causer, Martin O. Leach, Ellen Warner, Linda Pointon, Kimberley Hill, Jan G.M. Klijn, Ruth M.L. Warren and Fiona J. Gilbert
    Clin Cancer Res December 15 2007 13 (24) 7357-7362; DOI:10.1158/1078-0432.CCR-07-0689

  • Imaging, Diagnosis, Prognosis
    Loss of Heterozygosity at D8S298 Is a Predictor for Long-term Survival of Patients with Tumor-Node-Metastasis Stage I of Hepatocellular Carcinoma
    Jin-Zhong Pang, Lun-Xiu Qin, Ning Ren, Zhen-Yu Hei, Qing-Hai Ye, Wei-Dong Jia, Bing-Sheng Sun, Guo-Ling Lin, Dao-Yong Liu, Yin-Kun Liu and Zhao-You Tang
    Clin Cancer Res December 15 2007 13 (24) 7363-7369; DOI:10.1158/1078-0432.CCR-07-0593

  • Imaging, Diagnosis, Prognosis
    Proteomic Profiling Identifies Afamin as a Potential Biomarker for Ovarian Cancer
    David Jackson, Rachel A. Craven, Richard C. Hutson, Ina Graze, Paul Lueth, Robert P. Tonge, Joanne L. Hartley, Janice A. Nickson, Steve J. Rayner, Colin Johnston, Benjamin Dieplinger, Michael Hubalek, Nafisa Wilkinson, Timothy J. Perren, Sean Kehoe, Geoffrey D. Hall, Guenter Daxenbichler, Hans Dieplinger, Peter J. Selby and Rosamonde E. Banks
    Clin Cancer Res December 15 2007 13 (24) 7370-7379; DOI:10.1158/1078-0432.CCR-07-0747

  • Imaging, Diagnosis, Prognosis
    PAM4-Reactive MUC1 Is a Biomarker for Early Pancreatic Adenocarcinoma
    David V. Gold, Zarir Karanjawala, David E. Modrak, David M. Goldenberg and Ralph H. Hruban
    Clin Cancer Res December 15 2007 13 (24) 7380-7387; DOI:10.1158/1078-0432.CCR-07-1488

  • Imaging, Diagnosis, Prognosis
    Hypoxia-Inducible Factor 1α in Clear Cell Renal Cell Carcinoma
    Tobias Klatte, David B. Seligson, Stephen B. Riggs, John T. Leppert, Maria K. Berkman, Mark D. Kleid, Hong Yu, Fairooz F. Kabbinavar, Allan J. Pantuck and Arie S. Belldegrun
    Clin Cancer Res December 15 2007 13 (24) 7388-7393; DOI:10.1158/1078-0432.CCR-07-0411

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib
    Nielka P. van Erp, Hans Gelderblom, Mats O. Karlsson, Jing Li, Ming Zhao, Jan Ouwerkerk, Johan W. Nortier, Henk-Jan Guchelaar, Sharyn D. Baker and Alex Sparreboom
    Clin Cancer Res December 15 2007 13 (24) 7394-7400; DOI:10.1158/1078-0432.CCR-07-0346

  • Cancer Therapy: Clinical
    Pharmacokinetic and Tumor Distribution Characteristics of Temsirolimus in Patients with Recurrent Malignant Glioma
    John G. Kuhn, Susan M. Chang, Patrick Y. Wen, Timothy F. Cloughesy, Harry Greenberg, David Schiff, Charles Conrad, Karen L. Fink, H. Ian Robins, Minesh Mehta, Lisa DeAngelis, Jeffrey Raizer, Kenneth Hess, Kathleen R. Lamborn, Janet Dancey, Michael D. Prados and ; for the North American Brain Tumor Consortium and the National Cancer Institute
    Clin Cancer Res December 15 2007 13 (24) 7401-7406; DOI:10.1158/1078-0432.CCR-07-0781

  • Cancer Therapy: Clinical
    l-Arginine Reduces Cell Proliferation and Ornithine Decarboxylase Activity in Patients with Colorectal Adenoma and Adenocarcinoma
    Qingyong Ma, Yunjian Wang, Xiaopeng Gao, Zhenhua Ma and Zhengjun Song
    Clin Cancer Res December 15 2007 13 (24) 7407-7412; DOI:10.1158/1078-0432.CCR-07-0751

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy
    Jennifer E. Quinn, Colin R. James, Gail E. Stewart, Jude M. Mulligan, Patricia White, Gary K.F. Chang, Paul B. Mullan, Patrick G. Johnston, Richard H. Wilson and D. Paul Harkin
    Clin Cancer Res December 15 2007 13 (24) 7413-7420; DOI:10.1158/1078-0432.CCR-07-1083

  • Cancer Therapy: Preclinical
    Pharmacodynamic Markers of Perifosine Efficacy
    Bryan T. Hennessy, Yiling Lu, Enrique Poradosu, Qianghua Yu, Shuangxing Yu, Hassan Hall, Mark S. Carey, Murali Ravoori, Ana Maria Gonzalez-Angulo, Robert Birch, I. Craig Henderson, Vikas Kundra and Gordon B. Mills
    Clin Cancer Res December 15 2007 13 (24) 7421-7431; DOI:10.1158/1078-0432.CCR-07-0760

  • Cancer Therapy: Preclinical
    Tumors Established with Cell Lines Selected for Oxaliplatin Resistance Respond to Oxaliplatin if Combined with Cetuximab
    Marie Prewett, Dhanvanthri S. Deevi, Rajiv Bassi, Fan Fan, Lee M. Ellis, Daniel J. Hicklin and James R. Tonra
    Clin Cancer Res December 15 2007 13 (24) 7432-7440; DOI:10.1158/1078-0432.CCR-07-1768

  • Cancer Therapy: Preclinical
    Modulation of Reactive Oxygen Species in Pancreatic Cancer
    Melissa L.T. Teoh, Wenqing Sun, Brian J. Smith, Larry W. Oberley and Joseph J. Cullen
    Clin Cancer Res December 15 2007 13 (24) 7441-7450; DOI:10.1158/1078-0432.CCR-07-0851

  • Cancer Therapy: Preclinical
    Differential Effects of Combined Ad5-Δ24RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma
    Martine L.M. Lamfers, Sander Idema, Lisette Bosscher, Stan Heukelom, Sharif Moeniralm, Ida H. van der Meulen-Muileman, Renée M. Overmeer, Paul van der Valk, Victor W. van Beusechem, Winald R. Gerritsen, W. Peter Vandertop and Clemens M.F. Dirven
    Clin Cancer Res December 15 2007 13 (24) 7451-7458; DOI:10.1158/1078-0432.CCR-07-1265

  • Cancer Therapy: Preclinical
    NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
    Cristina Maccalli, Daisuke Nonaka, Adriano Piris, Daniela Pende, Licia Rivoltini, Chiara Castelli and Giorgio Parmiani
    Clin Cancer Res December 15 2007 13 (24) 7459-7468; DOI:10.1158/1078-0432.CCR-07-1166

  • Cancer Therapy: Preclinical
    Allogeneic MHC Gene Transfer Enhances an Effective Antitumor Immunity in the Early Period of Autologous Hematopoietic Stem Cell Transplantation
    Akihiko Kobayashi, Hidehiko Hara, Masaki Ohashi, Takeshi Nishimoto, Kimiko Yoshida, Nobuhiro Ohkohchi, Teruhiko Yoshida and Kazunori Aoki
    Clin Cancer Res December 15 2007 13 (24) 7469-7479; DOI:10.1158/1078-0432.CCR-07-1163

  • Cancer Therapy: Preclinical
    Evidence for Microtubule Target Engagement in Tumors of Patients Receiving Ixabepilone
    Sen H. Zhuang, Y. Elizabeth Hung, Laura Hung, Robert W. Robey, Dan L. Sackett, W. Marston Linehan, Susan E. Bates, Tito Fojo and Marianne S. Poruchynsky
    Clin Cancer Res December 15 2007 13 (24) 7480-7486; DOI:10.1158/1078-0432.CCR-06-2883

  • Cancer Therapy: Preclinical
    Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer
    Aparna A. Kamat, William M. Merritt, Donna Coffey, Yvonne G. Lin, Pooja R. Patel, Russell Broaddus, Elizabeth Nugent, Liz Y. Han, Charles N. Landen Jr., Whitney A. Spannuth, Chunhua Lu, Robert L. Coleman, David M. Gershenson and Anil K. Sood
    Clin Cancer Res December 15 2007 13 (24) 7487-7495; DOI:10.1158/1078-0432.CCR-07-1017

  • Cancer Therapy: Preclinical
    Fractionated versus Standard Continuous Light Delivery in Interstitial Photodynamic Therapy of Dunning Prostate Carcinomas
    Zhengwen Xiao, Steve Halls, Dwayne Dickey, John Tulip and Ronald B. Moore
    Clin Cancer Res December 15 2007 13 (24) 7496-7505; DOI:10.1158/1078-0432.CCR-07-1561

Cancer Susceptibility and Prevention

  • Cancer Susceptibility and Prevention
    A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk
    Matjaž Rokavec, Christina Justenhoven, Werner Schroth, Monica Adina Istrate, Susanne Haas, Hans-Peter Fischer, Caren Vollmert, Thomas Illig, Ute Hamann, Yon-Dschun Ko, Damjan Glavač and Hiltrud Brauch
    Clin Cancer Res December 15 2007 13 (24) 7506-7514; DOI:10.1158/1078-0432.CCR-07-0457

  • Cancer Susceptibility and Prevention
    Analysis of hMLH1 Missense Mutations in East Asian Patients with Suspected Hereditary Nonpolyposis Colorectal Cancer
    Yimei Fan, Wei Wang, Ming Zhu, Jiji Zhou, Jingyuan Peng, Lizhi Xu, Zichun Hua, Xiang Gao and Yaping Wang
    Clin Cancer Res December 15 2007 13 (24) 7515-7521; DOI:10.1158/1078-0432.CCR-07-1028

Letters to the Editor

  • Letters to the Editor
    [11C]Docetaxel and Positron Emission Tomography for Noninvasive Measurements of Docetaxel Kinetics
    Astrid A.M. van der Veldt, Adriaan A. Lammertsma and N. Harry Hendrikse
    Clin Cancer Res December 15 2007 13 (24) 7522-7522; DOI:10.1158/1078-0432.CCR-07-1626

  • Letters to the Editor
    Daniel L. Gustafson, S. Gail Eckhardt and Erica L. Bradshaw-Pierce
    Clin Cancer Res December 15 2007 13 (24) 7522-7522; DOI:10.1158/1078-0432.CCR-07-1946

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Clinical Cancer Research: 13 (24)
December 2007
Volume 13, Issue 24
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Clinical Cancer Research
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