Drug-induced differentiation is considered a promising approach to eradicate stem-like tumor cells in glioma. In their study, Campos and colleagues analyzed potential effects of a retinoid-based differentiation therapy on the angiogenic behavior of stem-like glioma cells. The representative intravital fluorescence image on the cover shows vessel activity in the proximity of a retinoid-treated, green fluorescent protein-transfected tumor spheroid, placed on a cerebral mouse cortex. In vivo differentiated stem-like glioma cells showed only moderate signs of angiogenic activity and absent neovascularization, suggesting that differentiation therapy impairs their angiogenic behavior. For details, see the article by Campos and colleagues on page 2715 of this issue.