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Clinical Cancer Research

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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res November 1 2015 21 (21) 4741-4741;

CCR 20th Anniversary Commentary

  • CCR 20th Anniversary Commentary | Free Article
    CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer—Where Did It Start and Where Are We Now?
    Isabelle Gingras, Christine Desmedt, Michail Ignatiadis and Christos Sotiriou
    Clin Cancer Res November 1 2015 21 (21) 4743-4746; DOI:10.1158/1078-0432.CCR-14-3127

CCR Translations

  • CCR Translations
    Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations
    Rani E. George
    Clin Cancer Res November 1 2015 21 (21) 4747-4749; DOI:10.1158/1078-0432.CCR-15-1397

  • CCR Translations
    Less Can Be More for Gene Dose and Drug Sensitivity
    Susanne A. Gatz and Janet M. Shipley
    Clin Cancer Res November 1 2015 21 (21) 4750-4752; DOI:10.1158/1078-0432.CCR-15-1153

CCR New Strategies

  • CCR New Strategies
    New Strategies in Sarcoma: Linking Genomic and Immunotherapy Approaches to Molecular Subtype
    Jamie Lim, Neal M. Poulin and Torsten O. Nielsen
    Clin Cancer Res November 1 2015 21 (21) 4753-4759; DOI:10.1158/1078-0432.CCR-15-0831

CCR Perspectives in Drug Approval

  • CCR Perspectives in Drug Approval
    FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor–Positive, HER2-Negative Metastatic Breast Cancer
    Julia A. Beaver, Laleh Amiri-Kordestani, Rosane Charlab, Wei Chen, Todd Palmby, Amy Tilley, Jeanne Fourie Zirkelbach, Jingyu Yu, Qi Liu, Liang Zhao, Joyce Crich, Xiao Hong Chen, Minerva Hughes, Erik Bloomquist, Shenghui Tang, Rajeshwari Sridhara, Paul G. Kluetz, Geoffrey Kim, Amna Ibrahim, Richard Pazdur and Patricia Cortazar
    Clin Cancer Res November 1 2015 21 (21) 4760-4766; DOI:10.1158/1078-0432.CCR-15-1185

CCR Drug Updates

  • CCR Drug Updates | AuthorChoice
    Panobinostat for the Treatment of Multiple Myeloma
    Jacob P. Laubach, Philippe Moreau, Jesús F. San-Miguel and Paul G. Richardson
    Clin Cancer Res November 1 2015 21 (21) 4767-4773; DOI:10.1158/1078-0432.CCR-15-0530

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer
    Leticia Corrales and Thomas F. Gajewski
    Clin Cancer Res November 1 2015 21 (21) 4774-4779; DOI:10.1158/1078-0432.CCR-15-1362

  • Molecular Pathways
    Molecular Pathways: Targeting ATR in Cancer Therapy
    Larry M. Karnitz and Lee Zou
    Clin Cancer Res November 1 2015 21 (21) 4780-4785; DOI:10.1158/1078-0432.CCR-15-0479

Review

  • Review
    Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility
    Michail Ignatiadis, Mark Lee and Stefanie S. Jeffrey
    Clin Cancer Res November 1 2015 21 (21) 4786-4800; DOI:10.1158/1078-0432.CCR-14-1190

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
    David S. Hong, Razelle Kurzrock, Jennifer J. Wheler, Aung Naing, Gerald S. Falchook, Siqing Fu, Kevin B. Kim, Michael A. Davies, Ly M. Nguyen, Goldy C. George, Lucy Xu, Robert Shumaker, Min Ren, Jennifer Mink, Cynthia Bedell, Corina Andresen, Pallavi Sachdev, James P. O'Brien and John Nemunaitis
    Clin Cancer Res November 1 2015 21 (21) 4801-4810; DOI:10.1158/1078-0432.CCR-14-3063

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging | Free Article
    SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial
    Manuel Hidalgo, Carlos Plaza, Monica Musteanu, Peter Illei, Carrie B. Brachmann, Carla Heise, Daniel Pierce, Pedro P. Lopez-Casas, Camino Menendez, Josep Tabernero, Alfredo Romano, Xinyu Wei, Fernando Lopez-Rios and Daniel D. Von Hoff
    Clin Cancer Res November 1 2015 21 (21) 4811-4818; DOI:10.1158/1078-0432.CCR-14-3222

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors
    Shengjun Lu, Jinyu Zhang, Dai Liu, Guangfu Li, Kevin F. Staveley-O'Carroll, Zihai Li and Jennifer D. Wu
    Clin Cancer Res November 1 2015 21 (21) 4819-4830; DOI:10.1158/1078-0432.CCR-15-0845

  • Cancer Therapy: Preclinical | AuthorChoice
    Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
    Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers and Abdullah A. Osman
    Clin Cancer Res November 1 2015 21 (21) 4831-4844; DOI:10.1158/1078-0432.CCR-15-0279

  • Cancer Therapy: Preclinical
    siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
    Yoshiaki Yamamoto, Paulo J.C. Lin, Eliana Beraldi, Fan Zhang, Yoshihisa Kawai, Jeffrey Leong, Hidemasa Katsumi, Ladan Fazli, Robert Fraser, Pieter R. Cullis and Martin Gleave
    Clin Cancer Res November 1 2015 21 (21) 4845-4855; DOI:10.1158/1078-0432.CCR-15-0866

  • Cancer Therapy: Preclinical
    Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model
    Ruben Bill, Ernesta Fagiani, Adrian Zumsteg, Helena Antoniadis, David Johansson, Simon Haefliger, Imke Albrecht, Frank Hilberg and Gerhard Christofori
    Clin Cancer Res November 1 2015 21 (21) 4856-4867; DOI:10.1158/1078-0432.CCR-14-3036

Biology of Human Tumors

  • Biology of Human Tumors
    Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma
    Julie J.G. Kephart, Rosanne G.J. Tiller, Lisa E.S. Crose, Katherine K. Slemmons, Po-Han Chen, Ashley R. Hinson, Rex C. Bentley, Jen-Tsan Ashley Chi and Corinne M. Linardic
    Clin Cancer Res November 1 2015 21 (21) 4868-4880; DOI:10.1158/1078-0432.CCR-14-1797

  • Biology of Human Tumors
    MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
    Dong Qian, Kailin Chen, Haixia Deng, Huilan Rao, Huiqiang Huang, Yiji Liao, Xiaofei Sun, Suying Lu, Zhiyong Yuan, Dan Xie and Qingqing Cai
    Clin Cancer Res November 1 2015 21 (21) 4881-4891; DOI:10.1158/1078-0432.CCR-14-2947

  • Biology of Human Tumors
    LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
    Sofía Torres, Irene Garcia-Palmero, Mercedes Herrera, Rubén A. Bartolomé, Cristina Peña, M. Jesús Fernandez-Aceñero, Guillermo Padilla, Alberto Peláez-García, María Lopez-Lucendo, Rufo Rodriguez-Merlo, Antonio García de Herreros, Félix Bonilla and J. Ignacio Casal
    Clin Cancer Res November 1 2015 21 (21) 4892-4902; DOI:10.1158/1078-0432.CCR-14-3096

  • Biology of Human Tumors
    A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis
    Doug Hanniford, Judy Zhong, Lisa Koetz, Avital Gaziel-Sovran, Daniel J. Lackaye, Shulian Shang, Anna Pavlick, Richard Shapiro, Russell Berman, Farbod Darvishian, Yongzhao Shao, Iman Osman and Eva Hernando
    Clin Cancer Res November 1 2015 21 (21) 4903-4912; DOI:10.1158/1078-0432.CCR-14-2566

  • Biology of Human Tumors | AuthorChoice
    Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis
    Angela Bellini, Virginie Bernard, Quentin Leroy, Thomas Rio Frio, Gaelle Pierron, Valérie Combaret, Eve Lapouble, Nathalie Clement, Herve Rubie, Estelle Thebaud, Pascal Chastagner, Anne Sophie Defachelles, Christophe Bergeron, Nimrod Buchbinder, Sophie Taque, Anne Auvrignon, Dominique Valteau-Couanet, Jean Michon, Isabelle Janoueix-Lerosey, Olivier Delattre and Gudrun Schleiermacher
    Clin Cancer Res November 1 2015 21 (21) 4913-4921; DOI:10.1158/1078-0432.CCR-15-0423

  • Biology of Human Tumors
    miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
    Chao Cai, Qing-Biao Chen, Zhao-Dong Han, Yan-Qiong Zhang, Hui-Chan He, Jia-Hong Chen, Yan-Ru Chen, Sheng-Bang Yang, Yong-Ding Wu, Yan-Ru Zeng, Guo-Qiang Qin, Yu-Xiang Liang, Qi-Shan Dai, Fu-Neng Jiang, Shu-lin Wu, Guo-Hua Zeng, Wei-De Zhong and Chin-Lee Wu
    Clin Cancer Res November 1 2015 21 (21) 4922-4934; DOI:10.1158/1078-0432.CCR-15-0217

  • Biology of Human Tumors
    Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
    Konstantin Agelopoulos, Günther H.S. Richter, Eva Schmidt, Uta Dirksen, Kristina von Heyking, Benjamin Moser, Hans-Ulrich Klein, Udo Kontny, Martin Dugas, Kathrin Poos, Eberhard Korsching, Thorsten Buch, Matthias Weckesser, Isabell Schulze, Regina Besoke, Anika Witten, Monika Stoll, Gabriele Köhler, Wolfgang Hartmann, Eva Wardelmann, Claudia Rossig, Daniel Baumhoer, Heribert Jürgens, Stefan Burdach, Wolfgang E. Berdel and Carsten Müller-Tidow
    Clin Cancer Res November 1 2015 21 (21) 4935-4946; DOI:10.1158/1078-0432.CCR-14-2744

  • Biology of Human Tumors
    CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma
    Mary E. Olanich, Wenyue Sun, Stephen M. Hewitt, Zied Abdullaev, Svetlana D. Pack and Frederic G. Barr
    Clin Cancer Res November 1 2015 21 (21) 4947-4959; DOI:10.1158/1078-0432.CCR-14-2955

  • Biology of Human Tumors | AuthorChoice
    Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array
    Vinod Vathipadiekal, Victoria Wang, Wei Wei, Levi Waldron, Ronny Drapkin, Michael Gillette, Steven Skates and Michael Birrer
    Clin Cancer Res November 1 2015 21 (21) 4960-4969; DOI:10.1158/1078-0432.CCR-14-3173

  • Biology of Human Tumors
    Identification and Functional Validation of Reciprocal microRNA–mRNA Pairings in African American Prostate Cancer Disparities
    Bi-Dar Wang, Kristin Ceniccola, Qi Yang, Ramez Andrawis, Vyomesh Patel, Youngmi Ji, Johng Rhim, Jacqueline Olender, Anastas Popratiloff, Patricia Latham, Yinglei Lai, Steven R. Patierno and Norman H. Lee
    Clin Cancer Res November 1 2015 21 (21) 4970-4984; DOI:10.1158/1078-0432.CCR-14-1566

Letter to the Editor

  • Letter to the Editor
    AMER1 Is a Frequently Mutated Gene in Colorectal Cancer—Letter
    Pilar Mur, Gemma Aiza, Rebeca Sanz-Pamplona, Sara González, Matilde Navarro, Victor Moreno, Gabriel Capellá and Laura Valle
    Clin Cancer Res November 1 2015 21 (21) 4985-4985; DOI:10.1158/1078-0432.CCR-15-1756

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Clinical Cancer Research: 21 (21)
November 2015
Volume 21, Issue 21
  • Table of Contents
  • Table of Contents (PDF)
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Issue Highlights

  • miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
  • Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma
  • Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
  • MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
  • LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

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Clinical Cancer Research
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