Clinical Cancer Research: 21 (21)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res November 1 2015 21 (21) 4741-4741;

CCR 20th Anniversary Commentary

CCR 20th Anniversary Commentary | Free Article

CCR 20^th Anniversary Commentary: Gene-Expression Signature in Breast Cancer—Where Did It Start and Where Are We Now?

Isabelle Gingras, Christine Desmedt, Michail Ignatiadis and Christos Sotiriou

Clin Cancer Res November 1 2015 21 (21) 4743-4746; DOI:10.1158/1078-0432.CCR-14-3127

CCR Translations

CCR Translations

Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations

Rani E. George

Clin Cancer Res November 1 2015 21 (21) 4747-4749; DOI:10.1158/1078-0432.CCR-15-1397
CCR Translations

Less Can Be More for Gene Dose and Drug Sensitivity

Susanne A. Gatz and Janet M. Shipley

Clin Cancer Res November 1 2015 21 (21) 4750-4752; DOI:10.1158/1078-0432.CCR-15-1153

CCR New Strategies

CCR New Strategies

New Strategies in Sarcoma: Linking Genomic and Immunotherapy Approaches to Molecular Subtype

Jamie Lim, Neal M. Poulin and Torsten O. Nielsen

Clin Cancer Res November 1 2015 21 (21) 4753-4759; DOI:10.1158/1078-0432.CCR-15-0831

CCR Perspectives in Drug Approval

CCR Perspectives in Drug Approval

FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor–Positive, HER2-Negative Metastatic Breast Cancer

Julia A. Beaver, Laleh Amiri-Kordestani, Rosane Charlab, Wei Chen, Todd Palmby, Amy Tilley, Jeanne Fourie Zirkelbach, Jingyu Yu, Qi Liu, Liang Zhao, Joyce Crich, Xiao Hong Chen, Minerva Hughes, Erik Bloomquist, Shenghui Tang, Rajeshwari Sridhara, Paul G. Kluetz, Geoffrey Kim, Amna Ibrahim, Richard Pazdur and Patricia Cortazar

Clin Cancer Res November 1 2015 21 (21) 4760-4766; DOI:10.1158/1078-0432.CCR-15-1185

CCR Drug Updates

CCR Drug Updates | AuthorChoice

Panobinostat for the Treatment of Multiple Myeloma

Jacob P. Laubach, Philippe Moreau, Jesús F. San-Miguel and Paul G. Richardson

Clin Cancer Res November 1 2015 21 (21) 4767-4773; DOI:10.1158/1078-0432.CCR-15-0530

Molecular Pathways

Molecular Pathways

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

Leticia Corrales and Thomas F. Gajewski

Clin Cancer Res November 1 2015 21 (21) 4774-4779; DOI:10.1158/1078-0432.CCR-15-1362
Molecular Pathways

Molecular Pathways: Targeting ATR in Cancer Therapy

Larry M. Karnitz and Lee Zou

Clin Cancer Res November 1 2015 21 (21) 4780-4785; DOI:10.1158/1078-0432.CCR-15-0479

Review

Review

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility

Michail Ignatiadis, Mark Lee and Stefanie S. Jeffrey

Clin Cancer Res November 1 2015 21 (21) 4786-4800; DOI:10.1158/1078-0432.CCR-14-1190

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma

David S. Hong, Razelle Kurzrock, Jennifer J. Wheler, Aung Naing, Gerald S. Falchook, Siqing Fu, Kevin B. Kim, Michael A. Davies, Ly M. Nguyen, Goldy C. George, Lucy Xu, Robert Shumaker, Min Ren, Jennifer Mink, Cynthia Bedell, Corina Andresen, Pallavi Sachdev, James P. O'Brien and John Nemunaitis

Clin Cancer Res November 1 2015 21 (21) 4801-4810; DOI:10.1158/1078-0432.CCR-14-3063

Personalized Medicine and Imaging

Personalized Medicine and Imaging | Free Article

SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial

Manuel Hidalgo, Carlos Plaza, Monica Musteanu, Peter Illei, Carrie B. Brachmann, Carla Heise, Daniel Pierce, Pedro P. Lopez-Casas, Camino Menendez, Josep Tabernero, Alfredo Romano, Xinyu Wei, Fernando Lopez-Rios and Daniel D. Von Hoff

Clin Cancer Res November 1 2015 21 (21) 4811-4818; DOI:10.1158/1078-0432.CCR-14-3222

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors

Shengjun Lu, Jinyu Zhang, Dai Liu, Guangfu Li, Kevin F. Staveley-O'Carroll, Zihai Li and Jennifer D. Wu

Clin Cancer Res November 1 2015 21 (21) 4819-4830; DOI:10.1158/1078-0432.CCR-15-0845
Cancer Therapy: Preclinical | AuthorChoice

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV⁺ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers and Abdullah A. Osman

Clin Cancer Res November 1 2015 21 (21) 4831-4844; DOI:10.1158/1078-0432.CCR-15-0279
Cancer Therapy: Preclinical

siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer

Yoshiaki Yamamoto, Paulo J.C. Lin, Eliana Beraldi, Fan Zhang, Yoshihisa Kawai, Jeffrey Leong, Hidemasa Katsumi, Ladan Fazli, Robert Fraser, Pieter R. Cullis and Martin Gleave

Clin Cancer Res November 1 2015 21 (21) 4845-4855; DOI:10.1158/1078-0432.CCR-15-0866
Cancer Therapy: Preclinical

Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model

Ruben Bill, Ernesta Fagiani, Adrian Zumsteg, Helena Antoniadis, David Johansson, Simon Haefliger, Imke Albrecht, Frank Hilberg and Gerhard Christofori

Clin Cancer Res November 1 2015 21 (21) 4856-4867; DOI:10.1158/1078-0432.CCR-14-3036

Biology of Human Tumors

Biology of Human Tumors

Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma

Julie J.G. Kephart, Rosanne G.J. Tiller, Lisa E.S. Crose, Katherine K. Slemmons, Po-Han Chen, Ashley R. Hinson, Rex C. Bentley, Jen-Tsan Ashley Chi and Corinne M. Linardic

Clin Cancer Res November 1 2015 21 (21) 4868-4880; DOI:10.1158/1078-0432.CCR-14-1797
Biology of Human Tumors

MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16

Dong Qian, Kailin Chen, Haixia Deng, Huilan Rao, Huiqiang Huang, Yiji Liao, Xiaofei Sun, Suying Lu, Zhiyong Yuan, Dan Xie and Qingqing Cai

Clin Cancer Res November 1 2015 21 (21) 4881-4891; DOI:10.1158/1078-0432.CCR-14-2947
Biology of Human Tumors

LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

Sofía Torres, Irene Garcia-Palmero, Mercedes Herrera, Rubén A. Bartolomé, Cristina Peña, M. Jesús Fernandez-Aceñero, Guillermo Padilla, Alberto Peláez-García, María Lopez-Lucendo, Rufo Rodriguez-Merlo, Antonio García de Herreros, Félix Bonilla and J. Ignacio Casal

Clin Cancer Res November 1 2015 21 (21) 4892-4902; DOI:10.1158/1078-0432.CCR-14-3096
Biology of Human Tumors

A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis

Doug Hanniford, Judy Zhong, Lisa Koetz, Avital Gaziel-Sovran, Daniel J. Lackaye, Shulian Shang, Anna Pavlick, Richard Shapiro, Russell Berman, Farbod Darvishian, Yongzhao Shao, Iman Osman and Eva Hernando

Clin Cancer Res November 1 2015 21 (21) 4903-4912; DOI:10.1158/1078-0432.CCR-14-2566
Biology of Human Tumors | AuthorChoice

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis

Angela Bellini, Virginie Bernard, Quentin Leroy, Thomas Rio Frio, Gaelle Pierron, Valérie Combaret, Eve Lapouble, Nathalie Clement, Herve Rubie, Estelle Thebaud, Pascal Chastagner, Anne Sophie Defachelles, Christophe Bergeron, Nimrod Buchbinder, Sophie Taque, Anne Auvrignon, Dominique Valteau-Couanet, Jean Michon, Isabelle Janoueix-Lerosey, Olivier Delattre and Gudrun Schleiermacher

Clin Cancer Res November 1 2015 21 (21) 4913-4921; DOI:10.1158/1078-0432.CCR-15-0423
Biology of Human Tumors

miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer

Chao Cai, Qing-Biao Chen, Zhao-Dong Han, Yan-Qiong Zhang, Hui-Chan He, Jia-Hong Chen, Yan-Ru Chen, Sheng-Bang Yang, Yong-Ding Wu, Yan-Ru Zeng, Guo-Qiang Qin, Yu-Xiang Liang, Qi-Shan Dai, Fu-Neng Jiang, Shu-lin Wu, Guo-Hua Zeng, Wei-De Zhong and Chin-Lee Wu

Clin Cancer Res November 1 2015 21 (21) 4922-4934; DOI:10.1158/1078-0432.CCR-15-0217
Biology of Human Tumors

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

Konstantin Agelopoulos, Günther H.S. Richter, Eva Schmidt, Uta Dirksen, Kristina von Heyking, Benjamin Moser, Hans-Ulrich Klein, Udo Kontny, Martin Dugas, Kathrin Poos, Eberhard Korsching, Thorsten Buch, Matthias Weckesser, Isabell Schulze, Regina Besoke, Anika Witten, Monika Stoll, Gabriele Köhler, Wolfgang Hartmann, Eva Wardelmann, Claudia Rossig, Daniel Baumhoer, Heribert Jürgens, Stefan Burdach, Wolfgang E. Berdel and Carsten Müller-Tidow

Clin Cancer Res November 1 2015 21 (21) 4935-4946; DOI:10.1158/1078-0432.CCR-14-2744
Biology of Human Tumors

CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

Mary E. Olanich, Wenyue Sun, Stephen M. Hewitt, Zied Abdullaev, Svetlana D. Pack and Frederic G. Barr

Clin Cancer Res November 1 2015 21 (21) 4947-4959; DOI:10.1158/1078-0432.CCR-14-2955
Biology of Human Tumors | AuthorChoice

Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array

Vinod Vathipadiekal, Victoria Wang, Wei Wei, Levi Waldron, Ronny Drapkin, Michael Gillette, Steven Skates and Michael Birrer

Clin Cancer Res November 1 2015 21 (21) 4960-4969; DOI:10.1158/1078-0432.CCR-14-3173
Biology of Human Tumors

Identification and Functional Validation of Reciprocal microRNA–mRNA Pairings in African American Prostate Cancer Disparities

Bi-Dar Wang, Kristin Ceniccola, Qi Yang, Ramez Andrawis, Vyomesh Patel, Youngmi Ji, Johng Rhim, Jacqueline Olender, Anastas Popratiloff, Patricia Latham, Yinglei Lai, Steven R. Patierno and Norman H. Lee

Clin Cancer Res November 1 2015 21 (21) 4970-4984; DOI:10.1158/1078-0432.CCR-14-1566

Letter to the Editor

Letter to the Editor

AMER1 Is a Frequently Mutated Gene in Colorectal Cancer—Letter

Pilar Mur, Gemma Aiza, Rebeca Sanz-Pamplona, Sara González, Matilde Navarro, Victor Moreno, Gabriel Capellá and Laura Valle

Clin Cancer Res November 1 2015 21 (21) 4985-4985; DOI:10.1158/1078-0432.CCR-15-1756

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Table of Contents

Highlights

CCR 20th Anniversary Commentary

CCR Translations

CCR New Strategies

CCR Perspectives in Drug Approval

CCR Drug Updates

Molecular Pathways

Review

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

Letter to the Editor

Issue Highlights

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