Clinical Cancer Research: 22 (9)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res May 1 2016 22 (9) 2097-2097;

CCR Translations

CCR Translations

Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors

Eneda Toska and José Baselga

Clin Cancer Res May 1 2016 22 (9) 2099-2101; DOI:10.1158/1078-0432.CCR-16-0038
CCR Translations | Free Article

Predictive Biomarkers for PD-1 Axis Therapies: The Hidden Treasure or a Call for Research

Kurt A. Schalper, Edward Kaftan and Roy S. Herbst

Clin Cancer Res May 1 2016 22 (9) 2102-2104; DOI:10.1158/1078-0432.CCR-16-0169

CCR New Strategies

CCR New Strategies

New Strategies in Breast Cancer: Immunotherapy

Lajos Pusztai, Thomas Karn, Anton Safonov, Maysa M. Abu-Khalaf and Giampaolo Bianchini

Clin Cancer Res May 1 2016 22 (9) 2105-2110; DOI:10.1158/1078-0432.CCR-15-1315

CCR Perspectives in Regulatory Science and Policy

CCR Perspectives in Regulatory Science and Policy

The Majority of Expedited Investigational New Drug Safety Reports Are Uninformative

Jonathan P. Jarow, Sandra Casak, Meredith Chuk, Lori A. Ehrlich and Sean Khozin

Clin Cancer Res May 1 2016 22 (9) 2111-2113; DOI:10.1158/1078-0432.CCR-15-2082

Statistics in Clinical Cancer Research

Statistics in Clinical Cancer Research

Quantifying Treatment Benefit in Molecular Subgroups to Assess a Predictive Biomarker

Alexia Iasonos, Paul B. Chapman and Jaya M. Satagopan

Clin Cancer Res May 1 2016 22 (9) 2114-2120; DOI:10.1158/1078-0432.CCR-15-2517

Molecular Pathways

Molecular Pathways

Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment

Juan R. Cubillos-Ruiz, Sarah E. Bettigole and Laurie H. Glimcher

Clin Cancer Res May 1 2016 22 (9) 2121-2126; DOI:10.1158/1078-0432.CCR-15-1570

Perspectives

Perspectives | AuthorChoice

Are Doses and Schedules of Small-Molecule Targeted Anticancer Drugs Recommended by Phase I Studies Realistic?

Desamparados Roda, Begoña Jimenez and Udai Banerji

Clin Cancer Res May 1 2016 22 (9) 2127-2132; DOI:10.1158/1078-0432.CCR-15-1855
Perspectives | AuthorChoice

Defining the Value of a Comparative Approach to Cancer Drug Development

Amy K. LeBlanc, Christina N. Mazcko and Chand Khanna

Clin Cancer Res May 1 2016 22 (9) 2133-2138; DOI:10.1158/1078-0432.CCR-15-2347

Cancer Therapy: Clinical

Cancer Therapy: Clinical | AuthorChoice

A Phase Ib/II Study of Afatinib in Combination with Nimotuzumab in Non–Small Cell Lung Cancer Patients with Acquired Resistance to Gefitinib or Erlotinib

Ji Yun Lee, Jong-Mu Sun, Sung Hee Lim, Hae Su Kim, Kwai Han Yoo, Ki Sun Jung, Haa-Na Song, Bo Mi Ku, Jiae Koh, Yeon-Hee Bae, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park and Myung-Ju Ahn

Clin Cancer Res May 1 2016 22 (9) 2139-2145; DOI:10.1158/1078-0432.CCR-15-1653
Cancer Therapy: Clinical | AuthorChoice

A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors

Laura W. Goff, Roger B. Cohen, Jordan D. Berlin, Filippo G. de Braud, Andrej Lyshchik, Cristina Noberasco, Francesco Bertolini, Marina Carpentieri, Corrado Gallo Stampino, Antonello Abbattista, Erjan Wang and Hossein Borghaei

Clin Cancer Res May 1 2016 22 (9) 2146-2154; DOI:10.1158/1078-0432.CCR-15-1622
Cancer Therapy: Clinical | AuthorChoice

Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells

Gerty Schreibelt, Kalijn F. Bol, Harm Westdorp, Florian Wimmers, Erik H.J.G. Aarntzen, Tjitske Duiveman-de Boer, Mandy W.M.M. van de Rakt, Nicole M. Scharenborg, Annemiek J. de Boer, Jeanette M. Pots, Michel A.M. Olde Nordkamp, Tom G.M. van Oorschot, Jurjen Tel, Gregor Winkels, Katja Petry, Willeke A.M. Blokx, Michelle M. van Rossum, Marieke E.B. Welzen, Roel D.M. Mus, Sandra A.J. Croockewit, Rutger H.T. Koornstra, Joannes F.M. Jacobs, Sander Kelderman, Christian U. Blank, Winald R. Gerritsen, Cornelis J.A. Punt, Carl G. Figdor and I. Jolanda M. de Vries

Clin Cancer Res May 1 2016 22 (9) 2155-2166; DOI:10.1158/1078-0432.CCR-15-2205

Personalized Medicine and Imaging

Personalized Medicine and Imaging

Comparing Patient-Derived Xenograft and Computational Response Prediction for Targeted Therapy in Patients of Early-Stage Large Cell Lung Cancer

Jian Li, Changkun Ye and Ulrich R. Mansmann

Clin Cancer Res May 1 2016 22 (9) 2167-2176; DOI:10.1158/1078-0432.CCR-15-2401
Personalized Medicine and Imaging

Heterogeneity of Programmed Cell Death Ligand 1 Expression in Multifocal Lung Cancer

Aaron S. Mansfield, Stephen J. Murphy, Tobias Peikert, Eunhee S. Yi, George Vasmatzis, Dennis A. Wigle and Marie Christine Aubry

Clin Cancer Res May 1 2016 22 (9) 2177-2182; DOI:10.1158/1078-0432.CCR-15-2246
Personalized Medicine and Imaging | AuthorChoice

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors

Gregory V. Kryukov, Craig M. Bielski, Kaitlin Samocha, Menachem Fromer, Sara Seepo, Carleen Gentry, Benjamin Neale, Levi A. Garraway, Christopher J. Sweeney, Mary-Ellen Taplin and Eliezer M. Van Allen

Clin Cancer Res May 1 2016 22 (9) 2183-2189; DOI:10.1158/1078-0432.CCR-15-2317
Personalized Medicine and Imaging

Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[¹⁸F]fluoroethyl)-L-Tyrosine PET

Sied Kebir, Rolf Fimmers, Norbert Galldiks, Niklas Schäfer, Frederic Mack, Christina Schaub, Moritz Stuplich, Michael Niessen, Theophilos Tzaridis, Matthias Simon, Gabriele Stoffels, Karl-Josef Langen, Björn Scheffler, Martin Glas and Ulrich Herrlinger

Clin Cancer Res May 1 2016 22 (9) 2190-2196; DOI:10.1158/1078-0432.CCR-15-1334
Personalized Medicine and Imaging

Enumeration and Molecular Characterization of Tumor Cells in Lung Cancer Patients Using a Novel In Vivo Device for Capturing Circulating Tumor Cells

Tobias M. Gorges, Nicole Penkalla, Thomas Schalk, Simon A. Joosse, Sabine Riethdorf, Johannes Tucholski, Klaus Lücke, Harriet Wikman, Stephen Jackson, Nora Brychta, Oliver von Ahsen, Christian Schumann, Thomas Krahn and Klaus Pantel

Clin Cancer Res May 1 2016 22 (9) 2197-2206; DOI:10.1158/1078-0432.CCR-15-1416

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNFα/IL17 Dependent

Vy Phan-Lai, Yushe Dang, Ekram Gad, Jennifer Childs and Mary L. Disis

Clin Cancer Res May 1 2016 22 (9) 2207-2216; DOI:10.1158/1078-0432.CCR-15-2273
Cancer Therapy: Preclinical

The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma

Naiara Martínez-Vélez, Enric Xipell, Beatriz Vera, Arlet Acanda de la Rocha, Marta Zalacain, Lucía Marrodán, Marisol Gonzalez-Huarriz, Gemma Toledo, Manel Cascallo, Ramón Alemany, Ana Patiño and Marta M. Alonso

Clin Cancer Res May 1 2016 22 (9) 2217-2225; DOI:10.1158/1078-0432.CCR-15-1899
Cancer Therapy: Preclinical

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8⁺ T Cells

Julie S. Nielsen, Colin G. Sedgwick, Aniqa Shahid, Zusheng Zong, Zabrina L. Brumme, Stephen Yu, Lewis Liu, David R. Kroeger, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, Brian R. Berry, Marco A. Marra, Ryan D. Morin, Nicol Macpherson and Brad H. Nelson

Clin Cancer Res May 1 2016 22 (9) 2226-2236; DOI:10.1158/1078-0432.CCR-15-2023
Cancer Therapy: Preclinical

Identification of an Immunogenic Subset of Metastatic Uveal Melanoma

Luke D. Rothermel, Arvind C. Sabesan, Daniel J. Stephens, Smita S. Chandran, Biman C. Paria, Abhishek K. Srivastava, Robert Somerville, John R. Wunderlich, Chyi-Chia R. Lee, Liqiang Xi, Trinh H. Pham, Mark Raffeld, Parthav Jailwala, Manjula Kasoji and Udai S. Kammula

Clin Cancer Res May 1 2016 22 (9) 2237-2249; DOI:10.1158/1078-0432.CCR-15-2294
Cancer Therapy: Preclinical

Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

Wei Yang, Sarah R. Hosford, Lloye M. Dillon, Kevin Shee, Stephanie C. Liu, Jennifer R. Bean, Laurent Salphati, Jodie Pang, Xiaolin Zhang, Michelle A. Nannini, Eugene Demidenko, Darcy Bates, Lionel D. Lewis, Jonathan D. Marotti, Alan R. Eastman and Todd W. Miller

Clin Cancer Res May 1 2016 22 (9) 2250-2260; DOI:10.1158/1078-0432.CCR-15-2276

Biology of Human Tumors

Biology of Human Tumors

Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration

Chan-Young Ock, Bhumsuk Keam, Sehui Kim, Ju-Seog Lee, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung and Dae Seog Heo

Clin Cancer Res May 1 2016 22 (9) 2261-2270; DOI:10.1158/1078-0432.CCR-15-2834
Biology of Human Tumors

Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy

Stefania Catalano, Antonella Campana, Cinzia Giordano, Balázs Győrffy, Roberta Tarallo, Antonio Rinaldi, Giuseppina Bruno, Aurora Ferraro, Francesco Romeo, Marilena Lanzino, Fabio Naro, Daniela Bonofiglio, Sebastiano Andò and Ines Barone

Clin Cancer Res May 1 2016 22 (9) 2271-2282; DOI:10.1158/1078-0432.CCR-15-1900
Biology of Human Tumors

Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer

Neil M. Iyengar, Xi Kathy Zhou, Ayca Gucalp, Patrick G. Morris, Louise R. Howe, Dilip D. Giri, Monica Morrow, Hanhan Wang, Michael Pollak, Lee W. Jones, Clifford A. Hudis and Andrew J. Dannenberg

Clin Cancer Res May 1 2016 22 (9) 2283-2289; DOI:10.1158/1078-0432.CCR-15-2239
Biology of Human Tumors | AuthorChoice

Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas

Ryan D. Morin, Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, Stephen Yu, Daniel Fornika, Kevin Bushell, Torsten Holm Nielsen, Tina Petrogiannis-Haliotis, Michael Crump, Axel Tosikyan, Bruno M. Grande, David MacDonald, Caroline Rousseau, Maryam Bayat, Pierre Sesques, Remi Froment, Marco Albuquerque, Yury Monczak, Kathleen Klein Oros, Celia Greenwood, Yasser Riazalhosseini, Madeleine Arseneault, Errol Camlioglu, André Constantin, Qiang Pan-Hammarstrom, Roujun Peng, Koren K. Mann and Nathalie A. Johnson

Clin Cancer Res May 1 2016 22 (9) 2290-2300; DOI:10.1158/1078-0432.CCR-15-2123
Biology of Human Tumors

Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas

Rodrigo A. Toledo, Yuejuan Qin, Zi-Ming Cheng, Qing Gao, Shintaro Iwata, Gustavo M. Silva, Manju L. Prasad, I. Tolgay Ocal, Sarika Rao, Neil Aronin, Marta Barontini, Jan Bruder, Robert L. Reddick, Yidong Chen, Ricardo C.T. Aguiar and Patricia L.M. Dahia

Clin Cancer Res May 1 2016 22 (9) 2301-2310; DOI:10.1158/1078-0432.CCR-15-1841

Letter to the Editor

Letter to the Editor

Significance of FcγRIIIa-V158F Polymorphism—Letter

Janardan P. Pandey

Clin Cancer Res May 1 2016 22 (9) 2311-2311; DOI:10.1158/1078-0432.CCR-16-0428

Corrections

Corrections

Correction: Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET

Clin Cancer Res May 1 2016 22 (9) 2312-2312; DOI:10.1158/1078-0432.CCR-16-0034
Corrections

Correction: Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas

Clin Cancer Res May 1 2016 22 (9) 2313-2313; DOI:10.1158/1078-0432.CCR-16-0703

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Table of Contents

Highlights

CCR Translations

CCR New Strategies

CCR Perspectives in Regulatory Science and Policy

Statistics in Clinical Cancer Research

Molecular Pathways

Perspectives

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

Letter to the Editor

Corrections

Issue Highlights

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