Clinical Cancer Research: 23 (6)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res March 15 2017 23 (6) 1363-1363;

CCR Translations

CCR Translations

Predicting MEK Inhibitor Response in Lung Cancer: A Proper Signature Is Required

Yaohua Xue and Piro Lito

Clin Cancer Res March 15 2017 23 (6) 1365-1367; DOI:10.1158/1078-0432.CCR-16-2576

CCR Perspectives in Regulatory Science and Policy

CCR Perspectives in Regulatory Science and Policy

An FDA Perspective on the Regulatory Implications of Complex Signatures to Predict Response to Targeted Therapies

Julia A. Beaver, Abraham Tzou, Gideon M. Blumenthal, Amy E. McKee, Geoffrey Kim, Richard Pazdur and Reena Philip

Clin Cancer Res March 15 2017 23 (6) 1368-1372; DOI:10.1158/1078-0432.CCR-16-1098

Molecular Pathways

Molecular Pathways

Molecular Pathways: Mucins and Drug Delivery in Cancer

Chinthalapally V. Rao, Naveena B. Janakiram and Altaf Mohammed

Clin Cancer Res March 15 2017 23 (6) 1373-1378; DOI:10.1158/1078-0432.CCR-16-0862

Review

Review

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

Adeeb Derakhshan, Zhong Chen and Carter Van Waes

Clin Cancer Res March 15 2017 23 (6) 1379-1387; DOI:10.1158/1078-0432.CCR-16-2172

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

Chad Tang, James W. Welsh, Patricia de Groot, Erminia Massarelli, Joe Y. Chang, Kenneth R. Hess, Sreyashi Basu, Michael A. Curran, Maria E. Cabanillas, Vivek Subbiah, Siqing Fu, Apostolia M. Tsimberidou, Daniel Karp, Daniel R. Gomez, Adi Diab, Ritsuko Komaki, John V. Heymach, Padmanee Sharma, Aung Naing and David S. Hong

Clin Cancer Res March 15 2017 23 (6) 1388-1396; DOI:10.1158/1078-0432.CCR-16-1432
Cancer Therapy: Clinical

Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer

Jung-Min Lee, Cody J. Peer, Minshu Yu, Lauren Amable, Nicolas Gordon, Christina M. Annunziata, Nicole Houston, Andrew K.L. Goey, Tristan M. Sissung, Bernard Parker, Lori Minasian, Victoria L. Chiou, Robert F. Murphy, Brigitte C. Widemann, William D. Figg and Elise C. Kohn

Clin Cancer Res March 15 2017 23 (6) 1397-1406; DOI:10.1158/1078-0432.CCR-16-1546
Cancer Therapy: Clinical

Modifying the Clinical Research Infrastructure at a Dedicated Clinical Trials Unit: Assessment of Trial Development, Activation, and Participant Accrual

Chad Tang, Kenneth R. Hess, Dwana Sanders, Suzanne E. Davis, Aman U. Buzdar, Razelle Kurzrock, J. Jack Lee, Funda Meric-Bernstam and David S. Hong

Clin Cancer Res March 15 2017 23 (6) 1407-1413; DOI:10.1158/1078-0432.CCR-16-1936
Cancer Therapy: Clinical

Clinical Trial Characteristics and Barriers to Participant Accrual: The MD Anderson Cancer Center Experience over 30 years, a Historical Foundation for Trial Improvement

Chad Tang, Steven I. Sherman, Mellanie Price, Jun Weng, Suzanne E. Davis, David S. Hong, James C. Yao, Aman Buzdar, George Wilding and J. Jack Lee

Clin Cancer Res March 15 2017 23 (6) 1414-1421; DOI:10.1158/1078-0432.CCR-16-2439

Personalized Medicine and Imaging

Personalized Medicine and Imaging

Serum Metabolomic Profiles Identify ER-Positive Early Breast Cancer Patients at Increased Risk of Disease Recurrence in a Multicenter Population

Christopher D. Hart, Alessia Vignoli, Leonardo Tenori, Gemma Leonora Uy, Ta Van To, Clement Adebamowo, Syed Mozammel Hossain, Laura Biganzoli, Emanuela Risi, Richard R. Love, Claudio Luchinat and Angelo Di Leo

Clin Cancer Res March 15 2017 23 (6) 1422-1431; DOI:10.1158/1078-0432.CCR-16-1153
Personalized Medicine and Imaging | AuthorChoice

¹⁸F-fluoromisonidazole PET and Activity of Neoadjuvant Nintedanib in Early HER2-Negative Breast Cancer: A Window-of-Opportunity Randomized Trial

Miguel Quintela-Fandino, Ana Lluch, Luis Manso, Isabel Calvo, Javier Cortes, José Angel García-Saenz, Miguel Gil-Gil, Noelia Martinez-Jánez, Antonio Gonzalez-Martin, Encarna Adrover, Raquel de Andres, Gemma Viñas, Antonio Llombart-Cussac, Emilio Alba, Juan Guerra, Begoña Bermejo, Esther Zamora, Fernando Moreno-Anton, Sonia Pernas Simon, Alfredo Carrato, Antonio Lopez-Alonso, María José Escudero, Ruth Campo, Eva Carrasco, José Palacios, Francisca Mulero and Ramon Colomer

Clin Cancer Res March 15 2017 23 (6) 1432-1441; DOI:10.1158/1078-0432.CCR-16-0738
Personalized Medicine and Imaging

Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules

Ying Liu, Yoganand Balagurunathan, Thomas Atwater, Sanja Antic, Qian Li, Ronald C. Walker, Gary T. Smith, Pierre P. Massion, Matthew B. Schabath and Robert J. Gillies

Clin Cancer Res March 15 2017 23 (6) 1442-1449; DOI:10.1158/1078-0432.CCR-15-3102
Personalized Medicine and Imaging

Identification of Keratin 19–Positive Cancer Stem Cells Associating Human Hepatocellular Carcinoma Using ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

Takayuki Kawai, Kentaro Yasuchika, Satoru Seo, Tatsuya Higashi, Takamichi Ishii, Yuya Miyauchi, Hidenobu Kojima, Ryoya Yamaoka, Hokahiro Katayama, Elena Yukie Yoshitoshi, Satoshi Ogiso, Sadahiko Kita, Katsutaro Yasuda, Ken Fukumitsu, Yuji Nakamoto, Etsuro Hatano and Shinji Uemoto

Clin Cancer Res March 15 2017 23 (6) 1450-1460; DOI:10.1158/1078-0432.CCR-16-0871
Personalized Medicine and Imaging

Co-clinical Assessment of Tumor Cellularity in Pancreatic Cancer

Irina Heid, Katja Steiger, Marija Trajkovic-Arsic, Marcus Settles, Manuela R. Eßwein, Mert Erkan, Jörg Kleeff, Carsten Jäger, Helmut Friess, Bernhard Haller, Andreas Steingötter, Roland M. Schmid, Markus Schwaiger, Ernst J. Rummeny, Irene Esposito, Jens T. Siveke and Rickmer F. Braren

Clin Cancer Res March 15 2017 23 (6) 1461-1470; DOI:10.1158/1078-0432.CCR-15-2432
Personalized Medicine and Imaging | AuthorChoice

Clinically Viable Gene Expression Assays with Potential for Predicting Benefit from MEK Inhibitors

Roz Brant, Alan Sharpe, Tom Liptrot, Jonathan R. Dry, Elizabeth A. Harrington, J. Carl Barrett, Nicky Whalley, Christopher Womack, Paul Smith and Darren R. Hodgson

Clin Cancer Res March 15 2017 23 (6) 1471-1480; DOI:10.1158/1078-0432.CCR-16-0021

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models

Deborah DeRyckere, Alisa B. Lee-Sherick, Madeline G. Huey, Amanda A. Hill, Jeffrey W. Tyner, Kristen M. Jacobsen, Lauren S. Page, Gregory G. Kirkpatrick, Fatma Eryildiz, Stephanie A. Montgomery, Weihe Zhang, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp and Douglas K. Graham

Clin Cancer Res March 15 2017 23 (6) 1481-1492; DOI:10.1158/1078-0432.CCR-16-1330
Cancer Therapy: Preclinical

The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia

Alba Matas-Céspedes, Anna Vidal-Crespo, Vanina Rodriguez, Neus Villamor, Julio Delgado, Eva Giné, Heleia Roca-Ho, Pablo Menéndez, Elías Campo, Armando López-Guillermo, Dolors Colomer, Gaël Roué, Adrian Wiestner, Paul W.H.I. Parren, Parul Doshi, Jeroen Lammerts van Bueren and Patricia Pérez-Galán

Clin Cancer Res March 15 2017 23 (6) 1493-1505; DOI:10.1158/1078-0432.CCR-15-2095
Cancer Therapy: Preclinical | AuthorChoice

MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

Liqin Liu, Chia-Ying K. Lam, Vatana Long, Lusiana Widjaja, Yinhua Yang, Hua Li, Linda Jin, Steve Burke, Sergey Gorlatov, Jennifer Brown, Ralph Alderson, Margaret D. Lewis, Jeffrey L. Nordstrom, Scott Koenig, Paul A. Moore, Syd Johnson and Ezio Bonvini

Clin Cancer Res March 15 2017 23 (6) 1506-1518; DOI:10.1158/1078-0432.CCR-16-0666
Cancer Therapy: Preclinical | AuthorChoice

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus

Mohanraj Ramachandran, Di Yu, Matheus Dyczynski, Sathishkumar Baskaran, Lei Zhang, Aleksei Lulla, Valeria Lulla, Sirle Saul, Sven Nelander, Anna Dimberg, Andres Merits, Justyna Leja-Jarblad and Magnus Essand

Clin Cancer Res March 15 2017 23 (6) 1519-1530; DOI:10.1158/1078-0432.CCR-16-0925
Cancer Therapy: Preclinical

AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition

Hannah A. Scarborough, Barbara A. Helfrich, Matias Casás-Selves, Alwin G. Schuller, Shaun E. Grosskurth, Jihye Kim, Aik-Choon Tan, Daniel C. Chan, Zhiyong Zhang, Vadym Zaberezhnyy, Paul A. Bunn and James DeGregori

Clin Cancer Res March 15 2017 23 (6) 1531-1541; DOI:10.1158/1078-0432.CCR-16-1179
Cancer Therapy: Preclinical

BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Iris Sze Ue Luk, Raunak Shrestha, Hui Xue, Yuwei Wang, Fang Zhang, Dong Lin, Anne Haegert, Rebecca Wu, Xin Dong, Colin C. Collins, Amina Zoubeidi, Martin E. Gleave, Peter W. Gout and Yuzhuo Wang

Clin Cancer Res March 15 2017 23 (6) 1542-1551; DOI:10.1158/1078-0432.CCR-16-0718
Cancer Therapy: Preclinical | AuthorChoice

Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

Ying Chen, Sandra Catalina Camacho, Thomas R. Silvers, Albiruni R.A. Razak, Nashat Y. Gabrail, John F. Gerecitano, Eva Kalir, Elena Pereira, Brad R. Evans, Susan J. Ramus, Fei Huang, Nolan Priedigkeit, Estefania Rodriguez, Michael Donovan, Faisal Khan, Tamara Kalir, Robert Sebra, Andrew Uzilov, Rong Chen, Rileen Sinha, Richard Halpert, Jean-Noel Billaud, Sharon Shacham, Dilara McCauley, Yosef Landesman, Tami Rashal, Michael Kauffman, Mansoor R. Mirza, Morten Mau-Sørensen, Peter Dottino and John A. Martignetti

Clin Cancer Res March 15 2017 23 (6) 1552-1563; DOI:10.1158/1078-0432.CCR-16-1333
Cancer Therapy: Preclinical

Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response

Jingli Zhang, Swati Khanna, Qun Jiang, Christine Alewine, Markku Miettinen, Ira Pastan and Raffit Hassan

Clin Cancer Res March 15 2017 23 (6) 1564-1574; DOI:10.1158/1078-0432.CCR-16-1667

Biology of Human Tumors

Biology of Human Tumors | AuthorChoice

Interleukin-17–Producing Neutrophils Link Inflammatory Stimuli to Disease Progression by Promoting Angiogenesis in Gastric Cancer

Tuan-Jie Li, Yu-Ming Jiang, Yan-Feng Hu, Lei Huang, Jiang Yu, Li-Ying Zhao, Hai-Jun Deng, Ting-Yu Mou, Hao Liu, Yang Yang, Qi Zhang and Guo-Xin Li

Clin Cancer Res March 15 2017 23 (6) 1575-1585; DOI:10.1158/1078-0432.CCR-16-0617
Biology of Human Tumors

Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma

Phu Hung Nguyen, Julie Giraud, Lucie Chambonnier, Pierre Dubus, Linda Wittkop, Geneviève Belleannée, Denis Collet, Isabelle Soubeyran, Serge Evrard, Benoit Rousseau, Nathalie Senant-Dugot, Francis Mégraud, Frédéric Mazurier and Christine Varon

Clin Cancer Res March 15 2017 23 (6) 1586-1597; DOI:10.1158/1078-0432.CCR-15-2157
Biology of Human Tumors

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival

Joo Young Kim, Jacqueline A. Brosnan-Cashman, Soyeon An, Sung Joo Kim, Ki-Byung Song, Min-Sun Kim, Mi-Ju Kim, Dae Wook Hwang, Alan K. Meeker, Eunsil Yu, Song Cheol Kim, Ralph H. Hruban, Christopher M. Heaphy and Seung-Mo Hong

Clin Cancer Res March 15 2017 23 (6) 1598-1606; DOI:10.1158/1078-0432.CCR-16-1147
Biology of Human Tumors | AuthorChoice

Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer

Yi Zhong, Anne Macgregor-Das, Tyler Saunders, Martin C. Whittle, Alvin Makohon-Moore, Zachary A. Kohutek, Justin Poling, Brian T. Herbst, Breanna M. Javier, Leslie Cope, Steven D. Leach, Sunil R. Hingorani and Christine A. Iacobuzio-Donahue

Clin Cancer Res March 15 2017 23 (6) 1607-1620; DOI:10.1158/1078-0432.CCR-15-1615

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Table of Contents

Highlights

CCR Translations

CCR Perspectives in Regulatory Science and Policy

Molecular Pathways

Review

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

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