Clinical Cancer Research: 24 (8)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res April 15 2018 24 (8) 1771-1771;

Editorial

Editorial

Introducing a New Series: Immunotherapy Facts and Hopes

Ignacio Melero, Mario Sznol, Marlowe S. Tessmer, Theresa L. Whiteside and Jedd D. Wolchok

Clin Cancer Res April 15 2018 24 (8) 1773-1774; DOI:10.1158/1078-0432.CCR-18-0408

CCR Translations

CCR Translations

Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver

Matthew G. Oser and Pasi A. Jänne

Clin Cancer Res April 15 2018 24 (8) 1775-1776; DOI:10.1158/1078-0432.CCR-17-3646
CCR Translations

Harnessing the Power of Patient-Reported Outcomes in Oncology

Ryan D. Nipp and Jennifer S. Temel

Clin Cancer Res April 15 2018 24 (8) 1777-1779; DOI:10.1158/1078-0432.CCR-18-0037

CCR Perspectives in Regulatory Science and Policy

CCR Perspectives in Regulatory Science and Policy

Use of PRO Measures to Inform Tolerability in Oncology Trials: Implications for Clinical Review, IND Safety Reporting, and Clinical Site Inspections

Janice Kim, Harpreet Singh, Kassa Ayalew, Kristina Borror, Michelle Campbell, Laura Lee Johnson, Alyson Karesh, Ni A. Khin, Joanne R. Less, Jerry Menikoff, Lori Minasian, Sandra A. Mitchell, Elektra J. Papadopoulos, Richard L. Piekarz, Kevin A. Prohaska, Susan Thompson, Rajeshwari Sridhara, Richard Pazdur and Paul G. Kluetz

Clin Cancer Res April 15 2018 24 (8) 1780-1784; DOI:10.1158/1078-0432.CCR-17-2555

Review

Review

Analysis of Drug Development Paradigms for Immune Checkpoint Inhibitors

Denis L. Jardim, Débora de Melo Gagliato, Francis J. Giles and Razelle Kurzrock

Clin Cancer Res April 15 2018 24 (8) 1785-1794; DOI:10.1158/1078-0432.CCR-17-1970

Perspectives

Perspectives | AuthorChoice

Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain?

Sheheryar Kabraji, Jing Ni, Nancy U. Lin, Shaozhen Xie, Eric P. Winer and Jean J. Zhao

Clin Cancer Res April 15 2018 24 (8) 1795-1804; DOI:10.1158/1078-0432.CCR-17-3351

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Pembrolizumab Plus Pegylated Interferon alfa-2b or Ipilimumab for Advanced Melanoma or Renal Cell Carcinoma: Dose-Finding Results from the Phase Ib KEYNOTE-029 Study

Michael B. Atkins, F. Stephen Hodi, John A. Thompson, David F. McDermott, Wen-Jen Hwu, Donald P. Lawrence, Nancy A. Dawson, Deborah J. Wong, Shailender Bhatia, Marihella James, Lokesh Jain, Seth Robey, Xinxin Shu, Blanca Homet Moreno, Rodolfo F. Perini, Toni K. Choueiri and Antoni Ribas

Clin Cancer Res April 15 2018 24 (8) 1805-1815; DOI:10.1158/1078-0432.CCR-17-3436
Cancer Therapy: Clinical | AuthorChoice

Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer

Neil H. Segal, Aiwu R. He, Toshihiko Doi, Ronald Levy, Shailender Bhatia, Michael J. Pishvaian, Rossano Cesari, Ying Chen, Craig B. Davis, Bo Huang, Aron D. Thall and Ajay K. Gopal

Clin Cancer Res April 15 2018 24 (8) 1816-1823; DOI:10.1158/1078-0432.CCR-17-1922
Cancer Therapy: Clinical

Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials

Yu-Pei Chen, Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P. Hui, Anthony T.C. Chan, Whee-Sze Ong, Terence Tan, Joseph Wee, Wen-Fei Li, Lei Chen, Brigette B.Y. Ma, Macy Tong, Sze-Huey Tan, Shie-Lee Cheah, Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Ying Guo, Ai-Hua Lin, Ying Sun, Ming-Huang Hong, Su-Mei Cao, Ming-Yuan Chen and Jun Ma

Clin Cancer Res April 15 2018 24 (8) 1824-1833; DOI:10.1158/1078-0432.CCR-17-2656
Cancer Therapy: Clinical | AuthorChoice

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML

Andreas T. Björklund, Mattias Carlsten, Ebba Sohlberg, Lisa L. Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley, Jeffrey S. Miller, Monika Klimkowska, Marie Schaffer, Emma Watz, Kristina Wikström, Pontus Blomberg, Björn Engelbrekt Wahlin, Marzia Palma, Lotta Hansson, Per Ljungman, Eva Hellström-Lindberg, Hans-Gustaf Ljunggren and Karl-Johan Malmberg

Clin Cancer Res April 15 2018 24 (8) 1834-1844; DOI:10.1158/1078-0432.CCR-17-3196
Cancer Therapy: Clinical

Pathological Response in a Triple-Negative Breast Cancer Cohort Treated with Neoadjuvant Carboplatin and Docetaxel According to Lehmann's Refined Classification

Isabel Echavarria, Sara López-Tarruella, Antoni Picornell, Jose Ángel García-Saenz, Yolanda Jerez, Katherine Hoadley, Henry L. Gómez, Fernando Moreno, María Del Monte-Millan, Iván Márquez-Rodas, Enrique Alvarez, Rocío Ramos-Medina, Javier Gayarre, Tatiana Massarrah, Inmaculada Ocaña, María Cebollero, Hugo Fuentes, Agusti Barnadas, Ana Isabel Ballesteros, Uriel Bohn, Charles M. Perou and Miguel Martin

Clin Cancer Res April 15 2018 24 (8) 1845-1852; DOI:10.1158/1078-0432.CCR-17-1912

Personalized Medicine and Imaging

Personalized Medicine and Imaging | AuthorChoice

HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

Carlos D. Martins, Chiara Da Pieve, Thomas A. Burley, Rhodri Smith, Daniela M. Ciobota, Louis Allott, Kevin J. Harrington, Wim J.G. Oyen, Graham Smith and Gabriela Kramer-Marek

Clin Cancer Res April 15 2018 24 (8) 1853-1865; DOI:10.1158/1078-0432.CCR-17-2754
Personalized Medicine and Imaging

Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients

Britt I. Drögemöller, Beth Brooks, Carol Critchley, José G. Monzon, Galen E.B. Wright, Geoffrey Liu, Daniel J. Renouf, Christian K. Kollmannsberger, Philippe L. Bedard, Michael R. Hayden, Karen A. Gelmon, Bruce C. Carleton and Colin J.D. Ross

Clin Cancer Res April 15 2018 24 (8) 1866-1871; DOI:10.1158/1078-0432.CCR-17-2810
Personalized Medicine and Imaging

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA

Sarah B. Goldberg, Azeet Narayan, Adam J. Kole, Roy H. Decker, Jimmitti Teysir, Nicholas J. Carriero, Angela Lee, Roxanne Nemati, Sameer K. Nath, Shrikant M. Mane, Yanhong Deng, Nitin Sukumar, Daniel Zelterman, Daniel J. Boffa, Katerina Politi, Scott N. Gettinger, Lynn D. Wilson, Roy S. Herbst and Abhijit A. Patel

Clin Cancer Res April 15 2018 24 (8) 1872-1880; DOI:10.1158/1078-0432.CCR-17-1341
Personalized Medicine and Imaging | AuthorChoice

Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus

Alexa B. Schrock, Dean Pavlick, Samuel J. Klempner, Jon H. Chung, Brady Forcier, Allison Welsh, Lauren Young, Bryan Leyland-Jones, Rodolfo Bordoni, Richard D. Carvajal, Joseph Chao, Razelle Kurzrock, Jason K. Sicklick, Jeffrey S. Ross, Philip J. Stephens, Craig Devoe, Fadi Braiteh, Siraj M. Ali and Vincent A. Miller

Clin Cancer Res April 15 2018 24 (8) 1881-1890; DOI:10.1158/1078-0432.CCR-17-3103

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

Andrew Stiff, Prashant Trikha, Bethany Mundy-Bosse, Elizabeth McMichael, Thomas A. Mace, Brooke Benner, Kari Kendra, Amanda Campbell, Shalini Gautam, David Abood, Ian Landi, Vincent Hsu, Megan Duggan, Robert Wesolowski, Matthew Old, John Harrison Howard, Lianbo Yu, Nancy Stasik, Thomas Olencki, Natarajan Muthusamy, Susheela Tridandapani, John C. Byrd, Michael Caligiuri and William E. Carson

Clin Cancer Res April 15 2018 24 (8) 1891-1904; DOI:10.1158/1078-0432.CCR-17-0691
Cancer Therapy: Preclinical

A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers

Shoumin Zhu, Zheng Chen, Lihong Wang, Dunfa Peng, Abbes Belkhiri, A. Craig Lockhart and Wael El-Rifai

Clin Cancer Res April 15 2018 24 (8) 1905-1916; DOI:10.1158/1078-0432.CCR-17-1716
Cancer Therapy: Preclinical | AuthorChoice

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair

Cristina Maranto, Vindhya Udhane, David T. Hoang, Lei Gu, Vitali Alexeev, Kareem Malas, Karmel Cardenas, Jonathan R. Brody, Ulrich Rodeck, Carmen Bergom, Ken A. Iczkowski, Ken Jacobsohn, William See, Sara M. Schmitt and Marja T. Nevalainen

Clin Cancer Res April 15 2018 24 (8) 1917-1931; DOI:10.1158/1078-0432.CCR-17-2768
Cancer Therapy: Preclinical

Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

Jessica D. Lang, William P.D. Hendricks, Krystal A. Orlando, Hongwei Yin, Jeffrey Kiefer, Pilar Ramos, Ritin Sharma, Patrick Pirrotte, Elizabeth A. Raupach, Chris Sereduk, Nanyun Tang, Winnie S. Liang, Megan Washington, Salvatore J. Facista, Victoria L. Zismann, Emily M. Cousins, Michael B. Major, Yemin Wang, Anthony N. Karnezis, Aleksandar Sekulic, Ralf Hass, Barbara C. Vanderhyden, Praveen Nair, Bernard E. Weissman, David G. Huntsman and Jeffrey M. Trent

Clin Cancer Res April 15 2018 24 (8) 1932-1943; DOI:10.1158/1078-0432.CCR-17-1928
Cancer Therapy: Preclinical

Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors

Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse and Yves Pommier

Clin Cancer Res April 15 2018 24 (8) 1944-1953; DOI:10.1158/1078-0432.CCR-17-0443

Biology of Human Tumors

Biology of Human Tumors

Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1–Negative Human Lung Cancers

Haiying Cheng, Alain Borczuk, Murali Janakiram, Xiaoxin Ren, Juan Lin, Amer Assal, Balazs Halmos, Roman Perez-Soler and Xingxing Zang

Clin Cancer Res April 15 2018 24 (8) 1954-1964; DOI:10.1158/1078-0432.CCR-17-2924
Biology of Human Tumors | AuthorChoice

Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis

Matthew T. Chang, Alexander Penson, Neil B. Desai, Nicholas D. Socci, Ronglai Shen, Venkatraman E. Seshan, Ritika Kundra, Adam Abeshouse, Agnes Viale, Eugene K. Cha, Xueli Hao, Victor E. Reuter, Charles M. Rudin, Bernard H. Bochner, Jonathan E. Rosenberg, Dean F. Bajorin, Nikolaus Schultz, Michael F. Berger, Gopa Iyer, David B. Solit, Hikmat A. Al-Ahmadie and Barry S. Taylor

Clin Cancer Res April 15 2018 24 (8) 1965-1973; DOI:10.1158/1078-0432.CCR-17-2655
Biology of Human Tumors

PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer

Sebastian Lamprecht, Markus Kaller, Eva Marina Schmidt, Cristina Blaj, Tobias S. Schiergens, Jutta Engel, Andreas Jung, Heiko Hermeking, Thomas G.P. Grünewald, Thomas Kirchner and David Horst

Clin Cancer Res April 15 2018 24 (8) 1974-1986; DOI:10.1158/1078-0432.CCR-17-2572
Biology of Human Tumors

Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer

Rasmi R. Mishra, Nevin Belder, Suhail A. Ansari, Merve Kayhan, Hilal Bal, Umar Raza, Pelin G. Ersan, Ünal M. Tokat, Erol Eyüpoğlu, Özge Saatci, Pouria Jandaghi, Stefan Wiemann, Ayşegül Üner, Caglar Cekic, Yasser Riazalhosseini and Özgür Şahin

Clin Cancer Res April 15 2018 24 (8) 1987-2001; DOI:10.1158/1078-0432.CCR-17-2776
Biology of Human Tumors

Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer

Xin Chen, Zhenyao Chen, Shanxun Yu, Fengqi Nie, Shuai Yan, Pei Ma, Qinnan Chen, Chenchen Wei, Hangjiang Fu, Tianwei Xu, Shengnan Ren, Ming Sun and Zhaoxia Wang

Clin Cancer Res April 15 2018 24 (8) 2002-2014; DOI:10.1158/1078-0432.CCR-17-2376
Biology of Human Tumors

REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer

Qingwei Wang, Xiao Gao, Tong Yu, Lei Yuan, Jie Dai, Weicang Wang, Geng Chen, Chan Jiao, Wang Zhou, Quan Huang, Long Cui, Pei Zhang, Robb E. Moses, Jianhua Yang, Fengyuan Chen, Junjiang Fu, Jianru Xiao, Lei Li, Yongyan Dang and Xiaotao Li

Clin Cancer Res April 15 2018 24 (8) 2015-2025; DOI:10.1158/1078-0432.CCR-17-2986

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Highlights

Editorial

CCR Translations

CCR Perspectives in Regulatory Science and Policy

Review

Perspectives

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

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