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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res April 15 2018 24 (8) 1771-1771;

Editorial

  • Editorial
    Introducing a New Series: Immunotherapy Facts and Hopes
    Ignacio Melero, Mario Sznol, Marlowe S. Tessmer, Theresa L. Whiteside and Jedd D. Wolchok
    Clin Cancer Res April 15 2018 24 (8) 1773-1774; DOI:10.1158/1078-0432.CCR-18-0408

CCR Translations

  • CCR Translations
    Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver
    Matthew G. Oser and Pasi A. Jänne
    Clin Cancer Res April 15 2018 24 (8) 1775-1776; DOI:10.1158/1078-0432.CCR-17-3646

  • CCR Translations
    Harnessing the Power of Patient-Reported Outcomes in Oncology
    Ryan D. Nipp and Jennifer S. Temel
    Clin Cancer Res April 15 2018 24 (8) 1777-1779; DOI:10.1158/1078-0432.CCR-18-0037

CCR Perspectives in Regulatory Science and Policy

  • CCR Perspectives in Regulatory Science and Policy
    Use of PRO Measures to Inform Tolerability in Oncology Trials: Implications for Clinical Review, IND Safety Reporting, and Clinical Site Inspections
    Janice Kim, Harpreet Singh, Kassa Ayalew, Kristina Borror, Michelle Campbell, Laura Lee Johnson, Alyson Karesh, Ni A. Khin, Joanne R. Less, Jerry Menikoff, Lori Minasian, Sandra A. Mitchell, Elektra J. Papadopoulos, Richard L. Piekarz, Kevin A. Prohaska, Susan Thompson, Rajeshwari Sridhara, Richard Pazdur and Paul G. Kluetz
    Clin Cancer Res April 15 2018 24 (8) 1780-1784; DOI:10.1158/1078-0432.CCR-17-2555

Review

  • Review
    Analysis of Drug Development Paradigms for Immune Checkpoint Inhibitors
    Denis L. Jardim, Débora de Melo Gagliato, Francis J. Giles and Razelle Kurzrock
    Clin Cancer Res April 15 2018 24 (8) 1785-1794; DOI:10.1158/1078-0432.CCR-17-1970

Perspectives

  • Perspectives | AuthorChoice
    Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain?
    Sheheryar Kabraji, Jing Ni, Nancy U. Lin, Shaozhen Xie, Eric P. Winer and Jean J. Zhao
    Clin Cancer Res April 15 2018 24 (8) 1795-1804; DOI:10.1158/1078-0432.CCR-17-3351

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Pembrolizumab Plus Pegylated Interferon alfa-2b or Ipilimumab for Advanced Melanoma or Renal Cell Carcinoma: Dose-Finding Results from the Phase Ib KEYNOTE-029 Study
    Michael B. Atkins, F. Stephen Hodi, John A. Thompson, David F. McDermott, Wen-Jen Hwu, Donald P. Lawrence, Nancy A. Dawson, Deborah J. Wong, Shailender Bhatia, Marihella James, Lokesh Jain, Seth Robey, Xinxin Shu, Blanca Homet Moreno, Rodolfo F. Perini, Toni K. Choueiri and Antoni Ribas
    Clin Cancer Res April 15 2018 24 (8) 1805-1815; DOI:10.1158/1078-0432.CCR-17-3436

  • Cancer Therapy: Clinical | AuthorChoice
    Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer
    Neil H. Segal, Aiwu R. He, Toshihiko Doi, Ronald Levy, Shailender Bhatia, Michael J. Pishvaian, Rossano Cesari, Ying Chen, Craig B. Davis, Bo Huang, Aron D. Thall and Ajay K. Gopal
    Clin Cancer Res April 15 2018 24 (8) 1816-1823; DOI:10.1158/1078-0432.CCR-17-1922

  • Cancer Therapy: Clinical
    Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials
    Yu-Pei Chen, Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P. Hui, Anthony T.C. Chan, Whee-Sze Ong, Terence Tan, Joseph Wee, Wen-Fei Li, Lei Chen, Brigette B.Y. Ma, Macy Tong, Sze-Huey Tan, Shie-Lee Cheah, Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Ying Guo, Ai-Hua Lin, Ying Sun, Ming-Huang Hong, Su-Mei Cao, Ming-Yuan Chen and Jun Ma
    Clin Cancer Res April 15 2018 24 (8) 1824-1833; DOI:10.1158/1078-0432.CCR-17-2656

  • Cancer Therapy: Clinical | AuthorChoice
    Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
    Andreas T. Björklund, Mattias Carlsten, Ebba Sohlberg, Lisa L. Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley, Jeffrey S. Miller, Monika Klimkowska, Marie Schaffer, Emma Watz, Kristina Wikström, Pontus Blomberg, Björn Engelbrekt Wahlin, Marzia Palma, Lotta Hansson, Per Ljungman, Eva Hellström-Lindberg, Hans-Gustaf Ljunggren and Karl-Johan Malmberg
    Clin Cancer Res April 15 2018 24 (8) 1834-1844; DOI:10.1158/1078-0432.CCR-17-3196

  • Cancer Therapy: Clinical
    Pathological Response in a Triple-Negative Breast Cancer Cohort Treated with Neoadjuvant Carboplatin and Docetaxel According to Lehmann's Refined Classification
    Isabel Echavarria, Sara López-Tarruella, Antoni Picornell, Jose Ángel García-Saenz, Yolanda Jerez, Katherine Hoadley, Henry L. Gómez, Fernando Moreno, María Del Monte-Millan, Iván Márquez-Rodas, Enrique Alvarez, Rocío Ramos-Medina, Javier Gayarre, Tatiana Massarrah, Inmaculada Ocaña, María Cebollero, Hugo Fuentes, Agusti Barnadas, Ana Isabel Ballesteros, Uriel Bohn, Charles M. Perou and Miguel Martin
    Clin Cancer Res April 15 2018 24 (8) 1845-1852; DOI:10.1158/1078-0432.CCR-17-1912

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging | AuthorChoice
    HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging
    Carlos D. Martins, Chiara Da Pieve, Thomas A. Burley, Rhodri Smith, Daniela M. Ciobota, Louis Allott, Kevin J. Harrington, Wim J.G. Oyen, Graham Smith and Gabriela Kramer-Marek
    Clin Cancer Res April 15 2018 24 (8) 1853-1865; DOI:10.1158/1078-0432.CCR-17-2754

  • Personalized Medicine and Imaging
    Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients
    Britt I. Drögemöller, Beth Brooks, Carol Critchley, José G. Monzon, Galen E.B. Wright, Geoffrey Liu, Daniel J. Renouf, Christian K. Kollmannsberger, Philippe L. Bedard, Michael R. Hayden, Karen A. Gelmon, Bruce C. Carleton and Colin J.D. Ross
    Clin Cancer Res April 15 2018 24 (8) 1866-1871; DOI:10.1158/1078-0432.CCR-17-2810

  • Personalized Medicine and Imaging
    Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA
    Sarah B. Goldberg, Azeet Narayan, Adam J. Kole, Roy H. Decker, Jimmitti Teysir, Nicholas J. Carriero, Angela Lee, Roxanne Nemati, Sameer K. Nath, Shrikant M. Mane, Yanhong Deng, Nitin Sukumar, Daniel Zelterman, Daniel J. Boffa, Katerina Politi, Scott N. Gettinger, Lynn D. Wilson, Roy S. Herbst and Abhijit A. Patel
    Clin Cancer Res April 15 2018 24 (8) 1872-1880; DOI:10.1158/1078-0432.CCR-17-1341

  • Personalized Medicine and Imaging | AuthorChoice
    Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus
    Alexa B. Schrock, Dean Pavlick, Samuel J. Klempner, Jon H. Chung, Brady Forcier, Allison Welsh, Lauren Young, Bryan Leyland-Jones, Rodolfo Bordoni, Richard D. Carvajal, Joseph Chao, Razelle Kurzrock, Jason K. Sicklick, Jeffrey S. Ross, Philip J. Stephens, Craig Devoe, Fadi Braiteh, Siraj M. Ali and Vincent A. Miller
    Clin Cancer Res April 15 2018 24 (8) 1881-1890; DOI:10.1158/1078-0432.CCR-17-3103

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function
    Andrew Stiff, Prashant Trikha, Bethany Mundy-Bosse, Elizabeth McMichael, Thomas A. Mace, Brooke Benner, Kari Kendra, Amanda Campbell, Shalini Gautam, David Abood, Ian Landi, Vincent Hsu, Megan Duggan, Robert Wesolowski, Matthew Old, John Harrison Howard, Lianbo Yu, Nancy Stasik, Thomas Olencki, Natarajan Muthusamy, Susheela Tridandapani, John C. Byrd, Michael Caligiuri and William E. Carson
    Clin Cancer Res April 15 2018 24 (8) 1891-1904; DOI:10.1158/1078-0432.CCR-17-0691

  • Cancer Therapy: Preclinical
    A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers
    Shoumin Zhu, Zheng Chen, Lihong Wang, Dunfa Peng, Abbes Belkhiri, A. Craig Lockhart and Wael El-Rifai
    Clin Cancer Res April 15 2018 24 (8) 1905-1916; DOI:10.1158/1078-0432.CCR-17-1716

  • Cancer Therapy: Preclinical | AuthorChoice
    STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair
    Cristina Maranto, Vindhya Udhane, David T. Hoang, Lei Gu, Vitali Alexeev, Kareem Malas, Karmel Cardenas, Jonathan R. Brody, Ulrich Rodeck, Carmen Bergom, Ken A. Iczkowski, Ken Jacobsohn, William See, Sara M. Schmitt and Marja T. Nevalainen
    Clin Cancer Res April 15 2018 24 (8) 1917-1931; DOI:10.1158/1078-0432.CCR-17-2768

  • Cancer Therapy: Preclinical
    Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition
    Jessica D. Lang, William P.D. Hendricks, Krystal A. Orlando, Hongwei Yin, Jeffrey Kiefer, Pilar Ramos, Ritin Sharma, Patrick Pirrotte, Elizabeth A. Raupach, Chris Sereduk, Nanyun Tang, Winnie S. Liang, Megan Washington, Salvatore J. Facista, Victoria L. Zismann, Emily M. Cousins, Michael B. Major, Yemin Wang, Anthony N. Karnezis, Aleksandar Sekulic, Ralf Hass, Barbara C. Vanderhyden, Praveen Nair, Bernard E. Weissman, David G. Huntsman and Jeffrey M. Trent
    Clin Cancer Res April 15 2018 24 (8) 1932-1943; DOI:10.1158/1078-0432.CCR-17-1928

  • Cancer Therapy: Preclinical
    Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors
    Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse and Yves Pommier
    Clin Cancer Res April 15 2018 24 (8) 1944-1953; DOI:10.1158/1078-0432.CCR-17-0443

Biology of Human Tumors

  • Biology of Human Tumors
    Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1–Negative Human Lung Cancers
    Haiying Cheng, Alain Borczuk, Murali Janakiram, Xiaoxin Ren, Juan Lin, Amer Assal, Balazs Halmos, Roman Perez-Soler and Xingxing Zang
    Clin Cancer Res April 15 2018 24 (8) 1954-1964; DOI:10.1158/1078-0432.CCR-17-2924

  • Biology of Human Tumors | AuthorChoice
    Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis
    Matthew T. Chang, Alexander Penson, Neil B. Desai, Nicholas D. Socci, Ronglai Shen, Venkatraman E. Seshan, Ritika Kundra, Adam Abeshouse, Agnes Viale, Eugene K. Cha, Xueli Hao, Victor E. Reuter, Charles M. Rudin, Bernard H. Bochner, Jonathan E. Rosenberg, Dean F. Bajorin, Nikolaus Schultz, Michael F. Berger, Gopa Iyer, David B. Solit, Hikmat A. Al-Ahmadie and Barry S. Taylor
    Clin Cancer Res April 15 2018 24 (8) 1965-1973; DOI:10.1158/1078-0432.CCR-17-2655

  • Biology of Human Tumors
    PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer
    Sebastian Lamprecht, Markus Kaller, Eva Marina Schmidt, Cristina Blaj, Tobias S. Schiergens, Jutta Engel, Andreas Jung, Heiko Hermeking, Thomas G.P. Grünewald, Thomas Kirchner and David Horst
    Clin Cancer Res April 15 2018 24 (8) 1974-1986; DOI:10.1158/1078-0432.CCR-17-2572

  • Biology of Human Tumors
    Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer
    Rasmi R. Mishra, Nevin Belder, Suhail A. Ansari, Merve Kayhan, Hilal Bal, Umar Raza, Pelin G. Ersan, Ünal M. Tokat, Erol Eyüpoğlu, Özge Saatci, Pouria Jandaghi, Stefan Wiemann, Ayşegül Üner, Caglar Cekic, Yasser Riazalhosseini and Özgür Şahin
    Clin Cancer Res April 15 2018 24 (8) 1987-2001; DOI:10.1158/1078-0432.CCR-17-2776

  • Biology of Human Tumors
    Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer
    Xin Chen, Zhenyao Chen, Shanxun Yu, Fengqi Nie, Shuai Yan, Pei Ma, Qinnan Chen, Chenchen Wei, Hangjiang Fu, Tianwei Xu, Shengnan Ren, Ming Sun and Zhaoxia Wang
    Clin Cancer Res April 15 2018 24 (8) 2002-2014; DOI:10.1158/1078-0432.CCR-17-2376

  • Biology of Human Tumors
    REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer
    Qingwei Wang, Xiao Gao, Tong Yu, Lei Yuan, Jie Dai, Weicang Wang, Geng Chen, Chan Jiao, Wang Zhou, Quan Huang, Long Cui, Pei Zhang, Robb E. Moses, Jianhua Yang, Fengyuan Chen, Junjiang Fu, Jianru Xiao, Lei Li, Yongyan Dang and Xiaotao Li
    Clin Cancer Res April 15 2018 24 (8) 2015-2025; DOI:10.1158/1078-0432.CCR-17-2986

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Clinical Cancer Research: 24 (8)
April 2018
Volume 24, Issue 8
  • Table of Contents
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Issue Highlights

  • Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer
  • Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1–Negative Human Lung Cancers
  • Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials
  • HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

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Clinical Cancer Research
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