Table of Contents

Regular Articles

• Clinical Trials

  • Regular Articles

    Phase I Study of TLK286 (Glutathione S-Transferase P1-1 Activated Glutathione Analogue) in Advanced Refractory Solid Malignancies

    Lee S. Rosen, Joseph Brown, Bernadette Laxa, Leny Boulos, Laura Reiswig, William D. Henner, Robert T. Lum, Steve R. Schow, Christopher A. Maack, James G. Keck, Julie C. Mascavage, Jacqueline A. Dombroski, Reinaldo F. Gomez and Gail L. Brown

    Clin Cancer Res May 1 2003 9 (5) 1628-1638;

    
    
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    A Phase I Dose-Escalation Study of Sibrotuzumab in Patients with Advanced or Metastatic Fibroblast Activation Protein-positive Cancer

    Andrew M. Scott, Greg Wiseman, Sydney Welt, Alex Adjei, Fook-Thean Lee, Wendie Hopkins, Chaitan R. Divgi, Lorelei H. Hanson, Paul Mitchell, Denise N. Gansen, Steven M. Larson, James N. Ingle, Eric W. Hoffman, Paul Tanswell, Gerd Ritter, Leonard S. Cohen, Peter Bette, Lisa Arvay, Andree Amelsberg, Dan Vlock, Wolfgang J. Rettig and Lloyd J. Old

    Clin Cancer Res May 1 2003 9 (5) 1639-1647;

    
    
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    Efficacy and Toxicity of the Angiogenesis Inhibitor SU5416 As a Single Agent in Patients with Advanced Renal Cell Carcinoma, Melanoma, and Soft Tissue Sarcoma

    Bart C. Kuenen, Jose Tabernero, Jose Baselga, Franco Cavalli, Elisabeth Pfanner, Pier Franco Conte, Siegfried Seeber, Srinivasan Madhusudan, Gael Deplanque, Holgen Huisman, Paul Scigalla, Klaas Hoekman and Adrian L. Harris

    Clin Cancer Res May 1 2003 9 (5) 1648-1655;

    
    
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    Chronic Lymphocytic Leukemia-reactive T Cells during Disease Progression and after Autologous Tumor Cell Vaccines

    Elena Gitelson, Caitlin Hammond, Jenny Mena, Maria Lorenzo, Rena Buckstein, Neil L. Berinstein, Kevin Imrie and David E. Spaner

    Clin Cancer Res May 1 2003 9 (5) 1656-1665;

    
    
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    Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer

    Bruce G. Redman, Peg Esper, Quintin Pan, Rodney L. Dunn, Hero K. Hussain, Thomas Chenevert, George J. Brewer and Sofia D. Merajver

    Clin Cancer Res May 1 2003 9 (5) 1666-1672;

    
    
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    Phase I Evaluation of Sequential Topoisomerase Targeting with Irinotecan/Cisplatin Followed by Etoposide in Patients with Advanced Malignancy

    Edward J. Licitra, Viral Vyas, Kathy Nelson, Rita Musanti, Stephanie Beers, Cecilia Thomas, Elizabeth Poplin, Sharon Smith, Yong Lin, Larry. J. Schaaf, Joseph Aisner, Murugesan Gounder, Rajeev Rajendra, Ahamed Saleem, Deborah Toppmeyer and Eric H. Rubin

    Clin Cancer Res May 1 2003 9 (5) 1673-1679;

    
    
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    Thalidomide Metabolites in Mice and Patients with Multiple Myeloma

    Jun Lu, Brian D. Palmer, Phillip Kestell, Peter Browett, Bruce C. Baguley, George Muller and Lai-Ming Ching

    Clin Cancer Res May 1 2003 9 (5) 1680-1688;

    
    
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    Multicenter Randomized Phase II Study of Paclitaxel (1-Hour Infusion), Fluorouracil, Hydroxyurea, and Concomitant Twice Daily Radiation with or without Erythropoietin for Advanced Head and Neck Cancer

    Fred R. Rosen, Daniel J. Haraf, Merrill S. Kies, Kerstin Stenson, Louis Portugal, Marcy A. List, Bruce E. Brockstein, Bharat B. Mittal, Alfred W. Rademaker, Mary Ellyn Witt, Harold Pelzer, Ralph R. Weichselbaum and Everett E. Vokes

    Clin Cancer Res May 1 2003 9 (5) 1689-1697;

    
    
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    Induction Docetaxel and Carboplatin Followed by Weekly Docetaxel and Carboplatin with Concurrent Radiotherapy, then Surgery in Stage III Non-Small Cell Lung Cancer

    Lori J. Wirth, Joan Lucca, Patricia Ostler, Panos Fidias, Cathy Lynch, Pasi A. Jänne, Roy S. Herbst, Bruce E. Johnson, David J. Sugarbaker, Douglas J. Mathisen, Jeanne M. Lukanich, Noah C. Choi, Stuart M. Berman and Arthur T. Skarin

    Clin Cancer Res May 1 2003 9 (5) 1698-1704;

    
    

• Molecular Oncology, Markers, Clinical Correlates

  • Regular Articles

    Cytochrome P450 and Glutathione Transferase Expression in Human Breast Cancer

    Basil F. El-Rayes, Shadan Ali, Lance K. Heilbrun, Samir Lababidi, David Bouwman, David Visscher and Philip A. Philip

    Clin Cancer Res May 1 2003 9 (5) 1705-1709;

    
    
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    Differential Splicing of KLK5 and KLK7 in Epithelial Ovarian Cancer Produces Novel Variants with Potential as Cancer Biomarkers

    Ying Dong, Aneel Kaushal, Maria Brattsand, Jim Nicklin and Judith A. Clements

    Clin Cancer Res May 1 2003 9 (5) 1710-1720;

    
    
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    Serum CYFRA 21-1 in Advanced Stage Non-Small Cell Lung Cancer

    Robin T. Vollmer, Ramaswamy Govindan, Stephen L. Graziano, Gary Gamble, Jennifer Garst, Michael J. Kelley and Robert H. Christenson

    Clin Cancer Res May 1 2003 9 (5) 1728-1733;

    
    
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    Expression of Thrombospondin-derived 4N1K Peptide-containing Proteins in Renal Cell Carcinoma Tissues Is Associated with a Decrease in Tumor Growth and Angiogenesis

    Yasuyoshi Miyata, Shigehiko Koga, Kousuke Takehara, Hiroshi Kanetake and Shigeru Kanda

    Clin Cancer Res May 1 2003 9 (5) 1734-1740;

    
    
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    Expression of Cyclooxygenase-2 in Renal Cell Carcinoma

    Yasuyoshi Miyata, Shigehiko Koga, Shigeru Kanda, Masaharu Nishikido, Tomayoshi Hayashi and Hiroshi Kanetake

    Clin Cancer Res May 1 2003 9 (5) 1741-1749;

    
    
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    Skp2 Overexpression Is a Prognostic Factor in Patients with Ovarian Adenocarcinoma

    Kazushi Shigemasa, Lijun Gu, Timothy J. O’Brien and Koso Ohama

    Clin Cancer Res May 1 2003 9 (5) 1756-1763;

    
    
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    Overexpression of CDC25A Phosphatase Is Associated with Hypergrowth Activity and Poor Prognosis of Human Hepatocellular Carcinomas

    Xundi Xu, Hirofumi Yamamoto, Masato Sakon, Masayoshi Yasui, Chew Yee Ngan, Hiroki Fukunaga, Tetsushi Morita, Minoru Ogawa, Hiroaki Nagano, Shoji Nakamori, Mitsugu Sekimoto, Nariaki Matsuura and Morito Monden

    Clin Cancer Res May 1 2003 9 (5) 1764-1772;

    
    
  • Regular Articles

    Promoter Methylation of INK4a/ARF As Detected in Bile-Significance for the Differential Diagnosis in Biliary Disease

    Bodo Klump, Chih-Jen Hsieh, Stephan Dette, Karlheinz Holzmann, Ralf Kieβlich, Michael Jung, Udo Sinn, Marianne Ortner, Rainer Porschen and Michael Gregor

    Clin Cancer Res May 1 2003 9 (5) 1773-1778;

    
    
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    RECK Expression in Pancreatic Cancer

    Toshihiko Masui, Ryuichiro Doi, Takatomo Koshiba, Koji Fujimoto, Shoichiro Tsuji, Sanae Nakajima, Masayuki Koizumi, Eiji Toyoda, Sidhartha Tulachan, Daisuke Ito, Kazuhiro Kami, Tomohiko Mori, Michihiko Wada, Makoto Noda and Masayuki Imamura

    Clin Cancer Res May 1 2003 9 (5) 1779-1784;

    
    
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    Classification of Follicular Thyroid Tumors by Molecular Signature

    Catherine B. Barden, Katherine W. Shister, Baixin Zhu, Gerardo Guiter, David Y. Greenblatt, Martha A. Zeiger and Thomas J. Fahey III

    Clin Cancer Res May 1 2003 9 (5) 1792-1800;

    
    
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    β-Catenin-related Anomalies in Apoptosis-resistant and Hormone-refractory Prostate Cancer Cells

    Alexandre de la Taille, Mark A. Rubin, Min-Wei Chen, Francis Vacherot, Sixtina Gil-Diez de Medina, Martin Burchardt, Ralph Buttyan and Dominique Chopin

    Clin Cancer Res May 1 2003 9 (5) 1801-1807;

    
    
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    Gain of Chromosome 8q23–24 Is a Predictive Marker for Lymph Node Positivity in Colorectal Cancer

    B. Michael Ghadimi, Marian Grade, Torsten Liersch, Claus Langer, Alexander Siemer, László Füzesi and Heinz Becker

    Clin Cancer Res May 1 2003 9 (5) 1808-1814;

    
    

• Molecular Oncolology, Markers, Clinical Correlates

  • Regular Articles

    Characterization of Human Lymphocyte Antigen Class I Antigen-processing Machinery Defects in Renal Cell Carcinoma Lesions with Special Emphasis on Transporter-associated with Antigen-processing Down-Regulation

    Barbara Seliger, Derek Atkins, Michaela Bock, Ulrike Ritz, Soldano Ferrone, Christoph Huber and Stefan Störkel

    Clin Cancer Res May 1 2003 9 (5) 1721-1727;

    
    
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    The Gene Ratios c-MYC:Cyclin-dependent Kinase (CDK)N2A and CCND1:CDKN2A Correlate with Poor Prognosis in Squamous Cell Carcinoma of the Head and Neck

    Jan Akervall, Ulrike Bockmühl, I. Petersen, Kun Yang, Thomas E. Carey and David M. Kurnit

    Clin Cancer Res May 1 2003 9 (5) 1750-1755;

    
    
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    Lack of Interleukin-10 Expression Could Predict Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer

    Jean-Charles Soria, Chulso Moon, Bonnie L. Kemp, Diane D. Liu, Lei Feng, Ximing Tang, Yoon-Soo Chang, Li Mao and Fadlo R. Khuri

    Clin Cancer Res May 1 2003 9 (5) 1785-1791;

    
    
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    The Loss of 5α-Reductase Type I and Type II mRNA Expression in Metastatic Prostate Cancer to Bone and Lymph Node Metastasis

    Fouad K. Habib, Margaret Ross, Colin W. Bayne, Prasad Bollina, Ken Grigor and Karen Chapman

    Clin Cancer Res May 1 2003 9 (5) 1815-1819;

    
    

• Experimental Therapeutics, Preclinical Pharmacology

  • Regular Articles

    Stroma Cells

    Chiara Corsini, Patrizia Mancuso, Saki Paul, Alessandra Burlini, Giovanni Martinelli, Giancarlo Pruneri and Francesco Bertolini

    Clin Cancer Res May 1 2003 9 (5) 1820-1825;

    
    
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    Effect of Interleukin (IL)-4 Cytotoxin on Breast Tumor Growth after in Vivo Gene Transfer of IL-4 Receptor α Chain

    Koji Kawakami, Mariko Kawakami, Syed R. Husain and Raj K. Puri

    Clin Cancer Res May 1 2003 9 (5) 1826-1836;

    
    
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    Vaccine Therapy of Established Tumors in the Absence of Autoimmunity

    James W. Hodge, Douglas W. Grosenbach, Wilhelmina M. Aarts, Diane J. Poole and Jeffrey Schlom

    Clin Cancer Res May 1 2003 9 (5) 1837-1849;

    
    
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    Identification of HLA-A*0201-restricted Cytotoxic T Lymphocyte Epitope from TRAG-3 Antigen

    Bo Zhu, Zhengtang Chen, Xiaoming Cheng, Zhihua Lin, Jianxiu Guo, Zhengcai Jia, Liyun Zou, Zhixin Wang, Yide Hu, Dongling Wang and Yuzhang Wu

    Clin Cancer Res May 1 2003 9 (5) 1850-1857;

    
    
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    Administration of Optimal Biological Dose and Schedule of Interferon α Combined with Gemcitabine Induces Apoptosis in Tumor-associated Endothelial Cells and Reduces Growth of Human Pancreatic Carcinoma Implanted Orthotopically in Nude Mice

    Carmen C. Solorzano, Rosa Hwang, Cheryl H. Baker, Corazon D. Bucana, Peter W. Pisters, Douglas B. Evans, Jerald J. Killion and Isaiah J. Fidler

    Clin Cancer Res May 1 2003 9 (5) 1858-1867;

    
    
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    Specific and High-Level Targeting of Radiolabeled Octreotide Analogues to Human Medulloblastoma Xenografts

    Ganesan Vaidyanathan, Henry S. Friedman, Donna J. Affleck, Margaret Schottelius, Hans-Jürgen Wester and Michael R. Zalutsky

    Clin Cancer Res May 1 2003 9 (5) 1868-1876;

    
    
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    Cyclin D1 Overexpression Sensitizes Breast Cancer Cells to Fenretinide

    Andreja Pirkmaier, Kally Yuen, Joy Hendley, Matthew J. O’Connell and Doris Germain

    Clin Cancer Res May 1 2003 9 (5) 1877-1884;

    
    
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    The Cyclooxygenase 2-selective Inhibitor NS398 Inhibits Proliferation of Oral Carcinoma Cell Lines by Mechanisms Dependent and Independent of Reduced Prostaglandin E₂ Synthesis

    Helena A. Minter, John W. Eveson, Suzanne Huntley, Douglas J. E. Elder and Angela Hague

    Clin Cancer Res May 1 2003 9 (5) 1885-1897;

    
    
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    Dual Action of NAMI-A in Inhibition of Solid Tumor Metastasis

    Gianni Sava, Sonia Zorzet, Claudia Turrin, Francesca Vita, MariaRosa Soranzo, Giuliano Zabucchi, Moreno Cocchietto, Alberta Bergamo, Stefano DiGiovine, Gabriella Pezzoni, Luigi Sartor and Spiridione Garbisa

    Clin Cancer Res May 1 2003 9 (5) 1898-1905;

    
    
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    Novel Kidney Cancer Immunotherapy Based on the Granulocyte- Macrophage Colony-stimulating Factor and Carbonic Anhydrase IX Fusion Gene

    José M. Hernández, Matthew H. T. Bui, Ken-ryu Han, Hideki Mukouyama, Danielo G. Freitas, David Nguyen, Randy Caliliw, Peter I. Shintaku, Sun H. Paik, Cho-Lea Tso, Robert A. Figlin and Arie S. Belldegrun

    Clin Cancer Res May 1 2003 9 (5) 1906-1916;

    
    
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    In Vitro and in Vivo Antitumor Activity of Methotrexate Conjugated to Human Serum Albumin in Human Cancer Cells

    Katja Wosikowski, Elfi Biedermann, Benno Rattel, Norbert Breiter, Peter Jank, Roland Löser, Gerrit Jansen and Godefridus J. Peters

    Clin Cancer Res May 1 2003 9 (5) 1917-1926;

    
    
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    Chemoprevention of Benzo(a)pyrene-induced Lung Tumors in Mice by the Farnesyltransferase Inhibitor R115777

    William T. Gunning, Paula M. Kramer, Ronald A. Lubet, Vernon E. Steele, David W. End, Walter Wouters and Michael A. Pereira

    Clin Cancer Res May 1 2003 9 (5) 1927-1930;

    
    
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    Bcl-2 Antisense (G3139, Genasense) Enhances the in Vitro and in Vivo Response of Epstein-Barr Virus-associated Lymphoproliferative Disease to Rituximab

    Regina Loomis, Rocco Carbone, Michael Reiss and Jill Lacy

    Clin Cancer Res May 1 2003 9 (5) 1931-1939;