MicroRNAs (miRNAs) are approximately 18-25 nucleotides in length and affect gene expression by silencing the translation of messenger RNAs. Since each miRNA regulate the expression of hundreds of different genes, miRNAs can function as master-coordinators, efficiently regulating and coordinating multiple cellular pathways and processes. By coordinating the expression of multiple genes, miRNAs are responsible for fine-tuning the cell's most important processes like the ones involved in cellular growth and proliferation. Dysregulation of miRNAs appears to play a fundamental role in the onset, progression and dissemination of many cancers, and replacement of down regulated miRNAs in tumor cells results in a positive therapeutic response. Thus, in theory, inhibition of a particular miRNA linked to cancer onset or progression can remove the inhibition of the translation of a therapeutic protein - and conversely, administration of a miRNA mimetic can boost the endogenous miRNA population repressing the translation of an oncogenic protein. Although several basic questions regarding their biological principles still remain to be answered, and in spite of the fact that all data with respect to miRNAs and therapy are still at the preclinical level, many specific characteristics of miRNAs in combination with compelling therapeutic efficacy data have triggered the research community to start exploring the possibilities of employing miRNAs as potential therapeutic candidates.
- Received March 22, 2012.
- Revision received May 23, 2012.
- Accepted May 25, 2012.
- Copyright © 2012, American Association for Cancer Research.