Radiation induces galectin-1 secretion by tumors, which induces CD8+ T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Galectin-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
- Received October 17, 2014.
- Accepted October 21, 2014.
- Copyright © 2014, American Association for Cancer Research.