The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of non-representative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures.
- Received May 31, 2016.
- Accepted June 2, 2016.
- Copyright ©2016, American Association for Cancer Research.