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OnlineFirst

Biology of Human Tumors

  • Biology of Human Tumors | AuthorChoice
    Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma
    David G.P. van IJzendoorn, Stefan Sleijfer, Hans Gelderblom, Ferry A.L.M. Eskens, Geert J.L.H. van Leenders, Karoly Szuhai and Judith V.M.G. Bovée
    Clin Cancer Res April 20 2018 DOI:10.1158/1078-0432.CCR-17-3512

  • Biology of Human Tumors
    Combination Approach for Detecting Different Types of Alterations in Circulating Tumor DNA in Leiomyosarcoma
    Joanna Przybyl, Jacob J. Chabon, Lien Spans, Kristen N. Ganjoo, Sujay Vennam, Aaron M. Newman, Erna Forgó, Sushama Varma, Shirley Zhu, Maria Debiec-Rychter, Ash A. Alizadeh, Maximilian Diehn and Matt van de Rijn
    Clin Cancer Res April 19 2018 DOI:10.1158/1078-0432.CCR-17-3704

  • Biology of Human Tumors | AuthorChoice
    Lymph Node Metastases in Colon Cancer Are Polyclonal
    Peter J. Ulintz, Joel K. Greenson, Rong Wu, Eric R. Fearon and Karin M. Hardiman
    Clin Cancer Res April 18 2018 DOI:10.1158/1078-0432.CCR-17-1425

  • Biology of Human Tumors | AuthorChoice
    Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
    Luke Piggott, Andreia Silva, Timothy Robinson, Angelica Santiago-Gómez, Bruno M. Simões, Michael Becker, Iduna Fichtner, Ladislav Andera, Philippa Young, Christine Morris, Peter Barrett-Lee, Fouad Alchami, Marco Piva, Maria dM. Vivanco, Robert B. Clarke, Julia Gee and Richard Clarkson
    Clin Cancer Res April 18 2018 DOI:10.1158/1078-0432.CCR-17-1381

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    A pan-cancer landscape of interactions between solid tumors and infiltrating immune cell populations
    David Tamborero, Carlota Rubio-Perez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep Maria Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas and Abel Gonzalez-Perez
    Clin Cancer Res April 17 2018 DOI:10.1158/1078-0432.CCR-17-3509

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Integrated genomic and immunophenotypic classification of pancreatic cancer reveals three distinct subtypes with prognostic/predictive significance
    Martin Wartenberg, Silvia Cibin, Inti Zlobec, Erik Vassella, Serenella M.M. Eppenberger-Castori, Luigi Terracciano, Micha Eichmann, Mathias Worni, Beat Gloor, Aurel Perren and Eva Karamitopoulou
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-3401

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Interferon-stimulated genes are involved in cross-resistance to radiotherapy in tamoxifen-resistant breast cancer
    Annemarie E.M. Post, Marcel Smid, Anika Nagelkerke, John W.M. Martens, Johan Bussink, Fred CJG Sweep and Paul N Span
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-2551

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Targeting the Leukemia Antigen PR1 with Immunotherapy for the treatment of Multiple Myeloma
    Gheath Alatrash, Alexander A Perakis, Celine Kerros, Haley L Peters, Pariya Sukhumalchandra, Mao Zhang, Haroon Jakher, Madhushree Zope, Rebecca S. Patenia, Anna Sergeeva, Shuhua Yi, Ken H. Young, Anne V Philips, Amanda C Herrmann, Haven R Garber, Na Qiao, Jinsheng Weng, Lisa S. St. John, Sijie Lu, Karen Clise-Dwyer, Elizabeth A. Mittendorf, Qing Ma and Jeffrey J. Molldrem
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-2626

  • Biology of Human Tumors
    Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation
    Satoshi Takagi, Shokichi Tsukamoto, Jihye Park, Kelly E. Johnson, Yawara Kawano, Michele Moschetta, Chia-Jen Liu, Yuji Mishima, Katsutoshi Kokubun, Salomon Manier, Karma Z. Salem, Daisy Huynh, Antonio Sacco, Jodi Forward, Aldo M. Roccaro, Elisabeth M. Battinelli and Irene M. Ghobrial
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-2003

  • Biology of Human Tumors
    Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial–Mesenchymal Transition
    Fanyang Kong, Tao Sun, Xiangyu Kong, Dacheng Xie, Zhaoshen Li and Keping Xie
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-3346

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    Mitotic Exit dysfunction through the deregulation of APC/C characterizes cisplatin resistant state in epithelial ovarian cancer
    Anil Belur Nagaraj, Olga Kovalenko, Rita A. Avelar, Peronne Joseph, Annalyn Brown, Arshia Surti, Sandra Mantilla and Analisa DiFeo
    Clin Cancer Res April 13 2018 DOI:10.1158/1078-0432.CCR-17-2885

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples
    Wina Verlaat, Barbara C Snoek, Daniëlle A.M. Heideman, Saskia M Wilting, Peter J.F. Snijders, Putri W. Novianti, Annina P. van Splunter, Carel F.W. Peeters, Nienke E van Trommel, Leon F.A.G. Massuger, Ruud L.M. Bekkers, Willem JG Melchers, Folkert J. van Kemenade, Johannes Berkhof, Mark A. van de Wiel, Chris J.L.M. Meijer and Renske D.M. Steenbergen
    Clin Cancer Res April 9 2018 DOI:10.1158/1078-0432.CCR-17-3615

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.
    Mingyang Liu, Jingxuan Yang, Yuqing Zhang, Zhijun Zhou, Xiaobo Cui, Liyang Zhang, Kar-Ming Fung, Wei Zheng, Felicia D Allard, Eric U Yee, Kai Ding, Huanwen Wu, Zhiyong Liang, Lei Zheng, Martin E Fernandez-Zapico, Yiping Li, Michael S. Bronze, Katherine T. Morris, Russell G Postier, Courtney W Houchen, Jing Yang and Min Li
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-18-0263

  • Biology of Human Tumors
    TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy
    Ye Tao, Erich M. Sturgis, Zhigang Huang, Ying Wang, Peng Wei, Jennifer Rui Wang, Qingyi Wei and Guojun Li
    Clin Cancer Res March 27 2018 DOI:10.1158/1078-0432.CCR-17-1904

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    Epigenome-wide SRC-1 mediated gene silencing represses cellular differentiation in advanced breast cancer
    Elspeth Ward, Damir Vareslija, Sara Charmsaz, Ailis Fagan, Alacoque L Browne, Nicola S Cosgrove, Sinead Cocchiglia, Siobhan P Purcell, Lance Hudson, Sudipto Das, Darran O'Connor, Phillip J O'Halloran, Andrew H Sims, Arnold D. Hill and Leonie S Young
    Clin Cancer Res March 22 2018 DOI:10.1158/1078-0432.CCR-17-2615

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    False positive plasma genotyping due to clonal hematopoiesis
    Yuebi Hu, Bryan Ulrich, Julianna Supplee, Yanan Kuang, Patrick H. Lizotte, Nora Feeney, Nicolas Guibert, Mark M. Awad, Kwok-Kin Wong, Pasi A. Janne, Cloud Peter Paweletz and Geoffrey R. Oxnard
    Clin Cancer Res March 22 2018 DOI:10.1158/1078-0432.CCR-18-0143

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-cell Targets in Human IDH-Mutant Glioma
    Steffen Dettling, Slava Stamova, Rolf Warta, Martina Schnölzer, Carmen Rapp, Anchana Rathinasamy, David Reuss, Kolja Pocha, Saskia Roesch, Christine Jungk, Uwe Warnken, Volker Eckstein, Niels Grabe, Christoph Schramm, Markus A. Weigand, Andreas von Deimling, Andreas Unterberg, Philipp Beckhove and Christel Herold-Mende
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-1839

  • Biology of Human Tumors
    Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma
    Wei Guo, Yun-Fan Sun, Min-Na Shen, Xiao-Lu Ma, Jiong Wu, Chun-Yan Zhang, Yan Zhou, Yang Xu, Bo Hu, Min Zhang, Gang Wang, Wei-Qin Chen, Lin Guo, Ren-Quan Lu, Chao-Hui Zhou, Xin Zhang, Ying-Hong Shi, Shuang-jian Qiu, Bai-shen Pan, Ya Cao, Jian Zhou, Xin-Rong Yang and Jia Fan
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-1753

  • Biology of Human Tumors
    Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women
    Megan A. Clarke, Ana Gradissimo, Mark Schiffman, Jessica Lam, Christopher C. Sollecito, Barbara Fetterman, Thomas Lorey, Nancy Poitras, Tina R. Raine-Bennett, Philip E. Castle, Nicolas Wentzensen and Robert D. Burk
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-3251

  • Biology of Human Tumors
    Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases
    Fengju Chen, Yiqun Zhang, Don L. Gibbons, Benjamin Deneen, David J. Kwiatkowski, Michael Ittmann and Chad J. Creighton
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-3378

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogs
    Inge C Van Gool, Emily Rayner, Elisabeth M Osse, Remi A Nout, Carien L Creutzberg, Ian Tomlinson, David N Church, Vincent T.H.B.M. Smit, Niels de Wind, Tjalling Bosse and Mark Drost
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-18-0266

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression
    Stephen Keysar, Justin Eagles, Bettina Miller, Brian C Jackson, Farshad N Chowdhury, Julie Reisinger, Tugs-Saikhan Chimed, Phuong N. Le, J. Jason Morton, Hilary Somerset, Marileila Varella-Garcia, Aik-Choon Tan, John I. Song, Daniel W. Bowles, Mary E. Reyland and Antonio Jimeno
    Clin Cancer Res March 19 2018 DOI:10.1158/1078-0432.CCR-17-3871

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    Exosome-based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients
    Elena Castellanos-Rizaldos, Dominik G. Grimm, Vasisht Tadigotla, James Hurley, John Healy, Patricia L Neal, Mia Sher, Raajdeep Venkatesan, Chris Karlovich, Mitch Raponi, Anne K. Krug, Mikkel Noerholm, Jihane Tannous, Bakhos A. Tannous, Luis E. Raez and Johan Skog
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-3369

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Lipidomic profiling links the Fanconi anemia pathway to glycosphingolipid metabolism in head and neck cancer cells
    Xueheng Zhao, Marion G Brusadelli, Sharon L. Sauter, Melinda Butsch Kovacic, Wujuan Zhang, Lindsey E Romick-Rosendale, Paul F Lambert, Kenneth D. Setchell and Susanne I Wells
    Clin Cancer Res March 12 2018 DOI:10.1158/1078-0432.CCR-17-3686

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression
    Lu Huang, Shruti Malu, Jodi A. McKenzie, Miles C Andrews, Amjad H. Talukder, Trang Tieu, Tatiana V. Karpinets, Cara Haymaker, Marie-Andrée Forget, Leila J. Williams, Zhe Wang, Rina Mbofung, Zhi-Qiang Wang, R. Eric Davis, Roger S. Lo, Jennifer A. Wargo, Michael A. Davies, Chantale Bernatchez, Timothy P. Heffernan, Rodabe N. Amaria, Anil Korkut, Weiyi Peng, Jason Roszik, Gregory Lizee, Scott E. Woodman and Patrick Hwu
    Clin Cancer Res March 1 2018 DOI:10.1158/1078-0432.CCR-17-2483

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Vitamin D-Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription
    Yu-Fang Huang, Yi-Hui Wu, Wen-Fang Cheng, Shu-Ling Peng, Wan-Lin Shen and Cheng-Yang Chou
    Clin Cancer Res February 23 2018 DOI:10.1158/1078-0432.CCR-17-2943

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer
    Chun Gong, Ellen PS Man, Ho Tsoi, Terence K. Lee, Paul Lee, Sai-Ting Ma, Lai-San Wong, Mai-Yee Luk, Emad A Rakha, Andrew R Green, Ian O Ellis, Kwok-Leung Cheung and Ui-Soon Khoo
    Clin Cancer Res February 2 2018 DOI:10.1158/1078-0432.CCR-17-2259

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Pancreatic juice mutation concentrations can help predict the grade of dysplasia in patients undergoing pancreatic surveillance
    Masaya Suenaga, Jun Yu, Koji Shindo, Koji Tamura, Jose Alejandro N Almario, Christopher M Zaykoski, P. Dane Witmer, Shah Fesharakizadeh, Michael Borges, Anne Marie Lennon, Eun J Shin, Marcia I Canto and Michael G. Goggins
    Clin Cancer Res January 4 2018 DOI:10.1158/1078-0432.CCR-17-2463

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models
    Mojgan Shourideh, Gissou Azabdaftari, Kristopher Attwood, Adam DePriest, Kristine M Wadosky, Bryan M Gillard, Ellen Karasik, Hannelore Heemers, Natasha Kyprianou, Irwin H. Gelman, Eva Corey, Robert L Vessella, James L. Mohler and Shahriar Koochekpour
    Clin Cancer Res July 14 2017 DOI:10.1158/1078-0432.CCR-16-0137

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer
    Silvia C. Formenti, Percy Lee, Sylvia Adams, Judith D. Goldberg, Xiaochun Li, Mike W. Xie, Josephine A. Ratikan, Carol Felix, Lin Hwang, Kym F. Faull, James W. Sayre, Sara Hurvitz, John A. Glaspy, Begoña Comin-Anduix, Sandra Demaria, Dörthe Schaue and William H. McBride
    Clin Cancer Res April 20 2018 DOI:10.1158/1078-0432.CCR-17-3322

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Combined BRAF and HSP90 inhibition in patients with unresectable BRAF V600E mutant melanoma
    Zeynep Eroglu, Yian Ann Chen, Geoffrey T Gibney, Jeffrey S. Weber, Ragini R. Kudchadkar, Nikhil I Khushalani, Joseph Markowitz, Andrew S Brohl, Leticia F. Tetteh, Howida Ramadan, Gina Arnone, Jiannong Li, Xiuhua Zhao, Ritin Sharma, Lancia N.F. Darville, Bin Fang, Inna Smalley, Jane L. Messina, John M. Koomen, Vernon K. Sondak and Keiran S.M. Smalley
    Clin Cancer Res April 19 2018 DOI:10.1158/1078-0432.CCR-18-0565

  • Cancer Therapy: Clinical | AuthorChoice
    A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA-Mutated Breast and Gynecologic Cancers
    Udai Banerji, Emma J. Dean, J. Alejandro Pérez-Fidalgo, Gerald Batist, Philippe L. Bedard, Benoit You, Shannon N. Westin, Peter Kabos, Michelle D. Garrett, Mathew Tall, Helen Ambrose, J. Carl Barrett, T. Hedley Carr, S.Y. Amy Cheung, Claire Corcoran, Marie Cullberg, Barry R. Davies, Elza C. de Bruin, Paul Elvin, Andrew Foxley, Peter Lawrence, Justin P.O. Lindemann, Rhiannon Maudsley, Martin Pass, Vicky Rowlands, Paul Rugman, Gaia Schiavon, James Yates and Jan H.M. Schellens
    Clin Cancer Res April 18 2018 DOI:10.1158/1078-0432.CCR-17-2260

  • Cancer Therapy: Clinical
    Updated Results of Rituximab Pre- and Post-BEAM with or without 90Yttrium Ibritumomab Tiuxetan during Autologous Transplant for Diffuse Large B-cell Lymphoma
    Jad Chahoud, Dawen Sui, William D. Erwin, Alison M. Gulbis, Martin Korbling, Mingzhi Zhang, Sairah Ahmed, Gheath Alatrash, Paolo Anderlini, Stefan O. Ciurea, Betul Oran, Luis E. Fayad, Roland L. Bassett Jr, Elias J. Jabbour, L. Jeffrey Medeiros, Homer A. Macapinlac, Ken H. Young and Issa F. Khouri
    Clin Cancer Res April 17 2018 DOI:10.1158/1078-0432.CCR-17-3561

  • Cancer Therapy: Clinical
    Molecular Alterations and Buparlisib Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck: Biomarker Analysis from BERIL-1
    Denis Soulières, Lisa Licitra, Ricard Mesía, Éva Remenár, Shau-Hsuan Li, Andrey Karpenko, Marie Chol, Ying A. Wang, Nadia Solovieff, Laurence Bourdeau, Dalila Sellami and Sandrine Faivre
    Clin Cancer Res April 17 2018 DOI:10.1158/1078-0432.CCR-17-2644

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemo-sensitivity
    Li-jun Di, Dapeng Hao, Jie Liu, Meng Chen, Jingjing Li, Li Wang, Guangyu Wang and Qi Zhao
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-3862

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Report from the SWOG Radiation Oncology Committee: Research Objectives Workshop 2017
    Paul Okunieff, Katherine Casey-Sawicki, Natalie A Lockney, Bradford S. Hoppe, Heiko Enderling, Chelsea C Pinnix, James W Welsh, Sunil Krishnan, Greg Yothers, J. Martin Brown, Susan J. Knox, Robert G. Bristow, Paul T Spellman, Timur Mitin, Nima Nabavizadeh, Jerry Jaboin, H. Charles Manning, Felix Y. Feng, Susan M Galbraith, Abhishek A Solanki, Matthew M. Harkenrider, Richard Tuli, Roy H Decker, Steven E. Finkelstein, Charles C. Hsu, Chul S Ha, Reshma Jagsi, Dean Shumway, Megan Daly, Tony J. C. Wang, Thomas J FitzGerald, Fran Laurie, David T. Marshall, David Raben, Louis S. Constine, Charles R. Thomas and Lisa A. Kachnic
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-3202

  • Cancer Therapy: Clinical
    Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial
    Patrick Neven, Lynn Jongen, Anneleen Lintermans, Kathleen Van Asten, Chantal Blomme, Diether Lambrechts, An Poppe, Hans Wildiers, Anne-Sophie Dieudonné, Olivier Brouckaert, Jan Decloedt, Patrick Berteloot, Didier Verhoeven, Markus Joerger, Peter Vuylsteke, Wim Wynendaele, Minne Casteels, Sabine Van Huffel, Willem Lybaert, Johan Van Ginderachter, Robert Paridaens, Ignace Vergote, Vincent Olaf Dezentjé, Ben Van Calster and Henk-Jan Guchelaar
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-17-3028

  • Cancer Therapy: Clinical
    Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile
    Nan Xie, Nicholas Matigian, Tharindu Vithanage, Kye Gregory, Zeyad D. Nassar, Peter J. Cabot, Paul N. Shaw, Carl M.J. Kirkpatrick, Kim-Anh Lê Cao, David Sturgess and Marie-Odile Parat
    Clin Cancer Res April 16 2018 DOI:10.1158/1078-0432.CCR-18-0172

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma
    David S. Hong, Kathleen N Moore, Manish R. Patel, Stefan C Grant, Howard A. Burris, William N. William, Suzanne Jones, Funda Meric-Bernstam, Jeffrey Infante, Lisa Golden, Wei Zhang, Ricardo Martinez, Sameera R Wijayawardana, Richard P. Beckmann, Aimee Bence Lin, Cathy Eng and Johanna C. Bendell
    Clin Cancer Res April 11 2018 DOI:10.1158/1078-0432.CCR-17-3347

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer
    Johanna C. Bendell, Anna M. Varghese, David M. Hyman, Todd M. Bauer, Shubham Pant, Sophie Callies, Ji Lin, Ricardo Martinez, Enaksha R. Wickremsinhe, Aaron Fink, Volker Wacheck and Kathleen N Moore
    Clin Cancer Res April 10 2018 DOI:10.1158/1078-0432.CCR-17-3421

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer
    Caroline E McCoach, Anh Le, Katherine Gowan, Kenneth L. Jones, Laura Schubert, Andrea Doak, Adriana Estrada-Bernal, Kurtis D Davies, Daniel T. Merrick, Paul A. Bunn, W. Thomas Purcell, Rafal Dziadziuszko, Marileila Varella-Garcia, Dara L. Aisner, D. Ross Camidge and Robert C. Doebele
    Clin Cancer Res April 10 2018 DOI:10.1158/1078-0432.CCR-17-2452

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Complete and durable responses in Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder with Zidovudine, Ganciclovir, Rituximab and Dexamethasone
    James P Dugan, Bradley M Haverkos, Linda Villagomez, Ludmila Martin, Mark E. Lustberg, John T Patton, Marisa Martin, Ying Huang, Gerard Nuovo, Fengting Yan, Robert Cavaliere, Joyce D Fingeroth, Shannon C Kenney, Richard F Ambinder, Gerard Lozanski, Pierluigi Porcu, Michael A. Caligiuri and Robert A. Baiocchi
    Clin Cancer Res April 9 2018 DOI:10.1158/1078-0432.CCR-17-2685

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Risk assessment after neoadjuvant chemotherapy in luminal breast cancer using a clinico-molecular predictor
    Sibylle Loibl, Karsten Weber, Jens Huober, Kristin Krappmann, Frederik Marmé, Christian Schem, Knut Engels, Berit M Pfitzner, Sherko Kümmel, Jenny Furlanetto, Arndt Hartmann, Silvia Darb-Esfahani, Volkmar Müller, Annette Staebler, Gunter von Minckwitz, Ralf Kronenwett and Carsten Denkert
    Clin Cancer Res April 4 2018 DOI:10.1158/1078-0432.CCR-17-2947

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    Change in topoisomerase 1 (Top1) positive circulating tumor cells impacts overall survival in patients with advanced breast cancer after treatment with etirinotecan pegol
    Hope S. Rugo, Javier Cortes, Ahmad Awada, Joyce O'Shaughnessey, Chris J Twelves, Seock-Ah Im, Alison Hannah, Lin Lu, Sherwin Sy, Katie Caygill, Deborah A Zajchowski, Darren W. Davis, Mary A Tagliaferri, Ute Hoch and Edith A Perez
    Clin Cancer Res April 4 2018 DOI:10.1158/1078-0432.CCR-17-3059

  • Cancer Therapy: Clinical
    Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer
    Andrew G. Hill, Michael P. Findlay, Matthew E. Burge, Christopher Jackson, Pilar Garcia Alfonso, Leslie Samuel, Vinod Ganju, Meinolf Karthaus, Alessio Amatu, Mark Jeffery, Maria Di Bartolomeo, John Bridgewater, Andrew L. Coveler, Manuel Hidalgo, Amy V. Kapp, Roxana I. Sufan, Bruce B. McCall, William D. Hanley, Elicia M. Penuel, Andrea Pirzkall and Josep Tabernero
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-17-0646

  • Cancer Therapy: Clinical | AuthorChoice
    The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome
    Carmela Ricciardelli, Tina Bianco-Miotto, Shalini Jindal, Lisa M. Butler, Samuel Leung, Catriona M. McNeil, Sandra A. O'Toole, Esmaeil Ebrahimie, Ewan K.A. Millar, Andrew J. Sakko, Alexandra I. Ruiz, Sarah L. Vowler, David G. Huntsman, Stephen N. Birrell, Robert L. Sutherland, Carlo Palmieri, Theresa E. Hickey and Wayne D. Tilley
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-17-1199

  • Cancer Therapy: Clinical | AuthorChoice
    A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses
    Daniela Matei, Sharad Ghamande, Lynda Roman, Angeles Alvarez Secord, John Nemunaitis, Merry Jennifer Markham, Kenneth P. Nephew, Simone Jueliger, Aram Oganesian, Sue Naim, Xiang Yao Su, Harold Keer, Mohammad Azab and Gini F. Fleming
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-17-3055

  • Cancer Therapy: Clinical | AuthorChoice
    Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS
    Michael R. Savona, Daniel A. Pollyea, Wendy Stock, Vivian G. Oehler, Mark A. Schroeder, Jeffrey Lancet, James McCloskey, Hagop M. Kantarjian, Weidong Wendy Ma, M. Naveed Shaik, A. Douglas Laird, Mirjana Zeremski, Ashleigh O'Connell, Geoffrey Chan and Jorge E. Cortes
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-17-2824

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Genetic analysis of 779 advanced differentiated and anaplastic thyroid cancers.
    Nikita Pozdeyev, Laurie Gay, Ethan S Sokol, Ryan J Hartmaier, Kelsi E Deaver, Stephanie N Davis, Jena D French, Pierre Vanden Borre, Daniel V LaBarbera, Aik-Choon Tan, Rebecca E. Schweppe, Lauren Fishbein, Jeffrey S. Ross, Bryan R. Haugen and Daniel W. Bowles
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-18-0373

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    Cell-free DNA modification dynamics in abiraterone acetate-treated prostate cancer patients
    Juozas Gordevičius, Algimantas Kriščiūnas, Daniel E. Groot, Steven M. Yip, Miki Susic, Andrew Kwan, Rafal Kustra, Anthony M. Joshua, Kim N. Chi, Art Petronis and Gabriel Oh
    Clin Cancer Res April 3 2018 DOI:10.1158/1078-0432.CCR-18-0101

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OnlineFirst articles are published online before they appear in a regular issue of the journal. Clinical Cancer Research publishes two types of OnlineFirst articles.

OnlineFirst Author Manuscripts are PDF versions of manuscripts that have been peer reviewed and accepted for publication, but not yet copyedited or typeset, allowing readers the most rapid access to accepted papers. They appear on the OnlineFirst page as submitted by the authors. The Author Manuscript remains on the OnlineFirst page until it is either replaced by the final proof version or when the final version of the paper is published in an online issue.

Please note that while we strive to post all accepted manuscripts within two days of their acceptance, there may be editorial considerations, such as a planned press release or the need to coordinate posting of related articles, which may preclude or delay Author Manuscript posting.

Author Manuscripts are normally replaced on the OnlineFirst page by the final proof version of the article, which incorporates author corrections but is not yet paginated.

When papers are published in an issue, they are removed from the OnlineFirst page and appear in the appropriate issue's table of contents. The date of first publication appears below each title, followed by the article's unique Digital Object Identifier (DOI).

While an article is OnlineFirst, it may be cited as shown in the following example:

Park E-K, Thomas PS, Johnson AR, Yates DH. Osteopontin Levels in an Asbestos Exposed Population. (January 27, 2009) Clin Cancer Res, 10.1158/1078-0432.CCR-08-0360.

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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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