Editorials:

Daniel J. DeAngelo and Jerome Ritz

Imatinib Therapy for Patients with Chronic Myelogenous Leukemia: Are Patients Living Longer?
Clin Cancer Res 2004 10: 1-3. [Full Text] [PDF]  

Review:

Richard D. Riley, David Heney, David R. Jones, Alex J. Sutton, Paul C. Lambert, Keith R. Abrams, Bridget Young, Alan J. Wailoo, and Susan A. Burchill

A Systematic Review of Molecular and Biological Tumor Markers in Neuroblastoma
Clin Cancer Res 2004 10: 4-12. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Arthur E. Frankel

Reducing the Immune Response to Immunotoxin: Commentary re R. Hassan et al., Pretreatment with Rituximab Does Not Inhibit the Human Immune Response against the Immunogenic Protein LMB-1. Clin. Cancer Res., 10: 16–18, 2004.
Clin Cancer Res 2004 10: 13-15. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Raffit Hassan, Juanita Williams-Gould, Thelma Watson, Lee Pai-Scherf, and Ira Pastan

Pretreatment with Rituximab Does Not Inhibit the Human Immune Response against the Immunogenic Protein LMB-1
Clin Cancer Res 2004 10: 16-18. [Abstract] [Full Text] [PDF]  

Chi-Kwong So, Yan Nie, Yunlong Song, Guang-Yu Yang, Suzie Chen, Caroline Wei, Li-Dong Wang, Norman A. Doggett, and Chung S. Yang

Loss of Heterozygosity and Internal Tandem Duplication Mutations of the CBP Gene Are Frequent Events in Human Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 19-27. [Abstract] [Full Text] [PDF]  

Rachel Krassenstein, Edward Sauter, Essel Dulaimi, Cristina Battagli, Hormoz Ehya, Andres Klein-Szanto, and Paul Cairns

Detection of Breast Cancer in Nipple Aspirate Fluid by CpG Island Hypermethylation
Clin Cancer Res 2004 10: 28-32. [Abstract] [Full Text] [PDF]  

Darren W. Davis, Yu Shen, Nizar A. Mullani, Sijin Wen, Roy S. Herbst, Michael O’Reilly, James L. Abbruzzese, and David J. McConkey

Quantitative Analysis of Biomarkers Defines an Optimal Biological Dose for Recombinant Human Endostatin in Primary Human Tumors
Clin Cancer Res 2004 10: 33-42. [Abstract] [Full Text] [PDF]  

William C. S. Cho, Timothy T. C. Yip, Christine Yip, Victor Yip, Vanitha Thulasiraman, Roger K. C. Ngan, Tai-Tung Yip, Wai-Hon Lau, Joseph S. K. Au, Stephen C. K. Law, Wai-Wai Cheng, Victor W. S. Ma, and Cadmon K. P. Lim

Identification of Serum Amyloid A Protein As a Potentially Useful Biomarker to Monitor Relapse of Nasopharyngeal Cancer by Serum Proteomic Profiling
Clin Cancer Res 2004 10: 43-52. [Abstract] [Full Text] [PDF]  

Darren R. Shafren, Gough G. Au, Tam Nguyen, Nicole G. Newcombe, Erin S. Haley, Leone Beagley, E. Susanne Johansson, Peter Hersey, and Richard D. Barry

Systemic Therapy of Malignant Human Melanoma Tumors by a Common Cold-Producing Enterovirus, Coxsackievirus A21
Clin Cancer Res 2004 10: 53-60. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Adhiambo M. Witlox, Victor W. van Beusechem, Bonnie Molenaar, Hans Bras, Gerard R. Schaap, Ramon Alemany, David T. Curiel, Herbert M. Pinedo, Paul I. J. M. Wuisman, and Winald R. Gerritsen

Conditionally Replicative Adenovirus with Tropism Expanded towards Integrins Inhibits Osteosarcoma Tumor Growth in Vitro and in Vivo
Clin Cancer Res 2004 10: 61-67. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Hagop Kantarjian, Susan O’Brien, Jorge Cortes, Francis Giles, Jianqin Shan, Mary Beth Rios, Stefan Faderl, Srdan Verstovsek, Guillermo Garcia-Manero, William Wierda, Steven Kornblau, Alessandra Ferrajoli, Michael Keating, and Moshe Talpaz

Survival Advantage with Imatinib Mesylate Therapy in Chronic-Phase Chronic Myelogenous Leukemia (CML-CP) after IFN- Failure and in Late CML-CP, Comparison with Historical Controls
Clin Cancer Res 2004 10: 68-75. [Abstract] [Full Text] [PDF]  

Malcolm S. Mitchell, June Kan-Mitchell, Philip R. Morrow, Denise Darrah, Vicky E. Jones, and Matthew F. Mescher

Phase I Trial of Large Multivalent Immunogen Derived from Melanoma Lysates in Patients with Disseminated Melanoma
Clin Cancer Res 2004 10: 76-83. [Abstract] [Full Text] [PDF]  

Brian H. Kushner, Kim Kramer, Shakeel Modak, and Nai-Kong V. Cheung

Camptothecin Analogs (Irinotecan or Topotecan) plus High-Dose Cyclophosphamide as Preparative Regimens for Antibody-Based Immunotherapy in Resistant Neuroblastoma
Clin Cancer Res 2004 10: 84-87. [Abstract] [Full Text] [PDF]  

Maurizio Zangari, Elias Anaissie, Alison Stopeck, Alyssa Morimoto, Nguyen Tan, Jeffrey Lancet, Maureen Cooper, Alison Hannah, Guillermo Garcia-Manero, Stephan Faderl, Hagop Kantarjian, Julie Cherrington, Maher Albitar, and Francis J. Giles

Phase II Study of SU5416, a Small Molecule Vascular Endothelial Growth Factor Tyrosine Kinase Receptor Inhibitor, in Patients with Refractory Multiple Myeloma
Clin Cancer Res 2004 10: 88-95. [Abstract] [Full Text] [PDF]  

Matthew M. Cooney, Tomas Radivoyevitch, Afshin Dowlati, Beth Overmoyer, Nathan Levitan, Kelly Robertson, Sandra L. Levine, Kathleen DeCaro, Carol Buchter, Anne Taylor, Bruce S. Stambler, and Scot C. Remick

Cardiovascular Safety Profile of Combretastatin A4 Phosphate in a Single-Dose Phase I Study in Patients with Advanced Cancer
Clin Cancer Res 2004 10: 96-100. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

V. Anne Westbrook, Pamela D. Schoppee, Alan B. Diekman, Kenneth L. Klotz, Margaretta Allietta, Kevin T. Hogan, Craig L. Slingluff, James W. Patterson, Henry F. Frierson, William P. Irvin, Jr., Charles J. Flickinger, Michael A. Coppola, and John C. Herr

Genomic Organization, Incidence, and Localization of the SPAN-X Family of Cancer-Testis Antigens in Melanoma Tumors and Cell Lines
Clin Cancer Res 2004 10: 101-112. [Abstract] [Full Text] [PDF]  

Matthew B. Schabath, Xifeng Wu, Rena Vassilopoulou-Sellin, Ara A. Vaporciyan, and Margaret R. Spitz

Hormone Replacement Therapy and Lung Cancer Risk: A Case-Control Analysis
Clin Cancer Res 2004 10: 113-123. [Abstract] [Full Text] [PDF]  

Wonshik Han, Daehee Kang, In Ae Park, Seok Won Kim, Ji Yeon Bae, Ki-Wook Chung, and Dong-Young Noh

Associations between Breast Cancer Susceptibility Gene Polymorphisms and Clinicopathological Features
Clin Cancer Res 2004 10: 124-130. [Abstract] [Full Text] [PDF]  

Zun-Wu Zhang, Nicola J. Laurence, Andrew Hollowood, Paul Newcomb, Moganaden Moorghen, Jyoti Gupta, Roger Feakins, Michael J. G. Farthing, Derek Alderson, and Jeff Holly

Prognostic Value of TP53 Codon 72 Polymorphism in Advanced Gastric Adenocarcinoma
Clin Cancer Res 2004 10: 131-135. [Abstract] [Full Text] [PDF]  

Amir Onn, Arlene M. Correa, Michael Gilcrease, Takeshi Isobe, Erminia Massarelli, Corazon D. Bucana, Michael S. O’Reilly, Waun K. Hong, Isaiah J. Fidler, Joe B. Putnam, and Roy S. Herbst

Synchronous Overexpression of Epidermal Growth Factor Receptor and HER2-neu Protein Is a Predictor of Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 136-143. [Abstract] [Full Text] [PDF]  

Irma Airoldi, Lizzia Raffaghello, Claudia Cocco, Roberta Guglielmino, Silvio Roncella, Franco Fedeli, Claudio Gambini, and Vito Pistoia

Heterogeneous Expression of Interleukin-18 and Its Receptor in B-Cell Lymphoproliferative Disorders Deriving from Naive, Germinal Center, and Memory B Lymphocytes
Clin Cancer Res 2004 10: 144-154. [Abstract] [Full Text] [PDF]  

Lee Anne McLean, Insa Gathmann, Renaud Capdeville, Mihael H. Polymeropoulos, and Marlene Dressman

Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib
Clin Cancer Res 2004 10: 155-165. [Abstract] [Full Text] [PDF]  

Sang-Chul Lim, Shichuan Zhang, Genichiro Ishii, Yasushi Endoh, Keiji Kodama, Shinichi Miyamoto, Ryuichi Hayashi, Satoshi Ebihara, Jae-Shik Cho, and Atsushi Ochiai

Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral Tongue
Clin Cancer Res 2004 10: 166-172. [Abstract] [Full Text] [PDF]  

Harriet M. Kluger, Marisa Dolled-Filhart, Sofya Rodov, Barry M. Kacinski, Robert L. Camp, and David L. Rimm

Macrophage Colony-Stimulating Factor-1 Receptor Expression Is Associated with Poor Outcome in Breast Cancer by Large Cohort Tissue Microarray Analysis
Clin Cancer Res 2004 10: 173-177. [Abstract] [Full Text] [PDF]  

Ronald Simon, Soti Panussis, Robert Maurer, Hanspeter Spichtin, Kathrin Glatz, Coya Tapia, Martina Mirlacher, Alex Rufle, Joachim Torhorst, and Guido Sauter

KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
Clin Cancer Res 2004 10: 178-183. [Abstract] [Full Text] [PDF]  

Domenico Coppola, Marianna Szabo, David Boulware, Patrick Muraca, Marwan Alsarraj, Ann F. Chambers, and Timothy J. Yeatman

Correlation of Osteopontin Protein Expression and Pathological Stage across a Wide Variety of Tumor Histologies
Clin Cancer Res 2004 10: 184-190. [Abstract] [Full Text] [PDF]  

Guoren Deng, Ian Bell, Suzanne Crawley, James Gum, Jonathan P. Terdiman, Brian A. Allen, Brindusa Truta, Marvin H. Sleisenger, and Young S. Kim

BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer
Clin Cancer Res 2004 10: 191-195. [Abstract] [Full Text] [PDF]  

Mohamed Saad Ismail, Wim Wynendaele, Joeri L. E. Aerts, Robert Paridaens, Rabab Gaafar, Nayera Shakankiry, Hussein M. Khaled, Marie-Rose Christiaens, Hans Wildiers, Sherif Omar, Philippe Vandekerckhove, and Allan T. van Oosterom

Detection of Micrometastatic Disease and Monitoring of Perioperative Tumor Cell Dissemination in Primary Operable Breast Cancer Patients Using Real-Time Quantitative Reverse Transcription-PCR
Clin Cancer Res 2004 10: 196-201. [Abstract] [Full Text] [PDF]  

Christian Parr, Gareth Watkins, Robert E. Mansel, and Wen G. Jiang

The Hepatocyte Growth Factor Regulatory Factors in Human Breast Cancer
Clin Cancer Res 2004 10: 202-211. [Abstract] [Full Text] [PDF]  

Shaan M. Raza, Gregory N. Fuller, Chang Hun Rhee, Suyun Huang, Kenneth Hess, Wei Zhang, and Raymond Sawaya

Identification of Necrosis-Associated Genes in Glioblastoma by cDNA Microarray Analysis
Clin Cancer Res 2004 10: 212-221. [Abstract] [Full Text] [PDF]  

Robert P. Caruso, Benjamin Levinson, Jonathan Melamed, Rosemary Wieczorek, Samir Taneja, David Polsky, Caroline Chang, Anne Zeleniuch-Jacquotte, Konstantin Salnikow, Herman Yee, Max Costa, and Iman Osman

Altered N-myc Downstream-Regulated Gene 1 Protein Expression in African-American Compared with Caucasian Prostate Cancer Patients
Clin Cancer Res 2004 10: 222-227. [Abstract] [Full Text] [PDF]  

Tracy T. Batchelor, Rebecca A. Betensky, J. Matthew Esposito, Loc-Duyen D. Pham, Molly V. Dorfman, Nicole Piscatelli, Sarah Jhung, David Rhee, and David N. Louis

Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma
Clin Cancer Res 2004 10: 228-233. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Lian Duan, Masaru Aoyagi, Masashi Tamaki, Yoshikazu Yoshino, Takashi Morimoto, Hiroaki Wakimoto, Yasuhiko Nagasaka, Kimiyoshi Hirakawa, Kikuo Ohno, and Kiyotaka Yamamoto

Impairment of Both Apoptotic and Cytoprotective Signalings in Glioma Cells Resistant to the Combined Use of Cisplatin and Tumor Necrosis Factor
Clin Cancer Res 2004 10: 234-243. [Abstract] [Full Text] [PDF]  

Rana P. Singh, Girish Sharma, G. U. Mallikarjuna, Sivanandhan Dhanalakshmi, Chapla Agarwal, and Rajesh Agarwal

In Vivo Suppression of Hormone-Refractory Prostate Cancer Growth by Inositol Hexaphosphate: Induction of Insulin-Like Growth Factor Binding Protein-3 and Inhibition of Vascular Endothelial Growth Factor
Clin Cancer Res 2004 10: 244-250. [Abstract] [Full Text] [PDF]  

Richard J. Wong, Mei-Ki Chan, Zhenkun Yu, Teresa H. Kim, Amit Bhargava, Brendon M. Stiles, Brian C. Horsburgh, Jatin P. Shah, Ronald A. Ghossein, Bhuvanesh Singh, and Yuman Fong

Effective Intravenous Therapy of Murine Pulmonary Metastases with an Oncolytic Herpes Virus Expressing Interleukin 12
Clin Cancer Res 2004 10: 251-259. [Abstract] [Full Text] [PDF]  

Makoto Sumitomo, Tomohiko Asano, Junichi Asakuma, Takako Asano, David M. Nanus, and Masamichi Hayakawa

Chemosensitization of Androgen-Independent Prostate Cancer with Neutral Endopeptidase
Clin Cancer Res 2004 10: 260-266. [Abstract] [Full Text] [PDF]  

Diana Kazanov, Hadas Dvory-Sobol, Marjorie Pick, Eliezer Liberman, Ludmila Strier, Efrat Choen-Noyman, Varda Deutsch, Talya Kunik, and Nadir Arber

Celecoxib But Not Rofecoxib Inhibits the Growth of Transformed Cells in Vitro
Clin Cancer Res 2004 10: 267-271. [Abstract] [Full Text] [PDF]  

Hio Chung Kang, Il-Jin Kim, Jae-Hyun Park, Yong Shin, Ja-Lok Ku, Mi Sun Jung, Byong Chul Yoo, Hark Kyun Kim, and Jae-Gahb Park

Identification of Genes with Differential Expression in Acquired Drug-Resistant Gastric Cancer Cells Using High-Density Oligonucleotide Microarrays
Clin Cancer Res 2004 10: 272-284. [Abstract] [Full Text] [PDF]  

Takeshi Kawashima, Shunsuke Kagawa, Naoya Kobayashi, Yoshiko Shirakiya, Tatsuo Umeoka, Fuminori Teraishi, Masaki Taki, Satoru Kyo, Noriaki Tanaka, and Toshiyoshi Fujiwara

Telomerase-Specific Replication-Selective Virotherapy for Human Cancer
Clin Cancer Res 2004 10: 285-292. [Abstract] [Full Text] [PDF]  

Daniel J. Boffa, Fulung Luan, Dolca Thomas, Hua Yang, Vijay K. Sharma, Milagros Lagman, and Manikkam Suthanthiran

Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 293-300. [Abstract] [Full Text] [PDF]  

Xiao-Han Tang, Beatrice Knudsen, Debra Bemis, Satish Tickoo, and Lorraine J. Gudas

Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice
Clin Cancer Res 2004 10: 301-313. [Abstract] [Full Text] [PDF]  

Daniel R. McCulloch, Pascal Akl, Hemamali Samaratunga, Adrian C. Herington, and Dimitri M. Odorico

Expression of the Disintegrin Metalloprotease, ADAM-10, in Prostate Cancer and Its Regulation by Dihydrotestosterone, Insulin-Like Growth Factor I, and Epidermal Growth Factor in the Prostate Cancer Cell Model LNCaP
Clin Cancer Res 2004 10: 314-323. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Eleftherios Tsiridis, Evangelia Maria Tsapakis, Manolis Heliotis, Simon T. Donell, and David G. Scott

Commentary re T. Morimoto et al., Increased Levels of Tissue Endostatin in Human Malignant Gliomas. Clin. Cancer Res., 8: 2933–2938, 2002.
Clin Cancer Res 2004 10: 324-325. [Full Text] [PDF]  

Masaru Aoyagi, Takashi Morimoto, Yoshikazu Yoshino, Hisae Hori, and Noriko Yamaguchi

Reply
Clin Cancer Res 2004 10: 325-326. [Full Text] [PDF]  

Corrections:

Correction
Clin Cancer Res 2004 10: 326. [Full Text] [PDF]  

Supplement Articles:

   Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer:

Steven E. Come, Aman U. Buzdar, Carlos L. Arteaga, Mina J. Bissell, Myles A. Brown, Matthew J. Ellis, Paul E. Goss, Jeffrey E. Green, James N. Ingle, Adrian V. Lee, Daniel Medina, Robert I. Nicholson, Richard J. Santen, Rachel Schiff, and Carol S. Hart

Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference Summary Statement
Clin Cancer Res 2004 10: 327S-330S. [Full Text] [PDF]  

Rachel Schiff, Suleiman A. Massarweh, Jiang Shou, Lavina Bharwani, Syed K. Mohsin, and C. Kent Osborne

Cross-Talk between Estrogen Receptor and Growth Factor Pathways as a Molecular Target for Overcoming Endocrine Resistance
Clin Cancer Res 2004 10: 331S-336S. [Abstract] [Full Text] [PDF]  

Richard J. Santen, Robert X. Song, Zhenguo Zhang, Wei Yue, and Rakesh Kumar

Adaptive Hypersensitivity to Estrogen: Mechanism for Sequential Responses to Hormonal Therapy in Breast Cancer
Clin Cancer Res 2004 10: 337S-345S. [Abstract] [Full Text] [PDF]  

Robert I. Nicholson, Iain R. Hutcheson, Janice M. Knowlden, Helen E. Jones, Maureen E. Harper, Nicola Jordan, Steve E. Hiscox, Denise Barrow, and Julia M. W. Gee

Nonendocrine Pathways and Endocrine Resistance: Observations with Antiestrogens and Signal Transduction Inhibitors in Combination
Clin Cancer Res 2004 10: 346S-354S. [Abstract] [Full Text] [PDF]  

Aman U. Buzdar

Data from the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trial: Implications for Use of Aromatase Inhibitors in 2003
Clin Cancer Res 2004 10: 355S-361S. [Abstract] [Full Text] [PDF]  

James N. Ingle

Sequencing of Endocrine Therapy in Postmenopausal Women with Advanced Breast Cancer
Clin Cancer Res 2004 10: 362S-367S. [Abstract] [Full Text] [PDF]  

Carlos L. Arteaga

Cdk Inhibitor p27^Kip1 and Hormone Dependence in Breast Cancer
Clin Cancer Res 2004 10: 368S-371S. [Abstract] [Full Text] [PDF]  

Paul E. Goss and Kathrin Strasser-Weippl

Prevention Strategies with Aromatase Inhibitors
Clin Cancer Res 2004 10: 372S-379S. [Abstract] [Full Text] [PDF]  

Daniel Medina

Breast Cancer: The Protective Effect of Pregnancy
Clin Cancer Res 2004 10: 380S-384S. [Abstract] [Full Text] [PDF]  

Jeffrey E. Green, Kartiki Desai, Yumei Ye, Claudine Kavanaugh, Alfonso Calvo, and Jung-Im Huh

Genomic Approaches to Understanding Mammary Tumor Progression in Transgenic Mice and Responses to Therapy
Clin Cancer Res 2004 10: 385S-390S. [Abstract] [Full Text] [PDF]  

Matthew J. Ellis

Neoadjuvant Endocrine Therapy as a Drug Development Strategy
Clin Cancer Res 2004 10: 391S-395S. [Abstract] [Full Text] [PDF]  

Xiaojiang Cui and Adrian V. Lee

Regulatory Nodes That Integrate and Coordinate Signaling as Potential Targets for Breast Cancer Therapy
Clin Cancer Res 2004 10: 396S-401S. [Abstract] [Full Text] [PDF]  

Virginia Novaro, Derek C. Radisky, Nancy E. Ramos Castro, Alessandro Weisz, and Mina J. Bissell

Malignant Mammary Cells Acquire Independence from Extracellular Context for Regulation of Estrogen Receptor
Clin Cancer Res 2004 10: 402S-409S. [Abstract] [Full Text] [PDF]  

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