Editorials:

Bruce E. Johnson

Imatinib for Small Cell Lung Cancer, Aiming for a Target in Vivo
Clin Cancer Res 2004 10: 3235-3236. [Full Text] [PDF]  

Reviews:

Russell D. Petty, Marianne C. Nicolson, Keith M. Kerr, Elaina Collie-Duguid, and Graeme I. Murray

Gene Expression Profiling in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application
Clin Cancer Res 2004 10: 3237-3248. [Abstract] [Full Text] [PDF]  

Laura G. Estévez and William J. Gradishar

Evidence-Based Use of Neoadjuvant Taxane in Operable and Inoperable Breast Cancer
Clin Cancer Res 2004 10: 3249-3261. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Ole Petter Veiby and Margaret A. Read

Chemoresistance: Impact of Nuclear Factor (NF)-B Inhibition by Small Interfering RNA: Commentary re J. Guo et al., Enhanced Chemosensitivity to Irinotecan by RNA Interference-Mediated Down-Regulation of the NF-B p65 Subunit. Clin Cancer Res 2004;10:3333–3341
Clin Cancer Res 2004 10: 3262-3264. [Full Text] [PDF]  

   Clinical Trials:

Alan Sandler, Michael Gordon, Dinesh P. de Alwis, Isabelle Pouliquen, Lisa Green, Phil Marder, Ajai Chaudhary, Karen Fife, Linda Battiato, Christopher Sweeney, Christopher Jordan, Michael Burgess, and Christopher A. Slapak

A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy
Clin Cancer Res 2004 10: 3265-3272. [Abstract] [Full Text] [PDF]  

Gustav J. Ullenhag, Jan-Erik Frödin, Mahmood Jeddi-Tehrani, Karin Strigård, Emma Eriksson, Ali Samanci, Aniruddha Choudhury, Bo Nilsson, Eva D. Rossmann, Szilvia Mosolits, and Håkan Mellstedt

Durable Carcinoembryonic Antigen (CEA)-Specific Humoral and Cellular Immune Responses in Colorectal Carcinoma Patients Vaccinated with Recombinant CEA and Granulocyte/Macrophage Colony-Stimulating Factor
Clin Cancer Res 2004 10: 3273-3281. [Abstract] [Full Text] [PDF]  

Cristina R. Antonescu, Agnes Viale, Lisa Sarran, Sylvia J. Tschernyavsky, Mithat Gonen, Neil H. Segal, Robert G. Maki, Nicholas D. Socci, Ronald P. DeMatteo, and Peter Besmer

Gene Expression in Gastrointestinal Stromal Tumors Is Distinguished by KIT Genotype and Anatomic Site
Clin Cancer Res 2004 10: 3282-3290. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Karen H. Lu, Andrea P. Patterson, Lin Wang, Rebecca T. Marquez, Edward N. Atkinson, Keith A. Baggerly, Lance R. Ramoth, Daniel G. Rosen, Jinsong Liu, Ingegerd Hellstrom, David Smith, Lynn Hartmann, David Fishman, Andrew Berchuck, Rosemarie Schmandt, Regina Whitaker, David M. Gershenson, Gordon B. Mills, and Robert C. Bast, Jr

Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis
Clin Cancer Res 2004 10: 3291-3300. [Abstract] [Full Text] [PDF]  

Dominic E. Warrino, Walter C. Olson, William T. Knapp, Meera I. Scarrow, Lori J. D’Ambrosio-Brennan, Richard S. Guido, Robert P. Edwards, W. Martin Kast, and Walter J. Storkus

Disease-Stage Variance in Functional CD4⁺ T-Cell Responses Against Novel Pan-Human Leukocyte Antigen-D Region Presented Human Papillomavirus-16 E7 Epitopes
Clin Cancer Res 2004 10: 3301-3308. [Abstract] [Full Text] [PDF]  

Stephanie Si Liu, Rebecca Ching-Yu Leung, Kelvin Yuen-Kwong Chan, Pui-Man Chiu, Annie Nga-Yin Cheung, Kar-Fai Tam, Tong-Yow Ng, Ling-Chui Wong, and Hextan Yuen-Sheung Ngan

p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy
Clin Cancer Res 2004 10: 3309-3316. [Abstract] [Full Text] [PDF]  

Alan K. Meeker, Jessica L. Hicks, Christine A. Iacobuzio-Donahue, Elizabeth A. Montgomery, William H. Westra, Theresa Y. Chan, Brigitte M. Ronnett, and Angelo M. De Marzo

Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis
Clin Cancer Res 2004 10: 3317-3326. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Mitsuharu Fukasawa and Murray Korc

Vascular Endothelial Growth Factor-Trap Suppresses Tumorigenicity of Multiple Pancreatic Cancer Cell Lines
Clin Cancer Res 2004 10: 3327-3332. [Abstract] [Full Text] [PDF]  

Jun Guo, Udit N. Verma, Richard B. Gaynor, Eugene P. Frenkel, and Carlos R. Becerra

Enhanced Chemosensitivity to Irinotecan by RNA Interference-Mediated Down-Regulation of the Nuclear Factor-B p65 Subunit
Clin Cancer Res 2004 10: 3333-3341. [Abstract] [Full Text] [PDF]  

Robert A. Nordal, Andras Nagy, Melania Pintilie, and C. Shun Wong

Hypoxia and Hypoxia-Inducible Factor-1 Target Genes in Central Nervous System Radiation Injury: A Role for Vascular Endothelial Growth Factor
Clin Cancer Res 2004 10: 3342-3353. [Abstract] [Full Text] [PDF]  

Mathias Gehrmann, Marion Brunner, Karin Pfister, Albrecht Reichle, Elisabeth Kremmer, and Gabriele Multhoff

Differential Up-Regulation of Cytosolic and Membrane-Bound Heat Shock Protein 70 in Tumor Cells by Anti-Inflammatory Drugs
Clin Cancer Res 2004 10: 3354-3364. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Walter M. Stadler, Dingcai Cao, Nicholas J. Vogelzang, Christopher W. Ryan, Kristin Hoving, Russell Wright, Theodore Karrison, and Everett E. Vokes

A Randomized Phase II Trial of the Antiangiogenic Agent SU5416 in Hormone-Refractory Prostate Cancer
Clin Cancer Res 2004 10: 3365-3370. [Abstract] [Full Text] [PDF]  

Jorge Cortes, Deborah Thomas, Charles Koller, Francis Giles, Elihu Estey, Stefan Faderl, Guillermo Garcia-Manero, David McConkey, Gira Patel, Roberto Guerciolini, John Wright, and Hagop Kantarjian

Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias
Clin Cancer Res 2004 10: 3371-3376. [Abstract] [Full Text] [PDF]  

Jérôme Alexandre, Eric Raymond, Mahmoud Ould Kaci, Etienne C. Brain, François Lokiec, Carmen Kahatt, Sandrine Faivre, Alejandro Yovine, François Goldwasser, Sheri L. Smith, John R. MacDonald, Jean-Louis Misset, and Esteban Cvitkovic

Phase I and Pharmacokinetic Study of Irofulven Administered Weekly or Biweekly in Advanced Solid Tumor Patients
Clin Cancer Res 2004 10: 3377-3385. [Abstract] [Full Text] [PDF]  

Jeany M. Rademaker-Lakhai, Catherine Terret, Stephen B. Howell, Christiane M. Baud, Richard F. de Boer, Dick Pluim, Jos H. Beijnen, Jan H. M. Schellens, and Jean-Pierre Droz

A Phase I and Pharmacological Study of the Platinum Polymer AP5280 Given as an Intravenous Infusion Once Every 3 Weeks in Patients with Solid Tumors
Clin Cancer Res 2004 10: 3386-3395. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Andreas Widschwendter, Conny Gattringer, Lennart Ivarsson, Heidi Fiegl, Alois Schneitter, Angela Ramoni, Hannes M. Müller, Annemarie Wiedemair, Susanne Jerabek, Elisabeth Müller-Holzner, Georg Goebel, Christian Marth, and Martin Widschwendter

Analysis of Aberrant DNA Methylation and Human Papillomavirus DNA in Cervicovaginal Specimens to Detect Invasive Cervical Cancer and Its Precursors
Clin Cancer Res 2004 10: 3396-3400. [Abstract] [Full Text] [PDF]  

William E. Carson, III, Charles L. Shapiro, Timothy R. Crespin, Lisa M. Thornton, and Barbara L. Andersen

Cellular Immunity in Breast Cancer Patients Completing Taxane Treatment
Clin Cancer Res 2004 10: 3401-3409. [Abstract] [Full Text] [PDF]  

Olga Modlich, Hans-Bernd Prisack, Gerald Pitschke, Uwe Ramp, Rolf Ackermann, Hans Bojar, Thomas A. Vögeli, and Marc-Oliver Grimm

Identifying Superficial, Muscle-Invasive, and Metastasizing Transitional Cell Carcinoma of the Bladder: Use of cDNA Array Analysis of Gene Expression Profiles
Clin Cancer Res 2004 10: 3410-3421. [Abstract] [Full Text] [PDF]  

Natalie Reimers, Kristine Zafrakas, Volker Assmann, Cornelia Egen, Lutz Riethdorf, Sabine Riethdorf, Jürgen Berger, Sebastian Ebel, Fritz Jänicke, Guido Sauter, and Klaus Pantel

Expression of Extracellular Matrix Metalloproteases Inducer on Micrometastatic and Primary Mammary Carcinoma Cells
Clin Cancer Res 2004 10: 3422-3428. [Abstract] [Full Text] [PDF]  

Stephen Boorjian, Satish K. Tickoo, Nigel P. Mongan, Huayin Yu, Dean Bok, Robert R. Rando, David M. Nanus, Douglas S. Scherr, and Lorraine J. Gudas

Reduced Lecithin: Retinol Acyltransferase Expression Correlates with Increased Pathologic Tumor Stage in Bladder Cancer
Clin Cancer Res 2004 10: 3429-3437. [Abstract] [Full Text] [PDF]  

Vidar Staalesen, Beryl Leirvaag, Johan Richard Lillehaug, and Per Eystein Lønning

Genetic and Epigenetic Changes in p21 and p21B Do Not Correlate with Resistance to Doxorubicin or Mitomycin and 5-Fluorouracil in Locally Advanced Breast Cancer
Clin Cancer Res 2004 10: 3438-3443. [Abstract] [Full Text] [PDF]  

Yoram Cohen, Eli Rosenbaum, Shahnaz Begum, David Goldenberg, Clemens Esche, Ofer Lavie, David Sidransky, and William H. Westra

Exon 15 BRAF Mutations Are Uncommon in Melanomas Arising in Nonsun-Exposed Sites
Clin Cancer Res 2004 10: 3444-3447. [Abstract] [Full Text] [PDF]  

Julia H. Carter, Larry E. Douglass, James A. Deddens, Bruce M. Colligan, Tejal R. Bhatt, Jackson O. Pemberton, Susan Konicek, Joanne Hom, Mark Marshall, and Jeremy R. Graff

Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis
Clin Cancer Res 2004 10: 3448-3456. [Abstract] [Full Text] [PDF]  

Rainer Gangnus, Sabine Langer, Elisabeth Breit, Klaus Pantel, and Michael R. Speicher

Genomic Profiling of Viable and Proliferative Micrometastatic Cells from Early-Stage Breast Cancer Patients
Clin Cancer Res 2004 10: 3457-3464. [Abstract] [Full Text] [PDF]  

Robert W. Veltri, Masood A. Khan, M. Craig Miller, Jonathan I. Epstein, Leslie A. Mangold, Patrick C. Walsh, and Alan W. Partin

Ability to Predict Metastasis Based On Pathology Findings and Alterations in Nuclear Structure Of Normal-Appearing and Cancer Peripheral Zone Epithelium in the Prostate
Clin Cancer Res 2004 10: 3465-3473. [Abstract] [Full Text] [PDF]  

John O. Schorge, Richard D. Drake, Hang Lee, Steven J. Skates, Ramababu Rajanbabu, David S. Miller, Jae-Hoon Kim, Daniel W. Cramer, Ross S. Berkowitz, and Samuel C. Mok

Osteopontin as an Adjunct to CA125 in Detecting Recurrent Ovarian Cancer
Clin Cancer Res 2004 10: 3474-3478. [Abstract] [Full Text] [PDF]  

Coralie Fouquet, Martine Antoine, Pascaline Tisserand, Reyna Favis, Marie Wislez, Fréderic Commo, Nathalie Rabbe, Marie France Carette, Bernard Milleron, Francis Barany, Jacques Cadranel, Gérard Zalcman, and Thierry Soussi

Rapid and Sensitive p53 Alteration Analysis in Biopsies from Lung Cancer Patients Using a Functional Assay and A Universal Oligonucleotide Array: A Prospective Study
Clin Cancer Res 2004 10: 3479-3489. [Abstract] [Full Text] [PDF]  

Gennaro Galizia, Eva Lieto, Francesca Ferraraccio, Michele Orditura, Ferdinando De Vita, Paolo Castellano, Vincenzo Imperatore, Ciro Romano, Fortunato Ciardiello, Bruno Agostini, and Carlo Pignatelli

Determination of Molecular Marker Expression Can Predict Clinical Outcome in Colon Carcinomas
Clin Cancer Res 2004 10: 3490-3499. [Abstract] [Full Text] [PDF]  

Maria Rosaria Raspollini, Gianni Amunni, Alessandro Villanucci, Pamela Pinzani, Lisa Simi, Milena Paglierani, and Gian Luigi Taddei

c-Kit Expression in Patients with Uterine Leiomyosarcomas: A Potential Alternative Therapeutic Treatment
Clin Cancer Res 2004 10: 3500-3503. [Abstract] [Full Text] [PDF]  

Liping Zhang, Raymond Scott Maul, JianYu Rao, Sophia Apple, David Seligson, Maryam Sartippour, Rosalio Rubio, and Mai N. Brooks

Expression Pattern of the Novel Gene EG-1 in Cancer
Clin Cancer Res 2004 10: 3504-3508. [Abstract] [Full Text] [PDF]  

Pier Paolo Claudio, Giuseppe Russo, Christine A. C. Y. Kumar, Corrado Minimo, Antonio Farina, Steve Tutton, Gennaro Nuzzo, Felice Giuliante, Giulia Angeloni, Vellone Maria, Fabio Maria Vecchio, Cristiana Di Campli, and Antonio Giordano

pRb2/p130, Vascular Endothelial Growth Factor, p27^(KIP1), and Proliferating Cell Nuclear Antigen Expression in Hepatocellular Carcinoma: Their Clinical Significance
Clin Cancer Res 2004 10: 3509-3517. [Abstract] [Full Text] [PDF]  

Peter Krippl, Uwe Langsenlehner, Wilfried Renner, Babak Yazdani-Biuki, Herwig Köppel, Andreas Leithner, Thomas C. Wascher, Bernhard Paulweber, and Hellmut Samonigg

The 5A/6A Polymorphism of the Matrix Metalloproteinase 3 Gene Promoter and Breast Cancer
Clin Cancer Res 2004 10: 3518-3520. [Abstract] [Full Text] [PDF]  

Stephen B. Fox, Philip Brown, Cheng Han, Sally Ashe, Russel D. Leek, Adrian L. Harris, and Alison H. Banham

Expression of the Forkhead Transcription Factor FOXP1 Is Associated with Estrogen Receptor and Improved Survival in Primary Human Breast Carcinomas
Clin Cancer Res 2004 10: 3521-3527. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Nicholas C. Wolff, Dwight E. Randle, Merrill J. Egorin, John D. Minna, and Robert L. Ilaria, Jr.

Imatinib Mesylate Efficiently Achieves Therapeutic Intratumor Concentrations in Vivo but Has Limited Activity in a Xenograft Model of Small Cell Lung Cancer
Clin Cancer Res 2004 10: 3528-3534. [Abstract] [Full Text] [PDF]  

Dietmar Jacob, John Davis, Hongbo Zhu, Lidong Zhang, Fuminori Teraishi, Shuhong Wu, Frank C. Marini, III, and Bingliang Fang

Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber-Modified Adenovector Expressing the TRAIL Gene from the Human Telomerase Reverse Transcriptase Promoter
Clin Cancer Res 2004 10: 3535-3541. [Abstract] [Full Text] [PDF]  

Camelia I. Spiridon, Sarah Guinn, and Ellen S. Vitetta

A Comparison of the in Vitro and in Vivo Activities of IgG and F(ab')₂ Fragments of a Mixture of Three Monoclonal Anti-Her-2 Antibodies
Clin Cancer Res 2004 10: 3542-3551. [Abstract] [Full Text] [PDF]  

Thomas M. Cardillo, Habibe Karacay, David M. Goldenberg, Dion Yeldell, Chien-Hsing Chang, David E. Modrak, Robert M. Sharkey, and David V. Gold

Improved Targeting of Pancreatic Cancer: Experimental Studies of a New Bispecific Antibody, Pretargeting Enhancement System for Immunoscintigraphy
Clin Cancer Res 2004 10: 3552-3561. [Abstract] [Full Text] [PDF]  

Daniel Broderick Longley, Wendy Louise Allen, Ultan McDermott, Timothy Richard Wilson, Tariq Latif, John Boyer, Maria Lynch, and Patrick Gerard Johnston

The Roles of Thymidylate Synthase and p53 in Regulating Fas-Mediated Apoptosis in Response to Antimetabolites
Clin Cancer Res 2004 10: 3562-3571. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Susan J. Morgan, John F. Seymour, H. Miles Prince, David A. Westerman, and Max M. Wolf

Confirmation of the Activity of the Interleukin-2 Fusion Toxin Denileukin Diftitox against Chemorefractory Chronic Lymphocytic Leukemia, including Cases with Chromosome 17p Deletions and without Detectable CD25 Expression
Clin Cancer Res 2004 10: 3572-3575. [Full Text] [PDF]  

Corrections:

Correction
Clin Cancer Res 2004 10: 3576. [Full Text] [PDF]  

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