Featured Articles:

   Clinical Trials:

Judith E. Karp, Ivana Gojo, Roberto Pili, Christopher D. Gocke, Jacqueline Greer, Chuanfa Guo, David Qian, Lawrence Morris, Michael Tidwell, Helen Chen, and James Zwiebel

Targeting Vascular Endothelial Growth Factor for Relapsed and Refractory Adult Acute Myelogenous Leukemias: Therapy with Sequential 1-ß-D-Arabinofuranosylcytosine, Mitoxantrone, and Bevacizumab
Clin Cancer Res 2004 10: 3577-3585. [Abstract] [Full Text] [PDF]  

Shigesaburo Miyakoshi, Koichiro Yuji, Masahiro Kami, Eiji Kusumi, Yukiko Kishi, Kazuhiko Kobayashi, Naoko Murashige, Tamae Hamaki, Sung-Won Kim, Jun-ichi Ueyama, Shin-ichiro Mori, Shin-ichi Morinaga, Yoshitomo Muto, Shigeru Masuo, Mineo Kanemaru, Tatsuyuki Hayashi, Yoichi Takaue, and Shuichi Taniguchi

Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Adult Patients with Advanced Hematological Diseases
Clin Cancer Res 2004 10: 3586-3592. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Margret Schottelius, Thorsten Poethko, Michael Herz, Jean-Claude Reubi, Horst Kessler, Markus Schwaiger, and Hans-Jürgen Wester

First ¹⁸F-Labeled Tracer Suitable for Routine Clinical Imaging of sst Receptor-Expressing Tumors Using Positron Emission Tomography
Clin Cancer Res 2004 10: 3593-3606. [Abstract] [Full Text] [PDF]  

Maarten P. Tabor, Ruud H. Brakenhoff, Henrique J. Ruijter-Schippers, J. Alain Kummer, C. René Leemans, and Boudewijn J. M. Braakhuis

Genetically Altered Fields as Origin of Locally Recurrent Head and Neck Cancer: A Retrospective Study
Clin Cancer Res 2004 10: 3607-3613. [Abstract] [Full Text] [PDF]  

Viola M. M. van Houten, C. René Leemans, J. Alain Kummer, Janny Dijkstra, Dirk J. Kuik, Michiel W. M. van den Brekel, Gordon B. Snow, and Ruud H. Brakenhoff

Molecular Diagnosis of Surgical Margins and Local Recurrence in Head and Neck Cancer Patients: A Prospective Study
Clin Cancer Res 2004 10: 3614-3620. [Abstract] [Full Text] [PDF]  

Zhibo Yang, Christopher J. Barnes, and Rakesh Kumar

Human Epidermal Growth Factor Receptor 2 Status Modulates Subcellular Localization of and Interaction with Estrogen Receptor in Breast Cancer Cells
Clin Cancer Res 2004 10: 3621-3628. [Abstract] [Full Text] [PDF]  

Eiji Tamoto, Mitsuhiro Tada, Katsuhiko Murakawa, Minoru Takada, Gaku Shindo, Ken-ichi Teramoto, Akihiro Matsunaga, Kazuteru Komuro, Motoshi Kanai, Akiko Kawakami, Yoshie Fujiwara, Nozomi Kobayashi, Katsutoshi Shirata, Norihiro Nishimura, Shun-ichi Okushiba, Satoshi Kondo, Jun-ichi Hamada, Takashi Yoshiki, Tetsuya Moriuchi, and Hiroyuki Katoh

Gene-Expression Profile Changes Correlated with Tumor Progression and Lymph Node Metastasis in Esophageal Cancer
Clin Cancer Res 2004 10: 3629-3638. [Abstract] [Full Text] [PDF]  

Silvestre Vicent, Mercedes Garayoa, José M. López-Picazo, María D. Lozano, Gemma Toledo, Frederik B. J. M. Thunnissen, Ramón G. Manzano, and Luis M. Montuenga

Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients
Clin Cancer Res 2004 10: 3639-3649. [Abstract] [Full Text] [PDF]  

Jeffrey L. Evelhoch, Patricia M. LoRusso, Zhanquan He, Zachary DelProposto, Lisa Polin, Thomas H. Corbett, Peter Langmuir, Catherine Wheeler, Andrew Stone, Joanna Leadbetter, Anderson J. Ryan, David C. Blakey, and John C. Waterton

Magnetic Resonance Imaging Measurements of the Response of Murine and Human Tumors to the Vascular-Targeting Agent ZD6126
Clin Cancer Res 2004 10: 3650-3657. [Abstract] [Full Text] [PDF]  

Kerstin Schag, Susanne M. Schmidt, Martin R. Müller, Toni Weinschenk, Silke Appel, Markus M. Weck, Frank Grünebach, Stefan Stevanovic, Hans-Georg Rammensee, and Peter Brossart

Identification of C-Met Oncogene as a Broadly Expressed Tumor-Associated Antigen Recognized by Cytotoxic T-Lymphocytes
Clin Cancer Res 2004 10: 3658-3666. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Yun Zhang, Yu-feng Zhang, Joshua Bryant, Andrew Charles, Ruben J. Boado, and William M. Pardridge

Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer
Clin Cancer Res 2004 10: 3667-3677. [Abstract] [Full Text] [PDF]  

Luba Benimetskaya, Timo Wittenberger, C. A. Stein, Hans-Peter Hofmann, Claudia Weller, Johnathan C. Lai, Paul Miller, and Volker Gekeler

Changes in Gene Expression Induced by Phosphorothioate Oligodeoxynucleotides (Including G3139) in PC3 Prostate Carcinoma Cells Are Recapitulated at Least in Part by Treatment with Interferon-ß and -
Clin Cancer Res 2004 10: 3678-3688. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Lee S. Rosen, Bernadette Laxa, Leny Boulos, Laura Wiggins, James G. Keck, Anneliese J. Jameson, Richard Parra, Kiran Patel, and Gail L. Brown

Phase 1 Study of TLK286 (Telcyta) Administered Weekly in Advanced Malignancies
Clin Cancer Res 2004 10: 3689-3698. [Abstract] [Full Text] [PDF]  

Stefan W. Krause, Robert Gastpar, Reinhard Andreesen, Catharina Gross, Heidrun Ullrich, Gerald Thonigs, Karin Pfister, and Gabriele Multhoff

Treatment of Colon and Lung Cancer Patients with ex Vivo Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells: A Clinical Phase I Trial
Clin Cancer Res 2004 10: 3699-3707. [Abstract] [Full Text] [PDF]  

Tae-You Kim, Dong-Wan Kim, Jae-Yong Chung, Sang Goo Shin, Sung-Chul Kim, Dae Seog Heo, Noe Kyeong Kim, and Yung-Jue Bang

Phase I and Pharmacokinetic Study of Genexol-PM, a Cremophor-Free, Polymeric Micelle-Formulated Paclitaxel, in Patients with Advanced Malignancies
Clin Cancer Res 2004 10: 3708-3716. [Abstract] [Full Text] [PDF]  

Jeany M. Rademaker-Lakhai, Desiree van den Bongard, Dick Pluim, Jos H. Beijnen, and Jan H. M. Schellens

A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Clin Cancer Res 2004 10: 3717-3727. [Abstract] [Full Text] [PDF]  

Sandrine Ostermann, Chantal Csajka, Thierry Buclin, Serge Leyvraz, Ferdy Lejeune, Laurent A. Decosterd, and Roger Stupp

Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Temozolomide in Malignant Glioma Patients
Clin Cancer Res 2004 10: 3728-3736. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Ingo Tamm, Stephan Richter, Doreen Oltersdorf, Ursula Creutzig, Jochen Harbott, Frank Scholz, Leonid Karawajew, Wolf-Dieter Ludwig, and Christian Wuchter

High Expression Levels of X-Linked Inhibitor of Apoptosis Protein and Survivin Correlate with Poor Overall Survival in Childhood de Novo Acute Myeloid Leukemia
Clin Cancer Res 2004 10: 3737-3744. [Abstract] [Full Text] [PDF]  

Francesca M. Buffa, Søren M. Bentzen, Frances M. Daley, Stanley Dische, Michele I. Saunders, Paul I. Richman, and George D. Wilson

Molecular Marker Profiles Predict Locoregional Control of Head and Neck Squamous Cell Carcinoma in a Randomized Trial of Continuous Hyperfractionated Accelerated Radiotherapy
Clin Cancer Res 2004 10: 3745-3754. [Abstract] [Full Text] [PDF]  

Iris Kuss, Bridget Hathaway, Robert L. Ferris, William Gooding, and Theresa L. Whiteside

Decreased Absolute Counts of T Lymphocyte Subsets and Their Relation to Disease in Squamous Cell Carcinoma of the Head and Neck
Clin Cancer Res 2004 10: 3755-3762. [Abstract] [Full Text] [PDF]  

Pascale Lévy, Ivan Bièche, Karen Leroy, Béatrice Parfait, Janine Wechsler, Ingrid Laurendeau, Pierre Wolkenstein, Michel Vidaud, and Dominique Vidaud

Molecular Profiles of Neurofibromatosis Type 1-Associated Plexiform Neurofibromas: Identification of a Gene Expression Signature of Poor Prognosis
Clin Cancer Res 2004 10: 3763-3771. [Abstract] [Full Text] [PDF] Supplementary Data  

Hidenori Takahashi, Tatsuya Oda, Takahiro Hasebe, Yasuyuki Aoyagi, Taira Kinoshita, Masaru Konishi, Toshio Nakagohri, Kazuto Inoue, Shinichiro Takahashi, Hiroshi Kawahira, Morito Monden, and Atsushi Ochiai

Biologically Different Subgroups of Invasive Ductal Carcinoma of the Pancreas: Dpc4 Status According to the Ratio of Intraductal Carcinoma Components
Clin Cancer Res 2004 10: 3772-3779. [Abstract] [Full Text] [PDF]  

Carmela Beger, Marco Ramadani, Stephan Meyer, Gerd Leder, Martin Krüger, Karl Welte, Frank Gansauge, and Hans G. Beger

Down-Regulation of BRCA1 in Chronic Pancreatitis and Sporadic Pancreatic Adenocarcinoma
Clin Cancer Res 2004 10: 3780-3787. [Abstract] [Full Text] [PDF]  

Kenji Kawata, Michiyuki Kanai, Tetsuro Sasada, Shingo Iwata, Naritaka Yamamoto, and Arimichi Takabayashi

Usefulness of ^99mTc-Sestamibi Scintigraphy in Suggesting the Therapeutic Effect of Chemotherapy against Gastric Cancer
Clin Cancer Res 2004 10: 3788-3793. [Abstract] [Full Text] [PDF]  

Ute Warnecke-Eberz, Ralf Metzger, Futoshi Miyazono, Stephan E. Baldus, Susanne Neiss, Jan Brabender, Hartmut Schaefer, Walter Doerfler, Elfriede Bollschweiler, Hans P. Dienes, Rolf P. Mueller, Peter V. Danenberg, Arnulf H. Hoelscher, and Paul M. Schneider

High Specificity of Quantitative Excision Repair Cross-Complementing 1 Messenger RNA Expression for Prediction of Minor Histopathological Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer
Clin Cancer Res 2004 10: 3794-3799. [Abstract] [Full Text] [PDF]  

Dan Theodorescu, L. M. Sapinoso, M. R. Conaway, G. Oxford, G. M. Hampton, and H. F. Frierson, Jr.

Reduced Expression of Metastasis Suppressor RhoGDI2 Is Associated with Decreased Survival for Patients with Bladder Cancer
Clin Cancer Res 2004 10: 3800-3806. [Abstract] [Full Text] [PDF]  

Yuko Mataki, Sonshin Takao, Kousei Maemura, Shinichiro Mori, Hiroyuki Shinchi, Shoji Natsugoe, and Takashi Aikou

Carcinoembryonic Antigen Messenger RNA Expression Using Nested Reverse Transcription-PCR in the Peripheral Blood During Follow-up Period of Patients Who Underwent Curative Surgery for Biliary-Pancreatic Cancer: Longitudinal Analyses
Clin Cancer Res 2004 10: 3807-3814. [Abstract] [Full Text] [PDF]  

Weiya Xia, Jin-Shing Chen, Xian Zhou, Pei-Rong Sun, Dung-Fang Lee, Yong Liao, Binhua P. Zhou, and Mien-Chie Hung

Phosphorylation/Cytoplasmic Localization of p21^Cip1/WAF1 Is Associated with HER2/neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients
Clin Cancer Res 2004 10: 3815-3824. [Abstract] [Full Text] [PDF]  

Shin-ichiro Maruya, Jean-Pierre J. Issa, Randal S. Weber, David I. Rosenthal, Joie C. Haviland, Reuben Lotan, and Adel K. El-Naggar

Differential Methylation Status of Tumor-Associated Genes in Head and Neck Squamous Carcinoma: Incidence and Potential Implications
Clin Cancer Res 2004 10: 3825-3830. [Abstract] [Full Text] [PDF]  

Wenguang Gu, Akira Ogose, Hiroyuki Kawashima, Masayuki Ito, Tomoyuki Ito, Atsushi Matsuba, Hiroshi Kitahara, Tetsuo Hotta, Kunihiko Tokunaga, Hiroshi Hatano, Tetsuro Morita, Sayuri Urakawa, Tatsuya Yoshizawa, Hiroyuki Kawashima, Ryozo Kuwano, and Naoto Endo

High-Level Expression of the Coxsackievirus and Adenovirus Receptor Messenger RNA in Osteosarcoma, Ewing’s Sarcoma, and Benign Neurogenic Tumors among Musculoskeletal Tumors
Clin Cancer Res 2004 10: 3831-3838. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Xin-Yan Pei, Yun Dai, and Steven Grant

Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors
Clin Cancer Res 2004 10: 3839-3852. [Abstract] [Full Text] [PDF]  

Masaaki Adachi, YuBin Zhang, Xudong Zhao, Takae Minami, Rina Kawamura, Yuji Hinoda, and Kohzoh Imai

Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells
Clin Cancer Res 2004 10: 3853-3862. [Abstract] [Full Text] [PDF]  

Yuen-Li Chung, Helen Troy, Ian R. Judson, Russell Leek, Martin O. Leach, Marion Stubbs, Adrian L. Harris, and John R. Griffiths

Noninvasive Measurements of Capecitabine Metabolism in Bladder Tumors Overexpressing Thymidine Phosphorylase by Fluorine-19 Magnetic Resonance Spectroscopy
Clin Cancer Res 2004 10: 3863-3870. [Abstract] [Full Text] [PDF]  

Takayoshi Murakami, Naoyuki Tokunaga, Toshihiko Waku, Shinya Gomi, Shunsuke Kagawa, Noriaki Tanaka, and Toshiyoshi Fujiwara

Antitumor Effect of Intratumoral Administration of Bone Marrow-Derived Dendritic Cells Transduced with Wild-Type p53 Gene
Clin Cancer Res 2004 10: 3871-3880. [Abstract] [Full Text] [PDF]  

Special Section:

Gary J. Kelloff, Robert C. Bast, Jr., Donald S. Coffey, Anthony V. D’Amico, Robert S. Kerbel, John W. Park, Raymond W. Ruddon, Gordon J. S. Rustin, Richard L. Schilsky, Caroline C. Sigman, and George F. Vande Woude

Biomarkers, Surrogate End Points, and the Acceleration of Drug Development for Cancer Prevention and Treatment: An Update Prologue
Clin Cancer Res 2004 10: 3881-3884. [Full Text] [PDF]  

John W. Park, Robert S. Kerbel, Gary J. Kelloff, J. Carl Barrett, Bruce A. Chabner, David R. Parkinson, Jonathan Peck, Raymond W. Ruddon, Caroline C. Sigman, and Dennis J. Slamon

Rationale for Biomarkers and Surrogate End Points in Mechanism-Driven Oncology Drug Development
Clin Cancer Res 2004 10: 3885-3896. [Full Text] [PDF]  

George F. Vande Woude, Gary J. Kelloff, Raymond W. Ruddon, Han-Mo Koo, Caroline C. Sigman, J. Carl Barrett, Robert W. Day, Adam P. Dicker, Robert S. Kerbel, David R. Parkinson, and William J. Slichenmyer

Reanalysis of Cancer Drugs: Old Drugs, New Tricks
Clin Cancer Res 2004 10: 3897-3907. [Full Text] [PDF]  

Gary J. Kelloff, Richard L. Schilsky, David S. Alberts, Robert W. Day, Kathryn Z. Guyton, Homer L. Pearce, Jonathan C. Peck, Robert Phillips, and Caroline C. Sigman

Colorectal Adenomas: A Prototype for the Use of Surrogate End Points in the Development of Cancer Prevention Drugs
Clin Cancer Res 2004 10: 3908-3918. [Full Text] [PDF]  

Gordon J. S. Rustin, Robert C. Bast, Jr., Gary J. Kelloff, J. Carl Barrett, Stephen K. Carter, Perry D. Nisen, Caroline C. Sigman, David R. Parkinson, and Raymond W. Ruddon

Use of CA-125 in Clinical Trial Evaluation of New Therapeutic Drugs for Ovarian Cancer
Clin Cancer Res 2004 10: 3919-3926. [Full Text] [PDF]  

Gary J. Kelloff, Donald S. Coffey, Bruce A. Chabner, Adam P. Dicker, Kathryn Z. Guyton, Perry D. Nisen, Howard R. Soule, and Anthony V. D’Amico

Prostate-Specific Antigen Doubling Time as a Surrogate Marker for Evaluation of Oncologic Drugs to Treat Prostate Cancer
Clin Cancer Res 2004 10: 3927-3933. [Full Text] [PDF]  

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