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β-catenin expression in a patient carrying sporadic colorectal cancer. Through molecular analyses, the tumor showed two distinct somatic APC mutations and microsatellite stability. β-catenin immunoreactivity is restricted to the plasma membrane in normal tissue (on the right) whereas it strongly decorates both cytoplasm and nucleus in tumoral tissue (on the left). For details, see the article by Frattini et al., in this issue.

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