Reviews:

Jill Gilbert, Steve D. Gore, James G. Herman, and Michael A. Carducci

The Clinical Application of Targeting Cancer through Histone Acetylation and Hypomethylation
Clin Cancer Res 2004 10: 4589-4596. [Abstract] [Full Text] [PDF]  

Simone Mocellin, Ena Wang, Monica Panelli, Pierluigi Pilati, and Francesco M. Marincola

DNA Array-Based Gene Profiling in Tumor Immunology
Clin Cancer Res 2004 10: 4597-4606. [Abstract] [Full Text] [PDF]  

Perspective:

Michael Wolf, Helen Swaisland, and Steven Averbuch

Development of the Novel Biologically Targeted Anticancer Agent Gefitinib: Determining the Optimum Dose for Clinical Efficacy
Clin Cancer Res 2004 10: 4607-4613. [Abstract] [Full Text] [PDF]  

Bulletin Board:

Jonathan Melamed, Milton W. Datta, Michael J. Becich, Jan M. Orenstein, Rajiv Dhir, Sylvia Silver, Marie Fidélia-Lambert, André Kadjacsy-Balla, Virgilia Macias, Ashokkumar Patel, Paul D. Walden, Maarten C. Bosland, and Jules J. Berman

The Cooperative Prostate Cancer Tissue Resource: A Specimen and Data Resource for Cancer Researchers
Clin Cancer Res 2004 10: 4614-4621. [Abstract] [Full Text] [PDF]  

Meeting Report:

Arthur Zelent, Samuel Waxman, Michael Carducci, John Wright, James Zweibel, and Steven D. Gore

State of the Translational Science: Summary of Baltimore Workshop on Gene Re-expression As a Therapeutic Target in Cancer January 2003
Clin Cancer Res 2004 10: 4622-4629. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Theresa M. Busch, Stephen M. Hahn, E. Paul Wileyto, Cameron J. Koch, Douglas L. Fraker, Paul Zhang, Mary Putt, Kristen Gleason, Daniel B. Shin, Michael J. Emanuele, Kevin Jenkins, Eli Glatstein, and Sydney M. Evans

Hypoxia and Photofrin Uptake in the Intraperitoneal Carcinomatosis and Sarcomatosis of Photodynamic Therapy Patients
Clin Cancer Res 2004 10: 4630-4638. [Abstract] [Full Text] [PDF]  

Li Zhu, Louis W. C. Chow, Wings T. Y. Loo, Xin-Yuan Guan, and Mazakazu Toi

Her2/neu Expression Predicts the Response to Antiaromatase Neoadjuvant Therapy in Primary Breast Cancer: Subgroup Analysis from Celecoxib Antiaromatase Neoadjuvant Trial
Clin Cancer Res 2004 10: 4639-4644. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

André Rogatko, James S. Babb, Hao Wang, Michael J. Slifker, and Gary R. Hudes

Patient Characteristics Compete with Dose as Predictors of Acute Treatment Toxicity in Early Phase Clinical Trials
Clin Cancer Res 2004 10: 4645-4651. [Abstract] [Full Text] [PDF]  

Xiaolong He, P. L. Rachel Ee, John S. Coon, and William T. Beck

Alternative Splicing of the Multidrug Resistance Protein 1/ATP Binding Cassette Transporter Subfamily Gene in Ovarian Cancer Creates Functional Splice Variants and Is Associated with Increased Expression of the Splicing Factors PTB and SRp20
Clin Cancer Res 2004 10: 4652-4660. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Goli Samimi, Roohangiz Safaei, Kuniyuki Katano, Alison K. Holzer, Myriam Rochdi, Mika Tomioka, Murray Goodman, and Stephen B. Howell

Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells
Clin Cancer Res 2004 10: 4661-4669. [Abstract] [Full Text] [PDF]  

Francesca Spinella, Laura Rosanò, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato

Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells
Clin Cancer Res 2004 10: 4670-4679. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Robert I. Haddad, Lisa J. Weinstein, Tad J. Wieczorek, Nandita Bhattacharya, Harry Raftopoulos, Martin W. Oster, Xinxin Zhang, Vaughan M. Latham, Jr., Rosemary Costello, Jarrod Faucher, Carolyn DeRosa, Murray Yule, Linda P. Miller, Massimo Loda, Marshall R. Posner, and Geoffrey I. Shapiro

A Phase II Clinical and Pharmacodynamic Study of E7070 in Patients with Metastatic, Recurrent, or Refractory Squamous Cell Carcinoma of the Head and Neck: Modulation of Retinoblastoma Protein Phosphorylation by a Novel Chloroindolyl Sulfonamide Cell Cycle Inhibitor
Clin Cancer Res 2004 10: 4680-4687. [Abstract] [Full Text] [PDF]  

Maria R. Parkhurst, John P. Riley, Takehito Igarashi, Yong Li, Paul F. Robbins, and Steven A. Rosenberg

Immunization of Patients with the hTERT:540-548 Peptide Induces Peptide-Reactive T Lymphocytes That Do Not Recognize Tumors Endogenously Expressing Telomerase
Clin Cancer Res 2004 10: 4688-4698. [Abstract] [Full Text] [PDF]  

David Avigan, Baldev Vasir, Jianlin Gong, Virginia Borges, Zekui Wu, Lynne Uhl, Michael Atkins, James Mier, David McDermott, Therese Smith, Nancy Giallambardo, Carolyn Stone, Kim Schadt, Jennifer Dolgoff, Jean-Claude Tetreault, Marisa Villarroel, and Donald Kufe

Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses
Clin Cancer Res 2004 10: 4699-4708. [Abstract] [Full Text] [PDF]  

Hubert Vesselle, Eric Turcotte, Linda Wiens, Rodney Schmidt, Julie E. Takasugi, Tasneem Lalani, Eric Vallières, and Douglas E. Wood

Relationship between Non-Small Cell Lung Cancer Fluorodeoxyglucose Uptake at Positron Emission Tomography and Surgical Stage with Relevance to Patient Prognosis
Clin Cancer Res 2004 10: 4709-4716. [Abstract] [Full Text] [PDF]  

Paul B. Chapman, Dianna Wu, Govind Ragupathi, Sharon Lu, Linda Williams, Wen-Jen Hwu, Diantha Johnson, and Philip O. Livingston

Sequential Immunization of Melanoma Patients with GD3 Ganglioside Vaccine and Anti-Idiotypic Monoclonal Antibody That Mimics GD3 Ganglioside
Clin Cancer Res 2004 10: 4717-4723. [Abstract] [Full Text] [PDF]  

Susan E. Bates, Susan Bakke, Min Kang, Robert W. Robey, Suoping Zhai, Paul Thambi, Clara C. Chen, Sheela Patil, Tom Smith, Seth M. Steinberg, Maria Merino, Barry Goldspiel, Beverly Meadows, Wilfred D. Stein, Peter Choyke, Frank Balis, William D. Figg, and Tito Fojo

A Phase I/II Study of Infusional Vinblastine with the P-Glycoprotein Antagonist Valspodar (PSC 833) in Renal Cell Carcinoma
Clin Cancer Res 2004 10: 4724-4733. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Han-Shui Hsu, Yu-Chien Wang, Ruo-Chia Tseng, Jer-Wei Chang, Jung-Ta Chen, Chuen-Ming Shih, Chih-Yi Chen, and Yi-Ching Wang

CpG Island Methylation Is Responsible for p14ARF Inactivation and Inversely Correlates with p53 Overexpression in Resected Non–Small Cell Lung Cancer
Clin Cancer Res 2004 10: 4734-4741. [Abstract] [Full Text] [PDF]  

Joan Carles, Josep Lloreta, Marta Salido, Albert Font, Marta Suarez, Veronica Baena, Miquel Nogue, Montserrat Domenech, and Xavier Fabregat

Her-2/neu Expression in Prostate Cancer: A Dynamic Process?
Clin Cancer Res 2004 10: 4742-4745. [Abstract] [Full Text] [PDF]  

Özlem Özen, Bjarne Krebs, Bernhard Hemmerlein, Arnulf Pekrun, Hans Kretzschmar, and Jochen Herms

Expression of Matrix Metalloproteinases and Their Inhibitors in Medulloblastomas and Their Prognostic Relevance
Clin Cancer Res 2004 10: 4746-4753. [Abstract] [Full Text] [PDF]  

Monique van Oijen, Adriaan Bins, Sjoerd Elias, Johan Sein, Pauline Weder, Gijsbert de Gast, Henk Mallo, Maarten Gallee, Harm van Tinteren, Ton Schumacher, and John Haanen

On the Role of Melanoma-Specific CD8⁺ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients
Clin Cancer Res 2004 10: 4754-4760. [Abstract] [Full Text] [PDF]  

Annukka Paju, Juhani Vartiainen, Caj Haglund, Outi Itkonen, Kristina von Boguslawski, Arto Leminen, Torsten Wahlström, and Ulf-Håkan Stenman

Expression of Trypsinogen-1, Trypsinogen-2, and Tumor-Associated Trypsin Inhibitor in Ovarian Cancer: Prognostic Study on Tissue and Serum
Clin Cancer Res 2004 10: 4761-4768. [Abstract] [Full Text] [PDF]  

Monica Spinola, Paola Pedotti, Tommaso A. Dragani, and Emanuela Taioli

Meta-Analysis Suggests Association of L-myc EcoRI Polymorphism with Cancer Prognosis
Clin Cancer Res 2004 10: 4769-4775. [Abstract] [Full Text] [PDF]  

Jörg Köninger, Nathalia A. Giese, Fabio Francesco di Mola, Pascal Berberat, Thomas Giese, Irene Esposito, Max G. Bachem, Markus W. Büchler, and Helmut Friess

Overexpressed Decorin in Pancreatic Cancer: Potential Tumor Growth Inhibition and Attenuation of Chemotherapeutic Action
Clin Cancer Res 2004 10: 4776-4783. [Abstract] [Full Text] [PDF]  

Salem I. Abdalla, Pierre Lao-Sirieix, Marco R. Novelli, Laurence B. Lovat, Ian R. Sanderson, and Rebecca C. Fitzgerald

Gastrin-Induced Cyclooxygenase-2 Expression in Barrett’s Carcinogenesis
Clin Cancer Res 2004 10: 4784-4792. [Abstract] [Full Text] [PDF]  

Jorma Isola, Minna Tanner, Amanda Forsyth, Timothy G. Cooke, Amanda D. Watters, and John M. S. Bartlett

Interlaboratory Comparison of HER-2 Oncogene Amplification as Detected by Chromogenic and Fluorescence in situ Hybridization
Clin Cancer Res 2004 10: 4793-4798. [Abstract] [Full Text] [PDF]  

Takao Kamai, Tomonori Yamanishi, Hiromichi Shirataki, Kentaro Takagi, Hidekazu Asami, Yuji Ito, and Ken-Ichiro Yoshida

Overexpression of RhoA, Rac1, and Cdc42 GTPases Is Associated with Progression in Testicular Cancer
Clin Cancer Res 2004 10: 4799-4805. [Abstract] [Full Text] [PDF]  

Scott G. Soltys, Quynh-Thu Le, Gongyi Shi, Robert Tibshirani, A. J. Giaccia, and Albert C. Koong

The Use of Plasma Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Proteomic Patterns for Detection of Head and Neck Squamous Cell Cancers
Clin Cancer Res 2004 10: 4806-4812. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Gurmeet Kaur, Dorina Belotti, Angelika M. Burger, Kirsten Fisher-Nielson, Patrizia Borsotti, Elena Riccardi, Jagada Thillainathan, Melinda Hollingshead, Edward A. Sausville, and Raffaella Giavazzi

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator
Clin Cancer Res 2004 10: 4813-4821. [Abstract] [Full Text] [PDF]  

Danila Coradini, Sonia Zorzet, Raffaella Rossin, Ignazio Scarlata, Cinzia Pellizzaro, Claudia Turrin, Michele Bello, Silvia Cantoni, Annalisa Speranza, Gianni Sava, Ulderico Mazzi, and Alberto Perbellini

Inhibition of Hepatocellular Carcinomas in vitro and Hepatic Metastases in vivo in Mice by the Histone Deacetylase Inhibitor HA-But
Clin Cancer Res 2004 10: 4822-4830. [Abstract] [Full Text] [PDF]  

Hidenobu Ochiai, Stephanie A. Moore, Gary E. Archer, Tatsunori Okamura, Tracy A. Chewning, Jeffrey R. Marks, John H. Sampson, and Matthias Gromeier

Treatment of Intracerebral Neoplasia and Neoplastic Meningitis with Regional Delivery of Oncolytic Recombinant Poliovirus
Clin Cancer Res 2004 10: 4831-4838. [Abstract] [Full Text] [PDF]  

Zane C. Neal, Jeannie C. Yang, Alexander L. Rakhmilevich, Ilia N. Buhtoiarov, Hillary E. Lum, Michael Imboden, Jacquelyn A. Hank, Holger N. Lode, Ralph A. Reisfeld, Stephen D. Gillies, and Paul M. Sondel

Enhanced Activity of Hu14.18-IL2 Immunocytokine against Murine NXS2 Neuroblastoma when Combined with Interleukin 2 Therapy
Clin Cancer Res 2004 10: 4839-4847. [Abstract] [Full Text] [PDF]  

Meihua Sui, Jennifer M. Dziadyk, Xueming Zhu, and Weimin Fan

Cell Cycle–Dependent Antagonistic Interactions between Paclitaxel and -Radiation in Combination Therapy
Clin Cancer Res 2004 10: 4848-4857. [Abstract] [Full Text] [PDF]  

Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Sabino De Placido, Corrado Ficorella, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello, and Giampaolo Tortora

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer
Clin Cancer Res 2004 10: 4858-4864. [Abstract] [Full Text] [PDF]  

Gianfranco Fassina, Roberta Venè, Monica Morini, Simona Minghelli, Roberto Benelli, Douglas M. Noonan, and Adriana Albini

Mechanisms of Inhibition of Tumor Angiogenesis and Vascular Tumor Growth by Epigallocatechin-3-Gallate
Clin Cancer Res 2004 10: 4865-4873. [Abstract] [Full Text] [PDF]  

Jose L. Dominguez-Escrig, John D. Kelly, David E. Neal, Sonya M. King, and Barry R. Davies

Evaluation of the Therapeutic Potential of the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Preclinical Models of Bladder Cancer
Clin Cancer Res 2004 10: 4874-4884. [Abstract] [Full Text] [PDF]  

Hiroaki Tanaka, Masakazu Yashiro, Takeshi Sunami, Yoji Sakate, Kinshi Kosaka, and Kosei Hirakawa

ICAM-2 Gene Therapy for Peritoneal Dissemination of Scirrhous Gastric Carcinoma
Clin Cancer Res 2004 10: 4885-4892. [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Treatment of B-Cell Lymphoma
Clin Cancer Res 2004 10: 4893. [Full Text] [PDF]  

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