Editorials:

Antontello DiPaolo and Edward Chu

The Role of Thymidylate Synthase as a Molecular Biomarker
Clin Cancer Res 2004 10: 411-412. [Full Text] [PDF]  

Roy B. Jones

Overcoming Methodological Weakness in Dose-Intense Alkylating Agent Studies through Pharmacology
Clin Cancer Res 2004 10: 413-414. [Full Text] [PDF]  

Review:

Philip E. Thorpe

Vascular Targeting Agents as Cancer Therapeutics
Clin Cancer Res 2004 10: 415-427. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Paul M. Harari and Shyh-Min Huang

Searching for Reliable Epidermal Growth Factor Receptor Response Predictors: Commentary re M. K. Nyati et al., Radiosensitization by Pan-ErbB Inhibitor CI-1033 in Vitro and in Vivo. Clin. Cancer Res., 10: 691–700, 2004.
Clin Cancer Res 2004 10: 428-432. [Full Text] [PDF]  

Featured Articles:

   Molecular Oncology, Markers, Clinical Correlates:

Kazumi Uchida, Kazuhiko Hayashi, Kazuyuki Kawakami, Sylke Schneider, Ji Min Yochim, Hidekazu Kuramochi, Ken Takasaki, Kathleen D. Danenberg, and Peter V. Danenberg

Loss of Heterozygosity at the Thymidylate Synthase (TS) Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene
Clin Cancer Res 2004 10: 433-439. [Abstract] [Full Text] [PDF]  

James L. Mohler, Christopher W. Gregory, O. Harris Ford, III, Desok Kim, Catharina M. Weaver, Peter Petrusz, Elizabeth M. Wilson, and Frank S. French

The Androgen Axis in Recurrent Prostate Cancer
Clin Cancer Res 2004 10: 440-448. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Zhila Khalkhali-Ellis, Abby L. Christian, Dawn A. Kirschmann, Elijah M. Edwards, Maryam Rezaie-Thompson, Mohammad A. Vasef, Lynn M. Gruman, Richard E. B. Seftor, Laura E. Norwood, and Mary J. C. Hendrix

Regulating the Tumor Suppressor Gene Maspin in Breast Cancer Cells: A Potential Mechanism for the Anticancer Properties of Tamoxifen
Clin Cancer Res 2004 10: 449-454. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

S. Murray Yule, Lisa Price, Alex D. McMahon, Andrew D. J. Pearson, and Alan V. Boddy

Cyclophosphamide Metabolism in Children with Non-Hodgkin’s Lymphoma
Clin Cancer Res 2004 10: 455-460. [Abstract] [Full Text] [PDF]  

Harry Openshaw, Karen Beamon, Timothy W. Synold, Jeff Longmate, Neal E. Slatkin, James H. Doroshow, Stephen Forman, Kim Margolin, Robert Morgan, Stephen Shibata, and George Somlo

Neurophysiological Study of Peripheral Neuropathy after High-Dose Paclitaxel: Lack of Neuroprotective Effect of Amifostine
Clin Cancer Res 2004 10: 461-467. [Abstract] [Full Text] [PDF]  

A. Craig Lockhart, Martin Howard, Kenneth R. Hande, Bruce J. Roth, Jordan D. Berlin, Franzanne Vreeland, Angela Campbell, Erminia Fontana, Francesca Fiorentini, Camilla Fowst, Victoria A. Paty, Odessa Lankford, and Mace L. Rothenberg

A Phase I Dose-Escalation and Pharmacokinetic Study of Brostallicin (PNU-166196A), a Novel DNA Minor Groove Binder, in Adult Patients with Advanced Solid Tumors
Clin Cancer Res 2004 10: 468-475. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Berthold Streubel, Daniela Huber, Stefan Wöhrer, Andreas Chott, and Markus Raderer

Frequency of Chromosomal Aberrations Involving MALT1 in Mucosa-Associated Lymphoid Tissue Lymphoma in Patients with Sjögren’s Syndrome
Clin Cancer Res 2004 10: 476-480. [Abstract] [Full Text] [PDF]  

Barbara M. Buttin, Matthew A. Powell, David G. Mutch, Janet S. Rader, Thomas J. Herzog, Randall K. Gibb, Phyllis Huettner, Tina Bocker Edmonston, and Paul J. Goodfellow

Increased Risk for Hereditary Nonpolyposis Colorectal Cancer-Associated Synchronous and Metachronous Malignancies in Patients with Microsatellite Instability-Positive Endometrial Carcinoma Lacking MLH1 Promoter Methylation
Clin Cancer Res 2004 10: 481-490. [Abstract] [Full Text] [PDF]  

Miriam B. Buck, Peter Fritz, Juergen Dippon, Gerhard Zugmaier, and Cornelius Knabbe

Prognostic Significance of Transforming Growth Factor ß Receptor II in Estrogen Receptor-Negative Breast Cancer Patients
Clin Cancer Res 2004 10: 491-498. [Abstract] [Full Text] [PDF]  

Tatyana A. Grushko, James J. Dignam, Soma Das, Anne M. Blackwood, Charles M. Perou, Karin K. Ridderstråle, Kristin N. Anderson, Min-Jie Wei, April J. Adams, Fitsum G. Hagos, Lise Sveen, Henry T. Lynch, Barbara L. Weber, and Olufunmilayo I. Olopade

MYC Is Amplified in BRCA1-Associated Breast Cancers
Clin Cancer Res 2004 10: 499-507. [Abstract] [Full Text] [PDF]  

Donatella Aldinucci, Dalisa Poletto, Debora Lorenzon, Paola Nanni, Massimo Degan, Karin Olivo, Barbara Rapanà, Antonio Pinto, and Valter Gattei

CD26 Expression Correlates with a Reduced Sensitivity to 2'-Deoxycoformycin-Induced Growth Inhibition and Apoptosis in T-Cell Leukemia/Lymphomas
Clin Cancer Res 2004 10: 508-520. [Abstract] [Full Text] [PDF]  

Andrea Ladányi, Beáta Somlai, Katalin Gilde, Zsuzsanna Fejös, István Gaudi, and József Tímár

T-Cell Activation Marker Expression on Tumor-Infiltrating Lymphocytes As Prognostic Factor in Cutaneous Malignant Melanoma
Clin Cancer Res 2004 10: 521-530. [Abstract] [Full Text] [PDF]  

Anja Ulmer, Oleg Schmidt-Kittler, Jörg Fischer, Ulf Ellwanger, Gernot Rassner, Gert Riethmüller, Gerhard Fierlbeck, and Christoph A. Klein

Immunomagnetic Enrichment, Genomic Characterization, and Prognostic Impact of Circulating Melanoma Cells
Clin Cancer Res 2004 10: 531-537. [Abstract] [Full Text] [PDF]  

Tiina-Liisa Erkinheimo, Heini Lassus, Patrik Finne, Bastiaan P. van Rees, Arto Leminen, Olavi Ylikorkala, Caj Haglund, Ralf Butzow, and Ari Ristimäki

Elevated Cyclooxygenase-2 Expression Is Associated with Altered Expression of p53 and SMAD4, Amplification of HER-2/neu, and Poor Outcome in Serous Ovarian Carcinoma
Clin Cancer Res 2004 10: 538-545. [Abstract] [Full Text] [PDF]  

Mohamed Mokhtar Desouki and Brian G. Rowan

Src Kinase and Mitogen-Activated Protein Kinases in the Progression from Normal to Malignant Endometrium
Clin Cancer Res 2004 10: 546-555. [Abstract] [Full Text] [PDF]  

Peter J. Wild, Albrecht Reichle, Reinhard Andreesen, Georg Röckelein, Wolfgang Dietmaier, Josef Rüschoff, Hagen Blaszyk, Ferdinand Hofstädter, and Arndt Hartmann

Microsatellite Instability Predicts Poor Short-Term Survival in Patients with Advanced Breast Cancer after High-Dose Chemotherapy and Autologous Stem-Cell Transplantation
Clin Cancer Res 2004 10: 556-564. [Abstract] [Full Text] [PDF] Supplementary Data  

Andreas Widschwendter, Hannes M. Müller, Heidi Fiegl, Lennart Ivarsson, Annemarie Wiedemair, Elisabeth Müller-Holzner, Georg Goebel, Christian Marth, and Martin Widschwendter

DNA Methylation in Serum and Tumors of Cervical Cancer Patients
Clin Cancer Res 2004 10: 565-571. [Abstract] [Full Text] [PDF] Supplementary Data  

Hiroichi Kobayashi, Junji Sagara, Hiroshi Kurita, Masayo Morifuji, Masamichi Ohishi, Kenji Kurashina, and Shun’ichiro Taniguchi

Clinical Significance of Cellular Distribution of Moesin in Patients with Oral Squamous Cell Carcinoma
Clin Cancer Res 2004 10: 572-580. [Abstract] [Full Text] [PDF]  

Kimi Fukahi, Mitsuharu Fukasawa, Gera Neufeld, Jun Itakura, and Murray Korc

Aberrant Expression of Neuropilin-1 and -2 in Human Pancreatic Cancer Cells
Clin Cancer Res 2004 10: 581-590. [Abstract] [Full Text] [PDF]  

Mazen A. Ghanem, Theo H. Van der Kwast, Mondastri K. Sudaryo, Rejiv B. Mathoera, Marry M. van den Heuvel, Abdel-Alim M. Al-Doray, Rien M. Nijman, and Gert J. van Steenbrugge

MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27^Kip1 Protein Expression in Nephroblastoma
Clin Cancer Res 2004 10: 591-597. [Abstract] [Full Text] [PDF]  

Ruochun Huang, Ying Lin, Qian Shi, Lisa Flowers, Sumathi Ramachandran, Ira R. Horowitz, Sampath Parthasarathy, and Ruo-Pan Huang

Enhanced Protein Profiling Arrays with ELISA-Based Amplification for High-Throughput Molecular Changes of Tumor Patients’ Plasma
Clin Cancer Res 2004 10: 598-609. [Abstract] [Full Text] [PDF]  

Mario Roselli, Tommaso C. Mineo, Stefania Basili, Francesca Martini, Sabrina Mariotti, Simona Aloe, Girolamo Del Monte, Vincenzo Ambrogi, Antonella Spila, Raffaele Palmirotta, Roberta D’Alessandro, Giovanni Davì, Fiorella Guadagni, and Patrizia Ferroni

Soluble CD40 Ligand Plasma Levels in Lung Cancer
Clin Cancer Res 2004 10: 610-614. [Abstract] [Full Text] [PDF]  

Lisa G. Horvath, Susan M. Henshall, James G. Kench, Darren N. Saunders, C.-Soon Lee, David Golovsky, Phillip C. Brenner, Gordon F. O’Neill, Raji Kooner, Phillip D. Stricker, John J. Grygiel, and Robert L. Sutherland

Membranous Expression of Secreted Frizzled-Related Protein 4 Predicts for Good Prognosis in Localized Prostate Cancer and Inhibits PC3 Cellular Proliferation in Vitro
Clin Cancer Res 2004 10: 615-625. [Abstract] [Full Text] [PDF]  

Thorsten Stiewe, Sebastian Tuve, Martin Peter, Andrea Tannapfel, Ahmet H. Elmaagacli, and Brigitte M. Pützer

Quantitative TP73 Transcript Analysis in Hepatocellular Carcinomas
Clin Cancer Res 2004 10: 626-633. [Abstract] [Full Text] [PDF]  

Akihiro Katayama, Nobuyuki Bandoh, Kan Kishibe, Miki Takahara, Takeshi Ogino, Satoshi Nonaka, and Yasuaki Harabuchi

Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis
Clin Cancer Res 2004 10: 634-640. [Abstract] [Full Text] [PDF]  

Christoph P. Dieterle, Michael Conzelmann, Ulrich Linnemann, and Martin R. Berger

Detection of Isolated Tumor Cells by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism for K-ras Mutations in Tissue Samples of 199 Colorectal Cancer Patients
Clin Cancer Res 2004 10: 641-650. [Abstract] [Full Text] [PDF]  

Shinji Yamamoto, Yasuhiko Tomita, Yoshihiko Hoshida, Masato Sakon, Masao Kameyama, Shingi Imaoka, Mitsugu Sekimoto, Shoji Nakamori, Morito Monden, and Katsuyuki Aozasa

Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis
Clin Cancer Res 2004 10: 651-657. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Zhibo Yang, Rozita Bagheri-Yarmand, Rui-An Wang, Liana Adam, Vali Vassiliki Papadimitrakopoulou, Gary L. Clayman, Adel El-Naggar, Reuben Lotan, Christopher J. Barnes, Waun Ki Hong, and Rakesh Kumar

The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses c-Src and Pak1 Pathways and Invasiveness of Human Cancer Cells
Clin Cancer Res 2004 10: 658-667. [Abstract] [Full Text] [PDF]  

Edwin B. Walker, Daniel Haley, William Miller, Kevin Floyd, Ketura P. Wisner, Nelson Sanjuan, Holden Maecker, Pedro Romero, Hong-Ming Hu, W. Gregory Alvord, John W. Smith, II, Bernard A. Fox, and Walter J. Urba

gp100_209–2M Peptide Immunization of Human Lymphocyte Antigen-A2⁺ Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD8⁺ T Cells
Clin Cancer Res 2004 10: 668-680. [Abstract] [Full Text] [PDF]  

Daniela Matei, David D. Chang, and Meei-Huey Jeng

Imatinib Mesylate (Gleevec) Inhibits Ovarian Cancer Cell Growth through a Mechanism Dependent on Platelet-Derived Growth Factor Receptor and Akt Inactivation
Clin Cancer Res 2004 10: 681-690. [Abstract] [Full Text] [PDF]  

Mukesh K. Nyati, Divya Maheshwari, Sheela Hanasoge, Arun Sreekumar, Susan D. Rynkiewicz, Arul M. Chinnaiyan, Wilbur R. Leopold, Stephen P. Ethier, and Theodore S. Lawrence

Radiosensitization by Pan ErbB Inhibitor CI-1033 in Vitro and in Vivo
Clin Cancer Res 2004 10: 691-700. [Abstract] [Full Text] [PDF]  

Lei Xu, Pooja S. Pathak, and Dai Fukumura

Hypoxia-Induced Activation of p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3'-Kinase Signaling Pathways Contributes to Expression of Interleukin 8 in Human Ovarian Carcinoma Cells
Clin Cancer Res 2004 10: 701-707. [Abstract] [Full Text] [PDF]  

Jozef Spychala, Eduardo Lazarowski, Anna Ostapkowicz, Lanier H. Ayscue, Aiwen Jin, and Beverly S. Mitchell

Role of Estrogen Receptor in the Regulation of Ecto-5'-Nucleotidase and Adenosine in Breast Cancer
Clin Cancer Res 2004 10: 708-717. [Abstract] [Full Text] [PDF]  

Rongbao Zhao, Feng Gao, Marie Hanscom, and I. David Goldman

A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors: Contribution to the Preservation of Methotrexate Pharmacologic Activity in HeLa Cells Lacking the Reduced Folate Carrier
Clin Cancer Res 2004 10: 718-727. [Abstract] [Full Text] [PDF]  

Sheela A. Abraham, Cheryl McKenzie, Dana Masin, Rebecca Ng, Troy O. Harasym, Lawrence D. Mayer, and Marcel B. Bally

In Vitro and in Vivo Characterization of Doxorubicin and Vincristine Coencapsulated within Liposomes through Use of Transition Metal Ion Complexation and pH Gradient Loading
Clin Cancer Res 2004 10: 728-738. [Abstract] [Full Text] [PDF]  

Pasquina Marzola, Anna Degrassi, Laura Calderan, Paolo Farace, Caterina Crescimanno, Elena Nicolato, Anna Giusti, Enrico Pesenti, Andrea Terron, Andrea Sbarbati, Tinya Abrams, Lesley Murray, and Francesco Osculati

In Vivo Assessment of Antiangiogenic Activity of SU6668 in an Experimental Colon Carcinoma Model
Clin Cancer Res 2004 10: 739-750. [Abstract] [Full Text] [PDF]  

Iranzu González, Enrique J. Andreu, Angel Panizo, Susana Inogés, Ana Fontalba, José Luis Fernández-Luna, Mirella Gaboli, Luis Sierrasesúmaga, Salvador Martín-Algarra, Javier Pardo, Felipe Prósper, and Enrique de Alava

Imatinib Inhibits Proliferation of Ewing Tumor Cells Mediated by the Stem Cell Factor/KIT Receptor Pathway, and Sensitizes Cells to Vincristine and Doxorubicin-Induced Apoptosis
Clin Cancer Res 2004 10: 751-761. [Abstract] [Full Text] [PDF]  

Hideto To, Mikiko Shin, Mayumi Tabuchi, Hiromi Sakaguchi, Ayako Takeuchi, Naoya Matsunaga, Shun Higuchi, and Shigehiro Ohdo

Influence of Dosing Schedule on Toxicity and Antitumor Effects of a Combination of Adriamycin and Docetaxel in Mice
Clin Cancer Res 2004 10: 762-769. [Abstract] [Full Text] [PDF]  

Masood A. Shammas, Robert J. Shmookler Reis, Cheng Li, Hemanta Koley, Laurence H. Hurley, Kenneth C. Anderson, and Nikhil C. Munshi

Telomerase Inhibition and Cell Growth Arrest After Telomestatin Treatment in Multiple Myeloma
Clin Cancer Res 2004 10: 770-776. [Abstract] [Full Text] [PDF]  

Xiaoping Duan, Zhichao Zhou, Shu-Fang Jia, Michael Colvin, Elizabeth A. Lafleur, and Eugenie S. Kleinerman

Interleukin-12 Enhances the Sensitivity of Human Osteosarcoma Cells to 4-Hydroperoxycyclophosphamide by a Mechanism Involving the Fas/Fas-Ligand Pathway
Clin Cancer Res 2004 10: 777-783. [Abstract] [Full Text] [PDF]  

Fortunato Ciardiello, Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Davide Melisi, Ferdinando De Vita, Sabino De Placido, A. Raffaele Bianco, and Giampaolo Tortora

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
Clin Cancer Res 2004 10: 784-793. [Abstract] [Full Text] [PDF]  

Makoto Sumitomo, Tomohiko Asano, Junichi Asakuma, Takako Asano, Akio Horiguchi, and Masamichi Hayakawa

ZD1839 Modulates Paclitaxel Response in Renal Cancer by Blocking Paclitaxel-Induced Activation of the Epidermal Growth Factor Receptor–Extracellular Signal-Regulated Kinase Pathway
Clin Cancer Res 2004 10: 794-801. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Caroline Ford, Margaret Faedo, Warick Delprado, and William Rawlinson

Correspondence re: C. Ford, et al. Mouse Mammary Tumor Virus-Like Gene Sequences in Breast Tumors of Australian and Vietnamese Women. Clin. Cancer Res., 9: 1118–1120, 2003.
Clin Cancer Res 2004 10: 802. [Full Text] [PDF]  

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