The Cover

Immunofluorescent localization of the epidermal growth factor receptor (EGFR; green), F-actin (red), and DNA (blue) in serum-starved (top panel) and epidermal growth factor (10 ng/ml for 20 minutes) stimulated (bottom panel) 1483 head and neck cancer cells. On ligand binding, some EGFR remains localized in newly formed motile structures at the membrane, while the majority of activated receptor is rapidly internalized, forming a gradient in the cytoplasm with perinuclear accumulation of EGFR-containing endocytosed vesicles. Yellow color resulted from overlap of green and red fluorescence.