Perspective:

Recurrent Ovarian Cancer: How Important Is It to Treat to Disease Progression?

Thomas J. Herzog
Clin Cancer Res 2004 10: 7439-7449. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

A Phase I Trial of Perifosine (NSC 639966) on a Loading Dose/Maintenance Dose Schedule in Patients with Advanced Cancer

Lynn Van Ummersen, Kim Binger, Jennifer Volkman, Rebecca Marnocha, Kendra Tutsch, Jill Kolesar, Rhoda Arzoomanian, Dona Alberti, and George Wilding
Clin Cancer Res 2004 10: 7450-7456. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients

Martin G. Friedrich, Daniel J. Weisenberger, Jonathan C. Cheng, Shahin Chandrasoma, Kimberly D. Siegmund, Mark L. Gonzalgo, Marieta I. Toma, Hartwig Huland, Christine Yoo, Yvonne C. Tsai, Peter W. Nichols, Bernard H. Bochner, Peter A. Jones, and Gangning Liang
Clin Cancer Res 2004 10: 7457-7465. [Abstract] [Full Text] [PDF]  

Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer

Isabelle Treilleux, Jean-Yves Blay, Nathalie Bendriss-Vermare, Isabelle Ray-Coquard, Thomas Bachelot, Jean-Paul Guastalla, Alain Bremond, Sophie Goddard, Jean-Jacques Pin, Clarisse Barthelemy-Dubois, and Serge Lebecque
Clin Cancer Res 2004 10: 7466-7474. [Abstract] [Full Text] [PDF]  

Epigenetic Inactivation of ID4 in Colorectal Carcinomas Correlates with Poor Differentiation and Unfavorable Prognosis

Naoyuki Umetani, Hiroya Takeuchi, Akihide Fujimoto, Masaru Shinozaki, Anton J. Bilchik, and Dave S. B. Hoon
Clin Cancer Res 2004 10: 7475-7483. [Abstract] [Full Text] [PDF]  

p16^INK4A Hypermethylation Is Associated with Hepatitis Virus Infection, Age, and Gender in Hepatocellular Carcinoma

Xin Li, Ai-Min Hui, Lin Sun, Kiyoshi Hasegawa, Guido Torzilli, Masami Minagawa, Tadatoshi Takayama, and Masatoshi Makuuchi
Clin Cancer Res 2004 10: 7484-7489. [Abstract] [Full Text] [PDF]  

Low Levels of Estrogen Receptor ß Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer

Torsten A. Hopp, Heidi L. Weiss, Irma S. Parra, Yukun Cui, C. Kent Osborne, and Suzanne A. W. Fuqua
Clin Cancer Res 2004 10: 7490-7499. [Abstract] [Full Text] [PDF]  

Proteomic Analysis to Identify Breast Cancer Biomarkers in Nipple Aspirate Fluid

Hannah Alexander, Andrew L. Stegner, Colette Wagner-Mann, Garrett C. Du Bois, Stephen Alexander, and Edward R. Sauter
Clin Cancer Res 2004 10: 7500-7510. [Abstract] [Full Text] [PDF]  

The Use of Real-Time Reverse Transcription-PCR for Prostate-Specific Antigen mRNA to Discriminate between Blood Samples from Healthy Volunteers and from Patients with Metastatic Prostate Cancer

Kinnari Patel, Peter J. Whelan, Stephen Prescott, Samantha C. Brownhill, Colin F. Johnston, Peter J. Selby, and Susan A. Burchill
Clin Cancer Res 2004 10: 7511-7519. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Differential Radiosensitization in DNA Mismatch Repair-Proficient and -Deficient Human Colon Cancer Xenografts with 5-Iodo-2-pyrimidinone-2'-deoxyribose

Yuji Seo, Tao Yan, Jane E. Schupp, Valdir Colussi, Kerri L. Taylor, and Timothy J. Kinsella
Clin Cancer Res 2004 10: 7520-7528. [Abstract] [Full Text] [PDF]  

The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma

Takashi Ishida, Shinsuke Iida, Yoshiki Akatsuka, Toshihiko Ishii, Mikinori Miyazaki, Hirokazu Komatsu, Hiroshi Inagaki, Noriko Okada, Teizo Fujita, Kenya Shitara, Shiro Akinaga, Toshitada Takahashi, Atae Utsunomiya, and Ryuzo Ueda
Clin Cancer Res 2004 10: 7529-7539. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor ß Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

Toshiaki Hayashi, Teru Hideshima, Aaron N. Nguyen, Olivier Munoz, Klaus Podar, Makoto Hamasaki, Kenji Ishitsuka, Hiroshi Yasui, Paul Richardson, Sarvajit Chakravarty, Alison Murphy, Dharminder Chauhan, Linda S. Higgins, and Kenneth C. Anderson
Clin Cancer Res 2004 10: 7540-7546. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Represses Cyclin D1 in Aerodigestive Tract Cancers

W. Jeffrey Petty, Konstantin H. Dragnev, Vincent A. Memoli, Yan Ma, Neil B. Desai, Adrian Biddle, Thomas H. Davis, William C. Nugent, Natalie Memoli, Marta Hamilton, Kenneth K. Iwata, James R. Rigas, and Ethan Dmitrovsky
Clin Cancer Res 2004 10: 7547-7554. [Abstract] [Full Text] [PDF]  

ING-1, a Monoclonal Antibody Targeting Ep-CAM in Patients with Advanced Adenocarcinomas

Johann S. de Bono, Anthony W. Tolcher, Andre Forero, Gertrude F. A. Vanhove, Chris Takimoto, Robert J. Bauer, Lisa A. Hammond, Amita Patnaik, Mark L. White, Sui Shen, Muhammad B. Khazaeli, Eric K. Rowinsky, and Albert F. LoBuglio
Clin Cancer Res 2004 10: 7555-7565. [Abstract] [Full Text] [PDF]  

Characterization and Multiparameter Analysis of Visual Adverse Events in Irofulven Single-Agent Phase I and II Trials

Eric Raymond, Carmen Kahatt, Marie Hélène Rigolet, William Sutherland, François Lokiec, Jérôme Alexandre, Bertrand Tombal, Michael Elman, Michael S. Lee, John R. MacDonald, Michael Cullen, Jean-Louis Misset, and Esteban Cvitkovic
Clin Cancer Res 2004 10: 7566-7574. [Abstract] [Full Text] [PDF]  

Associations between Serum Testosterone Fall and Cognitive Function in Prostate Cancer Patients

Eeva K. Salminen, Raija I. Portin, Aki Koskinen, Hans Helenius, and Martti Nurmi
Clin Cancer Res 2004 10: 7575-7582. [Abstract] [Full Text] [PDF]  

A Pilot Surrogate End Point Biomarker Trial of Perillyl Alcohol in Breast Neoplasia

Vered Stearns, Andrew Coop, Baljit Singh, Ann Gallagher, Hideko Yamauchi, Ronald Lieberman, Marie Pennanen, Bruce Trock, Daniel F. Hayes, and Matthew J. Ellis
Clin Cancer Res 2004 10: 7583-7591. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Methylenetetrahydrofolate Reductase Genotype Affects Risk of Relapse after Hematopoietic Cell Transplantation for Chronic Myelogenous Leukemia

Kim Robien, Cornelia M. Ulrich, Jeannette Bigler, Yutaka Yasui, Ted Gooley, Barbara Bruemmer, John D. Potter, and Jerald P. Radich
Clin Cancer Res 2004 10: 7592-7598. [Abstract] [Full Text] [PDF]  

CD34⁺ Cells from Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Normal Bone Marrow Display Different Apoptosis and Drug Resistance–Associated Phenotypes

Lilia Suárez, María-Belén Vidriales, José García-Laraña, Guillermo Sanz, María-José Moreno, Antonio López, Susana Barrena, Rafael Martínez, Mar Tormo, Luis Palomera, Esperanza Lavilla, Ma Consuelo López-Berges, María de Santiago, M. Encarnación Pérez de Equiza, Jesús F. San Miguel, Alberto Orfao for the PETHEMA Cooperative Group
Clin Cancer Res 2004 10: 7599-7606. [Abstract] [Full Text] [PDF]  

Inactivation of the FHIT Gene Favors Bladder Cancer Development

Andrea Vecchione, Cinzia Sevignani, Enrico Giarnieri, Nicola Zanesi, Hideshi Ishii, Rossano Cesari, Louise Y. Y. Fong, Leonard G. Gomella, Carlo M. Croce, and Raffaele Baffa
Clin Cancer Res 2004 10: 7607-7612. [Abstract] [Full Text] [PDF]  

A Clinicobiological Model Predicting Survival in Medulloblastoma

Amit Ray, Michael Ho, Jing Ma, Robert K. Parkes, Todd G. Mainprize, Shigeo Ueda, John McLaughlin, Eric Bouffet, James T. Rutka, and Cynthia E. Hawkins
Clin Cancer Res 2004 10: 7613-7620. [Abstract] [Full Text] [PDF]  

Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis

Johanna M. Pellikainen, Kirsi M. Ropponen, Vesa V. Kataja, Jari K. Kellokoski, Matti J. Eskelinen, and Veli-Matti Kosma
Clin Cancer Res 2004 10: 7621-7628. [Abstract] [Full Text] [PDF]  

Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma

Siu Tim Cheung, San Yu Wong, Ka Ling Leung, Xin Chen, Samuel So, Irene O. Ng, and Sheung Tat Fan
Clin Cancer Res 2004 10: 7629-7636. [Abstract] [Full Text] [PDF]  

HMGA1 Protein Overexpression in Human Breast Carcinomas: Correlation with ErbB2 Expression

Gennaro Chiappetta, Gerardo Botti, Mario Monaco, Rosa Pasquinelli, Francesca Pentimalli, Maurizio Di Bonito, Giuseppe D’Aiuto, Monica Fedele, Rodolfo Iuliano, Emiliano A. Palmieri, Giovanna Maria Pierantoni, Vincenzo Giancotti, and Alfredo Fusco
Clin Cancer Res 2004 10: 7637-7644. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Inhibition of Inhibitor of Nuclear Factor-B Phosphorylation Increases the Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models

Seiji Mabuchi, Masahide Ohmichi, Yukihiro Nishio, Tadashi Hayasaka, Akiko Kimura, Tsuyoshi Ohta, Jun Kawagoe, Kazuhiro Takahashi, Namiko Yada-Hashimoto, Hozumi Seino-Noda, Masahiro Sakata, Teiichi Motoyama, Hirohisa Kurachi, Joseph R. Testa, Keiichi Tasaka, and Yuji Murata
Clin Cancer Res 2004 10: 7645-7654. [Abstract] [Full Text] [PDF]  

The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma

Linda Nici, Barbara Monfils, and Paul Calabresi
Clin Cancer Res 2004 10: 7655-7661. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of Oblimersen Bcl-2 Antisense Oligonucleotide Alone and in Combination with Vinorelbine in Xenograft Models of Human Non–Small Cell Lung Cancer

YanPing Hu, Gwyn Bebb, Sophia Tan, Rebecca Ng, Hong Yan, Jason R. Sartor, Lawrence D. Mayer, and Marcel B. Bally
Clin Cancer Res 2004 10: 7662-7670. [Abstract] [Full Text] [PDF]  

Sensitization of Tumor-Associated Endothelial Cell Apoptosis by the Novel Vascular-Targeting Agent ZD6126 in Combination with Cisplatin

Hisatsugu Goto, Seiji Yano, Yuka Matsumori, Hirohisa Ogawa, David C. Blakey, and Saburo Sone
Clin Cancer Res 2004 10: 7671-7676. [Abstract] [Full Text] [PDF]  

Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy

Ze Lu, Teng-Kuang Yeh, Max Tsai, Jessie L.-S. Au, and M. Guill Wientjes
Clin Cancer Res 2004 10: 7677-7684. [Abstract] [Full Text] [PDF]  

Inhibition of Metastatic Tumor Growth in Mouse Lung by Repeated Administration of Polyethylene Glycol-Conjugated Catalase: Quantitative Analysis with Firefly Luciferase-Expressing Melanoma Cells

Kenji Hyoudou, Makiya Nishikawa, Yukari Umeyama, Yuki Kobayashi, Fumiyoshi Yamashita, and Mitsuru Hashida
Clin Cancer Res 2004 10: 7685-7691. [Abstract] [Full Text] [PDF]  

Species Differences in Troxacitabine Pharmacokinetics and Pharmacodynamics: Implications for Clinical Development

Henriette Gourdeau, Lorraine Leblond, Bettina Hamelin, Kelly Dong, France Ouellet, Chantal Boudreau, Dominique Custeau, Annie Richard, Marie-Josée Gilbert, and Jacques Jolivet
Clin Cancer Res 2004 10: 7692-7702. [Abstract] [Full Text] [PDF]  

Dietary Flaxseed Enhances the Inhibitory Effect of Tamoxifen on the Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) in Nude Mice

Jianmin Chen, Evon Hui, Terence Ip, and Lilian U. Thompson
Clin Cancer Res 2004 10: 7703-7711. [Abstract] [Full Text] [PDF]  

Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation

Hisataka Kobayashi, Koen Reijnders, Sean English, Alexander T. Yordanov, Diane E. Milenic, Anastasia L. Sowers, Deborah Citrin, Murali C. Krishna, Thomas A. Waldmann, James B. Mitchell, and Martin W. Brechbiel
Clin Cancer Res 2004 10: 7712-7720. [Abstract] [Full Text] [PDF]  

Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer

Junichi Yano, Kazuko Hirabayashi, Shin-ichiro Nakagawa, Tohru Yamaguchi, Masaki Nogawa, Isao Kashimori, Haruna Naito, Hidetoshi Kitagawa, Kouichi Ishiyama, Tadaaki Ohgi, and Tatsuro Irimura
Clin Cancer Res 2004 10: 7721-7726. [Abstract] [Full Text] [PDF]  

Regression of Mouse Prostatic Intraepithelial Neoplasia by Nonsteroidal Anti-inflammatory Drugs in the Transgenic Adenocarcinoma Mouse Prostate Model

Bhagavathi A. Narayanan, Narayanan K. Narayanan, Brian Pittman, and Bandaru S. Reddy
Clin Cancer Res 2004 10: 7727-7737. [Abstract] [Full Text] [PDF]  

Vector Targeting Makes 5-Fluorouracil Chemotherapy Less Toxic and More Effective in Animal Models of Epithelial Neoplasms

Hakan Akbulut, Yucheng Tang, Jonathan Maynard, Lixin Zhang, Giuseppe Pizzorno, and Albert Deisseroth
Clin Cancer Res 2004 10: 7738-7746. [Abstract] [Full Text] [PDF]  

Trastuzumab Down-Regulates Bcl-2 Expression and Potentiates Apoptosis Induction by Bcl-2/Bcl-X_L Bispecific Antisense Oligonucleotides in HER-2Gene–Amplified Breast Cancer Cells

Michele Milella, Daniela Trisciuoglio, Tiziana Bruno, Ludovica Ciuffreda, Marcella Mottolese, Anna Cianciulli, Francesco Cognetti, Uwe Zangemeister-Wittke, Donatella Del Bufalo, and Gabriella Zupi
Clin Cancer Res 2004 10: 7747-7756. [Abstract] [Full Text] [PDF]  

In vitro Effects of the BH3 Mimetic, (–)-Gossypol, on Head and Neck Squamous Cell Carcinoma Cells

Christopher L. Oliver, Joshua A. Bauer, Keith G. Wolter, Mathew L. Ubell, Ajita Narayan, Kathleen M. O’Connell, Susan G. Fisher, Shaomeng Wang, Xihan Wu, Min Ji, Thomas E. Carey, and Carol R. Bradford
Clin Cancer Res 2004 10: 7757-7763. [Abstract] [Full Text] [PDF]  

Deregulated Cyclin D1 Expression Is Associated with Decreased Efficacy of the Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cell Lines

Larry H. Kalish, Rhonda A. Kwong, Ian E. Cole, Richard M. Gallagher, Robert L. Sutherland, and Elizabeth A. Musgrove
Clin Cancer Res 2004 10: 7764-7774. [Abstract] [Full Text] [PDF]  

   Cancer Biology:

Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis

Soichi Tsutsumi, Takashi Yanagawa, Tatsuo Shimura, Hiroyuki Kuwano, and Avraham Raz
Clin Cancer Res 2004 10: 7775-7784. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

MIB-1 and p27^Kip1 Expression in Nephroblastoma

Chris Jones, Kathy Pritchard-Jones, Mazen A. Ghanem, Theo H. Van der Kwast, Rien M. Nijman, and Gert J. van Steenbrugge
Clin Cancer Res 2004 10: 7785-7786. [Full Text] [PDF]  

Corrections:

Correction: Article on The Na+/I-Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Downregulated in the Thyroid

Clin Cancer Res 2004 10: 7787. [Full Text] [PDF]  

Correction: Article on Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias

Clin Cancer Res 2004 10: 7787. [Full Text] [PDF]  

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