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Treatment effects as assessed by magnetic resonance imaging in mice bearing intracerebral glioblastoma (blue). Two representative three-dimensional reconstructions of Gdenhanced T1-weighted images, obtained from animals 21 days after beginning of treatment with local intracerebral microinfusions of PBS (left panel) or endostatin (right panel) at 2 mg/kg/d. For details, see Schmidt et al. in this issue.