Editorials:

Steven M. Larson

Positron Emission Tomography-Based Molecular Imaging in Human Cancer: Exploring the Link between Hypoxia and Accelerated Glucose Metabolism
Clin Cancer Res 2004 10: 2203-2204. [Full Text] [PDF]  

Steven Grant and Paul Dent

Kinase Inhibitors and Cytotoxic Drug Resistance
Clin Cancer Res 2004 10: 2205-2207. [Full Text] [PDF]  

Reviews:

Mujib Rahman, Hiroshi Miyamoto, and Chawnshang Chang

Androgen Receptor Coregulators in Prostate Cancer: Mechanisms and Clinical Implications
Clin Cancer Res 2004 10: 2208-2219. [Full Text] [PDF]  

The Biology Behind:

Chung S. Yang, Khew-Voon Chin, and Joshua D. Lambert

Cancer Chemoprevention by Targeting Proteasomal Degradation: Commentary re KA Dragnev et al, Specific Chemopreventive Agents Trigger Proteasomal Degradation of G₁ Cyclins: Implications for Combination Therapy. Clin Cancer Res, 2004;10:2570–7
Clin Cancer Res 2004 10: 2220-2221. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

David P. Ryan, Joseph P. Eder, Jr., Thomas Puchlaski, Michael V. Seiden, Thomas J. Lynch, Charles S. Fuchs, Philip C. Amrein, Darrell Sonnichsen, Jeffrey G. Supko, and Jeffrey W. Clark

Phase I Clinical Trial of the Farnesyltransferase Inhibitor BMS-214662 Given as a 1-Hour Intravenous Infusion in Patients with Advanced Solid Tumors
Clin Cancer Res 2004 10: 2222-2230. [Abstract] [Full Text] [PDF]  

Tuukka Mäkinen, Teuvo L. J. Tammela, Ulf-Håkan Stenman, Liisa Määttänen, Jussi Aro, Harri Juusela, Paula Martikainen, Matti Hakama, and Anssi Auvinen

Second Round Results of the Finnish Population-Based Prostate Cancer Screening Trial
Clin Cancer Res 2004 10: 2231-2236. [Abstract] [Full Text] [PDF]  

Milly E. de Jonge, H. J. G. Desirée van den Bongard, Alwin D. R. Huitema, Ron A. A. Mathôt, Hilde Rosing, Paul Baas, Nico van Zandwijk, Jos H. Beijnen, and Jan H. M. Schellens

Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 2237-2244. [Abstract] [Full Text] [PDF]  

Joseph G. Rajendran, David A. Mankoff, Finbarr O’Sullivan, Lanell M. Peterson, David L. Schwartz, Ernest U. Conrad, Alexander M. Spence, Mark Muzi, D. Greg Farwell, and Kenneth A. Krohn

Hypoxia and Glucose Metabolism in Malignant Tumors: Evaluation by [¹⁸F]Fluoromisonidazole and [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography Imaging
Clin Cancer Res 2004 10: 2245-2252. [Abstract] [Full Text] [PDF]  

William Larry Gluck, Deborah Hurst, Alan Yuen, Alexandra M. Levine, Mark A. Dayton, Jon P. Gockerman, Jennifer Lucas, Kimberly Denis-Mize, Barbara Tong, Dawn Navis, Anita Difrancesco, Sandra Milan, Susan E. Wilson, and Maurice Wolin

Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin’s Lymphoma: IL-2 Mediated Natural Killer Cell Expansion Correlations with Clinical Response
Clin Cancer Res 2004 10: 2253-2264. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Marlene A. Dressman, Rachel Malinowski, Lee Anne McLean, Insa Gathmann, Renaud Capdeville, Martee Hensley, and Mihael H. Polymeropoulos

Correlation of Major Cytogenetic Response with a Pharmacogenetic Marker in Chronic Myeloid Leukemia Patients Treated with Imatinib (STI571)
Clin Cancer Res 2004 10: 2265-2271. [Abstract] [Full Text] [PDF]  

Gennadi V. Glinsky, Takuya Higashiyama, and Anna B. Glinskii

Classification of Human Breast Cancer Using Gene Expression Profiling as a Component of the Survival Predictor Algorithm
Clin Cancer Res 2004 10: 2272-2283. [Abstract] [Full Text] [PDF] Supplementary Data  

Ozlem Topaloglu, Mohammad Obaidul Hoque, Yutaka Tokumaru, Juna Lee, Edward Ratovitski, David Sidransky, and Chul-so Moon

Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer
Clin Cancer Res 2004 10: 2284-2288. [Abstract] [Full Text] [PDF]  

Anne-Sofie Schrohl, Mads N. Holten-Andersen, Harry A. Peters, Maxine P. Look, Marion E. Meijer-van Gelder, Jan G. M. Klijn, Nils Brünner, and John A. Foekens

Tumor Tissue Levels of Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Marker in Primary Breast Cancer
Clin Cancer Res 2004 10: 2289-2298. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Kenji Yokoi and Isaiah J. Fidler

Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine
Clin Cancer Res 2004 10: 2299-2306. [Abstract] [Full Text] [PDF]  

Mark S. Duxbury, Hiromichi Ito, Michael J. Zinner, Stanley W. Ashley, and Edward E. Whang

Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells
Clin Cancer Res 2004 10: 2307-2318. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Claire F. Verschraegen, Brian E. Gilbert, Evelyne Loyer, Armando Huaringa, Garrett Walsh, Robert A. Newman, and Vernon Knight

Clinical Evaluation of the Delivery and Safety of Aerosolized Liposomal 9-Nitro-20(S)-Camptothecin in Patients with Advanced Pulmonary Malignancies
Clin Cancer Res 2004 10: 2319-2326. [Abstract] [Full Text] [PDF]  

S. Eralp Bellibas, Indra Patel, Emmanuel Chamorey, Bettyna Brivet, Ernest D. Bush, Catherine Kircher, Stephane Nave, Ludger Banken, Nicole Renée, and Gérard Milano

Single Ascending Dose Tolerability, Pharmacokinetic–Pharmacodynamic Study of Dihydropyrimidine Dehydrogenase Inhibitor Ro 09-4889
Clin Cancer Res 2004 10: 2327-2335. [Abstract] [Full Text] [PDF]  

Elton R. Kisanga, Jennifer Gjerde, Aliana Guerrieri-Gonzaga, Francesca Pigatto, Adriana Pesci-Feltri, Chris Robertson, Davide Serrano, Giuseppe Pelosi, Andrea Decensi, and Ernst A. Lien

Tamoxifen and Metabolite Concentrations in Serum and Breast Cancer Tissue during Three Dose Regimens in a Randomized Preoperative Trial
Clin Cancer Res 2004 10: 2336-2343. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Meera Srivastava, Lukas Bubendorf, Mark Raffeld, Christoph Bucher, Jochen Torhorst, Guido Sauter, Cara Olsen, Olli P. Kallioniemi, Ofer Eidelman, and Harvey B. Pollard

Prognostic Impact of ANX7-GTPase in Metastatic and HER2-Negative Breast Cancer Patients
Clin Cancer Res 2004 10: 2344-2350. [Abstract] [Full Text] [PDF]  

Hiroya Takeuchi, Akihide Fujimoto, Maki Tanaka, Tomoki Yamano, Eddy Hsueh, and Dave S. B. Hoon

CCL21 Chemokine Regulates Chemokine Receptor CCR7 Bearing Malignant Melanoma Cells
Clin Cancer Res 2004 10: 2351-2358. [Abstract] [Full Text] [PDF]  

Hong-Tao Zhang, Xiao-Feng Chen, Ming-Hua Wang, Jiu-Cun Wang, Qing-Yuan Qi, Rong-Mei Zhang, Wei-Qing Xu, Qing-Yan Fei, Fei Wang, Qi-Qun Cheng, Feng Chen, Cheng-Song Zhu, Shi-Heng Tao, and Zewei Luo

Defective Expression of Transforming Growth Factor ß Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer
Clin Cancer Res 2004 10: 2359-2367. [Abstract] [Full Text] [PDF]  

Jun Sugimura, Richard S. Foster, Oscar W. Cummings, Eric J. Kort, Masayuki Takahashi, Todd T. Lavery, Kyle A. Furge, Lawrence H. Einhorn, and Bin Tean Teh

Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis
Clin Cancer Res 2004 10: 2368-2378. [Abstract] [Full Text] [PDF]  

Susan V. Harden, David C. Thomas, Nicole Benoit, Khalid Minhas, William H. Westra, Joseph A. Califano, Wayne Koch, and David Sidransky

Real-Time Gap Ligase Chain Reaction: A Rapid Semiquantitative Assay for Detecting p53 Mutation at Low Levels in Surgical Margins and Lymph Nodes from Resected Lung and Head and Neck Tumors
Clin Cancer Res 2004 10: 2379-2385. [Abstract] [Full Text] [PDF]  

Jens Koopmann, Phillip Buckhaults, David A. Brown, Marianna L. Zahurak, Norihiro Sato, Noriyoshi Fukushima, Lori J. Sokoll, Daniel W. Chan, Charles J. Yeo, Ralph H. Hruban, Samuel N. Breit, Kenneth W. Kinzler, Bert Vogelstein, and Michael Goggins

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers
Clin Cancer Res 2004 10: 2386-2392. [Abstract] [Full Text] [PDF]  

Pia Wülfing, Christian Kersting, Joke Tio, Rudolph-Josef Fischer, Christian Wülfing, Christopher Poremba, Raihanatou Diallo, Werner Böcker, and Ludwig Kiesel

Endothelin-1-, Endothelin-A-, and Endothelin-B-Receptor Expression Is Correlated with Vascular Endothelial Growth Factor Expression and Angiogenesis in Breast Cancer
Clin Cancer Res 2004 10: 2393-2400. [Abstract] [Full Text] [PDF]  

Thian-Sze Wong, Dora Lai-Wan Kwong, Jonathan Shun-Tong Sham, William Ignace Wei, Yok-Lam Kwong, and Anthony Po-Wing Yuen

Quantitative Plasma Hypermethylated DNA Markers of Undifferentiated Nasopharyngeal Carcinoma
Clin Cancer Res 2004 10: 2401-2406. [Abstract] [Full Text] [PDF]  

Jian-Liu Wang, Bi-Ying Zheng, Xi-Dan Li, Tord Ångström, Mikael S. Lindström, and Keng-Ling Wallin

Predictive Significance of the Alterations of p16INK4A, p14ARF, p53, and Proliferating Cell Nuclear Antigen Expression in the Progression of Cervical Cancer
Clin Cancer Res 2004 10: 2407-2414. [Abstract] [Full Text] [PDF]  

Nuzhat Ahmed, Karen Oliva, Greg E Rice, and Michael A Quinn

Cell-Free 59 kDa Immunoreactive Integrin-Linked Kinase: A Novel Marker for Ovarian Carcinoma
Clin Cancer Res 2004 10: 2415-2420. [Abstract] [Full Text] [PDF]  

Carlo Palmieri, Eric W.-F. Lam, Janine Mansi, Claire MacDonald, Sami Shousha, Peter Madden, Yoko Omoto, Andrew Sunters, Margaret Warner, Jan-Åke Gustafsson, and R. Charles Coombes

The Expression of ERßcx in Human Breast Cancer and the Relationship to Endocrine Therapy and Survival
Clin Cancer Res 2004 10: 2421-2428. [Abstract] [Full Text] [PDF]  

Sarah Porter, Stuart D. Scott, Elaine M. Sassoon, Mark R. Williams, J. Louise Jones, Anne C. Girling, Richard Y. Ball, and Dylan R. Edwards

Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma
Clin Cancer Res 2004 10: 2429-2440. [Abstract] [Full Text] [PDF]  

Yue Wang, Naoya Kato, Yujin Hoshida, Motoyuki Otsuka, Hiroyoshi Taniguchi, Masaru Moriyama, Shuichiro Shiina, Takao Kawabe, Yoichi M. Ito, and Masao Omata

UDP-Glucuronosyltransferase 1A7 Genetic Polymorphisms Are Associated with Hepatocellular Carcinoma in Japanese Patients with Hepatitis C Virus Infection
Clin Cancer Res 2004 10: 2441-2446. [Abstract] [Full Text] [PDF]  

Naoki Yanagawa, Gen Tamura, Teiichiro Honda, Makoto Endoh, Satoshi Nishizuka, and Teiichi Motoyama

Demethylation of the Synuclein Gene CpG Island in Primary Gastric Cancers and Gastric Cancer Cell Lines
Clin Cancer Res 2004 10: 2447-2451. [Abstract] [Full Text] [PDF]  

Akira Ohkia, Youji Hu, Min Wang, Fernando U. Garcia, and Mark E. Stearns

Evidence for Prostate Cancer-Associated Diagnostic Marker-1: Immunohistochemistry and in Situ Hybridization Studies
Clin Cancer Res 2004 10: 2452-2458. [Abstract] [Full Text] [PDF]  

Tamotsu Kuroki, Sai Yendamuri, Francesco Trapasso, Ayumi Matsuyama, Rami I. Aqeilan, Hansjuerg Alder, Shashi Rattan, Rossano Cesari, Maria L. Nolli, Noel N. Williams, Masaki Mori, Takashi Kanematsu, and Carlo M. Croce

The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis
Clin Cancer Res 2004 10: 2459-2465. [Abstract] [Full Text] [PDF]  

Jeffrey S. Ross, Bhaskar V. S. Kallakury, Christine E. Sheehan, Hugh A. G. Fisher, Ronald P. Kaufman, Jr., Prabhjot Kaur, Karen Gray, and Bradley Stringer

Expression of Nuclear Factor-B and IB Proteins in Prostatic Adenocarcinomas: Correlation of Nuclear Factor-B Immunoreactivity with Disease Recurrence
Clin Cancer Res 2004 10: 2466-2472. [Abstract] [Full Text] [PDF]  

Sunil R. Lakhani, Sanjiv Manek, Frederique Penault-Llorca, Adrienne Flanagan, Laurent Arnout, Samantha Merrett, Lesley McGuffog, Dawn Steele, Peter Devilee, Jan G. M. Klijn, Hanne Meijers-Heijboer, Paolo Radice, Silvana Pilotti, Heli Nevanlinna, Ralf Butzow, Hagay Sobol, Jocylyne Jacquemier, Dominique Stoppa Lyonet, Susan L. Neuhausen, Barbara Weber, Teresa Wagner, Robert Winqvist, Yves-Jean Bignon, Franco Monti, Fernando Schmitt, Gilbert Lenoir, Susanne Seitz, Ute Hamman, Paul Pharoah, Geoff Lane, Bruce Ponder, D. Timothy Bishop, and Douglas F. Easton

Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers
Clin Cancer Res 2004 10: 2473-2481. [Abstract] [Full Text] [PDF]  

Nozomi Niitsu, Hirokazu Nakamine, Masataka Okamoto, Hiroko Akamatsu, Masaaki Higashihara, Yoshio Honma, Junko Okabe-Kado, and Masami Hirano

Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma
Clin Cancer Res 2004 10: 2482-2490. [Abstract] [Full Text] [PDF]  

Supaporn Suwiwat, Carmela Ricciardelli, Raija Tammi, Markku Tammi, Paivi Auvinen, Veli-Matti Kosma, Richard G. LeBaron, Wendy A. Raymond, Wayne D. Tilley, and David J. Horsfall

Expression of Extracellular Matrix Components Versican, Chondroitin Sulfate, Tenascin, and Hyaluronan, and Their Association with Disease Outcome in Node-Negative Breast Cancer
Clin Cancer Res 2004 10: 2491-2498. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

David Finkle, Zhi Ricky Quan, Vida Asghari, Jessica Kloss, Nazli Ghaboosi, Elaine Mai, Wai Lee Wong, Philip Hollingshead, Ralph Schwall, Hartmut Koeppen, and Sharon Erickson

HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice
Clin Cancer Res 2004 10: 2499-2511. [Abstract] [Full Text] [PDF]  

Corinna Warburton, Wieslawa H. Dragowska, Karen Gelmon, Stephen Chia, Hong Yan, Dana Masin, Tetyana Denyssevych, Anne E. Wallis, and Marcel B. Bally

Treatment of HER-2/neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction
Clin Cancer Res 2004 10: 2512-2524. [Abstract] [Full Text] [PDF]  

Kathleen Neville, Robert A. Parise, Patrick Thompson, Alexander Aleksic, Merrill J. Egorin, Frank M. Balis, Leticia McGuffey, Cynthia McCully, Stacey L. Berg, and Susan M. Blaney

Plasma and Cerebrospinal Fluid Pharmacokinetics of Imatinib after Administration to Nonhuman Primates
Clin Cancer Res 2004 10: 2525-2529. [Abstract] [Full Text] [PDF]  

Puja Sapra and Theresa M. Allen

Improved Outcome When B-Cell Lymphoma Is Treated with Combinations of Immunoliposomal Anticancer Drugs Targeted to Both the CD19 and CD20 Epitopes
Clin Cancer Res 2004 10: 2530-2537. [Abstract] [Full Text] [PDF]  

Koji Kono, Eiji Sato, Hirofumi Naganuma, Akihiro Takahashi, Kousaku Mimura, Hideaki Nukui, and Hideki Fujii

Trastuzumab (Herceptin) Enhances Class I-Restricted Antigen Presentation Recognized by HER-2/neu-Specific T Cytotoxic Lymphocytes
Clin Cancer Res 2004 10: 2538-2544. [Abstract] [Full Text] [PDF]  

Haruhiko Kamada, Yasuo Tsutsumi, Yasuo Yoshioka, Yoko Yamamoto, Hiroshi Kodaira, Shin-ichi Tsunoda, Takayuki Okamoto, Yohei Mukai, Hiroko Shibata, Shinsaku Nakagawa, and Tadanori Mayumi

Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy
Clin Cancer Res 2004 10: 2545-2550. [Abstract] [Full Text] [PDF]  

Ki-Hyuk Shin, Mo K. Kang, Erica Dicterow, Ayako Kameta, Marcel A. Baluda, and No-Hee Park

Introduction of Human Telomerase Reverse Transcriptase to Normal Human Fibroblasts Enhances DNA Repair Capacity
Clin Cancer Res 2004 10: 2551-2560. [Abstract] [Full Text] [PDF]  

Shousong Cao, Farukh A. Durrani, and Youcef M. Rustum

Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts
Clin Cancer Res 2004 10: 2561-2569. [Abstract] [Full Text] [PDF]  

Konstantin H. Dragnev, Ian Pitha-Rowe, Yan Ma, W. Jeffrey Petty, David Sekula, Bryan Murphy, Mara Rendi, Nanjoo Suh, Neil B. Desai, Michael B. Sporn, Sarah J. Freemantle, and Ethan Dmitrovsky

Specific Chemopreventive Agents Trigger Proteasomal Degradation of G₁ Cyclins: Implications for Combination Therapy
Clin Cancer Res 2004 10: 2570-2577. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Raj S. Rampaul, Sarah E. Pinder, Pete M. Wencyk, Rob I. Nicholson, Roger W. Blamey, John F. Robertson, and Ian O. Ellis

Epidermal Growth Factor Receptor Status in Operable Invasive Breast Cancer: Is It of Any Prognostic Value?
Clin Cancer Res 2004 10: 2578. [Full Text] [PDF]  

Corrections:

Correction
Clin Cancer Res 2004 10: 2579. [Full Text] [PDF]  

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