The Biology Behind:

Steven M. Frisch

E1A as a Tumor Suppressor Gene: Commentary re S. Madhusudan et al. A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene. Clin Cancer Res 2004;10:2905–2907.
Clin Cancer Res 2004 10: 2905-2907. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Francis Giles, Deborah Thomas, Guillermo Garcia-Manero, Stefan Faderl, Jorge Cortes, Srdan Verstovsek, Alessandra Ferrajoli, Sima Jeha, Miloslav Beran, Charles Koller, Michael Andreeff, Ann Cahill, Caroline Clairmont, Mario Sznol, and Hagop Kantarjian

A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia
Clin Cancer Res 2004 10: 2908-2917. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Tomas Kirchhoff, Noah D. Kauff, Nandita Mitra, Kedoudja Nafa, Helen Huang, Crystal Palmer, Tony Gulati, Eve Wadsworth, Sheri Donat, Mark E. Robson, Nathan A. Ellis, and Kenneth Offit

BRCA Mutations and Risk of Prostate Cancer in Ashkenazi Jews
Clin Cancer Res 2004 10: 2918-2921. [Abstract] [Full Text] [PDF]  

Giovanni Parmigiani, Elizabeth S. Garrett-Mayer, Ramaswamy Anbazhagan, and Edward Gabrielson

A Cross-Study Comparison of Gene Expression Studies for the Molecular Classification of Lung Cancer
Clin Cancer Res 2004 10: 2922-2927. [Abstract] [Full Text] [PDF]  

Takao Takahashi, Narayan Shivapurkar, Jyotsna Reddy, Hisayuki Shigematsu, Kuniharu Miyajima, Makoto Suzuki, Shinichi Toyooka, Sabine Zöchbauer-Müller, Johannes Drach, Gunjan Parikh, Yingye Zheng, Ziding Feng, Steven H. Kroft, Charles Timmons, Robert W. McKenna, and Adi F. Gazdar

DNA Methylation Profiles of Lymphoid and Hematopoietic Malignancies
Clin Cancer Res 2004 10: 2928-2935. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Elisa Giovannetti, Valentina Mey, Romano Danesi, Irene Mosca, and Mario Del Tacca

Synergistic Cytotoxicity and Pharmacogenetics of Gemcitabine and Pemetrexed Combination in Pancreatic Cancer Cell Lines
Clin Cancer Res 2004 10: 2936-2943. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Anton Stift, Monika Sachet, Rubina Yagubian, Clemens Bittermann, Peter Dubsky, Christine Brostjan, Roswitha Pfragner, Bruno Niederle, Raimund Jakesz, Michael Gnant, and Josef Friedl

Dendritic Cell Vaccination in Medullary Thyroid Carcinoma
Clin Cancer Res 2004 10: 2944-2953. [Abstract] [Full Text] [PDF]  

Lucy J. C. Smyth, Mariëtte I. E. van Poelgeest, Emma J. Davidson, Kitty M. C. Kwappenberg, Debbie Burt, Peter Sehr, Michael Pawlita, Stephen Man, Julian K. Hickling, Alison N. Fiander, Amanda Tristram, Henry C. Kitchener, Rienk Offringa, Peter L. Stern, and Sjoerd H. van der Burg

Immunological Responses in Women with Human Papillomavirus Type 16 (HPV-16)-Associated Anogenital Intraepithelial Neoplasia Induced by Heterologous Prime-Boost HPV-16 Oncogene Vaccination
Clin Cancer Res 2004 10: 2954-2961. [Abstract] [Full Text] [PDF]  

Paul Sabbatini, Carol Aghajanian, Mario Leitao, Ennapadam Venkatraman, Sybil Anderson, Jakob Dupont, Don Dizon, Catherine O’Flaherty, Jeffrey Bloss, Dennis Chi, and David Spriggs

Intraperitoneal Cisplatin with Intraperitoneal Gemcitabine in Patients with Epithelial Ovarian Cancer: Results of a Phase I/II Trial
Clin Cancer Res 2004 10: 2962-2967. [Abstract] [Full Text] [PDF]  

Fadlo R. Khuri, Bonnie S. Glisson, Edward S. Kim, Paul Statkevich, Peter F. Thall, Michael L. Meyers, Roy S. Herbst, Reginald F. Munden, Craig Tendler, Yali Zhu, Sandra Bangert, Elizabeth Thompson, Charles Lu, Xue-Mei Wang, Dong M. Shin, Merrill S. Kies, Vali Papadimitrakopoulou, Frank V. Fossella, Paul Kirschmeier, W. Robert Bishop, and Waun Ki Hong

Phase I Study of the Farnesyltransferase Inhibitor Lonafarnib with Paclitaxel in Solid Tumors
Clin Cancer Res 2004 10: 2968-2976. [Abstract] [Full Text] [PDF]  

Naiyu Zheng, Carolyn A. Felix, Shaokun Pang, Ray Boston, Peter Moate, Jennifer Scavuzzo, and Ian A. Blair

Plasma Etoposide Catechol Increases in Pediatric Patients Undergoing Multiple-Day Chemotherapy with Etoposide
Clin Cancer Res 2004 10: 2977-2985. [Abstract] [Full Text] [PDF]  

Srinivasan Madhusudan, Ayala Tamir, Nicholas Bates, Elizabeth Flanagan, Martin E. Gore, Desmond P. J. Barton, Peter Harper, Michael Seckl, Hilary Thomas, Nicholas R. Lemoine, Mark Charnock, Nagy A. Habib, Robert Lechler, Joanna Nicholls, Massimo Pignatelli, and Trivadi S. Ganesan

A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene
Clin Cancer Res 2004 10: 2986-2996. [Abstract] [Full Text] [PDF]  

Michael C. Frühwald, Christian H. Rickert, M. Sue O’Dorisio, Mark Madsen, Monika Warmuth-Metz, Geetika Khanna, Werner Paulus, Joachim Kühl, Heribert Jürgens, Peter Schneider, and Hermann L. Müller

Somatostatin Receptor Subtype 2 Is Expressed by Supratentorial Primitive Neuroectodermal Tumors of Childhood and Can Be Targeted for Somatostatin Receptor Imaging
Clin Cancer Res 2004 10: 2997-3006. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Yuichi Tsujimoto, Yasuhiko Tomita, Yoshihiko Hoshida, Takuro Kono, Toshitsugu Oka, Shinji Yamamoto, Norio Nonomura, Akihiko Okuyama, and Katsuyuki Aozasa

Elevated Expression of Valosin-Containing Protein (p97) Is Associated with Poor Prognosis of Prostate Cancer
Clin Cancer Res 2004 10: 3007-3012. [Abstract] [Full Text] [PDF]  

Seiji Suzuki, Kaku Egami, Koji Sasajima, Mohammad Ghazizadeh, Hajime Shimizu, Hidehiro Watanabe, Hirokazu Hasegawa, Shinya Iida, Takeshi Matsuda, Yuji Okihama, Masaru Hosone, Kazuo Shimizu, Oichi Kawanami, and Takashi Tajiri

Comparative Study between DNA Copy Number Aberrations Determined by Quantitative Microsatellite Analysis and Clinical Outcome in Patients with Stomach Cancer
Clin Cancer Res 2004 10: 3013-3019. [Abstract] [Full Text] [PDF]  

Stine-Kathrein Kraeft, Andras Ladanyi, Kevin Galiger, Anna Herlitz, Andrew C. Sher, Danielle E. Bergsrud, Gaelle Even, Stephanie Brunelle, Lyndsay Harris, Ravi Salgia, Tom Dahl, John Kesterson, and Lan Bo Chen

Reliable and Sensitive Identification of Occult Tumor Cells Using the Improved Rare Event Imaging System
Clin Cancer Res 2004 10: 3020-3028. [Abstract] [Full Text] [PDF]  

Annelise Bennaceur-Griscelli, Jacques Bosq, Serge Koscielny, François Lefrère, Ali Turhan, Nicole Brousse, Olivier Hermine, and Vincent Ribrag

High Level of Glutathione-S-Transferase Expression in Mantle Cell Lymphomas
Clin Cancer Res 2004 10: 3029-3034. [Abstract] [Full Text] [PDF]  

Pouya Pakneshan, Bernard Têtu, and Shafaat A. Rabbani

Demethylation of Urokinase Promoter as a Prognostic Marker in Patients with Breast Carcinoma
Clin Cancer Res 2004 10: 3035-3041. [Abstract] [Full Text] [PDF]  

Stanley E. Shackney, Charles A. Smith, Agnese Pollice, Kathryn Brown, Roger Day, Thomas Julian, and Jan F. Silverman

Intracellular Patterns of Her-2/neu, ras, and Ploidy Abnormalities in Primary Human Breast Cancers Predict Postoperative Clinical Disease-Free Survival
Clin Cancer Res 2004 10: 3042-3052. [Abstract] [Full Text] [PDF]  

Rami I. Aqeilan, Tamotsu Kuroki, Yuri Pekarsky, Omar Albagha, Francesco Trapasso, Raffaele Baffa, Kay Huebner, Pamela Edmonds, and Carlo M. Croce

Loss of WWOX Expression in Gastric Carcinoma
Clin Cancer Res 2004 10: 3053-3058. [Abstract] [Full Text] [PDF]  

Peter Melsheimer, Svetlana Vinokurova, Nicolas Wentzensen, Gunther Bastert, and Magnus von Knebel Doeberitz

DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri
Clin Cancer Res 2004 10: 3059-3063. [Abstract] [Full Text] [PDF]  

Liang Cheng, Chong-Xian Pan, Jian-Ting Zhang, Shaobo Zhang, Michael S. Kinch, Lang Li, Lee Ann Baldridge, Christopher Wade, Zhiqiang Hu, Michael O. Koch, Thomas M. Ulbright, and John N. Eble

Loss of 14-3-3 in Prostate Cancer and Its Precursors
Clin Cancer Res 2004 10: 3064-3068. [Abstract] [Full Text] [PDF]  

Murray B. Resnick, Justin Routhier, Tamako Konkin, Edmond Sabo, and Victor E. Pricolo

Epidermal Growth Factor Receptor, c-MET, ß-Catenin, and p53 Expression as Prognostic Indicators in Stage II Colon Cancer: A Tissue Microarray Study
Clin Cancer Res 2004 10: 3069-3075. [Abstract] [Full Text] [PDF]  

Tae Won Kim, Hyoungnam Lee, Yoon-Koo Kang, Mi Sun Choe, Min-Hee Ryu, Heung Moon Chang, Jung Sun Kim, Jeong Hwan Yook, Byung Sik Kim, and Jung Shin Lee

Prognostic Significance of c-kit Mutation in Localized Gastrointestinal Stromal Tumors
Clin Cancer Res 2004 10: 3076-3081. [Abstract] [Full Text] [PDF]  

Kazuo Konishi, Toshiko Yamochi, Reiko Makino, Kazuhiro Kaneko, Taikan Yamamoto, Hisako Nozawa, Atsushi Katagiri, Hiroaki Ito, Kentarou Nakayama, Hidekazu Ota, Keiji Mitamura, and Michio Imawari

Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas
Clin Cancer Res 2004 10: 3082-3090. [Abstract] [Full Text] [PDF]  

Bjørn Naume, Gro Wiedswang, Elin Borgen, Gunnar Kvalheim, Rolf Kåresen, Hanne Qvist, Jan Janbu, Torstein Harbitz, and Jahn M. Nesland

The Prognostic Value of Isolated Tumor Cells in Bone Marrow in Breast Cancer Patients: Evaluation of Morphological Categories and the Number of Clinically Significant Cells
Clin Cancer Res 2004 10: 3091-3097. [Abstract] [Full Text] [PDF]  

Giuseppina D’Andrilli, Valeria Masciullo, Luigi Bagella, Tiziana Tonini, Corrado Minimo, Gian Franco Zannoni, Robert L. Giuntoli, II, John A. Carlson, Jr., Dianne Robert Soprano, Kenneth J. Soprano, Giovanni Scambia, and Antonio Giordano

Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma
Clin Cancer Res 2004 10: 3098-3103. [Abstract] [Full Text] [PDF]  

Jyoti Mehrotra, Mustafa Vali, Megan McVeigh, Scott L. Kominsky, Mary Jo Fackler, Jaana Lahti-Domenici, Kornelia Polyak, Nicoletta Sacchi, Elizabeth Garrett-Mayer, Pedram Argani, and Saraswati Sukumar

Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung
Clin Cancer Res 2004 10: 3104-3109. [Abstract] [Full Text] [PDF]  

Henni Ruokolainen, Paavo Pääkkö, and Taina Turpeenniemi-Hujanen

Expression of Matrix Metalloproteinase-9 in Head and Neck Squamous Cell Carcinoma: A Potential Marker for Prognosis
Clin Cancer Res 2004 10: 3110-3116. [Abstract] [Full Text] [PDF]  

Gabriella Ferrandina, Franco Oreste Ranelletti, Francesco Legge, Marco Gessi, Vanda Salutari, Maria Grazia Distefano, Libero Lauriola, Gian Franco Zannoni, Enrica Martinelli, and Giovanni Scambia

Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer
Clin Cancer Res 2004 10: 3117-3123. [Abstract] [Full Text] [PDF]  

Delphine Lévy, Geneviève Plu-Bureau, Yves Decroix, Danielle Hugol, William Rostène, Adi Kimchi, and Anne Gompel

Death-Associated Protein Kinase Loss of Expression Is a New Marker for Breast Cancer Prognosis
Clin Cancer Res 2004 10: 3124-3130. [Abstract] [Full Text] [PDF]  

Meri Varga, Peter Obrist, Stephan Schneeberger, Gilbert Mühlmann, Christina Felgel-Farnholz, Dominic Fong, Mathias Zitt, Thomas Brunhuber, Georg Schäfer, Guenther Gastl, and Gilbert Spizzo

Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival
Clin Cancer Res 2004 10: 3131-3136. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Zhengsheng Yao, Meili Zhang, Kayhan Garmestani, Donald B. Axworthy, Robert W. Mallett, Alan R. Fritzberg, Lou J. Theodore, Paul S. Plascjak, William C. Eckelman, Thomas A. Waldmann, Ira Pastan, Chang H. Paik, Martin W. Brechbiel, and Jorge A. Carrasquillo

Pretargeted Emitting Radioimmunotherapy Using ²¹³Bi 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetraacetic Acid-Biotin
Clin Cancer Res 2004 10: 3137-3146. [Abstract] [Full Text] [PDF]  

Donna L. Dehn, Shannon L. Winski, and David Ross

Development of a New Isogenic Cell-Xenograft System for Evaluation of NAD(P)H:Quinone Oxidoreductase-Directed Antitumor Quinones: Evaluation of the Activity of RH1
Clin Cancer Res 2004 10: 3147-3155. [Abstract] [Full Text] [PDF]  

Anna Kruczynski, Jean-Marc Barret, Benoît van Hille, Nathalie Chansard, Jackie Astruc, Yoann Menon, Carole Duchier, Laurent Créancier, and Bridget T. Hill

Decreased Nucleotide Excision Repair Activity and Alterations of Topoisomerase II Are Associated with the in Vivo Resistance of a P388 Leukemia Subline to F11782, a Novel Catalytic Inhibitor of Topoisomerases I and II
Clin Cancer Res 2004 10: 3156-3168. [Abstract] [Full Text] [PDF]  

Sanjeev Shukla and Sanjay Gupta

Suppression of Constitutive and Tumor Necrosis Factor -Induced Nuclear Factor (NF)-B Activation and Induction of Apoptosis by Apigenin in Human Prostate Carcinoma PC-3 Cells: Correlation with Down-Regulation of NF-B-Responsive Genes
Clin Cancer Res 2004 10: 3169-3178. [Abstract] [Full Text] [PDF]  

Jenny Karlsson, Ingrid Øra, Isabella Pörn-Ares, and Sven Påhlman

Arsenic Trioxide-Induced Death of Neuroblastoma Cells Involves Activation of Bax and Does Not Require p53
Clin Cancer Res 2004 10: 3179-3188. [Abstract] [Full Text] [PDF]  

Meredith A. Preuss, John T. Lam, Minghui Wang, Charles A. Leath, III, Manjula Kataram, Parameshwar J. Mahasreshti, Ronald D. Alvarez, and David T. Curiel

Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor
Clin Cancer Res 2004 10: 3189-3194. [Abstract] [Full Text] [PDF]  

Anthony Raffo, Johnathan C. Lai, C. A. Stein, Paul Miller, Steven Scaringe, Anastasia Khvorova, and Luba Benimetskaya

Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen)
Clin Cancer Res 2004 10: 3195-3206. [Abstract] [Full Text] [PDF]  

Bei Zheng, Georgios V. Georgakis, Yang Li, Alok Bharti, David McConkey, Bharat B. Aggarwal, and Anas Younes

Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-B Mutations or Activation of the CD30, CD40, and RANK Receptors
Clin Cancer Res 2004 10: 3207-3215. [Abstract] [Full Text] [PDF]  

Chris A. Learn, Tristan L. Hartzell, Carol J. Wikstrand, Gary E. Archer, Jeremy N. Rich, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and John H. Sampson

Resistance to Tyrosine Kinase Inhibition by Mutant Epidermal Growth Factor Receptor Variant III Contributes to the Neoplastic Phenotype of Glioblastoma Multiforme
Clin Cancer Res 2004 10: 3216-3224. [Abstract] [Full Text] [PDF]  

Stephen F. Stanziale, Henrik Petrowsky, Prasad S. Adusumilli, Leah Ben-Porat, Mithat Gonen, and Yuman Fong

Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells: A Potential Target to Increase Anticancer Activity
Clin Cancer Res 2004 10: 3225-3232. [Abstract] [Full Text] [PDF]  

Corrections:

Correction
Clin Cancer Res 2004 10: 3233. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.