Editorials:

Clinical Cancer Research: The Next Decade

William N. Hait
Clin Cancer Res 2005 11: 1. [Full Text] [PDF]  

Biology Behind:

From Microarray to Bedside: Targeting NF-B for Therapy of Lymphomas

Arnold B. Rabson and David Weissmann
Clin Cancer Res 2005 11: 2-6. [Full Text] [PDF]  

Combining Innate Immunity With Radiation Therapy for Cancer Treatment

Gary K. Koski and Brian J. Czerniecki
Clin Cancer Res 2005 11: 7-11. [Full Text] [PDF]  

Report from the Food and Drug Administration:

U.S. Food and Drug Administration Drug Approval Summary: Conversion of Imatinib Mesylate (STI571; Gleevec) Tablets from Accelerated Approval to Full Approval

Martin H. Cohen, John R. Johnson, and Richard Pazdur
Clin Cancer Res 2005 11: 12-19. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Erythropoietin and Erythropoietin Receptor Expression in Head and Neck Cancer: Relationship to Tumor Hypoxia

Murat O. Arcasoy, Khalid Amin, Shu-Chuan Chou, Zishan A. Haroon, Mahesh Varia, and James A. Raleigh
Clin Cancer Res 2005 11: 20-27. [Abstract] [Full Text] [PDF]  

Small Molecule Inhibitors of IB Kinase Are Selectively Toxic for Subgroups of Diffuse Large B-Cell Lymphoma Defined by Gene Expression Profiling

Lloyd T. Lam, R. Eric Davis, Jackie Pierce, Michael Hepperle, Yajun Xu, Maria Hottelet, Yuhua Nong, Danyi Wen, Julian Adams, Lenny Dang, and Louis M. Staudt
Clin Cancer Res 2005 11: 28-40. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Is a Target of KRAS^D12, Which Facilitates the Outgrowth of Murine C26 Colorectal Liver Metastases

Niels Smakman, Onno Kranenburg, Jan M. Vogten, Alexander L.A. Bloemendaal, Paul van Diest, and Inne H.M. Borel Rinkes
Clin Cancer Res 2005 11: 41-48. [Abstract] [Full Text] [PDF]  

Inhibitory Effect of Antagonists of Bombesin and Growth Hormone-Releasing Hormone on Orthotopic and Intraosseous Growth and Invasiveness of PC-3 Human Prostate Cancer in Nude Mice

Anton Stangelberger, Andrew V. Schally, Jozsef L. Varga, Marta Zarandi, Karoly Szepeshazi, Patricia Armatis, and Gabor Halmos
Clin Cancer Res 2005 11: 49-57. [Abstract] [Full Text] [PDF]  

Vaccination of Dendritic Cells Loaded with Interleukin-12-Secreting Cancer Cells Augments In vivo Antitumor Immunity: Characteristics of Syngeneic and Allogeneic Antigen-Presenting Cell Cancer Hybrid Cells

Takuji Suzuki, Tatsuro Fukuhara, Masashi Tanaka, Akira Nakamura, Kenichi Akiyama, Tomohiro Sakakibara, Daizo Koinuma, Toshiaki Kikuchi, Ryushi Tazawa, Makoto Maemondo, Koichi Hagiwara, Yasuo Saijo, and Toshihiro Nukiwa
Clin Cancer Res 2005 11: 58-66. [Abstract] [Full Text] [PDF]  

HLA Class I Antigen Down-Regulation in Primary Ovary Carcinoma Lesions: Association with Disease Stage

Marco Vitale, Giuseppe Pelusi, Beatrice Taroni, Giuliana Gobbi, Cristina Micheloni, Rita Rezzani, Francesco Donato, Xinhui Wang, and Soldano Ferrone
Clin Cancer Res 2005 11: 67-72. [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor in Uveal Melanoma Is Independent of 6p21-Region Copy Number

Mohamed H. Abdel-Rahman, Elson L. Craig, Frederick H. Davidorf, and Charis Eng
Clin Cancer Res 2005 11: 73-78. [Abstract] [Full Text] [PDF]  

Determination of Genes Related to Gastrointestinal Tract Origin Cancer Cells Using a cDNA Microarray

Tae Moon Kim, Ha Jin Jeong, Min Young Seo, Sang Chul Kim, Gabee Cho, Chan Hee Park, Tae Soo Kim, Kyu Hyun Park, Hyun Cheol Chung, and Sun Young Rha
Clin Cancer Res 2005 11: 79-86. [Abstract] [Full Text] [PDF]  

Immunoglobulin Superfamily Receptor Translocation Associated 2 Protein on Lymphoma Cell Lines and Hairy Cell Leukemia Cells Detected by Novel Monoclonal Antibodies

Tomoko Ise, Hiroshi Maeda, Kenneth Santora, Laiman Xiang, Robert J. Kreitman, Ira Pastan, and Satoshi Nagata
Clin Cancer Res 2005 11: 87-96. [Abstract] [Full Text] [PDF]  

Colocalization of Carbonic Anhydrase 9 Expression and Cell Proliferation in Human Head and Neck Squamous Cell Carcinoma

Ilse J. Hoogsteen, Henri A.M. Marres, Karien I.E.M. Wijffels, Paul F.J.W. Rijken, Johannes P.W. Peters, Franciscus J.A. van den Hoogen, Egbert Oosterwijk, Albert J. van der Kogel, and Johannes H.A.M. Kaanders
Clin Cancer Res 2005 11: 97-106. [Abstract] [Full Text] [PDF]  

Quantitative Analysis of Melanoma-Induced Cytokine-Mediated Immunosuppression in Melanoma Sentinel Nodes

Jonathan H. Lee, Hitoe Torisu-Itakara, Alistair J. Cochran, Alan Kadison, Young Huynh, Donald L. Morton, and Richard Essner
Clin Cancer Res 2005 11: 107-112. [Abstract] [Full Text] [PDF]  

Peritoneal and Subperitoneal Stroma May Facilitate Regional Spread of Ovarian Cancer

Ena Wang, Yvonne Ngalame, Monica C. Panelli, Hoainam Nguyen-Jackson, Michael Deavers, Peter Mueller, Wei Hu, Cherylyn A. Savary, Ryuji Kobayashi, Ralph S. Freedman, and Francesco M. Marincola
Clin Cancer Res 2005 11: 113-122. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Visualization of Endogenous p53-Mediated Transcription In vivo Using Sodium Iodide Symporter

Kwang Il Kim, June-Key Chung, Joo Hyun Kang, Yong Jin Lee, Jae Hoon Shin, Hyun Jeong Oh, Jae Min Jeong, Dong Soo Lee, and Myung Chul Lee
Clin Cancer Res 2005 11: 123-128. [Abstract] [Full Text] [PDF]  

The Evolution of Antibodies into Versatile Tumor-Targeting Agents

Michael Z. Lin, Michael A. Teitell, and Gary J. Schiller
Clin Cancer Res 2005 11: 129-138. [Abstract] [Full Text] [PDF]  

A New Prostate Carcinoma Binding Peptide (DUP-1) for Tumor Imaging and Therapy

Sabine Zitzmann, Walter Mier, Arno Schad, Ralf Kinscherf, Vasileios Askoxylakis, Susanne Krämer, Annette Altmann, Michael Eisenhut, and Uwe Haberkorn
Clin Cancer Res 2005 11: 139-146. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Metastasis-Associated Protein S100A4 (Mts1) in Prostate Cancer Progression and Chemoprevention Regimens in an Autochthonous Mouse Model

Mohammad Saleem, Vaqar Mustafa Adhami, Nihal Ahmad, Sanjay Gupta, and Hasan Mukhtar
Clin Cancer Res 2005 11: 147-153. [Abstract] [Full Text] [PDF]  

Increased Vascularization Predicts Favorable Outcome in Follicular Lymphoma

Ad Koster, Joannes H.J.M. van Krieken, Marius A. MacKenzie, Margit Schraders, George F. Borm, Jeroen A.W.M. van der Laak, William Leenders, Konnie Hebeda, and John M.M. Raemaekers
Clin Cancer Res 2005 11: 154-161. [Abstract] [Full Text] [PDF]  

Expression of Receptor Activator of Nuclear Factor-B Ligand Is Inversely Correlated with Metastatic Phenotype in Breast Carcinoma

Pardeep Bhatia, M. Melinda Sanders, and Marc F. Hansen
Clin Cancer Res 2005 11: 162-165. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation in Benign Breast Epithelium in Relation to Predicted Breast Cancer Risk

Cheryl M. Lewis, Leslie R. Cler, Da-Wei Bu, Sabine Zöchbauer-Müller, Sara Milchgrub, Elizabeth Z. Naftalis, A. Marilyn Leitch, John D. Minna, and David M. Euhus
Clin Cancer Res 2005 11: 166-172. [Abstract] [Full Text] [PDF]  

Prognosis of Non–Small Cell Lung Cancer Patients by Detecting Circulating Cancer Cells in the Peripheral Blood with Multiple Marker Genes

Yuh-Pyng Sher, Jin-Yuan Shih, Pan-Chyr Yang, Steve R. Roffler, Yi-Wen Chu, Cheng-Wen Wu, Chia-Li Yu, and Konan Peck
Clin Cancer Res 2005 11: 173-179. [Abstract] [Full Text] [PDF]  

Prognostic Relevance of Fragile Histidine Triad Protein Expression in Patients with Small Cell Lung Cancer

Ulrich-Peter Rohr, Nina Rehfeld, Helene Geddert, Lucy Pflugfelder, Ingmar Bruns, Judith Neukirch, Astrid Rohrbeck, Hans J. Grote, Ulrich Steidl, Roland Fenk, Bertram Opalka, Helmut E. Gabbert, Ralf Kronenwett, and Rainer Haas
Clin Cancer Res 2005 11: 180-185. [Abstract] [Full Text] [PDF]  

The Expression of Fascin, an Actin-Bundling Motility Protein, Correlates with Hormone Receptor–Negative Breast Cancer and a More Aggressive Clinical Course

Brian J. Yoder, Elisa Tso, Marek Skacel, Jim Pettay, Shannon Tarr, Thomas Budd, Raymond R. Tubbs, Josephine C. Adams, and David G. Hicks
Clin Cancer Res 2005 11: 186-192. [Abstract] [Full Text] [PDF]  

ATBF1-A Messenger RNA Expression Is Correlated with Better Prognosis in Breast Cancer

Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Hiroshi Sugiura, Yoshiaki Ando, Keiko Mita, Maho Hamaguchi, Makoto Kawaguchi, Yutaka Miura, and Hirotaka Iwase
Clin Cancer Res 2005 11: 193-198. [Abstract] [Full Text] [PDF]  

Overexpression of h-prune in Breast Cancer is Correlated with Advanced Disease Status

Massimo Zollo, Alessandra Andrè, Antonio Cossu, Maria C. Sini, Anna D'Angelo, Natascia Marino, Mario Budroni, Francesco Tanda, Gianluigi Arrigoni, and Giuseppe Palmieri
Clin Cancer Res 2005 11: 199-205. [Abstract] [Full Text] [PDF]  

Insulin-Like Growth Factor Type 1 Receptor Expression Correlates to Good Prognosis in Highly Malignant Soft Tissue Sarcoma

Jan Åhlén, Johan Wejde, Otte Brosjö, Anette von Rosen, Wen-Hui Weng, Leonard Girnita, Olle Larsson, and Catharina Larsson
Clin Cancer Res 2005 11: 206-216. [Abstract] [Full Text] [PDF]  

A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas

Jeremy D. Henson, Jonathan A. Hannay, Stanley W. McCarthy, Janice A. Royds, Thomas R. Yeager, Robert A. Robinson, Stephen B. Wharton, David A. Jellinek, Susan M. Arbuckle, Jinyoung Yoo, Bruce G. Robinson, Diana L. Learoyd, Paul D. Stalley, S. Fiona Bonar, Dihua Yu, Raphael E. Pollock, and Roger R. Reddel
Clin Cancer Res 2005 11: 217-225. [Abstract] [Full Text] [PDF]  

Expression of EphA2 is Prognostic of Disease-Free Interval and Overall Survival in Surgically Treated Patients with Renal Cell Carcinoma

Christopher J. Herrem, Tomohide Tatsumi, Kathleen S. Olson, Keisuke Shirai, James H. Finke, Ronald M. Bukowski, Ming Zhou, Amy L. Richmond, Ithaar Derweesh, Michael S. Kinch, and Walter J. Storkus
Clin Cancer Res 2005 11: 226-231. [Abstract] [Full Text] [PDF]  

Prognostic Implications of Molecular and Immunohistochemical Profiles of the Rb and p53 Cell Cycle Regulatory Pathways in Primary Non–Small Cell Lung Carcinoma

Louise Burke, Douglas B. Flieder, Donald G. Guinee, Elizabeth Brambilla, Andrew N. Freedman, William P. Bennett, Raymond T. Jones, Andrew Borkowski, Neil A. Caporaso, Marian Fleming, Victor Trastek, Peter Pairolero, Henry Tazelaar, David Midthun, James R. Jett, Lance A. Liotta, William D. Travis, and Curtis C. Harris
Clin Cancer Res 2005 11: 232-241. [Abstract] [Full Text] [PDF] Supplementary Data  

Cyclin D3 Immunoreactivity Is an Independent Predictor of Survival in Laryngeal Squamous Cell Carcinoma

Giancarlo Pruneri, Lorenzo Pignataro, Stefano Valentini, Sonia Fabris, Patrick Maisonneuve, Nadia Carboni, Salvatore Pece, Maria Capra, Barbara Del Curto, Antonino Neri, and Giuseppe Viale
Clin Cancer Res 2005 11: 242-248. [Abstract] [Full Text] [PDF]  

Minichromosome Maintenance Protein 3 Elicits a Cancer-Restricted Immune Response in Patients with Brain Malignancies and Is a Strong Independent Predictor of Survival in Patients with Anaplastic Astrocytoma

Ariane Söling, Mirko Sackewitz, Michael Volkmar, Daniel Schaarschmidt, Roland Jacob, Hans-Jürgen Holzhausen, and Nikolai G. Rainov
Clin Cancer Res 2005 11: 249-258. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Jab1 Expression in Laryngeal Squamous Cell Carcinomas

Youyi Dong, Li Sui, Yasuo Watanabe, Fuminori Yamaguchi, Naoya Hatano, and Masaaki Tokuda
Clin Cancer Res 2005 11: 259-266. [Abstract] [Full Text] [PDF]  

Loss of the AP-2 Transcription Factor Is Associated with the Grade of Human Gliomas

Amy B. Heimberger, Eric C. McGary, Dima Suki, Maribelis Ruiz, Huamin Wang, Gregory N. Fuller, and Menashe Bar-Eli
Clin Cancer Res 2005 11: 267-272. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Accuracy, Feasibility, and Clinical Impact of Prospective Bayesian Pharmacokinetically Guided Dosing of Cyclophosphamide, Thiotepa, and Carboplatin in High-Dose Chemotherapy

Milly E. de Jonge, Alwin D.R. Huitema, Annemarie C. Tukker, Selma M. van Dam, Sjoerd Rodenhuis, and Jos H. Beijnen
Clin Cancer Res 2005 11: 273-282. [Abstract] [Full Text] [PDF]  

A Phase I Study of Estramustine, Weekly Docetaxel, and Carboplatin Chemotherapy in Patients with Hormone-Refractory Prostate Cancer

William K. Oh, Elizabeth Hagmann, Judith Manola, Daniel J. George, Timothy D. Gilligan, Joseph O. Jacobson, Matthew R. Smith, Donald S. Kaufman, and Philip W. Kantoff
Clin Cancer Res 2005 11: 284-289. [Abstract] [Full Text] [PDF]  

Addition of Histamine to Interleukin 2 Treatment Augments Type 1 T-Cell Responses in Patients with Melanoma In vivo: Immunologic Results from a Randomized Clinical Trial of Interleukin 2 with or without Histamine (MP 104)

Anne Marie Asemissen, Carmen Scheibenbogen, Anne Letsch, Kristoffer Hellstrand, Fredrik Thorén, Kurt Gehlsen, Alexander Schmittel, Eckhard Thiel, and Ulrich Keilholz
Clin Cancer Res 2005 11: 290-297. [Abstract] [Full Text] [PDF]  

Class III ß-Tubulin Overexpression Is a Prominent Mechanism of Paclitaxel Resistance in Ovarian Cancer Patients

Simona Mozzetti, Cristiano Ferlini, Paola Concolino, Flavia Filippetti, Giuseppina Raspaglio, Silvia Prislei, Daniela Gallo, Enrica Martinelli, Franco Oreste Ranelletti, Gabriella Ferrandina, and Giovanni Scambia
Clin Cancer Res 2005 11: 298-305. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Inhibition of Platelet-Derived Growth Factor Receptor Signaling Restricts the Growth of Human Breast Cancer in the Bone of Nude Mice

Dina Chelouche Lev, Sun Jin Kim, Amir Onn, Valerie Stone, Do-Hyun Nam, Sertac Yazici, Isaiah J. Fidler, and Janet E. Price
Clin Cancer Res 2005 11: 306-314. [Abstract] [Full Text] [PDF]  

TAS-108, a Novel Oral Steroidal Antiestrogenic Agent, Is a Pure Antagonist on Estrogen Receptor and a Partial Agonist on Estrogen Receptor ß with Low Uterotrophic Effect

Yasuji Yamamoto, Jiro Shibata, Kazuhiko Yonekura, Kouji Sato, Akihiro Hashimoto, Yoshimi Aoyagi, Konstanty Wierzba, Shingo Yano, Tetsuji Asao, Aman U. Buzdar, and Tadafumi Terada
Clin Cancer Res 2005 11: 315-322. [Abstract] [Full Text] [PDF]  

Growth Suppression of Ovarian Cancer Xenografts in Nude Mice by Vitamin D Analogue EB1089

Xiaohui Zhang, Feng Jiang, Pengfei Li, Chunrong Li, Qiuping Ma, Santo V. Nicosia, and Wenlong Bai
Clin Cancer Res 2005 11: 323-328. [Abstract] [Full Text] [PDF]  

Interstitial Diphtheria Toxin-Epidermal Growth Factor Fusion Protein Therapy Produces Regressions of Subcutaneous Human Glioblastoma Multiforme Tumors in Athymic Nude Mice

Tie Fu Liu, Philip D. Hall, Kimberley A. Cohen, Mark C. Willingham, Jiaozhong Cai, Andrew Thorburn, and Arthur E. Frankel
Clin Cancer Res 2005 11: 329-334. [Abstract] [Full Text] [PDF]  

Herstatin, an Autoinhibitor of the Epidermal Growth Factor (EGF) Receptor Family, Blocks the Intracranial Growth of Glioblastoma

Julia A. Staverosky, Leslie L. Muldoon, Shuhua Guo, Adam J. Evans, Edward A. Neuwelt, and Gail M. Clinton
Clin Cancer Res 2005 11: 335-340. [Abstract] [Full Text] [PDF]  

Development of a Syngeneic Rat Brain Tumor Model Expressing EGFRvIII and Its Use for Molecular Targeting Studies with Monoclonal Antibody L8A4

Weilian Yang, Rolf F. Barth, Gong Wu, Michael J. Ciesielski, Robert A. Fenstermaker, Bradford A. Moffat, Brian D. Ross, and Carol J. Wikstrand
Clin Cancer Res 2005 11: 341-350. [Abstract] [Full Text] [PDF]  

A Novel Assay to Assess Primary Human Cancer Infectibility by Replication-Selective Oncolytic Adenoviruses

Yaohe Wang, Stephen Thorne, Joseph Hannock, Jennelle Francis, Tina Au, Tony Reid, Nick Lemoine, David Kirn, and Gunnel Halldén
Clin Cancer Res 2005 11: 351-360. [Abstract] [Full Text] [PDF]  

Targeting Toll-like Receptor 9 with CpG Oligodeoxynucleotides Enhances Tumor Response to Fractionated Radiotherapy

Kathryn A. Mason, Hisanori Ariga, Robert Neal, David Valdecanas, Nancy Hunter, Arthur M. Krieg, John K. Whisnant, and Luka Milas
Clin Cancer Res 2005 11: 361-369. [Abstract] [Full Text] [PDF]  

CD8⁺ T-Cell–Dependent Immunity Following Xenogeneic DNA Immunization against CD20 in a Tumor Challenge Model of B-Cell Lymphoma

Maria Lia Palomba, Wendy K. Roberts, Tao Dao, Gregory Manukian, Jose A. Guevara-Patiño, Jedd D. Wolchok, David A. Scheinberg, and Alan N. Houghton
Clin Cancer Res 2005 11: 370-379. [Abstract] [Full Text] [PDF]  

Clinical and Molecular Evidence for c-kit Receptor as a Therapeutic Target in Neuroblastic Tumors

Stefania Uccini, Olga Mannarino, Heather P. McDowell, Ursula Pauser, Roberta Vitali, Pier Giorgio Natali, Pierluigi Altavista, Tiziana Andreano, Simona Coco, Renata Boldrini, Sandro Bosco, Anna Clerico, Denis Cozzi, Alberto Donfrancesco, Alessandro Inserra, George Kokai, Paul D. Losty, Maria R. Nicotra, Giuseppe Raschellà, Gian Paolo Tonini, and Carlo Dominici
Clin Cancer Res 2005 11: 380-389. [Abstract] [Full Text] [PDF]  

Results of a Phase II Double-Blinded Randomized Clinical Trial of Difluoromethylornithine for Cervical Intraepithelial Neoplasia Grades 2 to 3

Anne-Thérèse Vlastos, Loyd A. West, E. Neely Atkinson, Iouri Boiko, Anais Malpica, Waun K. Hong, and Michele Follen
Clin Cancer Res 2005 11: 390-396. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Resistance to Therapies Targeting the Epidermal Growth Factor Receptor

E. Ramsay Camp, Justin Summy, Todd W. Bauer, Wenbiao Liu, Gary E. Gallick, and Lee M. Ellis
Clin Cancer Res 2005 11: 397-405. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Commentary on the Contribution by Faedo et al. (Clin Cancer Res 2004;10:4417-4419)

Beatriz Pogo, Sylvie Menard, James F. Holland, Margaret Faedo, Caroline E. Ford, and William D. Rawlinson
Clin Cancer Res 2005 11: 406. [Full Text] [PDF]  

Anti-Vascular Endothelial Growth Factor Receptor-2 Antibody Accelerates Renal Disease in the NZB/W F₁ Murine Systemic Lupus Erythematosus Model

Hideaki Watanabe, Adam J. Mamelak, Elliot Weiss, Binghe Wang, Irwin Freed, Angela K. Brice, Lynn Wachtman, Kathleen L. Gabrielson, Naoko Yokota, Daniel J. Hicklin, Robert S. Kerbel, Mark Haas, and Daniel N. Sauder
Clin Cancer Res 2005 11: 407-409. [Full Text] [PDF]  

Targeted Therapeutics in Pancreatic Cancer: A Ray of Hope

Murray Korc
Clin Cancer Res 2005 11: 410-411. [Full Text] [PDF]  

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