Editorials:

Translating Research into Clinical Practice: Deliberations from the American Association for Cancer Research

William N. Hait
Clin Cancer Res 2005 11: 4275-4277. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Getting at MYC through RAS

Pavan Bachireddy, Pavan K. Bendapudi, and Dean W. Felsher
Clin Cancer Res 2005 11: 4278-4281. [Full Text] [PDF]  

Human Cancer Biology:

Regulation of Fibroblast Growth Factor-2 Activity by Human Ovarian Cancer Tumor Endothelium

Melissa K. Whitworth, Alison C. Backen, Andrew R. Clamp, Godfrey Wilson, Rhona McVey, Andreas Friedl, Alan C. Rapraeger, Guido David, Alan McGown, Richard J. Slade, John T. Gallagher, and Gordon C. Jayson
Clin Cancer Res 2005 11: 4282-4288. [Abstract] [Full Text] [PDF]  

Gefitinib-Sensitive Mutations of the Epidermal Growth Factor Receptor Tyrosine Kinase Domain in Chinese Patients with Non–Small Cell Lung Cancer

Xin Lin Mu, Long Yun Li, Xiao Tong Zhang, Men Zhao Wang, Rui E. Feng, Quan Cai Cui, Hai Sheng Zhou, and Bing Qing Guo
Clin Cancer Res 2005 11: 4289-4294. [Abstract] [Full Text] [PDF]  

Elevated Expression of Wnt Antagonists Is a Common Event in Hepatoblastomas

Arend Koch, Andreas Waha, Wolfgang Hartmann, Aksana Hrychyk, Ulrich Schüller, Anke Waha, Keith A. Wharton, Jr, Serge Y. Fuchs, Dietrich von Schweinitz, and Torsten Pietsch
Clin Cancer Res 2005 11: 4295-4304. [Abstract] [Full Text] [PDF]  

Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance

Guangbin Xia, S. Ram Kumar, Rizwan Masood, Michael Koss, Claire Templeman, David Quinn, Sutao Zhu, Ramachandra Reddy, Valery Krasnoperov, and Parkash S. Gill
Clin Cancer Res 2005 11: 4305-4315. [Abstract] [Full Text] [PDF]  

Coxsackie and Adenovirus Receptor Promotes Adenocarcinoma Cell Survival and Is Expressionally Activated after Transition from Preneoplastic Precursor Lesions to Invasive Adenocarcinomas

Ansgar Brüning, Elmar Stickeler, Daniel Diederich, Lioba Walz, Hendrik Rohleder, Klaus Friese, and Ingo B. Runnebaum
Clin Cancer Res 2005 11: 4316-4320. [Abstract] [Full Text] [PDF]  

Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth Arrest

Shira Yaari, Jasmine Jacob-Hirsch, Ninette Amariglio, Ronit Haklai, Gideon Rechavi, and Yoel Kloog
Clin Cancer Res 2005 11: 4321-4330. [Abstract] [Full Text] [PDF] URL for Supplementary Data  

Differential Expression of Full-length Telomerase Reverse Transcriptase mRNA and Telomerase Activity between Normal and Malignant Renal Tissues

Yidong Fan, Zhaoxu Liu, Xiaolei Fang, Zheng Ge, Nan Ge, Yong Jia, Peng Sun, Fenglan Lou, Magnus Björkholm, Astrid Gruber, Peter Ekman, and Dawei Xu
Clin Cancer Res 2005 11: 4331-4337. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Stability of Phosphoprotein as a Biological Marker of Tumor Signaling

Amanda F. Baker, Tomislav Dragovich, Nathan T. Ihle, Ryan Williams, Cecilia Fenoglio-Preiser, and Garth Powis
Clin Cancer Res 2005 11: 4338-4340. [Abstract] [Full Text] [PDF]  

2-[¹¹C]Thymidine Positron Emission Tomography Reproducibility in Humans

Paula Wells, Roger N. Gunn, Colin Steel, Alex S. Ranicar, Frank Brady, Safiye Osman, Terry Jones, and Pat Price
Clin Cancer Res 2005 11: 4341-4347. [Abstract] [Full Text] [PDF]  

Evaluation of the Combined Effect of p53 Codon 72 Polymorphism and Hotspot Mutations in Response to Anticancer Drugs

Faina Vikhanskaya, Mobin M. Siddique, Ming Kei Lee, Massimo Broggini, and Kanaga Sabapathy
Clin Cancer Res 2005 11: 4348-4356. [Abstract] [Full Text] [PDF]  

Aberrant Expression of Novel and Previously Described Cell Membrane Markers in Human Breast Cancer Cell Lines and Tumors

Huayi Huang, Jeff Groth, Khalid Sossey-Alaoui, Lesleyann Hawthorn, Stephanie Beall, and Joseph Geradts
Clin Cancer Res 2005 11: 4357-4364. [Abstract] [Full Text] [PDF]  

Steroid 5-Reductase Isozymes I and II in Recurrent Prostate Cancer

Mark A. Titus, Christopher W. Gregory, O. Harris Ford, III, Michael J. Schell, Susan J. Maygarden, and James L. Mohler
Clin Cancer Res 2005 11: 4365-4371. [Abstract] [Full Text] [PDF]  

Down-Regulated Xanthine Oxidoreductase Is a Feature of Aggressive Breast Cancer

Nina Linder, Johan Lundin, Jorma Isola, Mikael Lundin, Kari O. Raivio, and Heikki Joensuu
Clin Cancer Res 2005 11: 4372-4381. [Abstract] [Full Text] [PDF]  

Effects of Chemotherapy on the Cytogenetic Constitution of Wilms' Tumor

Thorsten Schlomm, Bastian Gunawan, Hans-Jürgen Schulten, Björn Sander, Karthinathan Thangavelu, Norbert Graf, Ivo Leuschner, Rolf-Hermann Ringert, and László Füzesi
Clin Cancer Res 2005 11: 4382-4387. [Abstract] [Full Text] [PDF]  

Low-Molecular Weight Caldesmon as a Potential Serum Marker for Glioma

Ping-Pin Zheng, Wim C. Hop, Peter A.E. Sillevis Smitt, Martin J. van den Bent, Cees J.J. Avezaat, Theodorus M. Luider, and Johan M. Kros
Clin Cancer Res 2005 11: 4388-4392. [Abstract] [Full Text] [PDF]  

Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice

Yan Ma, Laurence Lespagnard, Virginie Durbecq, Marianne Paesmans, Christine Desmedt, Maria Gomez-Galdon, Isabelle Veys, Fatima Cardoso, Christos Sotiriou, Angelo Di Leo, Martine J. Piccart, and Denis Larsimont
Clin Cancer Res 2005 11: 4393-4399. [Abstract] [Full Text] [PDF]  

Methylation Profiling of Archived Non–Small Cell Lung Cancer: A Promising Prognostic System

A. Mazin Safar, Horace Spencer, III, Xiaobo Su, Maureen Coffey, Craig A. Cooney, Luke D. Ratnasinghe, Laura F. Hutchins, and Chun-Yang Fan
Clin Cancer Res 2005 11: 4400-4405. [Abstract] [Full Text] [PDF]  

Validation of Genomics-Based Prognostic Tests in Malignant Pleural Mesothelioma

Gavin J. Gordon, Graham N. Rockwell, Paul A. Godfrey, Roderick V. Jensen, Jonathan N. Glickman, Beow Y. Yeap, William G. Richards, David J. Sugarbaker, and Raphael Bueno
Clin Cancer Res 2005 11: 4406-4414. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling of Progressive Papillary Noninvasive Carcinomas of the Urinary Bladder

Peter J. Wild, Alexander Herr, Christoph Wissmann, Robert Stoehr, Andre Rosenthal, Dirk Zaak, Ronald Simon, Ruth Knuechel, Christian Pilarsky, and Arndt Hartmann
Clin Cancer Res 2005 11: 4415-4429. [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

Unexpected Association between Induction of Immunity to the Universal Tumor Antigen CYP1B1 and Response to Next Therapy

John G. Gribben, David P. Ryan, Richard Boyajian, Robert G. Urban, Mary L. Hedley, Kathleen Beach, Patrick Nealon, Ursula Matulonis, Susana Campos, Timothy D. Gilligan, Paul G. Richardson, Blossom Marshall, Donna Neuberg, and Lee M. Nadler
Clin Cancer Res 2005 11: 4430-4436. [Abstract] [Full Text] [PDF]  

Marimastat in the Treatment of Patients with Biochemically Relapsed Prostate Cancer: A Prospective Randomized, Double-Blind, Phase I/II Trial

Eli Rosenbaum, Marianna Zahurak, Victoria Sinibaldi, Michael A. Carducci, Roberto Pili, Menachem Laufer, Theodore L. DeWeese, and Mario A. Eisenberger
Clin Cancer Res 2005 11: 4437-4443. [Abstract] [Full Text] [PDF]  

The Cyclin-Dependent Kinase Inhibitor UCN-01 Plus Cisplatin in Advanced Solid Tumors: A California Cancer Consortium Phase I Pharmacokinetic and Molecular Correlative Trial

Primo N. Lara, Jr, Philip C. Mack, Timothy Synold, Paul Frankel, Jeff Longmate, Paul H. Gumerlock, James H. Doroshow, and David R. Gandara
Clin Cancer Res 2005 11: 4444-4450. [Abstract] [Full Text] [PDF]  

First Clinical Experience with -Emitting Radium-223 in the Treatment of Skeletal Metastases

Sten Nilsson, Roy H. Larsen, Sophie D. Fosså, Lise Balteskard, Kari W. Borch, Jan-Erik Westlin, Gro Salberg, and Øyvind S. Bruland
Clin Cancer Res 2005 11: 4451-4459. [Abstract] [Full Text] [PDF]  

Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia

Zihai Li, Yi Qiao, Bei Liu, Elizabeth J. Laska, Priyamvadha Chakravarthi, Judith M. Kulko, Robert D. Bona, Min Fang, Upendra Hegde, Victor Moyo, Susan H. Tannenbaum, Antoine Ménoret, Judy Gaffney, Laura Glynn, Carolyn D. Runowicz, and Pramod K. Srivastava
Clin Cancer Res 2005 11: 4460-4468. [Abstract] [Full Text] [PDF]  

Delayed Disease Progression after Allogeneic Cell Vaccination in Hormone-Resistant Prostate Cancer and Correlation with Immunologic Variables

Agnieska Michael, Graham Ball, Nadine Quatan, Fatima Wushishi, Nick Russell, Joe Whelan, Prabir Chakraborty, David Leader, Michael Whelan, and Hardev Pandha
Clin Cancer Res 2005 11: 4469-4478. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Targeting the c-Met Pathway Potentiates Glioblastoma Responses to -Radiation

Bachchu Lal, Shuli Xia, Roger Abounader, and John Laterra
Clin Cancer Res 2005 11: 4479-4486. [Abstract] [Full Text] [PDF]  

In vivo RNA Interference–Mediated Ablation of MDR1 P-Glycoprotein

Andrea Pichler, Noam Zelcer, Julie L. Prior, Annemieke J. Kuil, and David Piwnica-Worms
Clin Cancer Res 2005 11: 4487-4494. [Abstract] [Full Text] [PDF]  

In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins

Hiroshi Fujiwara, J. Joseph Melenhorst, Frank El Ouriaghli, Sachiko Kajigaya, Matthias Grube, Giuseppe Sconocchia, Katayoun Rezvani, David A. Price, Nancy F. Hensel, Daniel C. Douek, and A. John Barrett
Clin Cancer Res 2005 11: 4495-4503. [Abstract] [Full Text] [PDF]  

Graft-versus-Leukemia Target Antigens in Chronic Myelogenous Leukemia Are Expressed on Myeloid Progenitor Cells

Catherine J. Wu, Melinda Biernacki, Jeffery L. Kutok, Shelby Rogers, Linyun Chen, Xiao-Feng Yang, Robert J. Soiffer, and Jerome Ritz
Clin Cancer Res 2005 11: 4504-4511. [Abstract] [Full Text] [PDF]  

Blockade of Transforming Growth Factor-ß Signaling Suppresses Progression of Androgen-Independent Human Prostate Cancer in Nude Mice

Fahao Zhang, Juwon Lee, Shan Lu, Curtis A. Pettaway, and Zhongyun Dong
Clin Cancer Res 2005 11: 4512-4520. [Abstract] [Full Text] [PDF]  

The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade

Patrizia Sini, Lorenza Wyder, Christian Schnell, Terence O'Reilly, Amanda Littlewood, Ralph Brandt, Nancy E. Hynes, and Jeanette Wood
Clin Cancer Res 2005 11: 4521-4532. [Abstract] [Full Text] [PDF]  

The Requirement of Multimodal Therapy (Vaccine, Local Tumor Radiation, and Reduction of Suppressor Cells) to Eliminate Established Tumors

Chie Kudo-Saito, Jeffrey Schlom, Kevin Camphausen, C. Norman Coleman, and James W. Hodge
Clin Cancer Res 2005 11: 4533-4544. [Abstract] [Full Text] [PDF]  

Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes

David A. Rodeberg, Rebecca A. Nuss, Sherine F. Elsawa, and Esteban Celis
Clin Cancer Res 2005 11: 4545-4552. [Abstract] [Full Text] [PDF]  

Oncolytic Viral Therapy for Cervical and Ovarian Cancer Cells by Sindbis Virus AR339 Strain

Youichi Unno, Yuji Shino, Fukuo Kondo, Natsuhiko Igarashi, Gang Wang, Ryuhi Shimura, Taketo Yamaguchi, Takehide Asano, Hiromitsu Saisho, Souei Sekiya, and Hiroshi Shirasawa
Clin Cancer Res 2005 11: 4553-4560. [Abstract] [Full Text] [PDF]  

Low Levels of Her2/neu Expressed by Ewing's Family Tumor Cell Lines Can Redirect Cytokine-Induced Killer Cells

Michael R. Verneris, Arash Arshi, Matthias Edinger, Martin Kornacker, Yaso Natkunam, Mobin Karami, Yu-an Cao, Neyssa Marina, Christopher H. Contag, and Robert S. Negrin
Clin Cancer Res 2005 11: 4561-4570. [Abstract] [Full Text] [PDF]  

Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine

Hideaki Dote, David Cerna, William E. Burgan, Donna J. Carter, Michael A. Cerra, Melinda G. Hollingshead, Kevin Camphausen, and Philip J. Tofilon
Clin Cancer Res 2005 11: 4571-4579. [Abstract] [Full Text] [PDF]  

Activation of p53-Dependent Apoptosis by Acute Ablation of Glycogen Synthase Kinase-3ß in Colorectal Cancer Cells

Jagadish C. Ghosh and Dario C. Altieri
Clin Cancer Res 2005 11: 4580-4588. [Abstract] [Full Text] [PDF]  

The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

Xin-Yan Pei, Yun Dai, Mohamed Rahmani, Weiqun Li, Paul Dent, and Steven Grant
Clin Cancer Res 2005 11: 4589-4600. [Abstract] [Full Text] [PDF]  

Systemic Treatment with Tetra-O-Methyl Nordihydroguaiaretic Acid Suppresses the Growth of Human Xenograft Tumors

Richard Park, Chih-Chuan Chang, Yu-Chuan Liang, Yousun Chung, Ryan A. Henry, Elaine Lin, David E. Mold, and Ru Chih C. Huang
Clin Cancer Res 2005 11: 4601-4609. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

The Transforming Growth Factor-ß Family Members Bone Morphogenetic Protein-2 and Macrophage Inhibitory Cytokine-1 as Mediators of the Antiangiogenic Activity of N-(4-Hydroxyphenyl)Retinamide

Nicoletta Ferrari, Ulrich Pfeffer, Raffaella Dell'Eva, Claudia Ambrosini, Douglas M. Noonan, and Adriana Albini
Clin Cancer Res 2005 11: 4610-4619. [Abstract] [Full Text] [PDF]  

Genetic Polymorphisms of Selected DNA Repair Genes, Estrogen and Progesterone Receptor Status, and Breast Cancer Risk

Kyoung-Mu Lee, Ji-Yeob Choi, Changwon Kang, Changsoo Paul Kang, Sue Kyung Park, Hyunmi Cho, Dae-Yeon Cho, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Chung-Gyu Park, Qingyi Wei, and Daehee Kang
Clin Cancer Res 2005 11: 4620-4626. [Abstract] [Full Text] [PDF]  

Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals

H-H. Sherry Chow, Iman A. Hakim, Donna R. Vining, James A. Crowell, James Ranger-Moore, Wade M. Chew, Catherine A. Celaya, Steven R. Rodney, Yukihiko Hara, and David S. Alberts
Clin Cancer Res 2005 11: 4627-4633. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Researchers Should Have Respect for the Originator of the Cell Lines

Yutaka Shimada and Qimin Zhan
Clin Cancer Res 2005 11: 4634. [Full Text] [PDF]  

Corrections:

Correction: Article on Overexpression of Aurora-A and Malignant Development of Human Esophageal Squamous Cell Carcinoma

Clin Cancer Res 2005 11: 4635. [Full Text] [PDF]  

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