Editorials:

Screening for Dihydropyrimidine Dehydrogenase Deficiency

Jean L. Grem
Clin Cancer Res 2005 11: 5067-5068. [Full Text] [PDF]  

The Biology Behind:

Measurement of Matrix Metalloproteinases in Serum of Patients with Melanoma: Snarled in Technical Pitfalls

Stanley Zucker and Jian Cao
Clin Cancer Res 2005 11: 5069-5070. [Full Text] [PDF]  

Human Cancer Biology:

GNAS1 T393C Polymorphism and Survival in Patients with Sporadic Colorectal Cancer

Ulrich H. Frey, Hakan Alakus, Jeremias Wohlschlaeger, Klaus J. Schmitz, Günther Winde, Hans G. van Calker, Karl-Heinz Jöckel, Winfried Siffert, and Kurt W. Schmid
Clin Cancer Res 2005 11: 5071-5077. [Abstract] [Full Text] [PDF]  

Analysis of Cell Cycle Regulator Proteins in Encapsulated Thymomas

Alfonso Baldi, Vincenzo Ambrogi, Davide Mineo, Pasquale Mellone, Mara Campioni, Gennaro Citro, and Tommaso Claudio Mineo
Clin Cancer Res 2005 11: 5078-5083. [Abstract] [Full Text] [PDF]  

Estrogen Receptor and ß are Prognostic Factors in Non–Small Cell Lung Cancer

Hideki Kawai, Akira Ishii, Kiyotada Washiya, Toshiko Konno, Hiroto Kon, Chiharu Yamaya, Iwao Ono, Yoshihiro Minamiya, and Junichi Ogawa
Clin Cancer Res 2005 11: 5084-5089. [Abstract] [Full Text] [PDF]  

High Expression of a New Marker PCA-1 in Human Prostate Carcinoma

Noboru Konishi, Mitsutoshi Nakamura, Eiwa Ishida, Keiji Shimada, Eika Mitsui, Rintaro Yoshikawa, Hiroshi Yamamoto, and Kazutake Tsujikawa
Clin Cancer Res 2005 11: 5090-5097. [Abstract] [Full Text] [PDF]  

Breast Cancer Patients with p53 Pro72 Homozygous Genotype Have a Poorer Survival

Johanna Tommiska, Hannaleena Eerola, Mira Heinonen, Laura Salonen, Milja Kaare, Jonna Tallila, Ari Ristimäki, Karl von Smitten, Kristiina Aittomäki, Päivi Heikkilä, Carl Blomqvist, and Heli Nevanlinna
Clin Cancer Res 2005 11: 5098-5103. [Abstract] [Full Text] [PDF]  

Dihydropyrimidine Dehydrogenase Activity in 150 Healthy Japanese Volunteers and Identification of Novel Mutations

Kenichiro Ogura, Tomokazu Ohnuma, Yoshiyuki Minamide, Atsuhiro Mizuno, Takahito Nishiyama, Satoru Nagashima, Mitsutaka Kanamaru, Akira Hiratsuka, Tadashi Watabe, and Toshihiko Uematsu
Clin Cancer Res 2005 11: 5104-5111. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

In vivo Evaluation of ¹⁷⁷Lu- and ^67/64Cu-Labeled Recombinant Fragments of Antibody chCE7 for Radioimmunotherapy and PET Imaging of L1-CAM-Positive Tumors

Jürgen Grünberg, Ilse Novak-Hofer, Michael Honer, Kurt Zimmermann, Karin Knogler, Peter Bläuenstein, Simon Ametamey, Helmut R. Maecke, and P. August Schubiger
Clin Cancer Res 2005 11: 5112-5120. [Abstract] [Full Text] [PDF]  

Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography

Thierry M. Muanza, Ana P. Cotrim, Mathew McAuliffe, Anastasia L. Sowers, Bruce J. Baum, John A. Cook, Felix Feldchtein, Paul Amazeen, C. Norman Coleman, and James B. Mitchell
Clin Cancer Res 2005 11: 5121-5127. [Abstract] [Full Text] [PDF]  

Clear Cell Renal Cell Carcinoma: Gene Expression Analyses Identify a Potential Signature for Tumor Aggressiveness

Farhad Kosari, Alexander S. Parker, Dagmar Marie Kube, Christine M. Lohse, Bradley C. Leibovich, Michael L. Blute, John C. Cheville, and George Vasmatzis
Clin Cancer Res 2005 11: 5128-5139. [Abstract] [Full Text] [PDF]  

Correlation between DNA Repair Capacity in Lymphocytes and Acute Side Effects to Skin during Radiotherapy in Nasopharyngeal Cancer Patients

Wei-dong Wang, Zheng-tang Chen, De-zhi Li, Zheng-huai Cao, Shi-liang Sun, Ping Pu, and Xiao-pin Chen
Clin Cancer Res 2005 11: 5140-5145. [Abstract] [Full Text] [PDF]  

Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer

Alexander Hermani, Jochen Hess, Barbara De Servi, Senad Medunjanin, Rainer Grobholz, Lutz Trojan, Peter Angel, and Doris Mayer
Clin Cancer Res 2005 11: 5146-5152. [Abstract] [Full Text] [PDF] Supplementary Data  

PTEN Expression in Melanoma: Relationship with Patient Survival, Bcl-2 Expression, and Proliferation

Maryann Mikhail, Elsa Velazquez, Richard Shapiro, Russell Berman, Anna Pavlick, Lian Sorhaindo, Joanna Spira, Carmen Mir, Katherine S. Panageas, David Polsky, and Iman Osman
Clin Cancer Res 2005 11: 5153-5157. [Abstract] [Full Text] [PDF]  

High Serum Levels of Matrix Metalloproteinase-9 and Matrix Metalloproteinase-1 Are Associated with Rapid Progression in Patients with Metastatic Melanoma

Johanna Nikkola, Pia Vihinen, Meri-Sisko Vuoristo, Pirkko Kellokumpu-Lehtinen, Veli-Matti Kähäri, and Seppo Pyrhönen
Clin Cancer Res 2005 11: 5158-5166. [Abstract] [Full Text] [PDF]  

Prognostic Significance of O⁶-Methylguanine-DNA Methyltransferase Determined by Promoter Hypermethylation and Immunohistochemical Expression in Anaplastic Gliomas

Marta Brell, Avelina Tortosa, Eugenia Verger, Juan Miguel Gil, Nuria Viñolas, Salvador Villá, Juan José Acebes, Lluis Caral, Teresa Pujol, Isidro Ferrer, Teresa Ribalta, and Francesc Graus
Clin Cancer Res 2005 11: 5167-5174. [Abstract] [Full Text] [PDF]  

Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

Sunil R. Lakhani, Jorge S. Reis-Filho, Laura Fulford, Frederique Penault-Llorca, Marc van der Vijver, Suzanne Parry, Timothy Bishop, Javier Benitez, Carmen Rivas, Yves-Jean Bignon, Jenny Chang-Claude, Ute Hamann, Cees J. Cornelisse, Peter Devilee, Matthias W. Beckmann, Carolin Nestle-Krämling, Peter A. Daly, Neva Haites, Jenny Varley, Fiona Lalloo, Gareth Evans, Christine Maugard, Hanne Meijers-Heijboer, Jan G.M. Klijn, Edith Olah, Barry A. Gusterson, Silvana Pilotti, Paolo Radice, Siegfried Scherneck, Hagay Sobol, Jocelyne Jacquemier, Teresa Wagner, Julian Peto, Michael R. Stratton, Lesley McGuffog, Douglas F. Easton, and the Breast Cancer Linkage Consortium
Clin Cancer Res 2005 11: 5175-5180. [Abstract] [Full Text] [PDF]  

EphB2 is a Prognostic Factor in Colorectal Cancer

Adrian M. Jubb, Fiona Zhong, Sheila Bheddah, Heike I. Grabsch, Gretchen D. Frantz, Wolfram Mueller, Vidya Kavi, Phil Quirke, Paul Polakis, and Hartmut Koeppen
Clin Cancer Res 2005 11: 5181-5187. [Abstract] [Full Text] [PDF]  

Evaluating the Expression and Prognostic Value of TRAIL-R1 and TRAIL-R2 in Breast Cancer

Mary M. McCarthy, Mario Sznol, Kyle A. DiVito, Robert L. Camp, David L. Rimm, and Harriet M. Kluger
Clin Cancer Res 2005 11: 5188-5194. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Baseline Reverse Transcriptase-PCR for Prostate-Specific Antigen in Men with Hormone-Refractory Prostate Cancer Treated with Chemotherapy

Robert W. Ross, Judith Manola, Kristen Hennessy, Matthew Galsky, Howard Scher, Eric Small, W. Kevin Kelly, and Philip W. Kantoff
Clin Cancer Res 2005 11: 5195-5198. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Cyclooxygenase-2 Expression in Postmastectomy Chest Wall Relapse

Janet H. Kim, Veerle Bossuyt, Teresa Ponn, Donald Lannin, and Bruce G. Haffty
Clin Cancer Res 2005 11: 5199-5205. [Abstract] [Full Text] [PDF]  

Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

Donald E. Thrall, Susan M. LaRue, Daohai Yu, Thaddeus Samulski, Linda Sanders, Beth Case, Gary Rosner, Chieko Azuma, Jeannie Poulson, Amy F. Pruitt, Wilma Stanley, Marlene L. Hauck, Laurel Williams, Paul Hess, and Mark W. Dewhirst
Clin Cancer Res 2005 11: 5206-5214. [Abstract] [Full Text] [PDF]  

Dose-Fractionated Radioimmunotherapy in Non-Hodgkin's Lymphoma Using DOTA-Conjugated, ⁹⁰Y-Radiolabeled, Humanized Anti-CD22 Monoclonal Antibody, Epratuzumab

Ola Lindén, Cecilia Hindorf, Eva Cavallin-Ståhl, William A. Wegener, David M. Goldenberg, Heather Horne, Tomas Ohlsson, Lars Stenberg, Sven-Erik Strand, and Jan Tennvall
Clin Cancer Res 2005 11: 5215-5222. [Abstract] [Full Text] [PDF]  

Prostate Cancer Clinical Trial End Points: "RECIST"ing a Step Backwards

Howard I. Scher, Michael J. Morris, William K. Kelly, Lawrence H. Schwartz, and Glenn Heller
Clin Cancer Res 2005 11: 5223-5232. [Abstract] [Full Text] [PDF]  

Neoadjuvant Docetaxel before Radical Prostatectomy in Patients with High-Risk Localized Prostate Cancer

Phillip G. Febbo, Jerome P. Richie, Daniel J. George, Massimo Loda, Judith Manola, Sridhar Shankar, Agnieska Szot Barnes, Clare Tempany, William Catalona, Philip W. Kantoff, and William K. Oh
Clin Cancer Res 2005 11: 5233-5240. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Detection of Spontaneous CD4⁺ T-Cell Responses in Melanoma Patients against a Tyrosinase-Related Protein-2–Derived Epitope Identified in HLA-DRB1*0301 Transgenic Mice

Annette Paschen, Mingxia Song, Wolfram Osen, Xuan Duc Nguyen, Jan Mueller-Berghaus, Daniela Fink, Nadine Daniel, Mariel Donzeau, Wolfgang Nagel, Harald Kropshofer, and Dirk Schadendorf
Clin Cancer Res 2005 11: 5241-5247. [Abstract] [Full Text] [PDF]  

Sulindac Enhances the Proteasome Inhibitor Bortezomib-Mediated Oxidative Stress and Anticancer Activity

Takae Minami, Masaaki Adachi, Rina Kawamura, Yubin Zhang, Yasuhisa Shinomura, and Kohzoh Imai
Clin Cancer Res 2005 11: 5248-5256. [Abstract] [Full Text] [PDF]  

Anti-CD74 Antibody-Doxorubicin Conjugate, IMMU-110, in a Human Multiple Myeloma Xenograft and in Monkeys

Puja Sapra, Rhona Stein, Jennifer Pickett, Zhengxing Qu, Serengulam V. Govindan, Thomas M. Cardillo, Hans J. Hansen, Ivan D. Horak, Gary L. Griffiths, and David M. Goldenberg
Clin Cancer Res 2005 11: 5257-5264. [Abstract] [Full Text] [PDF]  

Identification of the HLA-Cw*0702-Restricted Tumor-Associated Antigen Recognized by a CTL Clone from a Lung Cancer Patient

Yoshika Nagata, Takeshi Hanagiri, Mitsuhiro Takenoyama, Takashi Fukuyama, Makiko Mizukami, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Kenji Sugio, and Kosei Yasumoto
Clin Cancer Res 2005 11: 5265-5272. [Abstract] [Full Text] [PDF]  

Detection of Human Papillomavirus (HPV) 16-Specific CD4+ T-cell Immunity in Patients with Persistent HPV16-Induced Vulvar Intraepithelial Neoplasia in Relation to Clinical Impact of Imiquimod Treatment

Mariëtte I.E. van Poelgeest, Manon van Seters, Marc van Beurden, Kitty M.C. Kwappenberg, Claudia Heijmans-Antonissen, Jan W. Drijfhout, Cornelis J.M. Melief, Gemma G. Kenter, Theo J.M. Helmerhorst, Rienk Offringa, and Sjoerd H. van der Burg
Clin Cancer Res 2005 11: 5273-5280. [Abstract] [Full Text] [PDF]  

CHIR-258: A Potent Inhibitor of FLT3 Kinase in Experimental Tumor Xenograft Models of Human Acute Myelogenous Leukemia

Daniel E. Lopes de Menezes, Jing Peng, Evelyn N. Garrett, Sharianne G. Louie, Sang H. Lee, Marion Wiesmann, Yan Tang, Lee Shephard, Cheryl Goldbeck, Yoko Oei, Helen Ye, Sharon L. Aukerman, and Carla Heise
Clin Cancer Res 2005 11: 5281-5291. [Abstract] [Full Text] [PDF]  

Glioblastoma Patients Exhibit Circulating Tumor-Specific CD8+ T Cells

Jie Tang, Phyllis Flomenberg, Larry Harshyne, Lawrence Kenyon, and David W. Andrews
Clin Cancer Res 2005 11: 5292-5299. [Abstract] [Full Text] [PDF]  

Combination Treatment with Erlotinib and Pertuzumab against Human Tumor Xenografts Is Superior to Monotherapy

Thomas Friess, Werner Scheuer, and Max Hasmann
Clin Cancer Res 2005 11: 5300-5309. [Abstract] [Full Text] [PDF]  

Primary Allogeneic T-Cell Responses against Mantle Cell Lymphoma Antigen-Presenting Cells for Adoptive Immunotherapy after Stem Cell Transplantation

Mels Hoogendoorn, Judith Olde Wolbers, Willem M. Smit, M. Ronald Schaafsma, Inge Jedema, Renee M.Y. Barge, Roel Willemze, and J.H. Frederik Falkenburg
Clin Cancer Res 2005 11: 5310-5318. [Abstract] [Full Text] [PDF]  

Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer

Anne Boulay, Joelle Rudloff, Jingjing Ye, Sabine Zumstein-Mecker, Terence O'Reilly, Dean B. Evans, Shiuan Chen, and Heidi A. Lane
Clin Cancer Res 2005 11: 5319-5328. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Acknowledgment and Apology: Text Copied from Biochemical Journal

Kamel Izeradjene, Leslie Douglas, Addison Delaney, and Janet A. Houghton
Clin Cancer Res 2005 11: 5329. [Full Text] [PDF]  

Corrections:

Correction: Article on Akt-1 in Prostate Cancer and Non–Neoplastic Prostate Tissues

Clin Cancer Res 2005 11: 5330. [Full Text] [PDF]  

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