Editorials:

Immunogenic Targets in Non–Small Cell Lung Cancer: More Is More

Sacha Gnjatic
Clin Cancer Res 2005 11: 5331-5332. [Full Text] [PDF]  

The Biology Behind:

Getting to the Surface: A Link Between Tumor Antigen Discovery and Natural Presentation of Peptide-MHC Complexes

Carolyn E. Clark and Robert H. Vonderheide
Clin Cancer Res 2005 11: 5333-5336. [Full Text] [PDF]  

Perspectives:

Maintenance Therapy to Suppress Micrometastasis: The New Challenge for Adjuvant Cancer Treatment

Richard J. Epstein
Clin Cancer Res 2005 11: 5337-5341. [Abstract] [Full Text] [PDF]  

New Paradigm in Dose-Finding Trials: Patient-Specific Dosing and Beyond Phase I

André Rogatko, James S. Babb, Mourad Tighiouart, Fadlo R. Khuri, and Gary Hudes
Clin Cancer Res 2005 11: 5342-5346. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Multiple Mechanisms of Telomere Maintenance Exist in Liposarcomas

Jay E. Johnson, Robert J. Varkonyi, Jaclyn Schwalm, Ryan Cragle, Andres Klein-Szanto, Arthur Patchefsky, Edna Cukierman, Margaret von Mehren, and Dominique Broccoli
Clin Cancer Res 2005 11: 5347-5355. [Abstract] [Full Text] [PDF]  

S100P Promotes Pancreatic Cancer Growth, Survival, and Invasion

Thiruvengadam Arumugam, Diane M. Simeone, Kenneth Van Golen, and Craig D. Logsdon
Clin Cancer Res 2005 11: 5356-5364. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation Profile of Ovarian Epithelial Neoplasms

Prakash B. Makarla, M. Hossein Saboorian, Raheela Ashfaq, Kiyomi O. Toyooka, Shinichi Toyooka, John D. Minna, Adi F. Gazdar, and John O. Schorge
Clin Cancer Res 2005 11: 5365-5369. [Abstract] [Full Text] [PDF]  

Vitamin D₃ Metabolism in Human Glioblastoma Multiforme: Functionality of CYP27B1 Splice Variants, Metabolism of Calcidiol, and Effect of Calcitriol

Britta Diesel, Jens Radermacher, Matthias Bureik, Rita Bernhardt, Markus Seifert, Jörg Reichrath, Ulrike Fischer, and Eckart Meese
Clin Cancer Res 2005 11: 5370-5380. [Abstract] [Full Text] [PDF] Supplementary Data  

Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis

Scott P. Fraser, James K.J. Diss, Athina-Myrto Chioni, Maria E. Mycielska, Huiyan Pan, Rezan F. Yamaci, Filippo Pani, Zuzanna Siwy, Monika Krasowska, Zbigniew Grzywna, William J. Brackenbury, Dimis Theodorou, Meral Koyutürk, Handan Kaya, Esra Battaloglu, Manuela Tamburo De Bella, Martin J. Slade, Robert Tolhurst, Carlo Palmieri, Jie Jiang, David S. Latchman, R. Charles Coombes, and Mustafa B.A. Djamgoz
Clin Cancer Res 2005 11: 5381-5389. [Abstract] [Full Text] [PDF]  

The Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Plays a Role in Breast Tumor Growth and Is Present in the Urine of Breast Cancer Patients

Cecilia A. Fernández, Li Yan, Gwendolyn Louis, Jiang Yang, Jeffery L. Kutok, and Marsha A. Moses
Clin Cancer Res 2005 11: 5390-5395. [Abstract] [Full Text] [PDF]  

Angiogenesis in the Bone Marrow of Patients with Breast Cancer

Mariana Chavez-MacGregor, Alejandro Aviles-Salas, Dan Green, Adolfo Fuentes-Alburo, Celedonio Gómez-Ruiz, and Alvaro Aguayo
Clin Cancer Res 2005 11: 5396-5400. [Abstract] [Full Text] [PDF]  

Characterization of a Recurrent Germ Line Mutation of the E-Cadherin Gene: Implications for Genetic Testing and Clinical Management

Gianpaolo Suriano, Sandie Yew, Paulo Ferreira, Janine Senz, Pardeep Kaurah, James M. Ford, Teri A. Longacre, Jeffrey A. Norton, Nicki Chun, Sean Young, Maria J. Oliveira, Barbara MacGillivray, Arundhati Rao, Dawn Sears, Charles E. Jackson, Jeff Boyd, Cindy Yee, Carolyn Deters, G. Shashidhar Pai, Lyn S. Hammond, Bobbi J. McGivern, Diane Medgyesy, Denise Sartz, Banu Arun, Brant K. Oelschlager, Mellisa P. Upton, Whitney Neufeld-Kaiser, Orlando E. Silva, Talia R. Donenberg, David A. Kooby, Shobha Sharma, Björn-Anders Jonsson, Henrik Gronberg, Steve Gallinger, Raquel Seruca, Henry Lynch, and David G. Huntsman
Clin Cancer Res 2005 11: 5401-5409. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation Is the Predominant Mechanism in hMLH1 and hMSH2 Deregulation and Is a Poor Prognostic Factor in Nonsmoking Lung Cancer

Han-Shui Hsu, Chiao-Kai Wen, Yen-An Tang, Ruo-Kai Lin, Wing-Yin Li, Wen-Hu Hsu, and Yi-Ching Wang
Clin Cancer Res 2005 11: 5410-5416. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer

Feng Jiang, Nancy P. Caraway, Benjamin Nebiyou Bekele, Hua-Zhong Zhang, Abha Khanna, Huijun Wang, Ruiyun Li, Ricardo L. Fernandez, Tanweer M. Zaidi, Dennis A. Johnston, and Ruth L. Katz
Clin Cancer Res 2005 11: 5417-5424. [Abstract] [Full Text] [PDF]  

Detection of Melanoma Cells Displaying Multiple Genomic Changes in Histopathologically Negative Sentinel Lymph Nodes

Anja Ulmer, Jörg R. Fischer, Stefan Schanz, Karl Sotlar, Helmut Breuninger, Klaus Dietz, Gerhard Fierlbeck, and Christoph A. Klein
Clin Cancer Res 2005 11: 5425-5432. [Abstract] [Full Text] [PDF]  

Functional Polymorphisms of Matrix Metalloproteinase-9 Are Associated with Risk of Occurrence and Metastasis of Lung Cancer

Zhibin Hu, Xiang Huo, Daru Lu, Ji Qian, Jiannong Zhou, Yijiang Chen, Lin Xu, Hongxia Ma, Jingfu Zhu, Qingyi Wei, and Hongbing Shen
Clin Cancer Res 2005 11: 5433-5439. [Abstract] [Full Text] [PDF]  

A Predictive Model of Rectal Tumor Response to Preoperative Radiotherapy Using Classification and Regression Tree Methods

Inti Zlobec, Russell Steele, Nilima Nigam, and Carolyn C. Compton
Clin Cancer Res 2005 11: 5440-5443. [Abstract] [Full Text] [PDF]  

FGFR3 and Tp53 Mutations in T1G3 Transitional Bladder Carcinomas: Independent Distribution and Lack of Association with Prognosis

Silvia Hernández, Elena López-Knowles, Josep Lloreta, Manolis Kogevinas, Roberto Jaramillo, Alex Amorós, Adonina Tardón, Reina García-Closas, Consol Serra, Alfredo Carrato, Núria Malats, and Francisco X. Real
Clin Cancer Res 2005 11: 5444-5450. [Abstract] [Full Text] [PDF]  

Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers

Maryla Krajewska, Hoguen Kim, Chul Kim, Haeyoun Kang, Kate Welsh, Shu-ichi Matsuzawa, Michelle Tsukamoto, Ronald G. Thomas, Nuria Assa-Munt, Zhe Piao, Koichi Suzuki, Manuel Perucho, Stan Krajewski, and John C. Reed
Clin Cancer Res 2005 11: 5451-5461. [Abstract] [Full Text] [PDF]  

Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies

Maryla Krajewska, Hoguen Kim, Eunah Shin, Susan Kennedy, Michael J. Duffy, Yick F. Wong, David Marr, Jowita Mikolajczyk, Ahmed Shabaik, Ivo Meinhold-Heerlein, Xianshu Huang, Steven Banares, Hirad Hedayat, John C. Reed, and Stan Krajewski
Clin Cancer Res 2005 11: 5462-5471. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Safety and Pharmacokinetics of the Dual Action Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor, BAY 43-9006, in Patients with Advanced, Refractory Solid Tumors

Jeffrey W. Clark, Joseph P. Eder, David Ryan, Chetan Lathia, and Heinz-Josef Lenz
Clin Cancer Res 2005 11: 5472-5480. [Abstract] [Full Text] [PDF]  

Expression of Class III ß-Tubulin Is Predictive of Patient Outcome in Patients with Non–Small Cell Lung Cancer Receiving Vinorelbine-Based Chemotherapy

Pascal Sève, Sylvie Isaac, Olivier Trédan, Pierre-Jean Souquet, Yves Pachéco, Maurice Pérol, Laurence Lafanéchère, Aurélie Penet, Eva-Laure Peiller, and Charles Dumontet
Clin Cancer Res 2005 11: 5481-5486. [Abstract] [Full Text] [PDF]  

Phase I Study of OSI-7904L, a Novel Liposomal Thymidylate Synthase Inhibitor in Patients with Refractory Solid Tumors

Gernot Beutel, Hilary Glen, Patrick Schöffski, Jon Chick, Stan Gill, James Cassidy, and Chris Twelves
Clin Cancer Res 2005 11: 5487-5495. [Abstract] [Full Text] [PDF]  

XAGE-1 Expression in Non–Small Cell Lung Cancer and Antibody Response in Patients

Kazuhiko Nakagawa, Yuji Noguchi, Akiko Uenaka, Shuichiro Sato, Hideo Okumura, Motoyuki Tanaka, Michihide Shimono, Ali Mohamed Ali Eldib, Toshiro Ono, Nobuya Ohara, Tadashi Yoshino, Kazuki Yamashita, Tsukasa Tsunoda, Motoi Aoe, Nobuyoshi Shimizu, and Eiichi Nakayama
Clin Cancer Res 2005 11: 5496-5503. [Abstract] [Full Text] [PDF]  

A Multicenter Phase II Trial of Thalidomide and Celecoxib for Patients with Relapsed and Refractory Multiple Myeloma

H Miles Prince, Linda Mileshkin, Andrew Roberts, Vinod Ganju, Craig Underhill, John Catalano, Richard Bell, John F. Seymour, David Westerman, Paul J. Simmons, Kate Lillie, Alvin D. Milner, Juliana Di Iulio, Jerome B. Zeldis, and Robert Ramsay
Clin Cancer Res 2005 11: 5504-5514. [Abstract] [Full Text] [PDF]  

Dendritic Cell Vaccination in Glioblastoma Patients Induces Systemic and Intracranial T-cell Responses Modulated by the Local Central Nervous System Tumor Microenvironment

Linda M. Liau, Robert M. Prins, Sylvia M. Kiertscher, Sylvia K. Odesa, Thomas J. Kremen, Adrian J. Giovannone, Jia-Wei Lin, Dennis J. Chute, Paul S. Mischel, Timothy F. Cloughesy, and Michael D. Roth
Clin Cancer Res 2005 11: 5515-5525. [Abstract] [Full Text] [PDF]  

A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer

Helen Mackay, David Hedley, Pierre Major, Carol Townsley, Mary Mackenzie, Mark Vincent, Pam Degendorfer, Ming-Sound Tsao, Trudey Nicklee, Diana Birle, John Wright, Lillian Siu, Malcolm Moore, and Amit Oza
Clin Cancer Res 2005 11: 5526-5533. [Abstract] [Full Text] [PDF]  

Pilot Study of Concurrent Etoposide and Cisplatin Plus Accelerated Hyperfractionated Thoracic Radiotherapy Followed by Irinotecan and Cisplatin for Limited-Stage Small Cell Lung Cancer: Japan Clinical Oncology Group 9903

Kaoru Kubota, Yutaka Nishiwaki, Takahiko Sugiura, Kazumasa Noda, Kiyoshi Mori, Masaaki Kawahara, Shunichi Negoro, Koshiro Watanabe, Fumio Imamura, Tomohide Tamura, and Nagahiro Saijo
Clin Cancer Res 2005 11: 5534-5538. [Abstract] [Full Text] [PDF]  

Phase II Study of Gefitinib in Patients with Relapsed or Persistent Ovarian or Primary Peritoneal Carcinoma and Evaluation of Epidermal Growth Factor Receptor Mutations and Immunohistochemical Expression: A Gynecologic Oncology Group Study

Russell J. Schilder, Michael W. Sill, Xiaowei Chen, Kathleen M. Darcy, Steven L. Decesare, George Lewandowski, Roger B. Lee, Cletus A. Arciero, Hong Wu, and Andrew K. Godwin
Clin Cancer Res 2005 11: 5539-5548. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Receptors for Luteinizing Hormone Releasing Hormone Expressed on Human Renal Cell Carcinomas Can Be Used for Targeted Chemotherapy with Cytotoxic Luteinizing Hormone Releasing Hormone Analogues

Gunhild Keller, Andrew V. Schally, Timo Gaiser, Attila Nagy, Benjamin Baker, Gabor Halmos, and Jörg B. Engel
Clin Cancer Res 2005 11: 5549-5557. [Abstract] [Full Text] [PDF]  

Prediction of Active Drug Plasma Concentrations Achieved in Cancer Patients by Pharmacodynamic Biomarkers Identified from the Geo Human Colon Carcinoma Xenograft Model

Feng R. Luo, Zheng Yang, Huijin Dong, Amy Camuso, Kelly McGlinchey, Krista Fager, Christine Flefleh, David Kan, Ivan Inigo, Stephen Castaneda, Tai W. Wong, Robert A. Kramer, Robert Wild, and Francis Y. Lee
Clin Cancer Res 2005 11: 5558-5565. [Abstract] [Full Text] [PDF]  

Induction of CD4⁺ and CD8⁺ T-Cell Responses to the Human Stromal Antigen, Fibroblast Activation Protein: Implication for Cancer Immunotherapy

Martin Fassnacht, Jaewoo Lee, Caterina Milazzo, David Boczkowski, Zhen Su, Smita Nair, and Eli Gilboa
Clin Cancer Res 2005 11: 5566-5571. [Abstract] [Full Text] [PDF]  

Chemopreventive and Therapeutic Efficacy of Orally Active Tyrosine Kinase Inhibitors in a Transgenic Mouse Model of Gallbladder Carcinoma

Kaoru Kiguchi, Lynnsie Ruffino, Toru Kawamoto, Tetsuo Ajiki, and John DiGiovanni
Clin Cancer Res 2005 11: 5572-5580. [Abstract] [Full Text] [PDF]  

Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, MAGE-A4 and SAGE

Yoshihiro Miyahara, Hiroaki Naota, Lijie Wang, Atsunori Hiasa, Megumi Goto, Masato Watanabe, Shigehisa Kitano, Satoshi Okumura, Tetsushi Takemitsu, Atsushi Yuta, Yuichi Majima, François A. Lemonnier, Thierry Boon, and Hiroshi Shiku
Clin Cancer Res 2005 11: 5581-5589. [Abstract] [Full Text] [PDF]  

Prevention of Cancer Cachexia by a Novel Nuclear Factor B Inhibitor in Prostate Cancer

Kenji Kuroda, Yutaka Horiguchi, Jun Nakashima, Eiji Kikuchi, Kent Kanao, Akira Miyajima, Takashi Ohigashi, Kazuo Umezawa, and Masaru Murai
Clin Cancer Res 2005 11: 5590-5594. [Abstract] [Full Text] [PDF]  

VEGI-192, a New Isoform of TNFSF15, Specifically Eliminates Tumor Vascular Endothelial Cells and Suppresses Tumor Growth

Wen Hou, Dan Medynski, Shirley Wu, Xinli Lin, and Lu-Yuan Li
Clin Cancer Res 2005 11: 5595-5602. [Abstract] [Full Text] [PDF]  

Induction of Higher-Avidity Human CTLs by Vector-Mediated Enhanced Costimulation of Antigen-Presenting Cells

Sixun Yang, Kwong-Yok Tsang, and Jeffrey Schlom
Clin Cancer Res 2005 11: 5603-5615. [Abstract] [Full Text] [PDF]  

Melanoma Therapy via Peptide-Targeted -Radiation

Yubin Miao, Mark Hylarides, Darrell R. Fisher, Tiffani Shelton, Herbert Moore, Dennis W. Wester, Alan R. Fritzberg, Christopher T. Winkelmann, Timothy Hoffman, and Thomas P. Quinn
Clin Cancer Res 2005 11: 5616-5621. [Abstract] [Full Text] [PDF]  

Antiangiogenic Treatment with Three Thrombospondin-1 Type 1 Repeats versus Gemcitabine in an Orthotopic Human Pancreatic Cancer Model

Xuefeng Zhang, Eric Galardi, Mark Duquette, Jack Lawler, and Sareh Parangi
Clin Cancer Res 2005 11: 5622-5630. [Abstract] [Full Text] [PDF]  

Hsp90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Prevents Synovial Sarcoma Proliferation via Apoptosis in In vitro Models

Jefferson Terry, Joanna M. Lubieniecka, Wanda Kwan, Suzanne Liu, and Torsten O. Nielsen
Clin Cancer Res 2005 11: 5631-5638. [Abstract] [Full Text] [PDF]  

Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma

Vincenzo Damiano, Davide Melisi, Cataldo Bianco, David Raben, Rosa Caputo, Gabriella Fontanini, Roberto Bianco, Anderson Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, and Giampaolo Tortora
Clin Cancer Res 2005 11: 5639-5644. [Abstract] [Full Text] [PDF]  

Roxithromycin Inhibits Constitutive Activation of Nuclear Factor B by Diminishing Oxidative Stress in a Rat Model of Hepatocellular Carcinoma

Shinichi Ueno, Dai Aoki, Fumitake Kubo, Kiyokazu Hiwatashi, Kenji Matsushita, Tohru Oyama, Ikuro Maruyama, and Takashi Aikou
Clin Cancer Res 2005 11: 5645-5650. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

The Chemopreventive Agent Resveratrol Stimulates Cyclic AMP–Dependent Chloride Secretion In vitro

Irina Blumenstein, Benjamin Keserü, Freya Wolter, and Jürgen Stein
Clin Cancer Res 2005 11: 5651-5656. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Longtime Recirculating Tumor Cells in Breast Cancer Patients

Katharina Pachmann and Jonathan Uhr
Clin Cancer Res 2005 11: 5657-5658. [Full Text] [PDF]  

Corrections:

Correction: Article on Chronic Lymphocytic Leukemia

Clin Cancer Res 2005 11: 5659. [Full Text] [PDF]  

Correction: Article on In vitro Effects of the BH3 Mimetic, (–)-Gossypol, on Head and Neck Squamous Cell Carcinoma Cells

Clin Cancer Res 2005 11: 5659. [Full Text] [PDF]  

Correction: Article on Risk Assessment in Patients with Acute Myeloid Leukemia and a Normal Karyotype

Clin Cancer Res 2005 11: 5659. [Full Text] [PDF]  

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