The Biology Behind:

GADD45 Deregulation in Cancer: Frequently Methylated Tumor Suppressors and Potential Therapeutic Targets

Luiz F. Zerbini and Towia A. Libermann
Clin Cancer Res 2005 11: 6409-6413. [Full Text] [PDF]  

Report from the FDA:

Approval Summary for Erlotinib for Treatment of Patients with Locally Advanced or Metastatic Non–Small Cell Lung Cancer after Failure of at Least One Prior Chemotherapy Regimen

John R. Johnson, Martin Cohen, Rajeshwari Sridhara, Yeh-Fong Chen, Gene M. Williams, John Duan, Jogarao Gobburu, Brian Booth, Kimberly Benson, John Leighton, Li Shan Hsieh, Nallalerumal Chidambaram, Paul Zimmerman, and Richard Pazdur
Clin Cancer Res 2005 11: 6414-6421. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Gene Expression Profiles of Serous, Endometrioid, and Clear Cell Subtypes of Ovarian and Endometrial Cancer

Kristin K. Zorn, Tomas Bonome, Lisa Gangi, Gadisetti V.R. Chandramouli, Christopher S. Awtrey, Ginger J. Gardner, J. Carl Barrett, Jeff Boyd, and Michael J. Birrer
Clin Cancer Res 2005 11: 6422-6430. [Abstract] [Full Text] [PDF] Supplementary Data  

The –251T Allele of the Interleukin-8 Promoter Is Associated with Increased Risk of Gastric Carcinoma Featuring Diffuse-Type Histopathology in Chinese Population

Wei-Ping Lee, Dar-In Tai, Keng-Hsin Lan, Anna Fen-Yau Li, Hou-Ching Hsu, En-Ju Lin, Yi-Ping Lin, Meei-Ling Sheu, Chung-Pin Li, Full-Young Chang, Yee Chao, Shang-Heu Yen, and Shou-Dong Lee
Clin Cancer Res 2005 11: 6431-6441. [Abstract] [Full Text] [PDF]  

The Stress-Responsive Gene GADD45G Is a Functional Tumor Suppressor, with Its Response to Environmental Stresses Frequently Disrupted Epigenetically in Multiple Tumors

Jianming Ying, Gopesh Srivastava, Wen-Son Hsieh, Zifen Gao, Paul Murray, Shuen-Kuei Liao, Richard Ambinder, and Qian Tao
Clin Cancer Res 2005 11: 6442-6449. [Abstract] [Full Text] [PDF]  

EphB2 Expression across 138 Human Tumor Types in a Tissue Microarray: High Levels of Expression in Gastrointestinal Cancers

Alessandro Lugli, Hanspeter Spichtin, Robert Maurer, Martina Mirlacher, Jeff Kiefer, Pia Huusko, David Azorsa, Luigi Terracciano, Guido Sauter, Olli-P Kallioniemi, Spyro Mousses, and Luigi Tornillo
Clin Cancer Res 2005 11: 6450-6458. [Abstract] [Full Text] [PDF]  

Osteopontin Expression and Prognostic Significance in Non–Small Cell Lung Cancer

Valentina Donati, Laura Boldrini, Matteo Dell'Omodarme, Maria C. Prati, Pinuccia Faviana, Tiziano Camacci, Marco Lucchi, Alfredo Mussi, Massimo Santoro, Fulvio Basolo, and Gabriella Fontanini
Clin Cancer Res 2005 11: 6459-6465. [Abstract] [Full Text] [PDF]  

Isolated Loss of PMS2 Expression in Colorectal Cancers: Frequency, Patient Age, and Familial Aggregation

Sharlene Gill, Noralane M. Lindor, Lawrence J. Burgart, Regenia Smalley, Olga Leontovich, Amy J. French, Richard M. Goldberg, Daniel J. Sargent, Jeremy R. Jass, John L. Hopper, Mark A. Jenkins, Joanne Young, Melissa A. Barker, Michael D. Walsh, Andrew R. Ruszkiewicz, and Stephen N. Thibodeau
Clin Cancer Res 2005 11: 6466-6471. [Abstract] [Full Text] [PDF]  

Expression of Trefoil Factor Family Members Correlates with Patient Prognosis and Neoangiogenesis

Dipok Kumar Dhar, Timothy C. Wang, Hideki Tabara, Yasuhito Tonomoto, Riruke Maruyama, Mitsuo Tachibana, Hirofumi Kubota, and Naofumi Nagasue
Clin Cancer Res 2005 11: 6472-6478. [Abstract] [Full Text] [PDF]  

Possible Involvement of RUNX3 Silencing in the Peritoneal Metastases of Gastric Cancers

Chouhei Sakakura, Kazunori Hasegawa, Koji Miyagawa, Susumu Nakashima, Tetsuji Yoshikawa, Shuichi Kin, Yuenn Nakase, Shujiro Yazumi, Hisakazu Yamagishi, Takeshi Okanoue, Tsutomu Chiba, and Akeo Hagiwara
Clin Cancer Res 2005 11: 6479-6488. [Abstract] [Full Text] [PDF]  

NUP98 Is Fused to Topoisomerase (DNA) IIß 180 kDa (TOP2B) in a Patient with Acute Myeloid Leukemia with a New t(3;11)(p24;p15)

Karin Nebral, Helmut H. Schmidt, Oskar A. Haas, and Sabine Strehl
Clin Cancer Res 2005 11: 6489-6494. [Abstract] [Full Text] [PDF]  

Estrogen Inhibits Cell Proliferation through In situ Production in Human Thymoma

Hironori Ishibashi, Takashi Suzuki, Satoshi Suzuki, Takuya Moriya, Chika Kaneko, Taisuke Nakata, Makoto Sunamori, Masashi Handa, Takashi Kondo, and Hironobu Sasano
Clin Cancer Res 2005 11: 6495-6504. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Gene Promoter Methylation in Plasma and Sputum Increases with Lung Cancer Risk

Steven A. Belinsky, Donna M. Klinge, Joseph D. Dekker, Mitzi W. Smith, Theresa J. Bocklage, Frank D. Gilliland, Richard E. Crowell, Daniel D. Karp, Christine A. Stidley, and Maria A. Picchi
Clin Cancer Res 2005 11: 6505-6511. [Abstract] [Full Text] [PDF]  

Molecular Evidence Supporting Field Effect in Urothelial Carcinogenesis

Timothy D. Jones, Mingsheng Wang, John N. Eble, Gregory T. MacLennan, Antonio Lopez-Beltran, Shaobo Zhang, Amy Cocco, and Liang Cheng
Clin Cancer Res 2005 11: 6512-6519. [Abstract] [Full Text] [PDF]  

High Stem Cell Frequency in Acute Myeloid Leukemia at Diagnosis Predicts High Minimal Residual Disease and Poor Survival

Anna van Rhenen, Nicole Feller, Angèle Kelder, August H. Westra, Elwin Rombouts, Sonja Zweegman, Marjolein A. van der Pol, Quinten Waisfisz, Gert J. Ossenkoppele, and Gerrit Jan Schuurhuis
Clin Cancer Res 2005 11: 6520-6527. [Abstract] [Full Text] [PDF]  

Identification of Mammaglobin as a Novel Serum Marker for Breast Cancer

Jonine L. Bernstein, James H. Godbold, George Raptis, Mark A. Watson, Brooke Levinson, Stuart A. Aaronson, and Timothy P. Fleming
Clin Cancer Res 2005 11: 6528-6535. [Abstract] [Full Text] [PDF]  

Quantitation of Minimal Residual Disease in Acute Myeloid Leukemia by Tryptase Monitoring Identifies a Group of Patients with a High Risk of Relapse

Wolfgang R. Sperr, Margit Mitterbauer, Gerlinde Mitterbauer, Michael Kundi, Ulrich Jäger, Klaus Lechner, and Peter Valent
Clin Cancer Res 2005 11: 6536-6543. [Abstract] [Full Text] [PDF]  

DNA Methylation in Anal Intraepithelial Lesions and Anal Squamous Cell Carcinoma

Jun Zhang, Ciro R. Martins, Zoya B. Fansler, Kristina L. Roemer, Erik A. Kincaid, Karen S. Gustafson, Daniel F. Heitjan, and Douglas P. Clark
Clin Cancer Res 2005 11: 6544-6549. [Abstract] [Full Text] [PDF]  

Identification of Nicotinamide N-Methyltransferase as a Novel Serum Tumor Marker for Colorectal Cancer

Markus Roeßler, Wolfgang Rollinger, Stefan Palme, Marie-Luise Hagmann, Peter Berndt, Alfred M. Engel, Bernd Schneidinger, Michael Pfeffer, Herbert Andres, Johann Karl, Heinz Bodenmüller, Josef Rüschoff, Thomas Henkel, Gerhard Rohr, Siegbert Rossol, Wolfgang Rösch, Hanno Langen, Werner Zolg, and Michael Tacke
Clin Cancer Res 2005 11: 6550-6557. [Abstract] [Full Text] [PDF] Supplementary Data  

Messenger RNA Expression Ratios among Four Genes Predict Subtypes of Renal Cell Carcinoma and Distinguish Oncocytoma from Carcinoma

Yao-Tseng Chen, Jiangling J. Tu, Jean Kao, Xi K. Zhou, and Madhu Mazumdar
Clin Cancer Res 2005 11: 6558-6566. [Abstract] [Full Text] [PDF]  

Expression of Thrombospondin-1 in Resected Colorectal Liver Metastases Predicts Poor Prognosis

Christopher D. Sutton, Kenneth O'Byrne, Jonathan C. Goddard, Leslie-Jayne Marshall, Louise Jones, Giuseppe Garcea, Ashley R. Dennison, Graham Poston, David M. Lloyd, and David P. Berry
Clin Cancer Res 2005 11: 6567-6573. [Abstract] [Full Text] [PDF]  

Cytoplasmic CD24 Expression in Colorectal Cancer Independently Correlates with Shortened Patient Survival

Wilko Weichert, Carsten Denkert, Mick Burkhardt, Tserenchunt Gansukh, Joachim Bellach, Peter Altevogt, Manfred Dietel, and Glen Kristiansen
Clin Cancer Res 2005 11: 6574-6581. [Abstract] [Full Text] [PDF]  

Multigene Methylation Analysis for Detection and Staging of Prostate Cancer

Hideki Enokida, Hiroaki Shiina, Shinji Urakami, Mikio Igawa, Tatsuya Ogishima, Long-Cheng Li, Motoshi Kawahara, Masayuki Nakagawa, Christopher J. Kane, Peter R. Carroll, and Rajvir Dahiya
Clin Cancer Res 2005 11: 6582-6588. [Abstract] [Full Text] [PDF]  

Prognostic Role of E2F1 and Members of the CDKN2A Network in Gastrointestinal Stromal Tumors

Florian Haller, Bastian Gunawan, Anja von Heydebreck, Stefanie Schwager, Hans-Jürgen Schulten, Judith Wolf-Salgó, Claus Langer, Giuliano Ramadori, Holger Sültmann, and László Füzesi
Clin Cancer Res 2005 11: 6589-6597. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Diagnostic Evaluation of HER-2 as a Molecular Target: An Assessment of Accuracy and Reproducibility of Laboratory Testing in Large, Prospective, Randomized Clinical Trials

Michael F. Press, Guido Sauter, Leslie Bernstein, Ivonne E. Villalobos, Martina Mirlacher, Jian-Yuan Zhou, Rooba Wardeh, Yong-Tian Li, Roberta Guzman, Yanling Ma, Jane Sullivan-Halley, Angela Santiago, Jinha M. Park, Alessandro Riva, and Dennis J. Slamon
Clin Cancer Res 2005 11: 6598-6607. [Abstract] [Full Text] [PDF]  

Pulmonary Squamous Cell Carcinoma following Head and Neck Squamous Cell Carcinoma: Metastasis or Second Primary?

Tom W. Geurts, Petra M. Nederlof, Michiel W.M. van den Brekel, Laura J. van't Veer, Daphne de Jong, August A.M. Hart, Nico van Zandwijk, Houke Klomp, Alfons J.M. Balm, and Marie-Louise F. van Velthuysen
Clin Cancer Res 2005 11: 6608-6614. [Abstract] [Full Text] [PDF]  

Phase 1 Study of ABT-751, a Novel Microtubule Inhibitor, in Patients with Refractory Hematologic Malignancies

Karen W.L. Yee, Anne Hagey, Srdan Verstovsek, Jorge Cortes, Guillermo Garcia-Manero, Susan M. O'Brien, Stefan Faderl, Deborah Thomas, William Wierda, Steven Kornblau, Alessandra Ferrajoli, Maher Albitar, Evelyn McKeegan, David R. Grimm, Toby Mueller, Rhonda R. Holley-Shanks, Leonardo Sahelijo, Gary B. Gordon, Hagop M. Kantarjian, and Francis J. Giles
Clin Cancer Res 2005 11: 6615-6624. [Abstract] [Full Text] [PDF]  

A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer

Christopher Sweeney, Glenn Liu, Constantin Yiannoutsos, Jill Kolesar, Dorothea Horvath, Mary Jane Staab, Karen Fife, Victoria Armstrong, Anthony Treston, Carolyn Sidor, and George Wilding
Clin Cancer Res 2005 11: 6625-6633. [Abstract] [Full Text] [PDF]  

Targeting Cyclooxygenase-2 in Recurrent Non–Small Cell Lung Cancer: A Phase II Trial of Celecoxib and Docetaxel

Ildiko Csiki, Jason D. Morrow, Alan Sandler, Yu Shyr, John Oates, Myles K. Williams, Thao Dang, David P. Carbone, and David H. Johnson
Clin Cancer Res 2005 11: 6634-6640. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacologic Study of Infusional Topotecan and Carboplatin in Relapsed and Refractory Acute Leukemia

Scott H. Kaufmann, Judith E. Karp, Louis Letendre, Timothy J. Kottke, Stephanie Safgren, Jackie Greer, Ivana Gojo, Pamela Atherton, Phyllis A. Svingen, David A. Loegering, Mark R. Litzow, Jeff A. Sloan, Joel M. Reid, Matthew M. Ames, Alex A. Adjei, and Charles Erlichman
Clin Cancer Res 2005 11: 6641-6649. [Abstract] [Full Text] [PDF]  

Molecular Alterations in Tumors and Response to Combination Chemotherapy with Gefitinib for Advanced Colorectal Cancer

Shuji Ogino, Jeffrey A. Meyerhardt, Mami Cantor, Mohan Brahmandam, Jeffrey W. Clark, Chungdak Namgyal, Takako Kawasaki, Kate Kinsella, Ann L. Michelini, Peter C. Enzinger, Matthew H. Kulke, David P. Ryan, Massimo Loda, and Charles S. Fuchs
Clin Cancer Res 2005 11: 6650-6656. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Radiotherapy Sensitization by Tumor-Specific TRAIL Gene Targeting Improves Survival of Mice Bearing Human Non–Small Cell Lung Cancer

Xiaochun Zhang, Rex Min Cheung, Ritsuko Komaki, Bingliang Fang, and Joe Y. Chang
Clin Cancer Res 2005 11: 6657-6668. [Abstract] [Full Text] [PDF]  

Effect of Combination Therapy with a Novel Bisphosphonate, Minodronate (YM529), and Docetaxel on a Model of Bone Metastasis by Human Transitional Cell Carcinoma

Keiji Inoue, Takashi Karashima, Satoshi Fukata, Asuka Nomura, Chiaki Kawada, Atsushi Kurabayashi, Mutsuo Furihata, Yuji Ohtsuki, and Taro Shuin
Clin Cancer Res 2005 11: 6669-6677. [Abstract] [Full Text] [PDF]  

Metronomic Low-Dose Chemotherapy Boosts CD95-Dependent Antiangiogenic Effect of the Thrombospondin Peptide ABT-510: A Complementation Antiangiogenic Strategy

Ronald Yap, Dorina Veliceasa, Urban Emmenegger, Robert S. Kerbel, Laura M. McKay, Jack Henkin, and Olga V. Volpert
Clin Cancer Res 2005 11: 6678-6685. [Abstract] [Full Text] [PDF]  

Analysis of CD4⁺ T-Cell Responses to a Novel -Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients

Akeel Alisa, Annette Ives, Ansar A. Pathan, Cristina V. Navarrete, Roger Williams, Antonio Bertoletti, and Shahriar Behboudi
Clin Cancer Res 2005 11: 6686-6694. [Abstract] [Full Text] [PDF]  

Effects of Exercise Training on Antitumor Efficacy of Doxorubicin in MDA-MB-231 Breast Cancer Xenografts

Lee W. Jones, Neil D. Eves, Kerry S. Courneya, Brian K. Chiu, Vickie E. Baracos, John Hanson, Lorelei Johnson, and John R. Mackey
Clin Cancer Res 2005 11: 6695-6698. [Abstract] [Full Text] [PDF]  

Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes

Wei Peng Yong, Jacqueline Ramirez, Federico Innocenti, and Mark J. Ratain
Clin Cancer Res 2005 11: 6699-6704. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of the Breast Cancer Cell-Binding Peptide, p160

Vasileios Askoxylakis, Sabine Zitzmann, Walter Mier, Keith Graham, Susanne Krämer, Frederic von Wegner, Rainer H.A. Fink, Manfred Schwab, Michael Eisenhut, and Uwe Haberkorn
Clin Cancer Res 2005 11: 6705-6712. [Abstract] [Full Text] [PDF]  

Gemcitabine Selectively Eliminates Splenic Gr-1⁺/CD11b⁺ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

Eiji Suzuki, Veena Kapoor, Arminder Singh Jassar, Larry R. Kaiser, and Steven M. Albelda
Clin Cancer Res 2005 11: 6713-6721. [Abstract] [Full Text] [PDF]  

Combining Etoposide and Dexrazoxane Synergizes with Radiotherapy and Improves Survival in Mice with Central Nervous System Tumors

Kenneth Francis Hofland, Annemette Vinding Thougaard, Marielle Dejligbjerg, Lars H. Jensen, Paul E.G. Kristjansen, Pia Rengtved, Maxwell Sehested, and Peter Buhl Jensen
Clin Cancer Res 2005 11: 6722-6729. [Abstract] [Full Text] [PDF]  

Enhancement of Cisplatin Sensitivity of Cisplatin-Resistant Human Cervical Carcinoma Cells by Bryostatin 1

Sanghamitra Mohanty, Jie Huang, and Alakananda Basu
Clin Cancer Res 2005 11: 6730-6737. [Abstract] [Full Text] [PDF]  

Celecoxib and Curcumin Synergistically Inhibit the Growth of Colorectal Cancer Cells

Shahar Lev-Ari, Ludmila Strier, Diana Kazanov, Liora Madar-Shapiro, Hadas Dvory-Sobol, Ilya Pinchuk, Brigitte Marian, Dov Lichtenberg, and Nadir Arber
Clin Cancer Res 2005 11: 6738-6744. [Abstract] [Full Text] [PDF]  

Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH₂-Adenosine

Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, and Varsha Gandhi
Clin Cancer Res 2005 11: 6745-6752. [Abstract] [Full Text] [PDF]  

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