Editorials:

Chemokine Receptor 7, A New Player in Regulating Apoptosis of CD8⁺ T Cells in Cancer Patients

Giorgio Parmiani, Chiara Castelli, and Licia Rivoltini
Clin Cancer Res 2005 11: 7587-7588. [Full Text] [PDF]  

The Biology Behind:

A Dynamic De-Escalating Dosing Strategy to Determine the Optimal Biological Dose for Antiangiogenic Drugs

Urban Emmenegger and Robert S. Kerbel
Clin Cancer Res 2005 11: 7589-7592. [Full Text] [PDF]  

Human Cancer Biology:

Multidrug Resistance Proteins in Gastrointestinal Stromal Tumors: Site-Dependent Expression and Initial Response to Imatinib

Nathalie Théou, Sophie Gil, Anne Devocelle, Catherine Julié, Anne Lavergne-Slove, Alain Beauchet, Patrice Callard, Robert Farinotti, Axel Le Cesne, Antoinette Lemoine, Laurence Faivre-Bonhomme, and Jean-François Emile
Clin Cancer Res 2005 11: 7593-7598. [Abstract] [Full Text] [PDF]  

The Phenotypic Plasticity of Myeloma Plasma Cells as Expressed by Dedifferentiation into an Immature, Resilient, and Apoptosis-Resistant Phenotype

Shmuel Yaccoby
Clin Cancer Res 2005 11: 7599-7606. [Abstract] [Full Text] [PDF]  

Signal Pathway of Hypoxia-Inducible Factor-1 Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells

Seok J. Kwon, Jae J. Song, and Yong J. Lee
Clin Cancer Res 2005 11: 7607-7613. [Abstract] [Full Text] [PDF]  

Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

Stuart C. Winter, Ketan A. Shah, Leticia Campo, Helen Turley, Russell Leek, Rogan J. Corbridge, Graham J. Cox, and Adrian L. Harris
Clin Cancer Res 2005 11: 7614-7620. [Abstract] [Full Text] [PDF]  

X-Linked Inhibitor of Apoptosis Protein Expression Level in Colorectal Cancer Is Regulated by Hepatocyte Growth Factor/C-Met Pathway via Akt Signaling

Hiroya Takeuchi, Joseph Kim, Akihide Fujimoto, Naoyuki Umetani, Takuji Mori, Anton Bilchik, Rod Turner, Andy Tran, Christine Kuo, and Dave S.B. Hoon
Clin Cancer Res 2005 11: 7621-7628. [Abstract] [Full Text] [PDF]  

Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment

Tsuyoshi Kuroda, Yasuhiko Kitadai, Shinji Tanaka, Xiaoqin Yang, Naofumi Mukaida, Masaharu Yoshihara, and Kazuaki Chayama
Clin Cancer Res 2005 11: 7629-7636. [Abstract] [Full Text] [PDF]  

Tumor Lymphangiogenesis in Inflammatory Breast Carcinoma: A Histomorphometric Study

Ilse Van der Auwera, Gert G. Van den Eynden, Cecile G. Colpaert, Steven J. Van Laere, Peter van Dam, Eric A. Van Marck, Luc Y. Dirix, and Peter B. Vermeulen
Clin Cancer Res 2005 11: 7637-7642. [Abstract] [Full Text] [PDF]  

Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis

Eleanor B. Carson-Walter, Jessica Hampton, Eveline Shue, Daniel M. Geynisman, Pramod Kumar Pillai, Ramasri Sathanoori, Stephen L. Madden, Ronald L. Hamilton, and Kevin A. Walter
Clin Cancer Res 2005 11: 7643-7650. [Abstract] [Full Text] [PDF]  

Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Colleen M. Feltmate, Kenneth R. Lee, Michael Johnson, John O. Schorge, Kwong-kwok Wong, Ke Hao, William R. Welch, Debra A. Bell, Ross S. Berkowitz, and Samuel C. Mok
Clin Cancer Res 2005 11: 7651-7657. [Abstract] [Full Text] [PDF] Supplementary Data  

The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer

Jane L. Boddy, Stephen B. Fox, Cheng Han, Leticia Campo, Helen Turley, Suresh Kanga, Peter R. Malone, and Adrian L. Harris
Clin Cancer Res 2005 11: 7658-7663. [Abstract] [Full Text] [PDF]  

Plitidepsin Has a Cytostatic Effect in Human Undifferentiated (Anaplastic) Thyroid Carcinoma

Susana B. Bravo, María E.R. García-Rendueles, Rafael Seoane, Vanesa Dosil, José Cameselle-Teijeiro, Luis López-Lázaro, Juan Zalvide, Francisco Barreiro, Celia M. Pombo, and Clara V. Álvarez
Clin Cancer Res 2005 11: 7664-7673. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer

Harnisha Dalwadi, Kostyantyn Krysan, Nathalie Heuze-Vourc'h, Mariam Dohadwala, David Elashoff, Sherven Sharma, Nicholas Cacalano, Alan Lichtenstein, and Steven Dubinett
Clin Cancer Res 2005 11: 7674-7682. [Abstract] [Full Text] [PDF]  

Basic Fibroblast Growth Factor (FGF-2) Overexpression Is a Risk Factor for Esophageal Cancer Recurrence and Reduced Survival, which Is Ameliorated by Coexpression of the FGF-2 Antisense Gene

Christie Barclay, Audrey W. Li, Laurette Geldenhuys, Mark Baguma-Nibasheka, Geoffrey A. Porter, Paul J. Veugelers, Paul R. Murphy, and Alan G. Casson
Clin Cancer Res 2005 11: 7683-7691. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Immunization Using Autologous Dendritic Cells Pulsed with the Melanoma-Associated Antigen gp100-Derived G280-9V Peptide Elicits CD8⁺ Immunity

Gerald P. Linette, Dongsheng Zhang, F. Stephen Hodi, Eric P. Jonasch, Simonne Longerich, Christopher P. Stowell, Iain J. Webb, Heather Daley, Robert J. Soiffer, Amy M. Cheung, Sara G. Eapen, Sharon V. Fee, Krista M. Rubin, Arthur J. Sober, and Frank G. Haluska
Clin Cancer Res 2005 11: 7692-7699. [Abstract] [Full Text] [PDF]  

The HCCR Oncoprotein as a Biomarker for Human Breast Cancer

Sang Seol Jung, Hyung Soon Park, Insong James Lee, Hong Namkoong, Seung Min Shin, Goang Won Cho, Seon-Ah Ha, Yong Gyu Park, Youn Soo Lee, Jesang Ko, and Jin Woo Kim
Clin Cancer Res 2005 11: 7700-7708. [Abstract] [Full Text] [PDF]  

Role of Activating Fibroblast Growth Factor Receptor 3 Mutations in the Development of Bladder Tumors

Karsten Zieger, Lars Dyrskjøt, Carsten Wiuf, Jens L. Jensen, Claus L. Andersen, Klaus Møller-Ernst Jensen, and Torben Falck Ørntoft
Clin Cancer Res 2005 11: 7709-7719. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunogenotype Changes Prevail in Relapses of Young Children with TEL-AML1-Positive Acute Lymphoblastic Leukemia and Derive Mainly from Clonal Selection

E. Renate Panzer-Grümayer, Giovanni Cazzaniga, Vincent H.J. van der Velden, Laura del Giudice, Martina Peham, Georg Mann, Conny Eckert, Andre Schrauder, Giuseppe Germano, Jochen Harbott, Giuseppe Basso, Andrea Biondi, Jacques J.M. van Dongen, Helmut Gadner, and Oskar A. Haas
Clin Cancer Res 2005 11: 7720-7727. [Abstract] [Full Text] [PDF]  

Methylation Assay for the Diagnosis of Lung Cancer on Bronchial Aspirates: A Cohort Study

Viola Schmiemann, Alfred Böcking, Marietta Kazimirek, Alexandre Sherlley Casimiro Onofre, Helmut Erich Gabbert, Rainer Kappes, Claus Dieter Gerharz, and Hans Juergen Grote
Clin Cancer Res 2005 11: 7728-7734. [Abstract] [Full Text] [PDF]  

Racial Differences in Prognostic Value of Adult Height for Biochemical Progression Following Radical Prostatectomy

Stephen J. Freedland, William J. Aronson, Bruce Trock, Pinchas Cohen, Christopher J. Kane, Christopher L. Amling, Joseph C. Presti, Jr., Martha K. Terris for the Shared Equal Access Regional Cancer Hospital Database Study Group
Clin Cancer Res 2005 11: 7735-7742. [Abstract] [Full Text] [PDF]  

A Simple and Fast Method for the Simultaneous Detection of Nine Fibroblast Growth Factor Receptor 3 Mutations in Bladder Cancer and Voided Urine

Johanna M.M. van Oers, Irene Lurkin, Antonius J.A. van Exsel, Yvette Nijsen, Bas W.G. van Rhijn, Madelon N.M. van der Aa, and Ellen C. Zwarthoff
Clin Cancer Res 2005 11: 7743-7748. [Abstract] [Full Text] [PDF]  

Mesenchymal Stem Cell Targeting of Microscopic Tumors and Tumor Stroma Development Monitored by Noninvasive In vivo Positron Emission Tomography Imaging

Shih-Chieh Hung, Win-Ping Deng, Wen K. Yang, Ren-Shyan Liu, Chien-Chih Lee, Tzu-Chi Su, Rue-Jen Lin, Den-Mei Yang, Chi-Wei Chang, Wei-Hong Chen, Hon-Jian Wei, and Juri G. Gelovani
Clin Cancer Res 2005 11: 7749-7756. [Abstract] [Full Text] [PDF]  

Allogeneic Transplant with Reduced Intensity Conditioning Regimens may Overcome the Poor Prognosis of B-Cell Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Variable Heavy-Chain Gene and Chromosomal Abnormalities (11q– and 17p–)

Dolores Caballero, Jose A. García-Marco, Rodrigo Martino, Victoria Mateos, José M. Ribera, José Sarrá, Angel León, Guillermo Sanz, Javier de la Serna, Rafael Cabrera, Marcos González, Jorge Sierra, and Jesús San Miguel
Clin Cancer Res 2005 11: 7757-7763. [Abstract] [Full Text] [PDF]  

MRP3, BCRP, and P-Glycoprotein Activities are Prognostic Factors in Adult Acute Myeloid Leukemia

Zineb Benderra, Anne Marie Faussat, Lydia Sayada, Jean-Yves Perrot, Ruoping Tang, Driss Chaoui, Hamid Morjani, Christophe Marzac, Jean-Pierre Marie, and Ollivier Legrand
Clin Cancer Res 2005 11: 7764-7772. [Abstract] [Full Text] [PDF]  

Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure

Stephane Ferretti, Peter R. Allegrini, Terence O'Reilly, Christian Schnell, Michael Stumm, Markus Wartmann, Jeanette Wood, and Paul M.J. McSheehy
Clin Cancer Res 2005 11: 7773-7784. [Abstract] [Full Text] [PDF]  

The Role of S100A6 in Pancreatic Cancer Development and Its Clinical Implication as a Diagnostic Marker and Therapeutic Target

Kenoki Ohuchida, Kazuhiro Mizumoto, Nami Ishikawa, Kei Fujii, Hiroyuki Konomi, Eishi Nagai, Koji Yamaguchi, Masazumi Tsuneyoshi, and Masao Tanaka
Clin Cancer Res 2005 11: 7785-7793. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Pharmacokinetics and Tolerability of a Single Dose of DN-101, a New Formulation of Calcitriol, in Patients with Cancer

Tomasz M. Beer, Milind Javle, Gilbert N. Lam, W. David Henner, Alvin Wong, and Donald L. Trump
Clin Cancer Res 2005 11: 7794-7799. [Abstract] [Full Text] [PDF]  

Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan

Nielka P.H. van Erp, Sharyn D. Baker, Ming Zhao, Michelle A. Rudek, Henk-Jan Guchelaar, Johan W.R. Nortier, Alex Sparreboom, and Hans Gelderblom
Clin Cancer Res 2005 11: 7800-7806. [Abstract] [Full Text] [PDF]  

A Phase I Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously Daily for 5 Consecutive Days Every 3 Weeks in Patients with Advanced Solid Tumors

Scot Ebbinghaus, Eric Rubin, Evan Hersh, Lee D. Cranmer, Peter L. Bonate, Robert J. Fram, Antti Jekunen, Steve Weitman, and Lisa A. Hammond
Clin Cancer Res 2005 11: 7807-7816. [Abstract] [Full Text] [PDF]  

Phase I Study of Cloretazine (VNP40101M), a Novel Sulfonylhydrazine Alkylating Agent, Combined with Cytarabine in Patients with Refractory Leukemia

Francis Giles, Srdan Verstovsek, Deborah Thomas, Stanton Gerson, Jorge Cortes, Stefan Faderl, Alessandra Ferrajoli, Farhad Ravandi, Steven Kornblau, Guillermo Garcia-Manero, Elias Jabbour, Susan O'Brien, Verena Karsten, Ann Cahill, Karen Yee, Maher Albitar, Mario Sznol, and Hagop Kantarjian
Clin Cancer Res 2005 11: 7817-7824. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously on Days 1, 3, and 5 Every 3 Weeks in Patients with Advanced Solid Tumors

Casey Cunningham, Leonard J. Appleman, Miora Kirvan-Visovatti, David P. Ryan, Eileen Regan, Svetislava Vukelja, Peter L. Bonate, Francis Ruvuna, Robert J. Fram, Antti Jekunen, Steve Weitman, Lisa A. Hammond, and Joseph P. Eder, Jr.
Clin Cancer Res 2005 11: 7825-7833. [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules

Alan V. Boddy, E. Ruth Plummer, Radha Todd, Julieann Sludden, Melanie Griffin, Lesley Robson, James Cassidy, Donald Bissett, Alberto Bernareggi, Mark W. Verrill, and A. Hilary Calvert
Clin Cancer Res 2005 11: 7834-7840. [Abstract] [Full Text] [PDF]  

Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01

Andrew B. Lassman, Michael R. Rossi, Jeffrey R. Razier, Lauren E. Abrey, Frank S. Lieberman, Chelsea N. Grefe, Kathleen Lamborn, William Pao, Alan H. Shih, John G. Kuhn, Richard Wilson, Norma J. Nowak, John K. Cowell, Lisa M. DeAngelis, Patrick Wen, Mark R. Gilbert, Susan Chang, W.A. Yung, Michael Prados, and Eric C. Holland
Clin Cancer Res 2005 11: 7841-7850. [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I Trial of a Monoclonal Antibody Specific for _vß₃ Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion

Douglas G. McNeel, Jens Eickhoff, Fred T. Lee, David M. King, Dona Alberti, James P. Thomas, Andreas Friedl, Jill Kolesar, Rebecca Marnocha, Jennifer Volkman, Jianliang Zhang, Luz Hammershaimb, James A. Zwiebel, and George Wilding
Clin Cancer Res 2005 11: 7851-7860. [Abstract] [Full Text] [PDF]  

Phase II Trial of the O⁶-Alkylguanine DNA Alkyltransferase Inhibitor O⁶-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

Thomas F. Gajewski, Jeffrey Sosman, Stanton L. Gerson, Lili Liu, Eileen Dolan, Shang Lin, and Everett E. Vokes
Clin Cancer Res 2005 11: 7861-7865. [Abstract] [Full Text] [PDF]  

Phase 1 Study of Weekly Polyethylene Glycol-Camptothecin in Patients with Advanced Solid Tumors and Lymphomas

James A. Posey, III, M. Wasif Saif, Ronda Carlisle, Andrew Goetz, Jinee Rizzo, Suzanne Stevenson, Marc S. Rudoltz, Joseph Kwiatek, Paul Simmons, Eric K. Rowinsky, Chris H. Takimoto, and Anthony W. Tolcher
Clin Cancer Res 2005 11: 7866-7871. [Abstract] [Full Text] [PDF]  

Adaptive Signature Design: An Adaptive Clinical Trial Design for Generating and Prospectively Testing A Gene Expression Signature for Sensitive Patients

Boris Freidlin and Richard Simon
Clin Cancer Res 2005 11: 7872-7878. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Therapeutic Advantage of Pretargeted Radioimmunotherapy Using a Recombinant Bispecific Antibody in a Human Colon Cancer Xenograft

Habibe Karacay, Pierre-Yves Brard, Robert M. Sharkey, Chien-Hsing Chang, Edmund A. Rossi, William J. McBride, Dan R. Ragland, Ivan D. Horak, and David M. Goldenberg
Clin Cancer Res 2005 11: 7879-7885. [Abstract] [Full Text] [PDF]  

Oncolytic Herpes Simplex Virus Vector G47 in Combination with Androgen Ablation for the Treatment of Human Prostate Adenocarcinoma

Hiroshi Fukuhara, Robert L. Martuza, Samuel D. Rabkin, Yoshikazu Ito, and Tomoki Todo
Clin Cancer Res 2005 11: 7886-7890. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells

Shigeo Koido, Eiichi Hara, Sadamu Homma, Akira Torii, Yoichi Toyama, Hidejiro Kawahara, Michiaki Watanabe, Katsuhiko Yanaga, Kiyotaka Fujise, Hisao Tajiri, Jianlin Gong, and Gotaro Toda
Clin Cancer Res 2005 11: 7891-7900. [Abstract] [Full Text] [PDF]  

Chemokine C Receptor 7 Expression and Protection of Circulating CD8⁺ T Lymphocytes from Apoptosis

Jeong-Whun Kim, Robert L. Ferris, and Theresa L. Whiteside
Clin Cancer Res 2005 11: 7901-7910. [Abstract] [Full Text] [PDF]  

Establishment of a Serum Tumor Marker for Preclinical Trials of Mouse Prostate Cancer Models

Isaac Van Huizen, Guojun Wu, Madeleine Moussa, Joseph L. Chin, Aaron Fenster, James C. Lacefield, Hideki Sakai, Norman M. Greenberg, and Jim W. Xuan
Clin Cancer Res 2005 11: 7911-7919. [Abstract] [Full Text] [PDF]  

Radioimmunotherapy of CD22-Expressing Daudi Tumors in Nude Mice with a ⁹⁰Y-Labeled Anti-CD22 Monoclonal Antibody

Daniel A. Vallera, Martin W. Brechbiel, Linda J. Burns, Angela Panoskaltsis-Mortari, Katie E. Dusenbery, Dennis R. Clohisy, and Ellen S. Vitetta
Clin Cancer Res 2005 11: 7920-7928. [Abstract] [Full Text] [PDF]  

[¹³¹I]meta-Iodobenzylguanidine and Topotecan Combination Treatment of Tumors Expressing the Noradrenaline Transporter

Anthony G. McCluskey, Marie Boyd, Susan C. Ross, Emilio Cosimo, Anne Marie Clark, Wilson J. Angerson, Mark N. Gaze, and Robert J. Mairs
Clin Cancer Res 2005 11: 7929-7937. [Abstract] [Full Text] [PDF]  

Novel Phase I Dose De-escalation Design Trial to Determine the Biological Modulatory Dose of the Antiangiogenic Agent SU5416

Afshin Dowlati, Kelly Robertson, Tomas Radivoyevitch, John Waas, Nicholas P. Ziats, Paul Hartman, Fadi W. Abdul-Karim, Jay K. Wasman, Jack Jesberger, Jonathan Lewin, Keith McCrae, Percy Ivy, and Scot C. Remick
Clin Cancer Res 2005 11: 7938-7944. [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells

Isamu Hoshino, Hisahiro Matsubara, Naoyuki Hanari, Mikito Mori, Takanori Nishimori, Yasuo Yoneyama, Yasunori Akutsu, Haruhito Sakata, Kazuyuki Matsushita, Naohiko Seki, and Takenori Ochiai
Clin Cancer Res 2005 11: 7945-7952. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Prevention of Hepatocellular Carcinoma by Universal Vaccination against Hepatitis B Virus: The Effect and Problems

Mei-Hwei Chang, Tony Hsiu-Hsi Chen, Hsu-Mei Hsu, Tzee-Chung Wu, Man-Shan Kong, Der-Cherng Liang, Yen-Hsuan Ni, Chien-Jen Chen, Ding-Shinn Chen for the Taiwan Childhood HCC Study Group
Clin Cancer Res 2005 11: 7953-7957. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Independent Test Set Performance in the Prediction of Early Relapse in Ovarian Cancer with Gene Expression Profiles

Frank De Smet, Nathalie L.M.M. Pochet, Bart L.R. De Moor, Toon Van Gorp, Dirk Timmerman, Ignace B. Vergote, Lynn C. Hartmann, Andrew I. Damokosh, and Sebastian Hoersch
Clin Cancer Res 2005 11: 7958-7959. [Full Text] [PDF]  

Corrections:

Correction: Article on Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Clin Cancer Res 2005 11: 7960-7961. [Full Text] [PDF]  

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