Editors Note:

Introducing CCR Drug Updates

William N. Hait
Clin Cancer Res 2005 11: 8225. [Full Text] [PDF]  

The Biology Behind:

The Therapeutic Implications of Intratumoral Regulatory T Cells

Glenn Dranoff
Clin Cancer Res 2005 11: 8226-8229. [Full Text] [PDF]  

CCR Drug Updates:

Liposomal, Nanoparticle, and Conjugated Formulations of Anticancer Agents

William C. Zamboni
Clin Cancer Res 2005 11: 8230-8234. [Full Text] [PDF]  

Human Cancer Biology:

Genome-Wide Screening of Genomic Alterations and Their Clinicopathologic Implications in Non–Small Cell Lung Cancers

Tae-Min Kim, Seon-Hee Yim, Jung-Sook Lee, Mi-Seon Kwon, Jae-Wook Ryu, Hyun-Mi Kang, Heike Fiegler, Nigel P. Carter, and Yeun-Jun Chung
Clin Cancer Res 2005 11: 8235-8242. [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Neutrophils in Cutaneous T-Cell Lymphoma

Deborah S. Goddard, Kei-ichi Yamanaka, Thomas S. Kupper, and David A. Jones
Clin Cancer Res 2005 11: 8243-8249. [Abstract] [Full Text] [PDF]  

Expression of Interleukin-9 in Nasal Natural Killer/T-Cell Lymphoma Cell Lines and Patients

Toshihiro Nagato, Hiroya Kobayashi, Kan Kishibe, Miki Takahara, Takeshi Ogino, Hideyuki Ishii, Kensuke Oikawa, Naoko Aoki, Keisuke Sato, Shoji Kimura, Norio Shimizu, Masatoshi Tateno, and Yasuaki Harabuchi
Clin Cancer Res 2005 11: 8250-8257. [Abstract] [Full Text] [PDF]  

Identification of a Novel Estrogen-Regulated Gene, EIG121, Induced by Hormone Replacement Therapy and Differentially Expressed in Type I and Type II Endometrial Cancer

Lei Deng, Russell R. Broaddus, Adrienne McCampbell, Gregory L. Shipley, David S. Loose, George M. Stancel, James H. Pickar, and Peter J.A. Davies
Clin Cancer Res 2005 11: 8258-8264. [Abstract] [Full Text] [PDF]  

Identification of CCND3 and BYSL as Candidate Targets for the 6p21 Amplification in Diffuse Large B-Cell Lymphoma

Yumiko Kasugai, Hiroyuki Tagawa, Yoshihiro Kameoka, Yasuo Morishima, Shigeo Nakamura, and Masao Seto
Clin Cancer Res 2005 11: 8265-8272. [Abstract] [Full Text] [PDF] Supplementary Data  

Differential Expression of CXCR4 Is Associated with the Metastatic Potential of Human Non–Small Cell Lung Cancer Cells

Liping Su, Jinping Zhang, Huanbin Xu, Ying Wang, Yiwei Chu, Ruizi Liu, and Sidong Xiong
Clin Cancer Res 2005 11: 8273-8280. [Abstract] [Full Text] [PDF]  

Differing DNA Methylation Patterns and Gene Mutation Frequencies in Colorectal Carcinomas from Middle Eastern Countries

Annie O. Chan, Amr S. Soliman, Qing Zhang, Asif Rashid, Ahmed Bedeir, P. Scott Houlihan, Nadia Mokhtar, Nidal Al-Masri, Ugur Ozbek, Rami Yaghan, Ayten Kandilci, Sherif Omar, Yersu Kapran, Ferhunde Dizdaroglu, Melissa L. Bondy, Christopher I. Amos, Jean-Pierre Issa, Bernard Levin, and Stanley R. Hamilton
Clin Cancer Res 2005 11: 8281-8287. [Abstract] [Full Text] [PDF]  

Activated Epidermal Growth Factor Receptor–Stat-3 Signaling Promotes Tumor Survival In vivo in Non–Small Cell Lung Cancer

Eric B. Haura, Zhong Zheng, Lanxi Song, Alan Cantor, and Gerold Bepler
Clin Cancer Res 2005 11: 8288-8294. [Abstract] [Full Text] [PDF]  

Ghrelin and a Novel Preproghrelin Isoform Are Highly Expressed in Prostate Cancer and Ghrelin Activates Mitogen-Activated Protein Kinase in Prostate Cancer

Anthony H. Yeh, Penelope L. Jeffery, Russell P. Duncan, Adrian C. Herington, and Lisa K. Chopin
Clin Cancer Res 2005 11: 8295-8303. [Abstract] [Full Text] [PDF]  

Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors

Angelica Facoetti, Rosanna Nano, Paola Zelini, Patrizia Morbini, Eugenio Benericetti, Mauro Ceroni, Michael Campoli, and Soldano Ferrone
Clin Cancer Res 2005 11: 8304-8311. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Identification of Biomarkers for Breast Cancer in Nipple Aspiration and Ductal Lavage Fluid

Jinong Li, Jing Zhao, Xiaodong Yu, Julie Lange, Henry Kuerer, Savitri Krishnamurthy, Eric Schilling, Seema A. Khan, Saraswati Sukumar, and Daniel W. Chan
Clin Cancer Res 2005 11: 8312-8320. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation as an Independent Prognostic Factor for Relapse in Patients with Prostate Cancer Following Radical Prostatectomy

Eli Rosenbaum, Mohammad Obaidul Hoque, Yoram Cohen, Marianna Zahurak, Mario A. Eisenberger, Jonathan I. Epstein, Alan W. Partin, and David Sidransky
Clin Cancer Res 2005 11: 8321-8325. [Abstract] [Full Text] [PDF]  

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

Dominik Wolf, Anna M. Wolf, Holger Rumpold, Heidi Fiegl, Alain G. Zeimet, Elisabeth Muller-Holzner, Martina Deibl, Guenther Gastl, Eberhard Gunsilius, and Christian Marth
Clin Cancer Res 2005 11: 8326-8331. [Abstract] [Full Text] [PDF]  

Microsatellite Instability and Colorectal Cancer Prognosis

Piero Benatti, Roberta Gafà, Daniela Barana, Massimiliano Marino, Alessandra Scarselli, Monica Pedroni, Iva Maestri, Laura Guerzoni, Luca Roncucci, Mirco Menigatti, Barbara Roncari, Stefania Maffei, Giuseppina Rossi, Giovanni Ponti, Alessandra Santini, Lorena Losi, Carmela Di Gregorio, Cristina Oliani, Maurizio Ponz de Leon, and Giovanni Lanza
Clin Cancer Res 2005 11: 8332-8340. [Abstract] [Full Text] [PDF]  

High Cyclooxygenase-2 Expression Following Neoadjuvant Radiochemotherapy Is Associated with Minor Histopathologic Response and Poor Prognosis in Esophageal Cancer

Huan Xi, Stephan E. Baldus, Ute Warnecke-Eberz, Jan Brabender, Susanne Neiss, Ralf Metzger, Frederike C. Ling, Hans P. Dienes, Elfriede Bollschweiler, Stefan Moenig, Rolf P. Mueller, Arnulf H. Hoelscher, and Paul M. Schneider
Clin Cancer Res 2005 11: 8341-8347. [Abstract] [Full Text] [PDF]  

Expression of HER2 and the Coamplified Genes GRB7 and MLN64 in Human Breast Cancer: Quantitative Real-time Reverse Transcription-PCR as a Diagnostic Alternative to Immunohistochemistry and Fluorescence In situ Hybridization

Ursula Vinatzer, Brigitta Dampier, Berthold Streubel, Margit Pacher, Michael J. Seewald, Christian Stratowa, Klaus Kaserer, and Martin Schreiber
Clin Cancer Res 2005 11: 8348-8357. [Abstract] [Full Text] [PDF]  

Elevated Expression of Angiogenin in Prostate Cancer and Its Precursors

Terrence M. Katona, Blake Lee Neubauer, Philip W. Iversen, Shaobo Zhang, Lee Ann Baldridge, and Liang Cheng
Clin Cancer Res 2005 11: 8358-8363. [Abstract] [Full Text] [PDF]  

Peritumoral Lymphatic Vessel Density and Vascular Endothelial Growth Factor C Expression in Early-Stage Squamous Cell Carcinoma of the Uterine Cervix

Zoltan Gombos, Xiaowei Xu, Christina S. Chu, Paul J. Zhang, and Geza Acs
Clin Cancer Res 2005 11: 8364-8371. [Abstract] [Full Text] [PDF]  

Clinical Relevance of Dominant-Negative p73 Isoforms for Responsiveness to Chemotherapy and Survival in Ovarian Cancer: Evidence for a Crucial p53-p73 Cross-talk In vivo

Nicole Concin, Gerda Hofstetter, Astrid Berger, Adriana Gehmacher, Daniel Reimer, Rafal Watrowski, Dan Tong, Eva Schuster, Lukas Hefler, Kurt Heim, Elisabeth Mueller-Holzner, Christian Marth, Ute M. Moll, Alain G. Zeimet, and Robert Zeillinger
Clin Cancer Res 2005 11: 8372-8383. [Abstract] [Full Text] [PDF]  

Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian Cancer

Amanda Psyrri, Aris Bamias, Ziwei Yu, Paul M. Weinberger, Mohamad Kassar, Sophia Markakis, Diane Kowalski, Eleni Efstathiou, Robert L. Camp, David L. Rimm, and Meletios A. Dimopoulos
Clin Cancer Res 2005 11: 8384-8390. [Abstract] [Full Text] [PDF]  

The Use of Genetic Markers to Determine Risk for Prostate Cancer at Prostate Biopsy

Robert K. Nam, William W. Zhang, Michael A.S. Jewett, John Trachtenberg, Laurence H. Klotz, Marjan Emami, Linda Sugar, Joan Sweet, Ants Toi, and Steven A. Narod
Clin Cancer Res 2005 11: 8391-8397. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

The Nuclear Transcription Factor B/bcl-2 Pathway Correlates with Pathologic Complete Response to Doxorubicin-Based Neoadjuvant Chemotherapy in Human Breast Cancer

Thomas A. Buchholz, Amit K. Garg, Nitin Chakravarti, Bharat B. Aggarwal, Francisco J. Esteva, Henry M. Kuerer, S. Eva Singletary, Gabriel N. Hortobagyi, Lajos Pusztai, Massimo Cristofanilli, and Aysegul A. Sahin
Clin Cancer Res 2005 11: 8398-8402. [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Flavopiridol followed by 1-ß-D-Arabinofuranosylcytosine and Mitoxantrone in Relapsed and Refractory Adult Acute Leukemias

Judith E. Karp, Antonino Passaniti, Ivana Gojo, Scott Kaufmann, Keith Bible, Tushar S. Garimella, Jacqueline Greer, Janet Briel, B. Douglas Smith, Steven D. Gore, Michael L. Tidwell, Douglas D. Ross, John J. Wright, A. Dimitrios Colevas, and Kenneth S. Bauer
Clin Cancer Res 2005 11: 8403-8412. [Abstract] [Full Text] [PDF]  

Phase I Study of Low-Dose Interleukin-2, Fludarabine, and Cyclophosphamide for Previously Untreated Indolent Lymphoma and Chronic Lymphocytic Leukemia

Yvette L. Kasamon, Ian W. Flinn, Michael R. Grever, Louis F. Diehl, Elizabeth Garrett-Mayer, Steven N. Goodman, Margaret S. Lucas, and John C. Byrd
Clin Cancer Res 2005 11: 8413-8417. [Abstract] [Full Text] [PDF]  

Phase II Trial of Gefitinib 250 mg Daily in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck

Ezra E.W. Cohen, Madeleine A. Kane, Marcy A. List, Bruce E. Brockstein, Bhoomi Mehrotra, Dezheng Huo, Ann M. Mauer, Carolyn Pierce, Allison Dekker, and Everett E. Vokes
Clin Cancer Res 2005 11: 8418-8424. [Abstract] [Full Text] [PDF]  

High Thioredoxin Expression Is Associated with Resistance to Docetaxel in Primary Breast Cancer

Seung Jin Kim, Yasuo Miyoshi, Tetsuya Taguchi, Yasuhiro Tamaki, Hajime Nakamura, Junji Yodoi, Kikuya Kato, and Shinzaburo Noguchi
Clin Cancer Res 2005 11: 8425-8430. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Novel Oncolytic Adenovirus Selectively Targets Tumor-Associated Polo-Like Kinase 1 and Tumor Cell Viability

Jianfeng Zhou, Qinglei Gao, Gang Chen, Xiaoyuan Huang, Yunping Lu, Kanyan Li, Daxing Xie, Liang Zhuang, Jingniu Deng, and Ding Ma
Clin Cancer Res 2005 11: 8431-8440. [Abstract] [Full Text] [PDF]  

Silibinin Efficacy against Human Hepatocellular Carcinoma

Leyon Varghese, Chapla Agarwal, Alpana Tyagi, Rana P. Singh, and Rajesh Agarwal
Clin Cancer Res 2005 11: 8441-8448. [Abstract] [Full Text] [PDF]  

The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks

Lisa M. Smith, Elaine Willmore, Caroline A. Austin, and Nicola J. Curtin
Clin Cancer Res 2005 11: 8449-8457. [Abstract] [Full Text] [PDF]  

FTY720: A Promising Agent for Treatment of Metastatic Hepatocellular Carcinoma

Terence K. Lee, Kwan Man, Joanna W. Ho, Xiang Hong Wang, Ronnie T.P. Poon, Yang Xu, Kevin T. Ng, Alan C. Chu, Chris K. Sun, Irene O. Ng, Hui Chuan Sun, Zao You Tang, Ray Xu, and Sheung Tat Fan
Clin Cancer Res 2005 11: 8458-8466. [Abstract] [Full Text] [PDF]  

Synergistic Interaction between Histone Deacetylase and Topoisomerase II Inhibitors Is Mediated through Topoisomerase IIß

Douglas C. Marchion, Elona Bicaku, Joel G. Turner, Adil I. Daud, Daniel M. Sullivan, and Pamela N. Munster
Clin Cancer Res 2005 11: 8467-8475. [Abstract] [Full Text] [PDF]  

Site-Specific Drug Delivery by Photochemical Internalization Enhances the Antitumor Effect of Bleomycin

Kristian Berg, Andreas Dietze, Olav Kaalhus, and Anders Høgset
Clin Cancer Res 2005 11: 8476-8485. [Abstract] [Full Text] [PDF]  

Combination Immunotherapy with Clinical-Scale Enriched Human T cells, hu14.18 Antibody, and the Immunocytokine Fc-IL7 in Disseminated Neuroblastoma

Mario Otto, Raymond C. Barfield, William J. Martin, Rekha Iyengar, Wing Leung, Thasia Leimig, Stanley Chaleff, Stephen D. Gillies, and Rupert Handgretinger
Clin Cancer Res 2005 11: 8486-8491. [Abstract] [Full Text] [PDF]  

Combination B7-Fc Fusion Protein Treatment and Treg Cell Depletion Therapy

Aihong Liu, Peisheng Hu, Leslie A. Khawli, and Alan L. Epstein
Clin Cancer Res 2005 11: 8492-8502. [Abstract] [Full Text] [PDF]  

In vitro and In vivo Clinical Pharmacology of Dimethyl Benzoylphenylurea, a Novel Oral Tubulin-Interactive Agent

Michelle A. Rudek, Ming Zhao, Nicola F. Smith, Robert W. Robey, Ping He, Gurulingappa Hallur, Saeed Khan, Manuel Hidalgo, Antonio Jimeno, A. Dimitrios Colevas, Wells A. Messersmith, Antonio C. Wolff, and Sharyn D. Baker
Clin Cancer Res 2005 11: 8503-8511. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Prevention of N-Methyl-N-Nitrosourea–Induced Breast Cancer by -Fetoprotein (AFP)–Derived Peptide, a Peptide Derived from the Active Site of AFP

Rahul R. Parikh, Neil Gildener-Leapman, Amithi Narendran, Hung-Yun Lin, Nicole Lemanski, James A. Bennett, Herbert I. Jacobson, and Thomas T. Andersen
Clin Cancer Res 2005 11: 8512-8520. [Abstract] [Full Text] [PDF]  

Inhibition of Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Is Not Sufficient to Account for Indole-3-Carbinol–Induced Apoptosis in Some Breast and Prostate Tumor Cells

Lynne M. Howells, E. Ann Hudson, and Margaret M. Manson
Clin Cancer Res 2005 11: 8521-8527. [Abstract] [Full Text] [PDF]  

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