The Cover Three-color composite image showing the perivascular distribution of doxorubicin (blue) in relation to blood vessels (red) and hypoxic regions (green) in a tissue section from the 16C mouse mammary tumor. Doxorubicin was recognized by its autoflurescence, blood vessels by anti-CD31, and hypoxic regions by uptake of EF-5. For further details, please see Primeau et al on page 8782 in this issue.