Editorials:

Plasma Protein Profiling by Mass Spectrometry for Cancer Diagnosis: Opportunities and Limitations

Eleftherios P. Diamandis and Da-Elene van der Merwe
Clin Cancer Res 2005 11: 963-965. [Full Text] [PDF]  

Monocyte-Derived Dendritic Cells: A Promising Armament for Immunotherapy in Human Malignancies

Qing Yi and Larry W. Kwak
Clin Cancer Res 2005 11: 966-967. [Full Text] [PDF]  

The Biology Behind:

Profiling Tumor Counterattack: Do Fas Ligand–Containing Microvesicles Reduce Anticancer Immunity?

Osnat Bohana-Kashtan and Curt I. Civin
Clin Cancer Res 2005 11: 968-970. [Full Text] [PDF]  

Review:

50 Years of Preclinical Anticancer Drug Screening: Empirical to Target-Driven Approaches

Marie Suggitt and Michael C. Bibby
Clin Cancer Res 2005 11: 971-981. [Abstract] [Full Text] [PDF]  

Report from the Food and Drug Administration:

Pemetrexed in Malignant Pleural Mesothelioma

Maitreyee Hazarika, Robert M. White, Jr., Brian P. Booth, Yong-Cheng Wang, Doo Y. Lee Ham, Cheng Yi Liang, Atiqur Rahman, Jogarao V.S. Gobburu, Ning Li, Rajeshwari Sridhara, David E. Morse, Richard Lostritto, Patricia Garvey, John R. Johnson, and Richard Pazdur
Clin Cancer Res 2005 11: 982-992. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Expression of Erythropoietin and Erythropoietin Receptor in Non–Small Cell Lung Carcinomas

Koami Dagnon, Emilie Pacary, Frédéric Commo, Martine Antoine, Myriam Bernaudin, Jean-Francois Bernaudin, and Patrice Callard
Clin Cancer Res 2005 11: 993-999. [Abstract] [Full Text] [PDF]  

Aberrant Expression and Potency as a Cancer Immunotherapy Target of Inhibitor of Apoptosis Protein Family, Livin/ML-IAP in Lung Cancer

Hiroyuki Hariu, Yoshihiko Hirohashi, Toshihiko Torigoe, Hiroko Asanuma, Midori Hariu, Yasuaki Tamura, Katsuyuki Aketa, Chika Nabeta, Katsuya Nakanishi, Kenjiro Kamiguchi, Yoshinori Mano, Hiroshi Kitamura, Junichi Kobayashi, Tomohide Tsukahara, Noriharu Shijubo, and Noriyuki Sato
Clin Cancer Res 2005 11: 1000-1009. [Abstract] [Full Text] [PDF]  

Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Jeong Whun Kim, Eva Wieckowski, Douglas D. Taylor, Torsten E. Reichert, Simon Watkins, and Theresa L. Whiteside
Clin Cancer Res 2005 11: 1010-1020. [Abstract] [Full Text] [PDF]  

Aberrant Methylation and Silencing of the BNIP3 Gene in Colorectal and Gastric Cancer

Masafumi Murai, Minoru Toyota, Hiromu Suzuki, Ayumi Satoh, Yasushi Sasaki, Kimishige Akino, Masako Ueno, Fumihiko Takahashi, Masanobu Kusano, Hiroaki Mita, Kazuyoshi Yanagihara, Takao Endo, Yuji Hinoda, Takashi Tokino, and Kohzoh Imai
Clin Cancer Res 2005 11: 1021-1027. [Abstract] [Full Text] [PDF]  

Increased Heparanase Expression Is Caused by Promoter Hypomethylation and Up-Regulation of Transcriptional Factor Early Growth Response-1 in Human Prostate Cancer

Tatsuya Ogishima, Hiroaki Shiina, Julia E. Breault, Laura Tabatabai, William W. Bassett, Hideki Enokida, Long-Cheng Li, Toshifumi Kawakami, Shinji Urakami, Leopoldo A. Ribeiro-Filho, Masaharu Terashima, Makoto Fujime, Mikio Igawa, and Rajvir Dahiya
Clin Cancer Res 2005 11: 1028-1036. [Abstract] [Full Text] [PDF]  

Patterns of Cyclin E, Retinoblastoma Protein, and p21^Cip1/WAF1 Immunostaining in the Oncogenesis of Papillary Thyroid Carcinoma

Jan Brzezinski, Adam Migodzinski, Aleksandra Toczek, Józef Tazbir, and Marek Dedecjus
Clin Cancer Res 2005 11: 1037-1043. [Abstract] [Full Text] [PDF]  

Expression of 11 HOX Genes Is Deregulated in Esophageal Squamous Cell Carcinoma

Ke-Neng Chen, Zhen-Dong Gu, Yang Ke, Ji-You Li, Xiao-Tian Shi, and Guang-Wei Xu
Clin Cancer Res 2005 11: 1044-1049. [Abstract] [Full Text] [PDF]  

Macrophage Migration Inhibitory Factor Promotes Tumor Invasion and Metastasis via the Rho-Dependent Pathway

Bailong Sun, Jun Nishihira, Takashi Yoshiki, Masao Kondo, Yuji Sato, Fumiaki Sasaki, and Satoru Todo
Clin Cancer Res 2005 11: 1050-1058. [Abstract] [Full Text] [PDF]  

Coexpression of Erythropoietin and Erythropoietin Receptor in Von Hippel-Lindau Disease–Associated Renal Cysts and Renal Cell Carcinoma

Youn-Soo Lee, Alexander O. Vortmeyer, Irina A. Lubensky, Timothy W.A. Vogel, Barbara Ikejiri, Sophie Ferlicot, Gérard Benoît, Sophie Giraud, Edward H. Oldfield, W. Marston Linehan, Bin T. Teh, Stéphane Richard, and Zhengping Zhuang
Clin Cancer Res 2005 11: 1059-1064. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Expression of the FOXP1 Transcription Factor Is Strongly Associated with Inferior Survival in Patients with Diffuse Large B-Cell Lymphoma

Alison H. Banham, Joseph M. Connors, Philip J. Brown, Jacqueline L. Cordell, German Ott, Gayatri Sreenivasan, Pedro Farinha, Douglas E. Horsman, and Randy D. Gascoyne
Clin Cancer Res 2005 11: 1065-1072. [Abstract] [Full Text] [PDF]  

Serum Levels of an Isoform of Apolipoprotein A-II as a Potential Marker for Prostate Cancer

Gunjan Malik, Michael D. Ward, Saurabh K. Gupta, Michael W. Trosset, William E. Grizzle, Bao-Ling Adam, Jose I. Diaz, and O. John Semmes
Clin Cancer Res 2005 11: 1073-1085. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-12 Expression Correlates with Local Recurrence and Metastatic Disease in Non–Small Cell Lung Cancer Patients

Hans-Stefan Hofmann, Gesine Hansen, Günther Richter, Christiane Taege, Andreas Simm, Rolf-Edgar Silber, and Stefan Burdach
Clin Cancer Res 2005 11: 1086-1092. [Abstract] [Full Text] [PDF]  

Polymorphisms in ER- Gene Interact with Estrogen Receptor Status in Breast Cancer Survival

Sonia M. Boyapati, Xiao Ou Shu, Zhi Xian Ruan, Qiuyin Cai, Jeffrey R. Smith, Wanqing Wen, Yu-Tang Gao, and Wei Zheng
Clin Cancer Res 2005 11: 1093-1098. [Abstract] [Full Text] [PDF]  

Molecular Staging of Lymph Nodes from Patients with Esophageal Adenocarcinoma

Liqiang Xi, James D. Luketich, Siva Raja, William E. Gooding, Virginia R. Litle, Michael C. Coello, Sydney D. Finkelstein, Melissa L. Chestney, Rodney J. Landreneau, Steven J. Hughes, and Tony E. Godfrey
Clin Cancer Res 2005 11: 1099-1109. [Abstract] [Full Text] [PDF]  

Plasma Protein Profiling for Diagnosis of Pancreatic Cancer Reveals the Presence of Host Response Proteins

John M. Koomen, Lichen Nancy Shih, Kevin R. Coombes, Donghui Li, Lian-chun Xiao, Isaiah J. Fidler, James L. Abbruzzese, and Ryuji Kobayashi
Clin Cancer Res 2005 11: 1110-1118. [Abstract] [Full Text] [PDF] Supplementary Data  

Allelic Losses at 1p36 and 19q13 in Gliomas: Correlation with Histologic Classification, Definition of a 150-kb Minimal Deleted Region on 1p36, and Evaluation of CAMTA1 as a Candidate Tumor Suppressor Gene

Violetta Barbashina, Paulo Salazar, Eric C. Holland, Marc K. Rosenblum, and Marc Ladanyi
Clin Cancer Res 2005 11: 1119-1128. [Abstract] [Full Text] [PDF]  

The Expression of Hypoxia-Inducible Factor 1 Is a Favorable Independent Prognostic Factor in Renal Cell Carcinoma

Anders Lidgren, Ylva Hedberg, Kjell Grankvist, Torgny Rasmuson, Janos Vasko, and Börje Ljungberg
Clin Cancer Res 2005 11: 1129-1135. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of New and Highly Potent Analogues of Octreotide for Predictive Imaging and Targeted Radiotherapy

Mihaela Ginj, Jianhua Chen, Martin A. Walter, Veronique Eltschinger, Jean Claude Reubi, and Helmut R. Maecke
Clin Cancer Res 2005 11: 1136-1145. [Abstract] [Full Text] [PDF]  

A Predictor Based on the Somatic Genomic Changes of the BRCA1/BRCA2 Breast Cancer Tumors Identifies the Non-BRCA1/BRCA2 Tumors with BRCA1 Promoter Hypermethylation

Sara Alvarez, Ramon Diaz-Uriarte, Ana Osorio, Alicia Barroso, Lorenzo Melchor, Maria Fe Paz, Emiliano Honrado, Raquel Rodríguez, Miguel Urioste, Laura Valle, Orland Díez, Juan Cruz Cigudosa, Joaquin Dopazo, Manel Esteller, and Javier Benitez
Clin Cancer Res 2005 11: 1146-1153. [Abstract] [Full Text] [PDF]  

Prevalence of CD44⁺/CD24^–/low Cells in Breast Cancer May Not Be Associated with Clinical Outcome but May Favor Distant Metastasis

Benny K. Abraham, Peter Fritz, Monika McClellan, Petra Hauptvogel, Maria Athelogou, and Hiltrud Brauch
Clin Cancer Res 2005 11: 1154-1159. [Abstract] [Full Text] [PDF]  

Cyclin D1 Is a Valuable Prognostic Marker in Oropharyngeal Squamous Cell Carcinoma

Ziwei Yu, Paul M. Weinberger, Bruce G. Haffty, Clarence Sasaki, Cynthia Zerillo, John Joe, Diane Kowalski, James Dziura, Robert L. Camp, David L. Rimm, and Amanda Psyrri
Clin Cancer Res 2005 11: 1160-1166. [Abstract] [Full Text] [PDF]  

The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers

Masaki Tokumo, Shinichi Toyooka, Katsuyuki Kiura, Hisayuki Shigematsu, Kunitoshi Tomii, Motoi Aoe, Kouichi Ichimura, Toshihide Tsuda, Masaaki Yano, Kazunori Tsukuda, Masahiro Tabata, Hiroshi Ueoka, Mitsune Tanimoto, Hiroshi Date, Adi F. Gazdar, and Nobuyoshi Shimizu
Clin Cancer Res 2005 11: 1167-1173. [Abstract] [Full Text] [PDF]  

Slug Expression in the E-cadherin Preserved Tumors Is Related to Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Yasuto Uchikado, Shoji Natsugoe, Hiroshi Okumura, Tetsuro Setoyama, Masataka Matsumoto, Sumiya Ishigami, and Takashi Aikou
Clin Cancer Res 2005 11: 1174-1180. [Abstract] [Full Text] [PDF]  

Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Michael E. Burczynski, Natalie C. Twine, Gary Dukart, Bonnie Marshall, Manuel Hidalgo, Walter M. Stadler, Theodore Logan, Janice Dutcher, Gary Hudes, William L. Trepicchio, Andrew Strahs, Fred Immermann, Donna K. Slonim, and Andrew J. Dorner
Clin Cancer Res 2005 11: 1181-1189. [Abstract] [Full Text] [PDF] Supplementary Data  

The L1 Cell Adhesion Molecule Is Induced in Renal Cancer Cells and Correlates with Metastasis in Clear Cell Carcinomas

Yves Allory, Yasuko Matsuoka, Céline Bazille, Erik Ilsø Christensen, Pierre Ronco, and Hanna Debiec
Clin Cancer Res 2005 11: 1190-1197. [Abstract] [Full Text] [PDF]  

Expression of MDA-7/IL-24 and Its Clinical Significance in Resected Non–Small Cell Lung Cancer

Shinya Ishikawa, Tatsuo Nakagawa, Ryo Miyahara, Yozo Kawano, Kazumasa Takenaka, Kazuhiro Yanagihara, Yosuke Otake, Hiromichi Katakura, Hiromi Wada, and Fumihiro Tanaka
Clin Cancer Res 2005 11: 1198-1202. [Abstract] [Full Text] [PDF]  

Aberrantly Methylated CDKN2A, MGMT, and MLH1 in Colon Polyps and in Fecal DNA from Patients with Colorectal Polyps

Zsolt Petko, Mahan Ghiassi, Anthony Shuber, Janice Gorham, Walter Smalley, M. Kay Washington, Stephen Schultenover, Shiva Gautam, Sanford D. Markowitz, and William M. Grady
Clin Cancer Res 2005 11: 1203-1209. [Abstract] [Full Text] [PDF]  

Early Lymphocyte Recovery Predicts Superior Survival after Autologous Hematopoietic Stem Cell Transplantation for Patients with Primary Systemic Amyloidosis

Luis F. Porrata, Morie A. Gertz, Mark R. Litzow, Martha Q. Lacy, Angela Dispenzieri, David J. Inwards, Stephen M. Ansell, Ivanna N.M. Micallef, Dennis A. Gastineau, Michele Elliott, William J. Hogan, Suzanne R. Hayman, Ayalew Tefferi, and Svetomir N. Markovic
Clin Cancer Res 2005 11: 1210-1218. [Abstract] [Full Text] [PDF]  

Identification of Epigenetic Aberrant Promoter Methylation in Serum DNA Is Useful for Early Detection of Lung Cancer

Keiichi Fujiwara, Nobukazu Fujimoto, Masahiro Tabata, Kenji Nishii, Keitaro Matsuo, Katsuyuki Hotta, Toshiyuki Kozuki, Motoi Aoe, Katsuyuki Kiura, Hiroshi Ueoka, and Mitsune Tanimoto
Clin Cancer Res 2005 11: 1219-1225. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

UGT1A7 and UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with Capecitabine/Irinotecan

Leslie E. Carlini, Neal J. Meropol, John Bever, Michael L. Andria, Todd Hill, Philip Gold, Andre Rogatko, Hao Wang, and Rebecca L. Blanchard
Clin Cancer Res 2005 11: 1226-1236. [Abstract] [Full Text] [PDF]  

Impact of Gene Polymorphisms on Clinical Outcome for Stage IV Melanoma Patients Treated with Biochemotherapy: An Exploratory Study

Dongxin Liu, Steven J. O'Day, Dongyun Yang, Peter Boasberg, Robert Milford, Tim Kristedja, Susan Groshen, and Jeffrey Weber
Clin Cancer Res 2005 11: 1237-1246. [Abstract] [Full Text] [PDF]  

A Phase I Trial and Pharmacokinetic Study of Tipifarnib, a Farnesyltransferase Inhibitor, and Tamoxifen in Metastatic Breast Cancer

Peter F. Lebowitz, Jennifer Eng-Wong, Brigitte C. Widemann, Frank M. Balis, Nalini Jayaprakash, Catherine Chow, Geoff Clark, Susan B. Gantz, David Venzon, and JoAnne Zujewski
Clin Cancer Res 2005 11: 1247-1252. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Different Effect of Paclitaxel on Primary Tumor Mass, Tumor Cell Contents, and Metastases for Four Experimental Human Prostate Tumors Expressing Luciferase

Nadia El Hilali, Nuria Rubio, and Jerónimo Blanco
Clin Cancer Res 2005 11: 1253-1258. [Abstract] [Full Text] [PDF]  

Therapy of Hematogenous Melanoma Brain Metastases with Endostatin

Matthias Kirsch, Patrick Weigel, Thomas Pinzer, Rona S. Carroll, Peter McL. Black, Hans-Konrad Schackert, and Gabriele Schackert
Clin Cancer Res 2005 11: 1259-1267. [Abstract] [Full Text] [PDF]  

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor

Concetta Tuccillo, Marco Romano, Teresa Troiani, Erika Martinelli, Floriana Morgillo, Ferdinando De Vita, Roberto Bianco, Gabriella Fontanini, Raffaele A. Bianco, Giampaolo Tortora, and Fortunato Ciardiello
Clin Cancer Res 2005 11: 1268-1276. [Abstract] [Full Text] [PDF]  

Combination of IFN- and 5-Fluorouracil Induces Apoptosis through IFN-/ß Receptor in Human Hepatocellular Carcinoma Cells

Motoi Kondo, Hiroaki Nagano, Hiroshi Wada, Bazarragchaa Damdinsuren, Hirofumi Yamamoto, Nobuaki Hiraoka, Hidetoshi Eguchi, Atsushi Miyamoto, Tameyoshi Yamamoto, Hideo Ota, Masato Nakamura, Shigeru Marubashi, Keizo Dono, Koji Umeshita, Shoji Nakamori, Masato Sakon, and Morito Monden
Clin Cancer Res 2005 11: 1277-1286. [Abstract] [Full Text] [PDF]  

Targeting of Nuclear Factor B Pathways by Dehydroxymethylepoxyquinomicin, a Novel Inhibitor of Breast Carcinomas: Antitumor and Antiangiogenic Potential In vivo

Gaku Matsumoto, Jun-ichi Namekawa, Mariko Muta, Tadahiko Nakamura, Hiroko Bando, Kazumi Tohyama, Masakazu Toi, and Kazuo Umezawa
Clin Cancer Res 2005 11: 1287-1293. [Abstract] [Full Text] [PDF]  

Loss of Reduced Folate Carrier Function and Folate Depletion Result in Enhanced Pemetrexed Inhibition of Purine Synthesis

Rongbao Zhao, Shubing Zhang, Marie Hanscom, Shrikanta Chattopadhyay, and I. David Goldman
Clin Cancer Res 2005 11: 1294-1301. [Abstract] [Full Text] [PDF]  

Potentiation of a Dendritic Cell Vaccine for Murine Renal Cell Carcinoma by CpG Oligonucleotides

Fanny Chagnon, Simon Tanguay, Ozdem Levent Ozdal, Meng Guan, Zeynep Z. Ozen, Jean-Sébastien Ripeau, Mario Chevrette, Mostafa M. Elhilali, and Lu Ann Thompson-Snipes
Clin Cancer Res 2005 11: 1302-1311. [Abstract] [Full Text] [PDF]  

Human Monocyte-Derived Dendritic Cells Pulsed with Wild-Type p53 Protein Efficiently Induce CTLs against p53 Overexpressing Human Cancer Cells

Naoyuki Tokunaga, Takayoshi Murakami, Yoshikatsu Endo, Masahiko Nishizaki, Shunsuke Kagawa, Noriaki Tanaka, and Toshiyoshi Fujiwara
Clin Cancer Res 2005 11: 1312-1318. [Abstract] [Full Text] [PDF]  

Transcriptional Profiling Identifies Gene Expression Changes Associated with IFN- Tolerance in Hepatitis C–Related Hepatocellular Carcinoma Cells

Nathalie Wong, Kathy Y-Y. Chan, Pascale F. Macgregor, Paul B-S. Lai, Jeremy A. Squire, Ben Beheshti, Monique Albert, and Thomas W-T. Leung
Clin Cancer Res 2005 11: 1319-1326. [Abstract] [Full Text] [PDF]  

A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Daniel T. Rein, Martina Breidenbach, Tyler O. Kirby, Tie Han, Gene P. Siegal, Gerd J. Bauerschmitz, Minghui Wang, Dirk M. Nettelbeck, Yuko Tsuruta, Masato Yamamoto, Peter Dall, Akseli Hemminki, and David T. Curiel
Clin Cancer Res 2005 11: 1327-1335. [Abstract] [Full Text] [PDF]  

Dual Inhibition of RET and FGFR4 Restrains Medullary Thyroid Cancer Cell Growth

Shereen Ezzat, Ping Huang, Alan Dackiw, and Sylvia L. Asa
Clin Cancer Res 2005 11: 1336-1341. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Recombinant Adeno-Associated Virus 2-Mediated Antiangiogenic Prevention in a Mouse Model of Intraperitoneal Ovarian Cancer

Tatyana Isayeva, Changchun Ren, and Selvarangan Ponnazhagan
Clin Cancer Res 2005 11: 1342-1347. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Linkage Disequilibrium across the UGT1A Locus Should Not Be Ignored in Association Studies of Cancer Susceptibility

Wanqing Liu, Federico Innocenti, Mark J. Ratain, Naoya Kato, Yue Wang, and Masao Omata
Clin Cancer Res 2005 11: 1348-1349. [Full Text] [PDF]  

Cyclooxygenase Inhibitor Ketorolac or Mast Cell Stabilizers: Immunologic Challenges in Cancer Therapy

Mahin Khatami and James Mulshine
Clin Cancer Res 2005 11: 1350-1352. [Full Text] [PDF]  

Corrections:

Correction: Article on Prognostic Significance of Metastasis-Associated Protein SlOOA4 in Prostate Cancer

Clin Cancer Res 2005 11: 1353. [Full Text] [PDF]  

Correction: Article on Overexpression of h-prune in Breast Cancer

Clin Cancer Res 2005 11: 1353. [Full Text] [PDF]  

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