Editorials:

A Randomized, Double-Blinded, Placebo-Controlled Phase II Trial of Recombinant Human Leukemia Inhibitory Factor (rhuLIF, emfilermin, AM424) to Prevent Chemotherapy-Induced Peripheral Neuropathy

Patrick Y. Wen
Clin Cancer Res 2005 11: 1685-1686. [Full Text] [PDF]  

The Biology Behind:

AKR1B10: A New Diagnostic Marker of Non–Small Cell Lung Carcinoma in Smokers

Trevor M. Penning
Clin Cancer Res 2005 11: 1687-1690. [Full Text] [PDF]  

Prevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor

Martin J. van den Bent
Clin Cancer Res 2005 11: 1691-1693. [Full Text] [PDF]  

Human Cancer Biology:

Identification of a 40S Ribosomal Protein S4–Derived H-Y Epitope Able to Elicit a Lymphoblast-Specific Cytotoxic T Lymphocyte Response

Roman Ivanov, Tineke Aarts, Samantha Hol, Angeline Doornenbal, Anton Hagenbeek, Eefke Petersen, and Saskia Ebeling
Clin Cancer Res 2005 11: 1694-1703. [Abstract] [Full Text] [PDF]  

Heregulin-Induced Activation of HER2 and HER3 Increases Androgen Receptor Transactivation and CWR-R1 Human Recurrent Prostate Cancer Cell Growth

Christopher W. Gregory, Young E. Whang, Wesley McCall, Xiaoyin Fei, Yuanbo Liu, Liliana A. Ponguta, Frank S. French, Elizabeth M. Wilson, and H. Shelton Earp, III
Clin Cancer Res 2005 11: 1704-1712. [Abstract] [Full Text] [PDF]  

An Orthotopic Model of Anaplastic Thyroid Carcinoma in Athymic Nude Mice

Seungwon Kim, Young-Wook Park, Bradley A. Schiff, Dao D. Doan, Yasemin Yazici, Samar A. Jasser, Maher Younes, Mahitosh Mandal, Benjamin N. Bekele, and Jeffrey N. Myers
Clin Cancer Res 2005 11: 1713-1721. [Abstract] [Full Text] [PDF]  

2-Methoxyestradiol Is an Estrogen Receptor Agonist That Supports Tumor Growth in Murine Xenograft Models of Breast Cancer

Tara E. Sutherland, Michael Schuliga, Trudi Harris, Bedrich L. Eckhardt, Robin L. Anderson, Lilly Quan, and Alastair G. Stewart
Clin Cancer Res 2005 11: 1722-1732. [Abstract] [Full Text] [PDF]  

Influence of CD80, Interleukin-2, and Interleukin-7 Expression in Human Renal Cell Carcinoma on the Expansion, Function, and Survival of Tumor-Specific CTLs

Bernhard Frankenberger, Heike Pohla, Elfriede Noessner, Gerald Willimsky, Britta Papier, Antonio Pezzutto, Joachim Kopp, Ralph Oberneder, Thomas Blankenstein, and Dolores J. Schendel
Clin Cancer Res 2005 11: 1733-1742. [Abstract] [Full Text] [PDF]  

Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer

Carl C. Schimanski, Stefan Schwald, Nektaria Simiantonaki, Caren Jayasinghe, Ursula Gönner, Vanessa Wilsberg, Theodor Junginger, Martin R. Berger, Peter R. Galle, and Markus Moehler
Clin Cancer Res 2005 11: 1743-1750. [Abstract] [Full Text] [PDF]  

Up-Regulation of the Peripheral Benzodiazepine Receptor during Human Colorectal Carcinogenesis and Tumor Spread

Kerstin Maaser, Patricia Grabowski, Yelda Oezdem, Antje Krahn, Bernhard Heine, Harald Stein, Heinz Buhr, Martin Zeitz, and Hans Scherübl
Clin Cancer Res 2005 11: 1751-1756. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Elevated Serum Cytokines Correlated with Altered Behavior, Serum Cortisol Rhythm, and Dampened 24-Hour Rest-Activity Patterns in Patients with Metastatic Colorectal Cancer

Tyvin Rich, Pasquale F. Innominato, Julie Boerner, M. Christine Mormont, Stefano Iacobelli, Benoit Baron, Claude Jasmin, and Francis Lévi
Clin Cancer Res 2005 11: 1757-1764. [Abstract] [Full Text] [PDF]  

Allelotypes and Fluorescence In situ Hybridization Profiles of Poorly Differentiated Endocrine Carcinomas of Different Sites

Daniela Furlan, Barbara Bernasconi, Silvia Uccella, Roberta Cerutti, Ileana Carnevali, and Carlo Capella
Clin Cancer Res 2005 11: 1765-1775. [Abstract] [Full Text] [PDF]  

Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas

Shin-ichi Fukumoto, Naoko Yamauchi, Hisashi Moriguchi, Yoshitaka Hippo, Akira Watanabe, Junji Shibahara, Hirokazu Taniguchi, Shumpei Ishikawa, Hirotaka Ito, Shogo Yamamoto, Hiroko Iwanari, Mitsugu Hironaka, Yuichi Ishikawa, Toshiro Niki, Yasunori Sohara, Tatsuhiko Kodama, Masaharu Nishimura, Masashi Fukayama, Hirotoshi Dosaka-Akita, and Hiroyuki Aburatani
Clin Cancer Res 2005 11: 1776-1785. [Abstract] [Full Text] [PDF]  

Prognostic Validation of the International Classification of Immunoglobulin M Gammopathies: A Survival Advantage for Patients with Immunoglobulin M Monoclonal Gammopathy of Undetermined Significance?

Paolo G. Gobbi, Luca Baldini, Chiara Broglia, Maria Goldaniga, Mario Comelli, Pierre Morel, Enrica Morra, Sergio Cortelazzo, Roberto Bettini, and Giampaolo Merlini
Clin Cancer Res 2005 11: 1786-1790. [Abstract] [Full Text] [PDF]  

Fractional Genomic Alteration Detected by Array-Based Comparative Genomic Hybridization Independently Predicts Survival after Hepatic Resection for Metastatic Colorectal Cancer

Kshama R. Mehta, Kentaro Nakao, Marlene B. Zuraek, Daniel T. Ruan, Emily K. Bergsland, Alan P. Venook, Dan H. Moore, Taku A. Tokuyasu, Ajay N. Jain, Robert S. Warren, Jonathan P. Terdiman, and Frederic M. Waldman
Clin Cancer Res 2005 11: 1791-1797. [Abstract] [Full Text] [PDF]  

Neutral Endopeptidase 24.11/CD10 Suppresses Progressive Potential in Ovarian Carcinoma In vitro and In vivo

Hiroaki Kajiyama, Kiyosumi Shibata, Mikio Terauchi, Takanori Morita, Kazuhiko Ino, Shigehiko Mizutani, and Fumitaka Kikkawa
Clin Cancer Res 2005 11: 1798-1808. [Abstract] [Full Text] [PDF]  

Expression Profile of Cancer-Testis Genes in 121 Human Colorectal Cancer Tissue and Adjacent Normal Tissue

Ming Li, Yan-Hua Yuan, Yan Han, Yue-Xiang Liu, Li Yan, Yu Wang, and Jin Gu
Clin Cancer Res 2005 11: 1809-1814. [Abstract] [Full Text] [PDF]  

The Prognostic Significance of Plasma Interleukin-6 Levels in Patients with Metastatic Hormone-Refractory Prostate Cancer: Results from Cancer and Leukemia Group B 9480

Daniel J. George, Susan Halabi, Timothy F. Shepard, Ben Sanford, Nicholas J. Vogelzang, Eric J. Small, and Philip W. Kantoff
Clin Cancer Res 2005 11: 1815-1820. [Abstract] [Full Text] [PDF]  

Heterogeneous Patterns of CEBP Mutation Status in the Progression of Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia to Acute Myelogenous Leukemia

Lee-Yung Shih, Chein-Fuang Huang, Tung-Liang Lin, Jin-Hou Wu, Po-Nan Wang, Po Dunn, Ming-Chung Kuo, and Tzung-Chih Tang
Clin Cancer Res 2005 11: 1821-1826. [Abstract] [Full Text] [PDF]  

The Clinical Significance of Aurora-A/STK15/BTAK Expression in Human Esophageal Squamous Cell Carcinoma

Eiji Tanaka, Yosuke Hashimoto, Tetsuo Ito, Tomoyuki Okumura, Takatsugu Kan, Go Watanabe, Masayuki Imamura, Johji Inazawa, and Yutaka Shimada
Clin Cancer Res 2005 11: 1827-1834. [Abstract] [Full Text] [PDF]  

Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant Melanoma

Stefania Scala, Alessandro Ottaiano, Paolo Antonio Ascierto, Manuela Cavalli, Ester Simeone, Paola Giuliano, Maria Napolitano, Renato Franco, Gerardo Botti, and Giuseppe Castello
Clin Cancer Res 2005 11: 1835-1841. [Abstract] [Full Text] [PDF]  

B7-H4 Is Highly Expressed in Ductal and Lobular Breast Cancer

Barbara Tringler, Shaoqiu Zhuo, Glenn Pilkington, Kathleen C. Torkko, Meenakshi Singh, M. Scott Lucia, David E. Heinz, Jackie Papkoff, and Kenneth R. Shroyer
Clin Cancer Res 2005 11: 1842-1848. [Abstract] [Full Text] [PDF]  

NBS1 Expression as a Prognostic Marker in Uveal Melanoma

Justis P. Ehlers and J. William Harbour
Clin Cancer Res 2005 11: 1849-1853. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Clinical and Pharmacokinetic Study of Kahalalide F in Patients with Advanced Androgen Refractory Prostate Cancer

Jeany M. Rademaker-Lakhai, Simon Horenblas, Willem Meinhardt, Ellen Stokvis, Theo M. de Reijke, José M. Jimeno, Luis Lopez-Lazaro, José A. Lopez Martin, Jos H. Beijnen, and Jan H.M. Schellens
Clin Cancer Res 2005 11: 1854-1862. [Abstract] [Full Text] [PDF]  

Induction of p53 Up-Regulated Modulator of Apoptosis Messenger RNA by Chemotherapeutic Treatment of Locally Advanced Breast Cancer

Rutger Middelburg, Richard R. de Haas, Henk Dekker, Ron M. Kerkhoven, Paula R. Pohlmann, Adolfo Fuentes-Alburo, Alejandro Mohar, Herbert M. Pinedo, and Jan Lankelma
Clin Cancer Res 2005 11: 1863-1869. [Abstract] [Full Text] [PDF]  

Phase II Evaluation of Docetaxel-Modulated Capecitabine in Previously Treated Patients with Non–Small Cell Lung Cancer

Tamila Kindwall-Keller, Gregory A. Otterson, Donn Young, Anterpreet Neki, Tamara Criswell, Gerard Nuovo, Richie Soong, Robert Diasio, and Miguel A. Villalona-Calero
Clin Cancer Res 2005 11: 1870-1876. [Abstract] [Full Text] [PDF]  

A Phase I Trial of the Novel Farnesyl Protein Transferase Inhibitor, BMS-214662, in Combination with Paclitaxel and Carboplatin in Patients with Advanced Cancer

Grace K. Dy, Laura M. Bruzek, Gary A. Croghan, Sumithra Mandrekar, Charles Erlichman, Prema Peethambaram, Henry C. Pitot, Lorelei J. Hanson, Joel M. Reid, Alfred Furth, Shinta Cheng, Robert E. Martell, Scott H. Kaufmann, and Alex A. Adjei
Clin Cancer Res 2005 11: 1877-1883. [Abstract] [Full Text] [PDF]  

Phase I Trial and Pharmacokinetic Study of Raltitrexed in Children with Recurrent or Refractory Leukemia: A Pediatric Oncology Group Study

Terzah M. Horton, Susan M. Blaney, Anne-Marie Langevin, John Kuhn, Barton Kamen, Stacey L. Berg, Mark Bernstein, and Steven Weitman
Clin Cancer Res 2005 11: 1884-1889. [Abstract] [Full Text] [PDF]  

A Randomized, Double-Blinded, Placebo-Controlled Phase II Trial of Recombinant Human Leukemia Inhibitory Factor (rhuLIF, Emfilermin, AM424) to Prevent Chemotherapy-Induced Peripheral Neuropathy

Ian D. Davis, Lynette Kiers, Lachlan MacGregor, Michael Quinn, Joseph Arezzo, Michael Green, Mark Rosenthal, Michael Chia, Michael Michael, Peter Bartley, Leonie Harrison, and Michael Daly
Clin Cancer Res 2005 11: 1890-1898. [Abstract] [Full Text] [PDF]  

Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor

Carla M.L. van Herpen, Jeroen A.W.M. van der Laak, I. Jolanda M. de Vries, Johan H. van Krieken, Peter C. de Wilde, Michiel G.J. Balvers, Gosse J. Adema, and Pieter H.M. De Mulder
Clin Cancer Res 2005 11: 1899-1909. [Abstract] [Full Text] [PDF]  

A Phase I Study of -Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

Aki Ishikawa, Shinichiro Motohashi, Eiichi Ishikawa, Hiroki Fuchida, Kazuko Higashino, Mizuto Otsuji, Toshihiko Iizasa, Toshinori Nakayama, Masaru Taniguchi, and Takehiko Fujisawa
Clin Cancer Res 2005 11: 1910-1917. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems

Manjeshwar S. Baliga, Sreelatha Meleth, and Santosh K. Katiyar
Clin Cancer Res 2005 11: 1918-1927. [Abstract] [Full Text] [PDF]  

Effects of Imatinib on Monocyte-Derived Dendritic Cells Are Mediated by Inhibition of Nuclear Factor-B and Akt Signaling Pathways

Silke Appel, Anette Rupf, Markus M. Weck, Oliver Schoor, Tim H. Brümmendorf, Toni Weinschenk, Frank Grünebach, and Peter Brossart
Clin Cancer Res 2005 11: 1928-1940. [Abstract] [Full Text] [PDF]  

Cure of Mammary Carcinomas in Her-2 Transgenic Mice through Sequential Stimulation of Innate (Neoadjuvant Interleukin-12) and Adaptive (DNA Vaccine Electroporation) Immunity

Michela Spadaro, Elena Ambrosino, Manuela Iezzi, Emma Di Carlo, Pamela Sacchetti, Claudia Curcio, Augusto Amici, Wei-Zen Wei, Piero Musiani, Pier-Luigi Lollini, Federica Cavallo, and Guido Forni
Clin Cancer Res 2005 11: 1941-1952. [Abstract] [Full Text] [PDF]  

Triterpenoid Electrophiles (Avicins) Suppress Heat Shock Protein-70 and X-Linked Inhibitor of Apoptosis Proteins in Malignant Cells by Activation of Ubiquitin Machinery: Implications for Proapoptotic Activity

Amos Gaikwad, Ann Poblenz, Valsala Haridas, Chunlei Zhang, Madeleine Duvic, and Jordan Gutterman
Clin Cancer Res 2005 11: 1953-1962. [Abstract] [Full Text] [PDF]  

AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice

Young Wook Park, Maher N. Younes, Samar A. Jasser, Orhan G. Yigitbasi, Ge Zhou, Corazon D. Bucana, Benjamin N. Bekele, and Jeffrey N. Myers
Clin Cancer Res 2005 11: 1963-1973. [Abstract] [Full Text] [PDF]  

Growth Inhibition of Multiple Myeloma Cells by a Novel IB Kinase Inhibitor

Takaomi Sanda, Shinsuke Iida, Hiroka Ogura, Kaori Asamitsu, Toshiki Murata, Kevin B. Bacon, Ryuzo Ueda, and Takashi Okamoto
Clin Cancer Res 2005 11: 1974-1982. [Abstract] [Full Text] [PDF]  

Pulsatile Administration of the Epidermal Growth Factor Receptor Inhibitor Gefitinib Is Significantly More Effective than Continuous Dosing for Sensitizing Tumors to Paclitaxel

David B. Solit, Yuhong She, Jose Lobo, Mark G. Kris, Howard I. Scher, Neal Rosen, and Frank M. Sirotnak
Clin Cancer Res 2005 11: 1983-1989. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of bcl-2 and c-myc Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence

Gabriella Zupi, Marco Scarsella, Sean C. Semple, Marcella Mottolese, Pier G. Natali, and Carlo Leonetti
Clin Cancer Res 2005 11: 1990-1998. [Abstract] [Full Text] [PDF]  

Celecoxib Inhibits Prostate Cancer Growth: Evidence of a Cyclooxygenase-2-Independent Mechanism

Manish I. Patel, Kotha Subbaramaiah, Baoheng Du, Mindy Chang, Peiying Yang, Robert A. Newman, Carlos Cordon-Cardo, Howard T. Thaler, and Andrew J. Dannenberg
Clin Cancer Res 2005 11: 1999-2007. [Abstract] [Full Text] [PDF]  

Herceptin Down-Regulates HER-2/neu and Vascular Endothelial Growth Factor Expression and Enhances Taxol-Induced Cytotoxicity of Human Ewing's Sarcoma Cells In vitro and In vivo

Hui Guan, Shu-Fang Jia, Zhichao Zhou, John Stewart, and Eugenie S. Kleinerman
Clin Cancer Res 2005 11: 2008-2017. [Abstract] [Full Text] [PDF]  

Effect of Polyethylene Glycol Linker Chain Length of Folate-Linked Microemulsions Loading Aclacinomycin A on Targeting Ability and Antitumor Effect In vitro and In vivo

Tomonori Shiokawa, Yoshiyuki Hattori, Kumi Kawano, Yukino Ohguchi, Hiroko Kawakami, Kazunori Toma, and Yoshie Maitani
Clin Cancer Res 2005 11: 2018-2025. [Abstract] [Full Text] [PDF]  

Farnesyltransferase Inhibitors and Human Malignant Pleural Mesothelioma: A First-Step Comparative Translational Study

Alfredo Cesario, Alessia Catassi, Luigi Festi, Andrea Imperatori, Andrea Pericelli, Domenico Galetta, Stefano Margaritora, Venanzio Porziella, Vittorio Cardaci, Pierluigi Granone, Lorenzo Dominioni, and Patrizia Russo
Clin Cancer Res 2005 11: 2026-2037. [Abstract] [Full Text] [PDF]  

Flavopiridol Blocks Integrin-Mediated Survival in Dormant Breast Cancer Cells

Saltanat Najmi, Reju Korah, Rachna Chandra, Maha Abdellatif, and Robert Wieder
Clin Cancer Res 2005 11: 2038-2046. [Abstract] [Full Text] [PDF]  

Antisense Inhibition of Methylenetetrahydrofolate Reductase Reduces Cancer Cell Survival In vitro and Tumor Growth In vivo

Jitka Stankova, Jijun Shang, and Rima Rozen
Clin Cancer Res 2005 11: 2047-2052. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling of the Irinotecan Pathway in Colorectal Cancer

Jinsheng Yu, William D. Shannon, Mark A. Watson, and Howard L. McLeod
Clin Cancer Res 2005 11: 2053-2062. [Abstract] [Full Text] [PDF]  

Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871

Bruce D. Cohen, Deborah A. Baker, Catherine Soderstrom, George Tkalcevic, Ann Marie Rossi, Penny E. Miller, Mark W. Tengowski, Faye Wang, Antonio Gualberto, Jean S. Beebe, and James D. Moyer
Clin Cancer Res 2005 11: 2063-2073. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Telomere Shortening and Telomerase Reverse Transcriptase Expression in Preinvasive Bronchial Lesions

Sylvie Lantuejoul, Jean Charles Soria, Luc Morat, Philippe Lorimier, Denis Moro-Sibilot, Laure Sabatier, Christian Brambilla, and Elisabeth Brambilla
Clin Cancer Res 2005 11: 2074-2082. [Abstract] [Full Text] [PDF]  

Effect of the Synthetic Retinoid Fenretinide on Circulating Free Prostate-Specific Antigen, Insulin-Like Growth Factor-I, and Insulin-Like Growth Factor Binding Protein-3 Levels in Men with Superficial Bladder Cancer

Davide Serrano, Laura Baglietto, Harriet Johansson, Frederique Mariette, Rosalba Torrisi, Marina Onetto, Michela Paganuzzi, and Andrea Decensi
Clin Cancer Res 2005 11: 2083-2088. [Abstract] [Full Text] [PDF]  

Overexpression of 5-Lipoxygenase and Cyclooxygenase 2 in Hamster and Human Oral Cancer and Chemopreventive Effects of Zileuton and Celecoxib

Ning Li, Sandeep Sood, Su Wang, Mingzhu Fang, Peng Wang, Zheng Sun, Chung S. Yang, and Xiaoxin Chen
Clin Cancer Res 2005 11: 2089-2096. [Abstract] [Full Text] [PDF]  

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