Review:

Caspase Regulation in Non–Small Cell Lung Cancer and its Potential for Therapeutic Exploitation

Dean A. Fennell
Clin Cancer Res 2005 11: 2097-2105. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Sei Hoon Yang, Leah E. Mechanic, Ping Yang, Maria Teresa Landi, Elise D. Bowman, Jason Wampfler, Daoud Meerzaman, Kyeong Man Hong, Felicia Mann, Tatiana Dracheva, Junya Fukuoka, William Travis, Neil E. Caporaso, Curtis C. Harris, and Jin Jen
Clin Cancer Res 2005 11: 2106-2110. [Abstract] [Full Text] [PDF]  

Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer

Eddie Myers, Arnold D.K. Hill, Gabrielle Kelly, Enda W. McDermott, Niall J. O'Higgins, Yvonne Buggy, and Leonie S. Young
Clin Cancer Res 2005 11: 2111-2122. [Abstract] [Full Text] [PDF]  

Histologic Type, Organ of Origin, and Wnt Pathway Status: Effect on Gene Expression in Ovarian and Uterine Carcinomas

Kerby A. Shedden, Malti P. Kshirsagar, Donald R. Schwartz, Rong Wu, Hongfeng Yu, David E. Misek, Samir Hanash, Hidetaka Katabuchi, Lora Hedrick Ellenson, Eric R. Fearon, and Kathleen R. Cho
Clin Cancer Res 2005 11: 2123-2131. [Abstract] [Full Text] [PDF]  

Transfer of the sFLT-1 Gene in Morris Hepatoma Results in Decreased Growth and Perfusion and Induction of Genes Associated with Stress Response

Kerstin Schmidt, Johannes Hoffend, Annette Altmann, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Britta Engelhardt, Dirk Koczan, Jörg Peter, Silke Vorwald, Helmut Eskerski, Michael Eisenhut, Jürgen Metz, Ralf Kinscherf, and Uwe Haberkorn
Clin Cancer Res 2005 11: 2132-2140. [Abstract] [Full Text] [PDF]  

Morphology of Tumor Cell Nuclei Is Significantly Related with Survival Time of Patients with Glioblastomas

Reinhold Nafe, Kea Franz, Wolfgang Schlote, and Berthold Schneider
Clin Cancer Res 2005 11: 2141-2148. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy

Lynn C. Hartmann, Karen H. Lu, Gerald P. Linette, William A. Cliby, Kimberly R. Kalli, David Gershenson, Robert C. Bast, James Stec, Natalia Iartchouk, David I. Smith, Jeffrey S. Ross, Sebastian Hoersch, Viji Shridhar, James Lillie, Scott H. Kaufmann, Edwin A. Clark, and Andrew I. Damokosh
Clin Cancer Res 2005 11: 2149-2155. [Abstract] [Full Text] [PDF]  

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

Masaru Shinozaki, Dave S.B. Hoon, Armando E. Giuliano, Nora M. Hansen, He-Jing Wang, Roderick Turner, and Bret Taback
Clin Cancer Res 2005 11: 2156-2162. [Abstract] [Full Text] [PDF]  

Absence of HER4 Expression Predicts Recurrence of Ductal Carcinoma In situ of the Breast

Nicola L.P. Barnes, Sahar Khavari, Gary P. Boland, Angela Cramer, W. Fiona Knox, and Nigel J. Bundred
Clin Cancer Res 2005 11: 2163-2168. [Abstract] [Full Text] [PDF]  

Association of NCOA3 Polymorphisms with Breast Cancer Risk

Barbara Burwinkel, Michael Wirtenberger, Rüdiger Klaes, Rita K. Schmutzler, Ewa Grzybowska, Asta Försti, Bernd Frank, Justo Lorenzo Bermejo, Peter Bugert, Barbara Wappenschmidt, Dorota Butkiewicz, Jolanta Pamula, Wioletta Pekala, Helena Zientek, Danuta Mielzynska, Ewa Siwinska, Claus R. Bartram, and Kari Hemminki
Clin Cancer Res 2005 11: 2169-2174. [Abstract] [Full Text] [PDF]  

Glutathione S-transferase P1 Genotype and Prognosis in Hodgkin's Lymphoma

Stefan Hohaus, Annalisa Di Ruscio, Annalaura Di Febo, Giuseppina Massini, Francesco D'Alo', Francesco Guidi, Giovanna Mansueto, Maria Teresa Voso, and Giuseppe Leone
Clin Cancer Res 2005 11: 2175-2179. [Abstract] [Full Text] [PDF]  

Microsatellite Instability Testing in Colorectal Carcinoma: Choice of Markers Affects Sensitivity of Detection of Mismatch Repair–Deficient Tumors

Stephanie B. Hatch, Harry M. Lightfoot, Jr., Christopher P. Garwacki, Dominic T. Moore, Benjamin F. Calvo, John T. Woosley, Janiece Sciarrotta, William K. Funkhouser, and Rosann A. Farber
Clin Cancer Res 2005 11: 2180-2187. [Abstract] [Full Text] [PDF]  

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Tomoya Segawa, Makio Shozu, Kouich Murakami, Tadayuki Kasai, Kazunori Shinohara, Kazuhito Nomura, Satoshi Ohno, and Masaki Inoue
Clin Cancer Res 2005 11: 2188-2194. [Abstract] [Full Text] [PDF]  

Generation of PRL-3- and PRL-1-Specific Monoclonal Antibodies as Potential Diagnostic Markers for Cancer Metastases

Jie Li, Ke Guo, Vicki Wei Chyi Koh, Jing Ping Tang, Bin Qi Gan, Hong Shi, Hui Xiang Li, and Qi Zeng
Clin Cancer Res 2005 11: 2195-2204. [Abstract] [Full Text] [PDF]  

Accurate Discrimination of Barrett's Esophagus and Esophageal Adenocarcinoma Using a Quantitative Three-Tiered Algorithm and Multimarker Real-time Reverse Transcription-PCR

Michael Mitas, Jonas S. Almeida, Kaidi Mikhitarian, William E. Gillanders, David N. Lewin, Demetri D. Spyropoulos, Loretta Hoover, Amanda Graham, Tammy Glenn, Peter King, David J. Cole, Robert Hawes, Carolyn E. Reed, and Brenda J. Hoffman
Clin Cancer Res 2005 11: 2205-2214. [Abstract] [Full Text] [PDF]  

High Gene Expression of TS1, GSTP1, and ERCC1 Are Risk Factors for Survival in Patients Treated with Trimodality Therapy for Esophageal Cancer

Mary-Beth Moore Joshi, Yoshinori Shirota, Kathleen D. Danenberg, Debbi H. Conlon, Dennis S. Salonga, James E. Herndon, II, Peter V. Danenberg, and David H. Harpole, Jr.
Clin Cancer Res 2005 11: 2215-2221. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Co-expression of RON and MET Receptors in Node-Negative Breast Cancer Patients

Wen-Ying Lee, Helen H.W. Chen, Nan-Haw Chow, Wu-Chou Su, Pin-Wen Lin, and How-Ran Guo
Clin Cancer Res 2005 11: 2222-2228. [Abstract] [Full Text] [PDF]  

Signet-Ring Cell or Mucinous Histology after Preoperative Chemoradiation and Survival in Patients with Esophageal or Esophagogastric Junction Adenocarcinoma

Lucian R. Chirieac, Stephen G. Swisher, Arlene M. Correa, Jaffer A. Ajani, Ritsuko R. Komaki, Asif Rashid, Stanley R. Hamilton, and Tsung-Teh Wu
Clin Cancer Res 2005 11: 2229-2236. [Abstract] [Full Text] [PDF]  

Reg IV: A Promising Marker of Hormone Refractory Metastatic Prostate Cancer

Zhennan Gu, Mark A. Rubin, Yu Yang, Samuel E. Deprimo, Hongjuan Zhao, Steven Horvath, James D. Brooks, Massimo Loda, and Robert E. Reiter
Clin Cancer Res 2005 11: 2237-2243. [Abstract] [Full Text] [PDF]  

Predictors of the Response to Gefitinib in Refractory Non–Small Cell Lung Cancer

Kyu-Sik Kim, Ju-Yeon Jeong, Young-Chul Kim, Kook-Joo Na, Yun-Hyeon Kim, Sung-Ja Ahn, Sun-Mi Baek, Chang-Soo Park, Chang-Min Park, Yu-Il Kim, Sung-Chul Lim, and Kyung-Ok Park
Clin Cancer Res 2005 11: 2244-2251. [Abstract] [Full Text] [PDF]  

Stratification of Intermediate-Risk Endometrial Cancer Patients into Groups at High Risk or Low Risk for Recurrence Based on Tumor Gene Expression Profiles

Sarah E. Ferguson, Adam B. Olshen, Agnès Viale, Richard R. Barakat, and Jeff Boyd
Clin Cancer Res 2005 11: 2252-2257. [Abstract] [Full Text] [PDF]  

YKL-40 Is a Differential Diagnostic Marker for Histologic Subtypes of High-Grade Gliomas

Catherine L. Nutt, Rebecca A. Betensky, Melissa A. Brower, Tracy T. Batchelor, David N. Louis, and Anat O. Stemmer-Rachamimov
Clin Cancer Res 2005 11: 2258-2264. [Abstract] [Full Text] [PDF]  

Cytoplasmic Phospholipase A₂ Levels Correlate with Apoptosis in Human Colon Tumorigenesis

Mei Dong, Michael Johnson, Anahita Rezaie, Jillian N.M. Ilsley, Masako Nakanishi, Melinda M. Sanders, Faripour Forouhar, Joel Levine, David C. Montrose, Charles Giardina, and Daniel W. Rosenberg
Clin Cancer Res 2005 11: 2265-2271. [Abstract] [Full Text] [PDF]  

Stromelysin 3, Ets-1, and Vascular Endothelial Growth Factor Expression in Oral Precancerous and Cancerous Lesions: Correlation with Microvessel Density, Progression, and Prognosis

Shilpi Arora, Jatinder Kaur, Chavvi Sharma, Meera Mathur, Sudhir Bahadur, Nootan K. Shukla, Suryanaryana V.S. Deo, and Ranju Ralhan
Clin Cancer Res 2005 11: 2272-2284. [Abstract] [Full Text] [PDF]  

Quantitative Assessment of Telomerase Activity and Human Telomerase Reverse Transcriptase Messenger RNA Levels in Pancreatic Juice Samples for the Diagnosis of Pancreatic Cancer

Kenoki Ohuchida, Kazuhiro Mizumoto, Yasuhiro Ogura, Nami Ishikawa, Eishi Nagai, Koji Yamaguchi, and Masao Tanaka
Clin Cancer Res 2005 11: 2285-2292. [Abstract] [Full Text] [PDF]  

Legumain Expression in Relation to Clinicopathologic and Biological Variables in Colorectal Cancer

Raghavendra Vasudeva Murthy, Gunnar Arbman, Jingfang Gao, G. David Roodman, and Xiao-Feng Sun
Clin Cancer Res 2005 11: 2293-2299. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Gefitinib in Patients with Malignant Mesothelioma: A Phase II Study by the Cancer and Leukemia Group B

Ramaswamy Govindan, Robert A. Kratzke, James E. Herndon, II, Gloria A. Niehans, Robin Vollmer, Dorothy Watson, Mark R. Green, Hedy L. Kindler on behalf of the Cancer and Leukemia Group B
Clin Cancer Res 2005 11: 2300-2304. [Abstract] [Full Text] [PDF]  

9-cis-Retinoic Acid Treatment Increases Serum Concentrations of -Tocopherol in Former Smokers

Ji-Youn Han, Diane D. Liu, J. Jack Lee, Jonathan Kurie, Reuben Lotan, Waun K. Hong, and Ho-Young Lee
Clin Cancer Res 2005 11: 2305-2311. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

A Selective Small Molecule c-MET Inhibitor, PHA665752, Cooperates with Rapamycin

Patrick C. Ma, Erik Schaefer, James G. Christensen, and Ravi Salgia
Clin Cancer Res 2005 11: 2312-2319. [Abstract] [Full Text] [PDF]  

Cyclosporin A Is a Broad-Spectrum Multidrug Resistance Modulator

Misbah Qadir, Kieran L. O'Loughlin, Stacy M. Fricke, Nicole A. Williamson, William R. Greco, Hans Minderman, and Maria R. Baer
Clin Cancer Res 2005 11: 2320-2326. [Abstract] [Full Text] [PDF]  

Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density

Rinpei Niwa, Mikiko Sakurada, Yukari Kobayashi, Aya Uehara, Kouji Matsushima, Ryuzo Ueda, Kazuyasu Nakamura, and Kenya Shitara
Clin Cancer Res 2005 11: 2327-2336. [Abstract] [Full Text] [PDF]  

Antiangiogenic Treatment with the Three Thrombospondin-1 Type 1 Repeats Recombinant Protein in an Orthotopic Human Pancreatic Cancer Model

Xuefeng Zhang, Eric Galardi, Mark Duquette, Marko Delic, Jack Lawler, and Sareh Parangi
Clin Cancer Res 2005 11: 2337-2344. [Abstract] [Full Text] [PDF]  

4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27^Kip1, and Modulation of Bcl-2 Family Members

Juliette Gauduchon, Fabrice Gouilleux, Sébastien Maillard, Véronique Marsaud, Jack-Michel Renoir, and Brigitte Sola
Clin Cancer Res 2005 11: 2345-2354. [Abstract] [Full Text] [PDF]  

Casein Kinase 2 Regulates Both Apoptosis and the Cell Cycle Following DNA Damage Induced by 6-Thioguanine

Kazuhiko Yamane and Timothy J. Kinsella
Clin Cancer Res 2005 11: 2355-2363. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family

Surita Dalal, Andrea M. Berry, Catherine J. Cullinane, D. Charles Mangham, Robert Grimer, Ian J. Lewis, Colin Johnston, Valerie Laurence, and Susan A. Burchill
Clin Cancer Res 2005 11: 2364-2378. [Abstract] [Full Text] [PDF]  

Methylseleninic Acid Potentiates Apoptosis Induced by Chemotherapeutic Drugs in Androgen-Independent Prostate Cancer Cells

Hongbo Hu, Cheng Jiang, Clement Ip, Youcef M. Rustum, and Junxuan Lü
Clin Cancer Res 2005 11: 2379-2388. [Abstract] [Full Text] [PDF]  

Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma

Saminathan S. Nathan, Gene R. DiResta, Jorge E. Casas-Ganem, Bang H. Hoang, Rebecca Sowers, Rui Yang, Andrew G. Huvos, Richard Gorlick, and John H. Healey
Clin Cancer Res 2005 11: 2389-2397. [Abstract] [Full Text] [PDF]  

Targeting the Mevalonate Pathway Inhibits the Function of the Epidermal Growth Factor Receptor

Angela J. Mantha, Jennifer E.L. Hanson, Glenwood Goss, Alain E. Lagarde, Ian A. Lorimer, and Jim Dimitroulakos
Clin Cancer Res 2005 11: 2398-2407. [Abstract] [Full Text] [PDF]  

Effective Inhibition of Experimental Human Ovarian Cancers with a Targeted Cytotoxic Bombesin Analogue AN-215

Jörg B. Engel, Gunhild Keller, Andrew V. Schally, Gabor Halmos, Brian Hammann, and Attila Nagy
Clin Cancer Res 2005 11: 2408-2415. [Abstract] [Full Text] [PDF]  

Induction of an Antigen Cascade by Diversified Subcutaneous/Intratumoral Vaccination Is Associated with Antitumor Responses

Chie Kudo-Saito, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2005 11: 2416-2426. [Abstract] [Full Text] [PDF]  

Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4⁺ Adult T-Cell Leukemia Cells

Takatoshi Shimauchi, Satoshi Imai, Ryosuke Hino, and Yoshiki Tokura
Clin Cancer Res 2005 11: 2427-2435. [Abstract] [Full Text] [PDF]  

Breast Cancer Resistance Protein in Drug Resistance of Primitive CD34+38– Cells in Acute Myeloid Leukemia

Marc H.G.P. Raaijmakers, Elke P.L.M. de Grouw, Leonie H.H. Heuver, Bert A. van der Reijden, Joop H. Jansen, Rik J. Scheper, George L. Scheffer, Theo J.M. de Witte, and Reinier A.P. Raymakers
Clin Cancer Res 2005 11: 2436-2444. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Coxsackievirus and Adenovirus Receptor Expression on Primary Osteosarcoma Specimens and Implications for Gene Therapy with Recombinant Adenoviruses

Harm C.A. Graat, Paul I.J.M. Wuisman, Victor W. van Beusechem, Jan E. Carette, Winald R. Gerritsen, Johannes Bras, Gerard R. Schaap, Gertjan J.L. Kaspers, Akira Ogose, Wenguang Gu, Hiroyuki Kawashima, and Tetsuo Hotta
Clin Cancer Res 2005 11: 2445-2448. [Full Text] [PDF]  

Corrections:

Correction: Article on the Enforced Expression of Wild-Type p53 and the Transcription of the O⁶-Methylguanine-DNA Methyltransferase Gene

Clin Cancer Res 2005 11: 2449. [Full Text] [PDF]  

Correction: Article on the Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors

Clin Cancer Res 2005 11: 2449. [Full Text] [PDF]  

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