Editorials:

Sustaining the Clinical in Clinical Translational Research

William N. Hait
Clin Cancer Res 2006 12: 1-2. [Full Text] [PDF]  

Velcade and Vitamin C: Too Much of a Good Thing?

Laurence Catley and Kenneth C. Anderson
Clin Cancer Res 2006 12: 3-4. [Full Text] [PDF]  

Review:

Biological and Prognostic Significance of Chromosome 5q Deletions in Myeloid Malignancies

Aristoteles A.N. Giagounidis, Ulrich Germing, and Carlo Aul
Clin Cancer Res 2006 12: 5-10. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

Tanya Gritsko, Ann Williams, James Turkson, Satoshi Kaneko, Tammy Bowman, Mei Huang, Sangkil Nam, Ibrahim Eweis, Nils Diaz, Daniel Sullivan, Sean Yoder, Steve Enkemann, Steven Eschrich, Ji-Hyun Lee, Craig A. Beam, Jin Cheng, Susan Minton, Carlos A. Muro-Cacho, and Richard Jove
Clin Cancer Res 2006 12: 11-19. [Abstract] [Full Text] [PDF]  

Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

Nills Diaz, Susan Minton, Charles Cox, Tammy Bowman, Tanya Gritsko, Roy Garcia, Ibrahim Eweis, Marek Wloch, Sandy Livingston, Ed Seijo, Alan Cantor, Ji-Hyun Lee, Craig A. Beam, Daniel Sullivan, Richard Jove, and Carlos A. Muro-Cacho
Clin Cancer Res 2006 12: 20-28. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Messenger RNA Expression Level Is Preserved in Liver Metastases Compared with Corresponding Primary Colorectal Cancer

Hidekazu Kuramochi, Kazuhiko Hayashi, Kazumi Uchida, Satoru Miyakura, Daisuke Shimizu, Daniel Vallböhmer, Seongjin Park, Kathleen D. Danenberg, Ken Takasaki, and Peter V. Danenberg
Clin Cancer Res 2006 12: 29-33. [Abstract] [Full Text] [PDF]  

Detection of Wilms' Tumor Antigen–Specific CTL in Tumor-Draining Lymph Nodes of Patients with Early Breast Cancer

Roopinder Gillmore, Shao-An Xue, Angelika Holler, Jaspal Kaeda, Dimitri Hadjiminas, Vourneen Healy, Roberto Dina, Suzanne C. Parry, Ilaria Bellantuono, Yasmeen Ghani, R. Charles Coombes, Jonathan Waxman, and Hans J. Stauss
Clin Cancer Res 2006 12: 34-42. [Abstract] [Full Text] [PDF]  

Detection of EGFR Gene Mutation in Lung Cancer by Mutant-Enriched Polymerase Chain Reaction Assay

Hiroaki Asano, Shinichi Toyooka, Masaki Tokumo, Kouichi Ichimura, Keisuke Aoe, Sachio Ito, Kazunori Tsukuda, Mamoru Ouchida, Motoi Aoe, Hideki Katayama, Akio Hiraki, Kazuro Sugi, Katsuyuki Kiura, Hiroshi Date, and Nobuyoshi Shimizu
Clin Cancer Res 2006 12: 43-48. [Abstract] [Full Text] [PDF]  

PC Cell–Derived Growth Factor Confers Resistance to Dexamethasone and Promotes Tumorigenesis in Human Multiple Myeloma

Wengang Wang, Jun Hayashi, and Ginette Serrero
Clin Cancer Res 2006 12: 49-56. [Abstract] [Full Text] [PDF]  

Somatic Mutations of ERBB2 Kinase Domain in Gastric, Colorectal, and Breast Carcinomas

Jong Woo Lee, Young Hwa Soung, Si Hyung Seo, Su Young Kim, Cho Hyun Park, Young Pil Wang, Kyeongmee Park, Suk Woo Nam, Won Sang Park, Sang Ho Kim, Jung Young Lee, Nam Jin Yoo, and Sug Hyung Lee
Clin Cancer Res 2006 12: 57-61. [Abstract] [Full Text] [PDF]  

Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection

Thierry Soussi, Bernard Asselain, Dalil Hamroun, Shunsuke Kato, Chikashi Ishioka, Mireille Claustres, and Christophe Béroud
Clin Cancer Res 2006 12: 62-69. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Peptidyl-Prolyl Isomerase-Like 1 Is Associated with the Growth of Colon Cancer Cells

Kazutaka Obama, Tatsushi Kato, Suguru Hasegawa, Seiji Satoh, Yusuke Nakamura, and Yoichi Furukawa
Clin Cancer Res 2006 12: 70-76. [Abstract] [Full Text] [PDF]  

CXCL12 Does Not Attract CXCR4⁺ Human Metastatic Neuroblastoma Cells: Clinical Implications

Irma Airoldi, Lizzia Raffaghello, Erich Piovan, Claudia Cocco, Barbara Carlini, Alberto Amadori, Maria Valeria Corrias, and Vito Pistoia
Clin Cancer Res 2006 12: 77-82. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Prediction of Lymph Node Metastasis in Patients with Endometrioid Endometrial Cancer Using Expression Microarray

Michael A. Bidus, John I. Risinger, Gadisetti V.R. Chandramouli, Lou A. Dainty, Tracy J. Litzi, Andrew Berchuck, J. Carl Barrett, and G. Larry Maxwell
Clin Cancer Res 2006 12: 83-88. [Abstract] [Full Text] [PDF] Supplementary Data  

Measurement of Serum Levels of Macrophage Inhibitory Cytokine 1 Combined with Prostate-Specific Antigen Improves Prostate Cancer Diagnosis

David A. Brown, Carsten Stephan, Robyn L. Ward, Mathew Law, Mark Hunter, Asne R. Bauskin, Janaki Amin, Klaus Jung, Eleftherios P. Diamandis, Garret M. Hampton, Pamela J. Russell, Graham G. Giles, and Samuel N. Breit
Clin Cancer Res 2006 12: 89-96. [Abstract] [Full Text] [PDF]  

Value of ¹⁸F-Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography/Computed Tomography in Non–Small-Cell Lung Cancer for Prediction of Pathologic Response and Times to Relapse after Neoadjuvant Chemoradiotherapy

Christoph Pöttgen, Sabine Levegrün, Dirk Theegarten, Simone Marnitz, Sara Grehl, Roman Pink, Wilfried Eberhardt, Georgios Stamatis, Thomas Gauler, Gerald Antoch, Andreas Bockisch, and Martin Stuschke
Clin Cancer Res 2006 12: 97-106. [Abstract] [Full Text] [PDF]  

Definition of an Immunologic Response Using the Major Histocompatibility Complex Tetramer and Enzyme-Linked Immunospot Assays

Begoña Comin-Anduix, Antonio Gualberto, John A. Glaspy, Elisabeth Seja, Maribel Ontiveros, Deborah L. Reardon, Roberto Renteria, Brigitte Englahner, James S. Economou, Jesus Gomez-Navarro, and Antoni Ribas
Clin Cancer Res 2006 12: 107-116. [Abstract] [Full Text] [PDF]  

Expression of Hepatoma-Derived Growth Factor Is Correlated with Lymph Node Metastasis and Prognosis of Gastric Carcinoma

Shinji Yamamoto, Yasuhiko Tomita, Yoshihiko Hoshida, Shuji Takiguchi, Yoshiyuki Fujiwara, Takushi Yasuda, Yuichiro Doki, Kenya Yoshida, Katsuyuki Aozasa, Hideji Nakamura, and Morito Monden
Clin Cancer Res 2006 12: 117-122. [Abstract] [Full Text] [PDF]  

The Role of HER1-HER4 and EGFRvIII in Hormone-Refractory Prostate Cancer

Joanne Edwards, Pamela Traynor, Alison F. Munro, Catherine F. Pirret, Barbara Dunne, and John M.S. Bartlett
Clin Cancer Res 2006 12: 123-130. [Abstract] [Full Text] [PDF]  

Reduced Expression of CAMTA1 Correlates with Adverse Outcome in Neuroblastoma Patients

Kai-Oliver Henrich, Matthias Fischer, Daniel Mertens, Axel Benner, Ruprecht Wiedemeyer, Benedikt Brors, André Oberthuer, Frank Berthold, Jun Stephen Wei, Javed Khan, Manfred Schwab, and Frank Westermann
Clin Cancer Res 2006 12: 131-138. [Abstract] [Full Text] [PDF]  

Evaluation for Surrogacy of End Points by Using Data from Observational Studies: Tumor Downstaging for Evaluating Neoadjuvant Chemotherapy in Invasive Bladder Cancer

Satoshi Teramukai, Hiroyuki Nishiyama, Yoshiyuki Matsui, Osamu Ogawa, and Masanori Fukushima
Clin Cancer Res 2006 12: 139-143. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Trial of Sorafenib and Gemcitabine in Advanced Solid Tumors with an Expanded Cohort in Advanced Pancreatic Cancer

Lillian L. Siu, Ahmad Awada, Chris H. Takimoto, Martine Piccart, Brian Schwartz, Tom Giannaris, Chetan Lathia, Oana Petrenciuc, and Malcolm J. Moore
Clin Cancer Res 2006 12: 144-151. [Abstract] [Full Text] [PDF]  

Application of Oligonucleotide Microarrays to Assess the Biological Effects of Neoadjuvant Imatinib Mesylate Treatment for Localized Prostate Cancer

Phillip G. Febbo, Aaron Thorner, Mark A. Rubin, Massimo Loda, Philip W. Kantoff, William K. Oh, Todd Golub, and Daniel George
Clin Cancer Res 2006 12: 152-158. [Abstract] [Full Text] [PDF] Supplementary Data  

Prognostic and Predictive Effects of Immunohistochemical Factors in High-Risk Primary Breast Cancer Patients

Nicolaus Kröger, Karin Milde-Langosch, Sabine Riethdorf, Claudia Schmoor, Martin Schumacher, Axel R. Zander, and Thomas Löning
Clin Cancer Res 2006 12: 159-168. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Docetaxel Followed by Castration Improves Outcomes in LNCaP Prostate Cancer–Bearing Severe Combined Immunodeficient Mice

Yao Tang, Mohammad A. Khan, Olga Goloubeva, Dong I. Lee, Danijela Jelovac, Angela M. Brodie, and Arif Hussain
Clin Cancer Res 2006 12: 169-174. [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Activity of Cisplatin, Paclitaxel, and Gemcitabine with Tumor Vasculature-Targeted Tumor Necrosis Factor-

Angelina Sacchi, Anna Gasparri, Corrado Gallo-Stampino, Salvatore Toma, Flavio Curnis, and Angelo Corti
Clin Cancer Res 2006 12: 175-182. [Abstract] [Full Text] [PDF]  

Anti-CD3 x Anti-Epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-Cell Cytolytic Activity to EGFR-Positive Cancers In vitro and in an Animal Model

Ursula Reusch, Magesh Sundaram, Pamela A. Davol, Sarah D. Olson, James B. Davis, Kurt Demel, Julie Nissim, Ritesh Rathore, Paul Y. Liu, and Lawrence G. Lum
Clin Cancer Res 2006 12: 183-190. [Abstract] [Full Text] [PDF]  

A Novel Cancer Testis Antigen That Is Frequently Expressed in Pancreatic, Lung, and Endometrial Cancers

Takaho Okada, Masanori Akada, Tomonobu Fujita, Takashi Iwata, Yasufumi Goto, Kenji Kido, Tsutomu Okada, Yuriko Matsuzaki, Kouichi Kobayashi, Seiki Matsuno, Makoto Sunamura, and Yutaka Kawakami
Clin Cancer Res 2006 12: 191-197. [Abstract] [Full Text] [PDF]  

Transient Improvement in Cognitive Function and Synaptic Plasticity in Rats Following Cancer Chemotherapy

Garrick D. Lee, Dan L. Longo, Yue Wang, Joseph M. Rifkind, Lilanie Abdul-Raman, Jacek A. Mamczarz, Kara B. Duffy, Edward L. Spangler, Dennis D. Taub, Mark P. Mattson, and Donald K. Ingram
Clin Cancer Res 2006 12: 198-205. [Abstract] [Full Text] [PDF]  

Motexafin-Gadolinium Taken Up In vitro by at Least 90% of Glioblastoma Cell Nuclei

Gelsomina De Stasio, Deepika Rajesh, Judith M. Ford, Matthew J. Daniels, Robert J. Erhardt, Bradley H. Frazer, Tolek Tyliszczak, Mary K. Gilles, Robert L. Conhaim, Steven P. Howard, John F. Fowler, François Estève, and Minesh P. Mehta
Clin Cancer Res 2006 12: 206-213. [Abstract] [Full Text] [PDF]  

Cycloxygenase-2 Inhibition Augments the Efficacy of a Cancer Vaccine

Andrew R. Haas, Jing Sun, Anil Vachani, Africa F. Wallace, Michael Silverberg, Veena Kapoor, and Steven M. Albelda
Clin Cancer Res 2006 12: 214-222. [Abstract] [Full Text] [PDF]  

Evaluation of the Antitumor Efficacy, Pharmacokinetics, and Pharmacodynamics of the Histone Deacetylase Inhibitor Depsipeptide in Childhood Cancer Models In vivo

Claire Graham, Chandra Tucker, Jeremy Creech, Edward Favours, Catherine A. Billups, Tiebin Liu, Maryam Fouladi, Burgess B. Freeman, III, Clinton F. Stewart, and Peter J. Houghton
Clin Cancer Res 2006 12: 223-234. [Abstract] [Full Text] [PDF]  

p8 Is a New Target of Gemcitabine in Pancreatic Cancer Cells

Valentin Giroux, Cédric Malicet, Marc Barthet, Meritxell Gironella, Cendrine Archange, Jean-Charles Dagorn, Sophie Vasseur, and Juan L. Iovanna
Clin Cancer Res 2006 12: 235-241. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of a Combination of CMC-544 (Inotuzumab Ozogamicin), a CD22-Targeted Cytotoxic Immunoconjugate of Calicheamicin, and Rituximab against Non-Hodgkin's B-Cell Lymphoma

John F. DiJoseph, Maureen M. Dougher, Lyka B. Kalyandrug, Douglas C. Armellino, Erwin R. Boghaert, Philip R. Hamann, Justin K. Moran, and Nitin K. Damle
Clin Cancer Res 2006 12: 242-249. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3-Kinase Inhibition by LY294002 Radiosensitizes Human Cervical Cancer Cell Lines

Christopher M. Lee, Christa B. Fuhrman, Vicente Planelles, Morgan R. Peltier, David K. Gaffney, Andrew P. Soisson, Mark K. Dodson, H. Dennis Tolley, Christopher L. Green, and Karen A. Zempolich
Clin Cancer Res 2006 12: 250-256. [Abstract] [Full Text] [PDF]  

Regression of High-Grade Malignancy in Mice by Bleomycin and Interleukin-12 Electrochemogenetherapy

Marina N. Torrero, William G. Henk, and Shulin Li
Clin Cancer Res 2006 12: 257-263. [Abstract] [Full Text] [PDF]  

Mechanical Analysis of Tumor Growth Regression by the Cyclooxygenase-2 Inhibitor, DFU, in a Walker256 Rat Tumor Model: Importance of Monocyte Chemoattractant Protein-1 Modulation

Mariko Muta, Gaku Matsumoto, Emi Nakashima, and Masakazu Toi
Clin Cancer Res 2006 12: 264-272. [Abstract] [Full Text] [PDF]  

Vitamin C Inactivates the Proteasome Inhibitor PS-341 in Human Cancer Cells

Wei Zou, Ping Yue, Na Lin, Min He, Zhongmei Zhou, Sagal Lonial, Fadlo R. Khuri, Binghe Wang, and Shi-Yong Sun
Clin Cancer Res 2006 12: 273-280. [Abstract] [Full Text] [PDF]  

A Physiologic Imaging Pilot Study of Breast Cancer Treated with AZD2171

Kathy D. Miller, Michael Miller, Sanjana Mehrotra, Beamon Agarwal, Bruce H. Mock, Qi-Huang Zheng, Sunil Badve, Gary D. Hutchins, and George W. Sledge, Jr.
Clin Cancer Res 2006 12: 281-288. [Abstract] [Full Text] [PDF]  

Optimizing a Novel Regional Chemotherapeutic Agent against Melanoma: Hyperthermia-Induced Enhancement of Temozolomide Cytotoxicity

Sae Hee Ko, Tomio Ueno, Yasunori Yoshimoto, Jin Soo Yoo, Omar I. Abdel-Wahab, Zeinab Abdel-Wahab, Edward Chu, Scott K. Pruitt, Henry S. Friedman, Mark W. Dewhirst, and Douglas S. Tyler
Clin Cancer Res 2006 12: 289-297. [Abstract] [Full Text] [PDF]  

Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-Bearing Mice

Gloria S. Huang, Lluis Lopez-Barcons, B. Scott Freeze, Amos B. Smith, III, Gary L. Goldberg, Susan Band Horwitz, and Hayley M. McDaid
Clin Cancer Res 2006 12: 298-304. [Abstract] [Full Text] [PDF] Supplementary Data  

CG0070, a Conditionally Replicating Granulocyte Macrophage Colony-Stimulating Factor–Armed Oncolytic Adenovirus for the Treatment of Bladder Cancer

Nagarajan Ramesh, Ying Ge, David L. Ennist, Mingzhu Zhu, Mervat Mina, Shanthi Ganesh, P. Seshidhar Reddy, and De-Chao Yu
Clin Cancer Res 2006 12: 305-313. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Celecoxib Decreases Ki-67 Proliferative Index in Active Smokers

Jenny T. Mao, Michael C. Fishbein, Bradley Adams, Michael D. Roth, Lee Goodglick, Longsheng Hong, Marie Burdick, E. Robert M. Strieter, Carmack Holmes, Donald P. Tashkin, and Steven M. Dubinett
Clin Cancer Res 2006 12: 314-320. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Phase 1 Dose-Finding Trials and Fibonacci

George A. Omura
Clin Cancer Res 2006 12: 321. [Full Text] [PDF]  

Corrections:

Article on Molecular Study of Malignant Gliomas

Clin Cancer Res 2006 12: 322. [Full Text] [PDF]  

Article on Combining Recombinant Cancer Vaccine with Radiotherapy

Clin Cancer Res 2006 12: 322. [Full Text] [PDF]  

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