The Biology Behind:

Coming Unglued

Richard M. Peek, Jr., Barbara G. Schneider, and Pelayo Correa
Clin Cancer Res 2006 12: 2951-2954. [Full Text] [PDF]  

Report from the FDA:

United States Food and Drug Administration Approval Summary: Bortezomib for the Treatment of Progressive Multiple Myeloma after One Prior Therapy

Robert C. Kane, Ann T. Farrell, Rajeshwari Sridhara, and Richard Pazdur
Clin Cancer Res 2006 12: 2955-2960. [Abstract] [Full Text] [PDF]  

CCR Drug Updates:

Erlotinib: Optimizing Therapy with Predictors of Response?

Susan Goodin
Clin Cancer Res 2006 12: 2961-2963. [Full Text] [PDF]  

Molecular Pathways:

Practicalities of Drugging the Phosphatidylinositol-3-Kinase/Akt Cell Survival Signaling Pathway

Garth Powis, Nathan Ihle, and D. Lynn Kirkpatrick
Clin Cancer Res 2006 12: 2964-2966. [Full Text] [PDF]  

Human Cancer Biology:

Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-Presenting Cells for the Generation of Effective Antitumor Responses

Naoto Hirano, Marcus O. Butler, Zhinan Xia, Alla Berezovskaya, Andrew P. Murray, Sascha Ansén, and Lee M. Nadler
Clin Cancer Res 2006 12: 2967-2975. [Abstract] [Full Text] [PDF]  

RNA Interference Suppression of MUC1 Reduces the Growth Rate and Metastatic Phenotype of Human Pancreatic Cancer Cells

Hideaki Tsutsumida, Benjamin J. Swanson, Pankaj K. Singh, Thomas C. Caffrey, Shinichi Kitajima, Masamichi Goto, Suguru Yonezawa, and Michael A. Hollingsworth
Clin Cancer Res 2006 12: 2976-2987. [Abstract] [Full Text] [PDF]  

Mixed Lineage Leukemia–Rearranged Childhood Pro-B and CD10-Negative Pre-B Acute Lymphoblastic Leukemia Constitute a Distinct Clinical Entity

Andishe Attarbaschi, Georg Mann, Margit König, Manuel Steiner, Sabine Strehl, Anita Schreiberhuber, Björn Schneider, Claus Meyer, Rolf Marschalek, Arndt Borkhardt, Winfried F. Pickl, Thomas Lion, Helmut Gadner, Oskar A. Haas, Michael N. Dworzak on behalf of the Austrian Berlin-Frankfurt-Münster Cooperative Study Group
Clin Cancer Res 2006 12: 2988-2994. [Abstract] [Full Text] [PDF]  

CpG Island M`ethylation Status in Gastric Carcinoma with and without Infection of Epstein-Barr Virus

Moon-Sung Chang, Hiroshi Uozaki, Ja-Mun Chong, Tetsuo Ushiku, Kazuya Sakuma, Shunpei Ishikawa, Rumi Hino, Rita Rani Barua, Yoshiaki Iwasaki, Kuniyoshi Arai, Hideki Fujii, Hideo Nagai, and Masashi Fukayama
Clin Cancer Res 2006 12: 2995-3002. [Abstract] [Full Text] [PDF]  

Glucocorticoids Suppress Tumor Angiogenesis and In vivo Growth of Prostate Cancer Cells

Akihiro Yano, Yasuhisa Fujii, Aki Iwai, Yukio Kageyama, and Kazunori Kihara
Clin Cancer Res 2006 12: 3003-3009. [Abstract] [Full Text] [PDF]  

17ß-Estradiol Induces Down-Regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-Related and Metastasis Suppressor Gene, in Human Breast Cancer Cells

Abbas Fotovati, Teruhiko Fujii, Miki Yamaguchi, Masayoshi Kage, Kazuo Shirouzu, Shinji Oie, Yuji Basaki, Mayumi Ono, Hideaki Yamana, and Michihiko Kuwano
Clin Cancer Res 2006 12: 3010-3018. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3'-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN

Wolfgang Hartmann, Boris Digon-Söntgerath, Arend Koch, Anke Waha, Elmar Endl, Indra Dani, Dorota Denkhaus, Cynthia G. Goodyer, Niels Sörensen, Otmar D. Wiestler, and Torsten Pietsch
Clin Cancer Res 2006 12: 3019-3027. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator–Activated Receptor Activation Decreases Metastatic Potential of Melanoma Cells In vitro via Down-Regulation of Akt

Maja Grabacka, Przemyslaw M. Plonka, Krystyna Urbanska, and Krzysztof Reiss
Clin Cancer Res 2006 12: 3028-3036. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Achieving a Major Molecular Response at the Time of a Complete Cytogenetic Response (CCgR) Predicts a Better Duration of CCgR in Imatinib-Treated Chronic Myeloid Leukemia Patients

Ilaria Iacobucci, Giuseppe Saglio, Gianantonio Rosti, Nicoletta Testoni, Fabrizio Pane, Marilina Amabile, Angela Poerio, Simona Soverini, Simona Bassi, Daniela Cilloni, Renato Bassan, Massimo Breccia, Francesco Lauria, Barbara Izzo, Serena Merante, Francesco Frassoni, Stefania Paolini, Enrico Montefusco, Michele Baccarani, Giovanni Martinelli for the GIMEMA Working Party on Chronic Myeloid Leukemia
Clin Cancer Res 2006 12: 3037-3042. [Abstract] [Full Text] [PDF]  

NOTCH1 Mutations in T-Cell Acute Lymphoblastic Leukemia: Prognostic Significance and Implication in Multifactorial Leukemogenesis

Yong-Mei Zhu, Wei-Li Zhao, Jian-Fei Fu, Jing-Yi Shi, Qin Pan, Jiong Hu, Xiao-Dong Gao, Bing Chen, Jun-Min Li, Shu-Min Xiong, Long-Jun Gu, Jing-Yi Tang, Hui Liang, Hui Jiang, Yong-Quan Xue, Zhi-Xiang Shen, Zhu Chen, and Sai-Juan Chen
Clin Cancer Res 2006 12: 3043-3049. [Abstract] [Full Text] [PDF]  

Glutathione S-Transferase P1 Polymorphism (Ile¹⁰⁵Val) Predicts Cumulative Neuropathy in Patients Receiving Oxaliplatin-Based Chemotherapy

Thierry Lecomte, Bruno Landi, Philippe Beaune, Pierre Laurent-Puig, and Marie-Anne Loriot
Clin Cancer Res 2006 12: 3050-3056. [Abstract] [Full Text] [PDF]  

Clinical Significance of TROP2 Expression in Colorectal Cancer

Takahiro Ohmachi, Fumiaki Tanaka, Koshi Mimori, Hiroshi Inoue, Katsuhiko Yanaga, and Masaki Mori
Clin Cancer Res 2006 12: 3057-3063. [Abstract] [Full Text] [PDF]  

Clinical and Immunologic Responses to Active Specific Cancer Vaccines in Human Colorectal Cancer

Dirk Nagorsen and Eckhard Thiel
Clin Cancer Res 2006 12: 3064-3069. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Activated AKT Expression in Soft-Tissue Sarcoma

Yasuhiko Tomita, Takaya Morooka, Yoshihiko Hoshida, Binglin Zhang, Ying Qiu, Itsuko Nakamichi, Ken-ichiro Hamada, Takafumi Ueda, Norifumi Naka, Ikuo Kudawara, and Katsuyuki Aozasa
Clin Cancer Res 2006 12: 3070-3077. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Epidermal Growth Factor Receptor Messenger RNA Expression, Gene Dosage, and Gefitinib Sensitivity in Non–Small Cell Lung Cancer

Rafal Dziadziuszko, Samir E. Witta, Federico Cappuzzo, Seongjin Park, Koji Tanaka, Peter V. Danenberg, Anna E. Barón, Lucio Crino, Wilbur A. Franklin, Paul A. Bunn, Jr., Marileila Varella-Garcia, Kathleen D. Danenberg, and Fred R. Hirsch
Clin Cancer Res 2006 12: 3078-3084. [Abstract] [Full Text] [PDF]  

Phase I Trial of the Trifunctional Anti-HER2 x Anti-CD3 Antibody Ertumaxomab in Metastatic Breast Cancer

Philipp Kiewe, Stephan Hasmüller, Steffen Kahlert, Maja Heinrigs, Brigitte Rack, Alexander Marmé, Agnieszka Korfel, Michael Jäger, Horst Lindhofer, Harald Sommer, Eckhard Thiel, and Michael Untch
Clin Cancer Res 2006 12: 3085-3091. [Abstract] [Full Text] [PDF]  

Phase II Clinical Trial Results Involving Treatment with Low-Dose Daily Oral Cyclophosphamide, Weekly Vinblastine, and Rofecoxib in Patients with Advanced Solid Tumors

Scott D. Young, Mark Whissell, Jonathan C.S. Noble, Pablo O. Cano, Pedro G. Lopez, and Colin J. Germond
Clin Cancer Res 2006 12: 3092-3098. [Abstract] [Full Text] [PDF]  

Effect of cA2 Anti–Tumor Necrosis Factor- Antibody Therapy on Hematopoiesis of Patients with Myelodysplastic Syndromes

Anna Boula, Michael Voulgarelis, Stavroula Giannouli, George Katrinakis, Maria Psyllaki, Charalambos Pontikoglou, Fotini Markidou, George D. Eliopoulos, and Helen A. Papadaki
Clin Cancer Res 2006 12: 3099-3108. [Abstract] [Full Text] [PDF]  

Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia

Scott M. Lippman, J. Jack Lee, Jack W. Martin, Adel K. El-Naggar, Xiaochun Xu, Dong M. Shin, Margaret Thomas, Li Mao, Herbert A. Fritsche, Jr., Xian Zhou, Vassiliki Papadimitrakopoulou, Fadlo R. Khuri, Hai Tran, Gary L. Clayman, Walter N. Hittelman, Waun Ki Hong, and Reuben Lotan
Clin Cancer Res 2006 12: 3109-3114. [Abstract] [Full Text] [PDF]  

Carbogen and Nicotinamide Increase Blood Flow and 5-Fluorouracil Delivery but not 5-Fluorouracil Retention in Colorectal Cancer Metastases in Patients

Nishi Gupta, Azeem Saleem, Barbara Kötz, Safiye Osman, Eric O. Aboagye, Robert Phillips, Clare Vernon, Harpreet Wasan, Terry Jones, Peter J. Hoskin, and Patricia M. Price
Clin Cancer Res 2006 12: 3115-3123. [Abstract] [Full Text] [PDF]  

Phase II Trial of Bevacizumab in Combination with Weekly Docetaxel in Metastatic Breast Cancer Patients

Bhuvaneswari Ramaswamy, Anthony D. Elias, Nicole T. Kelbick, Angela Dodley, Mark Morrow, Marsha Hauger, Joan Allen, Chris Rhoades, Kari Kendra, Helen X. Chen, S. Gail Eckhardt, and Charles L. Shapiro
Clin Cancer Res 2006 12: 3124-3129. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Detection and Functional Analysis of CD8⁺ T Cells Specific for PRAME: a Target for T-Cell Therapy

Marieke Griffioen, Jan H. Kessler, Martina Borghi, Ronald A. van Soest, Caroline E. van der Minne, Jan Nouta, Sjoerd H. van der Burg, Jan Paul Medema, Peter I. Schrier, J.H. Frederik Falkenburg, Susanne Osanto, and Cornelis J.M. Melief
Clin Cancer Res 2006 12: 3130-3136. [Abstract] [Full Text] [PDF]  

Infectivity-Enhanced Adenoviruses Deliver Efficacy in Clinical Samples and Orthotopic Models of Disseminated Gastric Cancer

Lotta Kangasniemi, Tuula Kiviluoto, Anna Kanerva, Mari Raki, Tuuli Ranki, Merja Sarkioja, Hongju Wu, Frank Marini, Krister Höckerstedt, Helena Isoniemi, Henrik Alfthan, Ulf-Håkan Stenman, David T. Curiel, and Akseli Hemminki
Clin Cancer Res 2006 12: 3137-3144. [Abstract] [Full Text] [PDF]  

Real-time, Image-Guided, Convection-Enhanced Delivery of Interleukin 13 Bound to Pseudomonas Exotoxin

Gregory J.A. Murad, Stuart Walbridge, Paul F. Morrison, Kayhan Garmestani, Jeffrey W. Degen, Martin W. Brechbiel, Edward H. Oldfield, and Russell R. Lonser
Clin Cancer Res 2006 12: 3145-3151. [Abstract] [Full Text] [PDF]  

Effective Treatment of Pancreatic Cancer Xenografts with a Conditionally Replicating Virus Derived from Type 2 Herpes Simplex Virus

Xinping Fu, Lihua Tao, Min Li, William E. Fisher, and Xiaoliu Zhang
Clin Cancer Res 2006 12: 3152-3157. [Abstract] [Full Text] [PDF]  

Immunogenic HLA-B*0702-Restricted Epitopes Derived from Human Telomerase Reverse Transcriptase That Elicit Antitumor Cytotoxic T-Cell Responses

Olivier Adotévi, Karine Mollier, Christine Neuveut, Sylvain Cardinaud, Emmanuelle Boulanger, Blandine Mignen, Wolf-Hervé Fridman, Maurizio Zanetti, Pierre Charneau, Eric Tartour, François Lemonnier, and Pierre Langlade-Demoyen
Clin Cancer Res 2006 12: 3158-3167. [Abstract] [Full Text] [PDF]  

Novel Cytosine Deaminase Fusion Gene Enhances the Effect of Radiation on Breast Cancer in Bone by Reducing Tumor Burden, Osteolysis, and Skeletal Fracture

Michael Goblirsch, Pawel Zwolak, Margaret L. Ramnaraine, Weihong Pan, Christine Lynch, Parham Alaei, and Denis R. Clohisy
Clin Cancer Res 2006 12: 3168-3176. [Abstract] [Full Text] [PDF]  

Evaluation of Toxicity following Electrically Mediated Interleukin-12 Gene Delivery in a B16 Mouse Melanoma Model

Loree Heller, Kathleen Merkler, Jeffrey Westover, Yolmari Cruz, Domenico Coppola, Kaaron Benson, Adil Daud, and Richard Heller
Clin Cancer Res 2006 12: 3177-3183. [Abstract] [Full Text] [PDF]  

Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer

Amelia E. Hochreiter, Hongling Xiao, Erin M. Goldblatt, Sergei M. Gryaznov, Kathy D. Miller, Sunil Badve, George W. Sledge, and Brittney-Shea Herbert
Clin Cancer Res 2006 12: 3184-3192. [Abstract] [Full Text] [PDF] Supplementary Data  

Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

Zhi-ping Yuan, Li-juan Chen, Lin-yu Fan, Ming-hai Tang, Guang-li Yang, Han-su Yang, Xiao-bo Du, Guo-qing Wang, Wen-xiu Yao, Qu-mei Zhao, Bin Ye, Rui Wang, Peng Diao, Wei Zhang, Hong-bin Wu, Xia Zhao, and Yu-Quan Wei
Clin Cancer Res 2006 12: 3193-3199. [Abstract] [Full Text] [PDF]  

Tumor-Targeting Properties of Novel Antibodies Specific to the Large Isoform of Tenascin-C

Simon S. Brack, Michela Silacci, Manfred Birchler, and Dario Neri
Clin Cancer Res 2006 12: 3200-3208. [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Prevention:

Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

Nicholas Hearle, Valérie Schumacher, Fred H. Menko, Sylviane Olschwang, Lisa A. Boardman, Johan J.P. Gille, Josbert J. Keller, Anne Marie Westerman, Rodney J. Scott, Wendy Lim, Jill D. Trimbath, Francis M. Giardiello, Stephen B. Gruber, G. Johan A. Offerhaus, Felix W.M. de Rooij, J.H. Paul Wilson, Anika Hansmann, Gabriela Möslein, Brigitte Royer-Pokora, Tilman Vogel, Robin K.S. Phillips, Allan D. Spigelman, and Richard S. Houlston
Clin Cancer Res 2006 12: 3209-3215. [Abstract] [Full Text] [PDF]  

Effects of Helicobacter pylori Eradication on Methylation Status of E-Cadherin Gene in Noncancerous Stomach

Wai K. Leung, Ellen P.S. Man, Jun Yu, Minnie Y.Y. Go, Ka-fai To, Yoshio Yamaoka, Victoria Y.Y. Cheng, Enders K.W. Ng, and Joseph J.Y. Sung
Clin Cancer Res 2006 12: 3216-3221. [Abstract] [Full Text] [PDF]  

Heterogeneous Nuclear Ribonucleoprotein G Shows Tumor Suppressive Effect against Oral Squamous Cell Carcinoma Cells

Ki-Hyuk Shin, Mo K. Kang, Reuben H. Kim, Russell Christensen, and No-Hee Park
Clin Cancer Res 2006 12: 3222-3228. [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Article on Evaluating the Efficiency of Targeted Designs

Clin Cancer Res 2006 12: 3229. [Full Text] [PDF]  

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