Editor's Note:

Updates

William N. Hait
Clin Cancer Res 2006 12: 5605. [Full Text] [PDF]  

Editorials:

Cancer Stem Cells and Metastasis: Lethal Seeds

Max S. Wicha
Clin Cancer Res 2006 12: 5606-5607. [Full Text] [PDF]  

The Biology Behind:

Monitoring Targeted Therapy: Is Fluorodeoxylucose Uptake a Marker of Early Response?

Hannah M. Linden, Kenneth A. Krohn, Robert B. Livingston, and David A. Mankoff
Clin Cancer Res 2006 12: 5608-5610. [Full Text] [PDF]  

Molecular Pathways:

Insulin-Like Growth Factor-I Axis as a Pathway for Cancer Chemoprevention

Vaqar Mustafa Adhami, Farrukh Afaq, and Hasan Mukhtar
Clin Cancer Res 2006 12: 5611-5614. [Full Text] [PDF]  

Human Cancer Biology:

Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype

Marija Balic, Henry Lin, Lillian Young, Debra Hawes, Armando Giuliano, George McNamara, Ram H. Datar, and Richard J. Cote
Clin Cancer Res 2006 12: 5615-5621. [Abstract] [Full Text] [PDF]  

Magnitude of Stromal Hemangiogenesis Correlates with Histologic Subtype of Non–Hodgkin's Lymphoma

Jia Ruan, Elizabeth Hyjek, Pouneh Kermani, Paul J. Christos, Andrea T. Hooper, Morton Coleman, Barbara Hempstead, John P. Leonard, Amy Chadburn, and Shahin Rafii
Clin Cancer Res 2006 12: 5622-5631. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling in Cervical Cancer: An Exploration of Intratumor Heterogeneity

Barbara Bachtiary, Paul C. Boutros, Melania Pintilie, Willa Shi, Carlo Bastianutto, Jian-Hua Li, Joerg Schwock, Wendy Zhang, Linda Z. Penn, Igor Jurisica, Anthony Fyles, and Fei-Fei Liu
Clin Cancer Res 2006 12: 5632-5640. [Abstract] [Full Text] [PDF] Supplementary Data  

Estrogenic Regulation of Host Immunity against an Estrogen Receptor–Negative Human Breast Cancer

Edward M. Curran, Barbara M. Judy, Ngozi A. Duru, Hui-Qun Wang, Leoncio A. Vergara, Dennis B. Lubahn, and D. Mark Estes
Clin Cancer Res 2006 12: 5641-5647. [Abstract] [Full Text] [PDF]  

Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density

Leonid L. Nikitenko, Tanya Cross, Leticia Campo, Helen Turley, Russell Leek, Sanjiv Manek, Roy Bicknell, and Margaret C.P. Rees
Clin Cancer Res 2006 12: 5648-5658. [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

Monitoring Tumor Glucose Utilization by Positron Emission Tomography for the Prediction of Treatment Response to Epidermal Growth Factor Receptor Kinase Inhibitors

Helen Su, Claudia Bodenstein, Rebecca A. Dumont, Yann Seimbille, Steven Dubinett, Michael E. Phelps, Harvey Herschman, Johannes Czernin, and Wolfgang Weber
Clin Cancer Res 2006 12: 5659-5667. [Abstract] [Full Text] [PDF]  

Interphase Fluorescence In situ Hybridization Analysis of Chromosome 12p Abnormalities Is Useful for Distinguishing Epidermoid Cysts of the Testis from Pure Mature Teratoma

Liang Cheng, Shaobo Zhang, Gregory T. MacLennan, Christopher K. Poulos, Ming-Tse Sung, Stephen D. Beck, and Richard S. Foster
Clin Cancer Res 2006 12: 5668-5672. [Abstract] [Full Text] [PDF]  

Increased Expression of Wiskott-Aldrich Syndrome Protein Family Verprolin-Homologous Protein 2 Correlated with Poor Prognosis of Hepatocellular Carcinoma

Lian-Yue Yang, Yi-Ming Tao, Di-Peng Ou, Wei Wang, Zhi-Gang Chang, and Fan Wu
Clin Cancer Res 2006 12: 5673-5679. [Abstract] [Full Text] [PDF]  

Peripheral Blood Stem Cell Tumor Cell Contamination and Survival of Neuroblastoma Patients

Maria Valeria Corrias, Riccardo Haupt, Barbara Carlini, Stefano Parodi, Lucia Rivabella, Alberto Garaventa, Vito Pistoia, and Sandro Dallorso
Clin Cancer Res 2006 12: 5680-5685. [Abstract] [Full Text] [PDF]  

The GNAS1 T393C Polymorphism Is Associated with Disease Progression and Survival in Chronic Lymphocytic Leukemia

Ulrich H. Frey, Holger Nückel, Ludger Sellmann, Dörte Siemer, Ralf Küppers, Jan Dürig, Ulrich Dührsen, and Winfried Siffert
Clin Cancer Res 2006 12: 5686-5692. [Abstract] [Full Text] [PDF]  

Does MYCN Amplification Manifested as Homogeneously Staining Regions at Diagnosis Predict a Worse Outcome in Children with Neuroblastoma? A Children's Oncology Group Study

Lisa A. Moreau, Patrick McGrady, Wendy B. London, Hiroyuki Shimada, Susan L. Cohn, John M. Maris, Lisa Diller, A. Thomas Look, and Rani E. George
Clin Cancer Res 2006 12: 5693-5697. [Abstract] [Full Text] [PDF]  

YKL-40 and Matrix Metalloproteinase-9 as Potential Serum Biomarkers for Patients with High-Grade Gliomas

Adília Hormigo, Bin Gu, Sasan Karimi, Elyn Riedel, Katherine S. Panageas, Mark A. Edgar, Meena K. Tanwar, Jasti S. Rao, Martin Fleisher, Lisa M. DeAngelis, and Eric C. Holland
Clin Cancer Res 2006 12: 5698-5704. [Abstract] [Full Text] [PDF]  

Gene Expression Profiles of Primary Breast Carcinomas from Patients at High Risk for Local Recurrence after Breast-Conserving Therapy

Bas Kreike, Hans Halfwerk, Petra Kristel, Annuska Glas, Hans Peterse, Harry Bartelink, and Marc J. van de Vijver
Clin Cancer Res 2006 12: 5705-5712. [Abstract] [Full Text] [PDF] Supplementary Data  

RNASEL Gene Polymorphisms and the Risk of Prostate Cancer: a Meta-analysis

Huihua Li and Bee Choo Tai
Clin Cancer Res 2006 12: 5713-5719. [Abstract] [Full Text] [PDF]  

Expression of Telomere-Associated Genes as Prognostic Markers for Overall Survival in Patients with Non–Small Cell Lung Cancer

Xin Lin, Jian Gu, Charles Lu, Margaret R. Spitz, and Xifeng Wu
Clin Cancer Res 2006 12: 5720-5725. [Abstract] [Full Text] [PDF]  

Prognostic Significance of the Epstein-Barr Virus, p53, Bcl-2, and Survivin in Nasopharyngeal Cancer

Kenneth W. Yip, Wei Shi, Melania Pintilie, Joseph D. Martin, Joseph D. Mocanu, Derek Wong, Christine MacMillan, Pat Gullane, Brian O'Sullivan, Carlo Bastianutto, and Fei-Fei Liu
Clin Cancer Res 2006 12: 5726-5732. [Abstract] [Full Text] [PDF]  

Extracellular pH and P-31 Magnetic Resonance Spectroscopic Variables are Related to Outcome in Canine Soft Tissue Sarcomas Treated with Thermoradiotherapy

Michaël Lora-Michiels, Daohai Yu, Linda Sanders, Jean M. Poulson, Chieko Azuma, Beth Case, Zeljko Vujaskovic, Donald E. Thrall, H. Cecil Charles, and Mark W. Dewhirst
Clin Cancer Res 2006 12: 5733-5740. [Abstract] [Full Text] [PDF]  

Nuclear Localization of Nuclear Factor-B p65 in Primary Prostate Tumors Is Highly Predictive of Pelvic Lymph Node Metastases

Laurent Lessard, Pierre I. Karakiewicz, Pascale Bellon-Gagnon, Mona Alam-Fahmy, Hazem A. Ismail, Anne-Marie Mes-Masson, and Fred Saad
Clin Cancer Res 2006 12: 5741-5745. [Abstract] [Full Text] [PDF]  

Identification of -Enolase as an Autoantigen in Lung Cancer: Its Overexpression Is Associated with Clinical Outcomes

Gee-Chen Chang, Ko-Jiunn Liu, Chia-Ling Hsieh, Tsai-Shu Hu, Suparat Charoenfuprasert, Hsiung-Kun Liu, Kwen-Tay Luh, Li-Han Hsu, Chew-Wen Wu, Chou-Chik Ting, Chih-Yi Chen, Kun-Chieh Chen, Tsung-Ying Yang, Teh-Ying Chou, Wen-Hua Wang, Jacqueline Whang-Peng, and Neng-Yao Shih
Clin Cancer Res 2006 12: 5746-5754. [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

A Phase I and Pharmacokinetic Study of Temsirolimus (CCI-779) Administered Intravenously Daily for 5 Days Every 2 Weeks to Patients with Advanced Cancer

Manuel Hidalgo, Jan C. Buckner, Charles Erlichman, Marilyn S. Pollack, Joseph P. Boni, Gary Dukart, Bonnie Marshall, Lisa Speicher, Laurence Moore, and Eric K. Rowinsky
Clin Cancer Res 2006 12: 5755-5763. [Abstract] [Full Text] [PDF]  

Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib

Takayuki Kosaka, Yasushi Yatabe, Hideki Endoh, Kimihide Yoshida, Toyoaki Hida, Masahiro Tsuboi, Hirohito Tada, Hiroyuki Kuwano, and Tetsuya Mitsudomi
Clin Cancer Res 2006 12: 5764-5769. [Abstract] [Full Text] [PDF]  

Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors

Robert L. Fine, Johnson Chen, Casilda Balmaceda, Jeffrey N. Bruce, May Huang, Manisha Desai, Michael B. Sisti, Guy M. McKhann, Robert R. Goodman, Joseph S. Bertino, Jr., Anne N. Nafziger, and Michael R. Fetell
Clin Cancer Res 2006 12: 5770-5776. [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

David S. Schrump, Maria R. Fischette, Dao M. Nguyen, Ming Zhao, Xinmin Li, Tricia F. Kunst, Ana Hancox, Julie A. Hong, G. Aaron Chen, Vitaliy Pishchik, William D. Figg, Anthony J. Murgo, and Seth M. Steinberg
Clin Cancer Res 2006 12: 5777-5785. [Abstract] [Full Text] [PDF] Supplementary Data  

Pharmacogenetic Screening of CYP3A and ABCB1 in Relation to Population Pharmacokinetics of Docetaxel

Tessa M. Bosch, Alwin D.R. Huitema, Valerie D. Doodeman, Robert Jansen, Els Witteveen, Wim M. Smit, Rob L. Jansen, Carla M. van Herpen, Marcel Soesan, Jos H. Beijnen, and Jan H.M. Schellens
Clin Cancer Res 2006 12: 5786-5793. [Abstract] [Full Text] [PDF]  

Overexpression of Caspase-3s Splice Variant in Locally Advanced Breast Carcinoma Is Associated with Poor Response to Neoadjuvant Chemotherapy

Frédérique Végran, Romain Boidot, Claire Oudin, Jean-Marc Riedinger, Franck Bonnetain, and Sarab Lizard-Nacol
Clin Cancer Res 2006 12: 5794-5800. [Abstract] [Full Text] [PDF]  

Intralymphatic Dendritic Cell Vaccination Induces Tumor Antigen–Specific, Skin-Homing T Lymphocytes

Amelia Grover, Grace J. Kim, Gregory Lizée, Mary Tschoi, Gang Wang, John R. Wunderlich, Steven A. Rosenberg, Sam T. Hwang, and Patrick Hwu
Clin Cancer Res 2006 12: 5801-5808. [Abstract] [Full Text] [PDF]  

Phase I Study of Bryostatin 1 and Fludarabine in Patients with Chronic Lymphocytic Leukemia and Indolent (Non-Hodgkin's) Lymphoma

John D. Roberts, Mitchell R. Smith, Eric J. Feldman, Louise Cragg, Michael M. Millenson, Gail J. Roboz, Connie Honeycutt, Rose Thune, Kristin Padavic-Shaller, W. Hans Carter, Viswanathan Ramakrishnan, Anthony J. Murgo, and Steven Grant
Clin Cancer Res 2006 12: 5809-5816. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Cisplatin Preferentially Binds Mitochondrial DNA and Voltage-Dependent Anion Channel Protein in the Mitochondrial Membrane of Head and Neck Squamous Cell Carcinoma: Possible Role in Apoptosis

Zejia Yang, Lisa M. Schumaker, Merrill J. Egorin, Eleanor G. Zuhowski, Zhongmin Guo, and Kevin J. Cullen
Clin Cancer Res 2006 12: 5817-5825. [Abstract] [Full Text] [PDF]  

A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice

Jan H. Beumer, Erin Joseph, Merrill J. Egorin, Robert S. Parker, David Z. D'argenio, Joseph M. Covey, and Julie L. Eiseman
Clin Cancer Res 2006 12: 5826-5833. [Abstract] [Full Text] [PDF]  

Vaccination with Viable Human Umbilical Vein Endothelial Cells Prevents Metastatic Tumors by Attack on Tumor Vasculature with Both Cellular and Humoral Immunity

Xin-Yuan Chen, Wei Zhang, Wang Zhang, Sheng Wu, Feng Bi, Yi-Jing Su, Xiang-Yang Tan, Jian-Ning Liu, and Jing Zhang
Clin Cancer Res 2006 12: 5834-5840. [Abstract] [Full Text] [PDF]  

Inhibition of Tumor Growth with Antiangiogenic Cancer Vaccine Using Epitope Peptides Derived from Human Vascular Endothelial Growth Factor Receptor 1

Hidenobu Ishizaki, Takuya Tsunoda, Satoshi Wada, Mai Yamauchi, Masabumi Shibuya, and Hideaki Tahara
Clin Cancer Res 2006 12: 5841-5849. [Abstract] [Full Text] [PDF]  

Multiparametric Flow Cytometric Analysis of Signal Transducer and Activator of Transcription 5 Phosphorylation in Immune Cell Subsets In vitro and following Interleukin-2 Immunotherapy

Kimberly A. Varker, Sri Vidya Kondadasula, Michael R. Go, Gregory B. Lesinski, Rupa Ghosh-Berkebile, Amy Lehman, J. Paul Monk, Thomas Olencki, Kari Kendra, and William E. Carson, III
Clin Cancer Res 2006 12: 5850-5858. [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Effect of Oncolytic Adenovirus Expressing Interleukin-12 and B7-1 in an Immunocompetent Murine Model

Young-Sook Lee, Joo-Hang Kim, Kyung-Ju Choi, Il-Kyu Choi, Hoguen Kim, Sungae Cho, Byoung Chul Cho, and Chae-Ok Yun
Clin Cancer Res 2006 12: 5859-5868. [Abstract] [Full Text] [PDF]  

Cotreatment with Vorinostat (Suberoylanilide Hydroxamic Acid) Enhances Activity of Dasatinib (BMS-354825) against Imatinib Mesylate–Sensitive or Imatinib Mesylate–Resistant Chronic Myelogenous Leukemia Cells

Warren Fiskus, Michael Pranpat, Maria Balasis, Purva Bali, Veronica Estrella, Sandhya Kumaraswamy, Rekha Rao, Kathy Rocha, Bryan Herger, Francis Lee, Victoria Richon, and Kapil Bhalla
Clin Cancer Res 2006 12: 5869-5878. [Abstract] [Full Text] [PDF]  

Sensitization by Dietary Docosahexaenoic Acid of Rat Mammary Carcinoma to Anthracycline: A Role for Tumor Vascularization

Séverine Colas, Karine Mahéo, Fabrice Denis, Caroline Goupille, Claude Hoinard, Pascal Champeroux, François Tranquart, and Philippe Bougnoux
Clin Cancer Res 2006 12: 5879-5886. [Abstract] [Full Text] [PDF]  

MLN120B, a Novel IB Kinase ß Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

Teru Hideshima, Paola Neri, Pierfranchesco Tassone, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine Mitsiades, Lenny Dang, Nikhil Munshi, Paul Richardson, David Schenkein, and Kenneth C. Anderson
Clin Cancer Res 2006 12: 5887-5894. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Vitamin D Inhibits the Formation of Prostatic Intraepithelial Neoplasia in Nkx3.1; Pten Mutant Mice

Whitney Banach-Petrosky, Xuesong Ouyang, Hui Gao, Kamyar Nader, Yan Ji, Nanjoo Suh, Robert S. DiPaola, and Cory Abate-Shen
Clin Cancer Res 2006 12: 5895-5901. [Abstract] [Full Text] [PDF]  

The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer

Karen Liby, Mara Rendi, Nanjoo Suh, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, William Lamph, Fernand Labrie, Stan Krajewski, Xiaochun Xu, Heetae Kim, Powel Brown, and Michael B. Sporn
Clin Cancer Res 2006 12: 5902-5909. [Abstract] [Full Text] [PDF]  

Isodeoxyelephantopin, a Novel Sesquiterpene Lactone, Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis through Suppression of Nuclear Factor-B (NF-B) Activation and NF-B-Regulated Gene Expression

Haruyo Ichikawa, Mangalam S. Nair, Yasunari Takada, D.B. Alan Sheeja, M.A. Suresh Kumar, Oommen V. Oommen, and Bharat B. Aggarwal
Clin Cancer Res 2006 12: 5910-5918. [Abstract] [Full Text] [PDF]  

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