The Biology Behind:

Ovarian Cancer Biomarkers in Urine

Ann F. Chambers and Barbara C. Vanderhyden
Clin Cancer Res 2006 12: 323-327. [Full Text] [PDF]  

Molecular Pathways:

Targeted Modulation of MGMT: Clinical Implications

Lili Liu and Stanton L. Gerson
Clin Cancer Res 2006 12: 328-331. [Abstract] [Full Text] [PDF]  

Reviews:

Erythropoietin Biology in Cancer

Matthew E. Hardee, Murat O. Arcasoy, Kimberly L. Blackwell, John P. Kirkpatrick, and Mark W. Dewhirst
Clin Cancer Res 2006 12: 332-339. [Abstract] [Full Text] [PDF]  

Eradication of Leukemia Stem Cells as a New Goal of Therapy in Leukemia

Farhad Ravandi and Zeev Estrov
Clin Cancer Res 2006 12: 340-344. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

High-Resolution Genomic Profiling Reveals Association of Chromosomal Aberrations on 1q and 16p with Histologic and Genetic Subgroups of Invasive Breast Cancer

Daniel E. Stange, Bernhard Radlwimmer, Falk Schubert, Frank Traub, Andreas Pich, Grischa Toedt, Frank Mendrzyk, Ulrich Lehmann, Roland Eils, Hans Kreipe, and Peter Lichter
Clin Cancer Res 2006 12: 345-352. [Abstract] [Full Text] [PDF]  

Expression of EphA2 and Ephrin A-1 in Carcinoma of the Urinary Bladder

Shaji Abraham, Deborah W. Knapp, Liang Cheng, Paul W. Snyder, Suresh K. Mittal, Dinesh S. Bangari, Michael Kinch, Lan Wu, Jay Dhariwal, and Sulma I. Mohammed
Clin Cancer Res 2006 12: 353-360. [Abstract] [Full Text] [PDF]  

Biological Significance of Isolated Tumor Cells and Micrometastasis in Lymph Nodes Evaluated Using a Green Fluorescent Protein–Tagged Human Gastric Cancer Cell Line

Hiroyuki Yokoyama, Hayao Nakanishi, Yasuhiro Kodera, Yuzuru Ikehara, Norifumi Ohashi, Yuichi Ito, Masahiko Koike, Michitaka Fujiwara, Masae Tatematsu, and Akimasa Nakao
Clin Cancer Res 2006 12: 361-368. [Abstract] [Full Text] [PDF]  

Stress Hormone–Mediated Invasion of Ovarian Cancer Cells

Anil K. Sood, Robert Bhatty, Aparna A. Kamat, Charles N. Landen, Liz Han, Premal H. Thaker, Yang Li, David M. Gershenson, Susan Lutgendorf, and Steven W. Cole
Clin Cancer Res 2006 12: 369-375. [Abstract] [Full Text] [PDF]  

Expression of Interleukin-18 and Caspase-1 in Cutaneous T-Cell Lymphoma

Kei-ichi Yamanaka, Rachael Clark, Rebecca Dowgiert, Daniel Hurwitz, Michio Shibata, Benjamin E. Rich, Kazuki Hirahara, David A. Jones, Sara Eapen, Hitoshi Mizutani, and Thomas S. Kupper
Clin Cancer Res 2006 12: 376-382. [Abstract] [Full Text] [PDF]  

Epigenetic Inactivation of Wnt Inhibitory Factor-1 Plays an Important Role in Bladder Cancer through Aberrant Canonical Wnt/ß-Catenin Signaling Pathway

Shinji Urakami, Hiroaki Shiina, Hideki Enokida, Toshifumi Kawakami, Takashi Tokizane, Tatsuya Ogishima, Yuichiro Tanaka, Long-Cheng Li, Leopoldo A. Ribeiro-Filho, Masaharu Terashima, Nobuyuki Kikuno, Hiroyuki Adachi, Tatsuaki Yoneda, Hirofumi Kishi, Kazushi Shigeno, Badrinath R. Konety, Mikio Igawa, and Rajvir Dahiya
Clin Cancer Res 2006 12: 383-391. [Abstract] [Full Text] [PDF]  

Int7G24A Variant of Transforming Growth Factor-ß Receptor Type I Is Associated with Invasive Breast Cancer

Taiping Chen, Chad R. Jackson, Andrew Link, Michael P. Markey, Bruce M. Colligan, Larry E. Douglass, Jackson O. Pemberton, James A. Deddens, Jeremy R. Graff, and Julia H. Carter
Clin Cancer Res 2006 12: 392-397. [Abstract] [Full Text] [PDF]  

Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4⁺ T Cells

Danila Valmori, Feng Qian, Maha Ayyoub, Christoph Renner, Andrea Merlo, Sacha Gjnatic, Elisabeth Stockert, Deborah Driscoll, Shashikant Lele, Lloyd J. Old, and Kunle Odunsi
Clin Cancer Res 2006 12: 398-404. [Abstract] [Full Text] [PDF]  

Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability

Bibo Yuan, Yi Xu, Ju-Hyung Woo, Yunyue Wang, Young Kyung Bae, Dae-Sung Yoon, Robert P. Wersto, Ellen Tully, Kathleen Wilsbach, and Edward Gabrielson
Clin Cancer Res 2006 12: 405-410. [Abstract] [Full Text] [PDF]  

Tumor-Associated Antigen Recognized by the 22-1-1 Monoclonal Antibody Encourages Colorectal Cancer Progression under the Scanty CD8⁺ T Cells

Taro Oshikiri, Masaki Miyamoto, Takayuki Morita, Miyoshi Fujita, Yuji Miyasaka, Naoto Senmaru, Hidehisa Yamada, Toshiyuki Takahashi, Shoichi Horita, and Satoshi Kondo
Clin Cancer Res 2006 12: 411-416. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Identification of Early-Stage Colorectal Cancer Patients at Risk of Relapse Post-Resection by Immunobead Reverse Transcription-PCR Analysis of Peritoneal Lavage Fluid for Malignant Cells

Julia M. Lloyd, Cassandra M. McIver, Sally-Anne Stephenson, Peter J. Hewett, Nicholas Rieger, and Jennifer E. Hardingham
Clin Cancer Res 2006 12: 417-423. [Abstract] [Full Text] [PDF]  

p95HER-2 Predicts Worse Outcome in Patients with HER-2-Positive Breast Cancer

Rosana Sáez, Miguel A. Molina, Elizabeth E. Ramsey, Federico Rojo, Edward J. Keenan, Joan Albanell, Ana Lluch, Javier García-Conde, José Baselga, and Gail M. Clinton
Clin Cancer Res 2006 12: 424-431. [Abstract] [Full Text] [PDF]  

Proteomic-Based Discovery and Characterization of Glycosylated Eosinophil-Derived Neurotoxin and COOH-Terminal Osteopontin Fragments for Ovarian Cancer in Urine

Bin Ye, Steven Skates, Samuel C. Mok, Nora K. Horick, Helene F. Rosenberg, Allison Vitonis, Dale Edwards, Patrick Sluss, Won K. Han, Ross S. Berkowitz, and Daniel W. Cramer
Clin Cancer Res 2006 12: 432-441. [Abstract] [Full Text] [PDF]  

Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9

Jens Koopmann, C. Nicole White Rosenzweig, Zhen Zhang, Marcia I. Canto, David A. Brown, Mark Hunter, Charles Yeo, Daniel W. Chan, Samuel N. Breit, and Michael Goggins
Clin Cancer Res 2006 12: 442-446. [Abstract] [Full Text] [PDF]  

Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer

Raffit Hassan, Alan T. Remaley, Maureen L. Sampson, Jingli Zhang, Derrick D. Cox, James Pingpank, Richard Alexander, Mark Willingham, Ira Pastan, and Masanori Onda
Clin Cancer Res 2006 12: 447-453. [Abstract] [Full Text] [PDF]  

Detection of Mononucleotide Repeat Sequence Alterations in a Large Background of Normal DNA for Screening High-Frequency Microsatellite Instability Cancers

Xiyuan Sun, Yiding Liu, Jim Lutterbaugh, Wei-Dong Chen, Sanford D. Markowitz, and Baochuan Guo
Clin Cancer Res 2006 12: 454-459. [Abstract] [Full Text] [PDF]  

Plasma Epstein-Barr Virus (EBV) DNA Is a Biomarker for EBV-Positive Hodgkin's Lymphoma

Maher K. Gandhi, Eleanore Lambley, Jacqueline Burrows, Ujjwal Dua, Suzanne Elliott, Peter J. Shaw, H. Miles Prince, Max Wolf, Kerrie Clarke, Craig Underhill, Tony Mills, Peter Mollee, Devinder Gill, Paula Marlton, John F. Seymour, and Rajiv Khanna
Clin Cancer Res 2006 12: 460-464. [Abstract] [Full Text] [PDF]  

Prognostic Value of Tumor-Infiltrating CD4⁺ T-Cell Subpopulations in Head and Neck Cancers

Cécile Badoual, Stéphane Hans, José Rodriguez, Severine Peyrard, Christophe Klein, Nour El Houda Agueznay, Véronique Mosseri, Ollivier Laccourreye, Patrick Bruneval, Wolf H. Fridman, Daniel F. Brasnu, and Eric Tartour
Clin Cancer Res 2006 12: 465-472. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Carbonic Anhydrase IX in Astrocytic Tumors Predicts Poor Prognosis

Joonas A. Haapasalo, Kristiina M. Nordfors, Mika Hilvo, Immo J. Rantala, Ylermi Soini, Anna-Kaisa Parkkila, Silvia Pastoreková, Jaromir Pastorek, Seppo M. Parkkila, and Hannu K. Haapasalo
Clin Cancer Res 2006 12: 473-477. [Abstract] [Full Text] [PDF]  

Correlations between Serum Monocyte Chemotactic Protein-1 Levels, Clinical Prognostic Factors, and HER-2/neu Vaccine-Related Immunity in Breast Cancer Patients

Zia A. Dehqanzada, Catherine E. Storrer, Matthew T. Hueman, Rebecca J. Foley, Katie A. Harris, Yusuf H. Jama, Tzu-Cheg Kao, Craig D. Shriver, Sathibalan Ponniah, and George E. Peoples
Clin Cancer Res 2006 12: 478-486. [Abstract] [Full Text] [PDF]  

Skp2 Overexpression Is Highly Representative of Intrinsic Biological Aggressiveness and Independently Associated with Poor Prognosis in Primary Localized Myxofibrosarcomas

Hsuan-Ying Huang, Hong-Yo Kang, Chien-Feng Li, Hock-Liew Eng, Shih-Cheng Chou, Ching-Nan Lin, and Ching-Yeh Hsiung
Clin Cancer Res 2006 12: 487-498. [Abstract] [Full Text] [PDF]  

Sex-Specific Survival Advantage with Parathyroid Hormone–Related Protein in Non–Small Cell Lung Carcinoma Patients

Randolph H. Hastings, Ann M.P. Laux, Andrea Casillas, Ronghui Xu, Zenaida Lukas, Karin Ernstrom, and Leonard J. Deftos
Clin Cancer Res 2006 12: 499-506. [Abstract] [Full Text] [PDF]  

Increased NBS1 Expression Is a Marker of Aggressive Head and Neck Cancer and Overexpression of NBS1 Contributes to Transformation

Muh-Hwa Yang, Wei-Chung Chiang, Teh-Ying Chou, Shyue-Yih Chang, Po-Min Chen, Shu-Chun Teng, and Kou-Juey Wu
Clin Cancer Res 2006 12: 507-515. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Evaluation of Oral and Intravenous Vinorelbine in Pediatric Cancer Patients: A Report from the Children's Oncology Group

Mary Johansen, John Kuttesch, W. Archie Bleyer, Mark Krailo, Matthew Ames, and Timothy Madden
Clin Cancer Res 2006 12: 516-522. [Abstract] [Full Text] [PDF]  

Phase I Study of the Taxane BMS-188797 in Combination with Carboplatin Administered Every 3 Weeks in Patients with Solid Malignancies

Mayer N. Fishman, Christopher R. Garrett, George R. Simon, Alberto A. Chiappori, Richard M. Lush, William R. Dinwoodie, J. Joseph Mahany, Anne M. Dellaportas, Alan Cantor, Ashwin Gollerki, Marvin B. Cohen, and Daniel M. Sullivan
Clin Cancer Res 2006 12: 523-528. [Abstract] [Full Text] [PDF]  

MOPPEBVCAD Chemotherapy with Limited and Conditioned Radiotherapy in Advanced Hodgkin's Lymphoma: 10-Year Results, Late Toxicity, and Second Tumors

Paolo G. Gobbi, Chiara Broglia, Alessandro Levis, Antonio La Sala, Francesco Valentino, Teodoro Chisesi, Stefano Sacchi, Franco Corbella, Luigi Cavanna, Emilio Iannitto, Vincenzo Pavone, Stefano Molica, Gino Roberto Corazza, and Massimo Federico
Clin Cancer Res 2006 12: 529-535. [Abstract] [Full Text] [PDF]  

Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer

Christopher J. Sweeney, Chris H. Takimoto, Jane E. Latz, Sharyn D. Baker, Daryl J. Murry, James H. Krull, Karen Fife, Linda Battiato, Ann Cleverly, Ajai K. Chaudhary, Tuhin Chaudhuri, Alan Sandler, Alain C. Mita, and Eric K. Rowinsky
Clin Cancer Res 2006 12: 536-542. [Abstract] [Full Text] [PDF]  

Long-term Clinical Outcome of Phase IIb Clinical Trial of Percutaneous Injection with Holmium-166/Chitosan Complex (Milican) for the Treatment of Small Hepatocellular Carcinoma

Ja Kyung Kim, Kwang-Hyub Han, Jong Tae Lee, Yong Han Paik, Sang Hoon Ahn, Jong Doo Lee, Kwan Sik Lee, Chae Yoon Chon, and Young Myoung Moon
Clin Cancer Res 2006 12: 543-548. [Abstract] [Full Text] [PDF]  

The Uracil Breath Test in the Assessment of Dihydropyrimidine Dehydrogenase Activity: Pharmacokinetic Relationship between Expired ¹³CO₂ and Plasma [2-¹³C]Dihydrouracil

Lori K. Mattison, Jeanne Fourie, Yukihiro Hirao, Toshihisa Koga, Renee A. Desmond, Jennifer R. King, Takefumi Shimizu, and Robert B. Diasio
Clin Cancer Res 2006 12: 549-555. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Delta-24 Increases the Expression and Activity of Topoisomerase I and Enhances the Antiglioma Effect of Irinotecan

Candelaria Gomez-Manzano, Marta M. Alonso, W.K. Alfred Yung, Frank McCormick, David T. Curiel, Frederick F. Lang, Hong Jiang, B. Nebiyou Bekele, Xian Zhou, Ramon Alemany, and Juan Fueyo
Clin Cancer Res 2006 12: 556-562. [Abstract] [Full Text] [PDF]  

DNA Polymerase Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair

Xinjian Lin, Julie Trang, Tsuyoshi Okuda, and Stephen B. Howell
Clin Cancer Res 2006 12: 563-568. [Abstract] [Full Text] [PDF]  

Human T Cells Armed with Her2/neu Bispecific Antibodies Divide, Are Cytotoxic, and Secrete Cytokines with Repeated Stimulation

Ryan C. Grabert, Leslie P. Cousens, Janelle A. Smith, Sarah Olson, Jonathan Gall, Wendy B. Young, Pamela A. Davol, and Lawrence G. Lum
Clin Cancer Res 2006 12: 569-576. [Abstract] [Full Text] [PDF]  

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

Vincenzo Damiano, Rosa Caputo, Roberto Bianco, Francesco P. D'Armiento, Antonio Leonardi, Sabino De Placido, A. Raffaele Bianco, Sudhir Agrawal, Fortunato Ciardiello, and Giampaolo Tortora
Clin Cancer Res 2006 12: 577-583. [Abstract] [Full Text] [PDF]  

Inhibition of Heat Shock Protein 90 Function by 17-Allylamino-17-Demethoxy-Geldanamycin in Hodgkin's Lymphoma Cells Down-Regulates Akt Kinase, Dephosphorylates Extracellular Signal–Regulated Kinase, and Induces Cell Cycle Arrest and Cell Death

Georgios V. Georgakis, Yang Li, Georgios Z. Rassidakis, Hector Martinez-Valdez, L. Jeffrey Medeiros, and Anas Younes
Clin Cancer Res 2006 12: 584-590. [Abstract] [Full Text] [PDF]  

Tipifarnib and Bortezomib Are Synergistic and Overcome Cell Adhesion–Mediated Drug Resistance in Multiple Myeloma and Acute Myeloid Leukemia

Niranjan Yanamandra, Nandita M. Colaco, Nancy A. Parquet, Robert W. Buzzeo, David Boulware, Gabriela Wright, Lia E. Perez, William S. Dalton, and Darrin M. Beaupre
Clin Cancer Res 2006 12: 591-599. [Abstract] [Full Text] [PDF]  

Cetuximab and Irinotecan Interact Synergistically to Inhibit the Growth of Orthotopic Anaplastic Thyroid Carcinoma Xenografts in Nude Mice

Seungwon Kim, Christopher N. Prichard, Maher N. Younes, Yasemin D. Yazici, Samar A. Jasser, B. Nebiyou Bekele, and Jeffrey N. Myers
Clin Cancer Res 2006 12: 600-607. [Abstract] [Full Text] [PDF]  

Transcriptional Regulation of the Human Reduced Folate Carrier in Childhood Acute Lymphoblastic Leukemia Cells

Mingjun Liu, Yubin Ge, Scott G. Payton, Amro Aboukameel, Stephen Buck, Robin M. Flatley, Christina Haska, Ramzi Mohammad, Jeffrey W. Taub, and Larry H. Matherly
Clin Cancer Res 2006 12: 608-616. [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Activity of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib and IFN- in Head and Neck Cancer Cells In vitro and In vivo

Francesca Bruzzese, Elena Di Gennaro, Antonio Avallone, Stefano Pepe, Claudio Arra, Michele Caraglia, Pierosandro Tagliaferri, and Alfredo Budillon
Clin Cancer Res 2006 12: 617-625. [Abstract] [Full Text] [PDF]  

Intermittent Exposure of Primitive Quiescent Chronic Myeloid Leukemia Cells to Granulocyte-Colony Stimulating Factor In vitro Promotes their Elimination by Imatinib Mesylate

Heather G. Jørgensen, Mhairi Copland, Elaine K. Allan, Xiaoyan Jiang, Allen Eaves, Connie Eaves, and Tessa L. Holyoake
Clin Cancer Res 2006 12: 626-633. [Abstract] [Full Text] [PDF]  

Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589

David Z. Qian, Yukihiko Kato, Shabana Shabbeer, Yongfeng Wei, Hendrik M.W. Verheul, Brenda Salumbides, Tolib Sanni, Peter Atadja, and Roberto Pili
Clin Cancer Res 2006 12: 634-642. [Abstract] [Full Text] [PDF]  

Triple Combination of Oncolytic Herpes Simplex Virus-1 Vectors Armed with Interleukin-12, Interleukin-18, or Soluble B7-1 Results in Enhanced Antitumor Efficacy

Yasushi Ino, Yoshinaga Saeki, Hiroshi Fukuhara, and Tomoki Todo
Clin Cancer Res 2006 12: 643-652. [Abstract] [Full Text] [PDF]  

Identification of Insulin-Like Growth Factor Binding Protein-3 as a Farnesyl Transferase Inhibitor SCH66336-Induced Negative Regulator of Angiogenesis in Head and Neck Squamous Cell Carcinoma

Seung-Hyun Oh, Woo-Young Kim, Jai-Hyun Kim, Maher N. Younes, Adel K. El-Naggar, Jeffrey N. Myers, Merril Kies, Pinchas Cohen, Fadlo Khuri, Waun K. Hong, and Ho-Young Lee
Clin Cancer Res 2006 12: 653-661. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Guggulsterone Inhibits Osteoclastogenesis Induced by Receptor Activator of Nuclear Factor-B Ligand and by Tumor Cells by Suppressing Nuclear Factor-B Activation

Haruyo Ichikawa and Bharat B. Aggarwal
Clin Cancer Res 2006 12: 662-668. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Reply to the Letter to the Editor by Diamandis

Tom Curran
Clin Cancer Res 2006 12: 669. [Full Text] [PDF]  

Lost in (the Business of) Translation: Invest in the Youth

Eleftherios P. Diamandis
Clin Cancer Res 2006 12: 669. [Full Text] [PDF]  

EGFR Expression Predicts BRCA1 Status in Patients with Breast Cancer

Paul J. van Diest, Petra van der Groep, and Elsken van der Wall
Clin Cancer Res 2006 12: 670. [Full Text] [PDF]  

Reply to the Letter to the Editor by van Diest, et al

Sunil R. Lakhani
Clin Cancer Res 2006 12: 671. [Full Text] [PDF]  

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