Editorials:

Epigenetic Biomarkers and Breast Cancer: Cause for Optimism

Kala Visvanathan, Saraswati Sukumar, and Nancy E. Davidson
Clin Cancer Res 2006 12: 6591-6593 doi: 10.1158/1078-0432.CCR-06-2001 [Full Text] [PDF]  

The Biology Behind:

Fluorescence Visualization in Oral Neoplasia: Shedding Light on an Old Problem

William H. Westra and David Sidransky
Clin Cancer Res 2006 12: 6594 -6597 doi: 10.1158/1078-0432.CCR-06-2253 [Full Text] [PDF]  

Molecular Pathways:

Of Spiders and Crabs: The Emergence of Lysophospholipids and Their Metabolic Pathways as Targets for Therapy in Cancer

Mandi Murph, Tamotsu Tanaka, Shuying Liu, and Gordon B. Mills
Clin Cancer Res 2006 12: 6598-6602 doi: 10.1158/1078-0432.CCR-06-1721 [Abstract] [Full Text] [PDF]  

Review:

Synopsis of a Roundtable on Validating Novel Therapeutics for Multiple Myeloma

William Dalton and Kenneth C. Anderson
Clin Cancer Res 2006 12: 6603-6610 doi: 10.1158/1078-0432.CCR-06-1489 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Enhanced RASGEF1A Expression Is Involved in the Growth and Migration of Intrahepatic Cholangiocarcinoma

Katsuaki Ura, Kazutaka Obama, Seiji Satoh, Yoshiharu Sakai, Yusuke Nakamura, and Yoichi Furukawa
Clin Cancer Res 2006 12: 6611-6616 doi: 10.1158/1078-0432.CCR-06-0783 [Abstract] [Full Text] [PDF]  

Identification of Carboxypeptidase of Glutamate Like-B as a Candidate Suppressor in Cell Growth and Metastasis in Human Hepatocellular Carcinoma

Pingping Zhang, David Wai Chan, YiYi Zhu, Jin Jun Li, Irene Oi-Lin Ng, Dafang Wan, and Jianren Gu
Clin Cancer Res 2006 12: 6617-6625 doi: 10.1158/1078-0432.CCR-06-1307 [Abstract] [Full Text] [PDF]  

Mapping Geographic Zones of Cancer Risk with Epigenetic Biomarkers in Normal Breast Tissue

Pearlly S. Yan, Chinnambally Venkataramu, Ashraf Ibrahim, Joseph C. Liu, Rulong Z. Shen, Nils M. Diaz, Barbara Centeno, Frank Weber, Yu-Wei Leu, Charles L. Shapiro, Charis Eng, Timothy J. Yeatman, and Tim H.-M. Huang
Clin Cancer Res 2006 12: 6626-6636 doi: 10.1158/1078-0432.CCR-06-0467 [Abstract] [Full Text] [PDF] Supplementary Data  

Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression

James P. Hamilton, Fumiaki Sato, Zhe Jin, Bruce D. Greenwald, Tetsuo Ito, Yuriko Mori, Bogdan C. Paun, Takatsugu Kan, Yulan Cheng, Suna Wang, Jian Yang, John M. Abraham, and Stephen J. Meltzer
Clin Cancer Res 2006 12: 6637-6642 doi: 10.1158/1078-0432.CCR-06-1781 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell Carcinoma

Federica Perrone, Simona Suardi, Elisa Pastore, Paola Casieri, Marta Orsenigo, Stefano Caramuta, Gianpaolo Dagrada, Marco Losa, Lisa Licitra, Paolo Bossi, Samantha Staurengo, Maria Oggionni, Laura Locati, Giulio Cantu, Massimo Squadrelli, Antonino Carbone, Marco A. Pierotti, and Silvana Pilotti
Clin Cancer Res 2006 12: 6643-6651 doi: 10.1158/1078-0432.CCR-06-1759 [Abstract] [Full Text] [PDF]  

FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

Jorge Sergio Reis-Filho, Pete T. Simpson, Nicholas C. Turner, Maryou Ballo Lambros, Chris Jones, Alan Mackay, Anita Grigoriadis, David Sarrio, Kay Savage, Tim Dexter, Marjan Iravani, Kerry Fenwick, Barbara Weber, David Hardisson, Fernando Carlos Schmitt, Jose Palacios, Sunil R. Lakhani, and Alan Ashworth
Clin Cancer Res 2006 12: 6652-6662 doi: 10.1158/1078-0432.CCR-06-1164 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

Nomograms Provide Improved Accuracy for Predicting Survival after Radical Cystectomy

Shahrokh F. Shariat, Pierre I. Karakiewicz, Ganesh S. Palapattu, Gilad E. Amiel, Yair Lotan, Craig G. Rogers, Amnon Vazina, Patrick J. Bastian, Amit Gupta, Arthur I. Sagalowsky, Mark Schoenberg, and Seth P. Lerner
Clin Cancer Res 2006 12: 6663-6676 doi: 10.1158/1078-0432.CCR-06-0372 [Abstract] [Full Text] [PDF]  

Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors

G. Ramachandra Reddy, Mahaveer S. Bhojani, Patrick McConville, Jonathan Moody, Bradford A. Moffat, Daniel E. Hall, Gwangseong Kim, Yong-Eun L. Koo, Michael J. Woolliscroft, James V. Sugai, Timothy D. Johnson, Martin A. Philbert, Raoul Kopelman, Alnawaz Rehemtulla, and Brian D. Ross
Clin Cancer Res 2006 12: 6677-6686 doi: 10.1158/1078-0432.CCR-06-0946 [Abstract] [Full Text] [PDF]  

Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular Carcinoma

Yunfei Yuan, Jianping Wang, Jinqing Li, Li Wang, Meixiang Li, Zuli Yang, Changqing Zhang, and Jia Le Dai
Clin Cancer Res 2006 12: 6687-6695 doi: 10.1158/1078-0432.CCR-06-0921 [Abstract] [Full Text] [PDF]  

Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients

Patrizia Querzoli, Massimo Pedriali, Rosa Rinaldi, Anna Rita Lombardi, Elia Biganzoli, Patrizia Boracchi, Stefano Ferretti, Claudia Frasson, Caterina Zanella, Sara Ghisellini, Federico Ambrogi, Laura Antolini, Mauro Piantelli, Stefano Iacobelli, Ettore Marubini, Saverio Alberti, and Italo Nenci
Clin Cancer Res 2006 12: 6696-6701 doi: 10.1158/1078-0432.CCR-06-0569 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of Breast Cancer Metastasis Suppressor 1 Protein Expression Predicts Reduced Disease-Free Survival in Subsets of Breast Cancer Patients

David G. Hicks, Brian J. Yoder, Sarah Short, Shannon Tarr, Nichole Prescott, Joseph P. Crowe, Andrea E. Dawson, G. Thomas Budd, Steven Sizemore, Muzaffer Cicek, Toni K. Choueiri, Raymond R. Tubbs, Daniel Gaile, Norma Nowak, Mary Ann Accavitti-Loper, Andra R. Frost, Danny R. Welch, and Graham Casey
Clin Cancer Res 2006 12: 6702-6708 doi: 10.1158/1078-0432.CCR-06-0635 [Abstract] [Full Text] [PDF]  

Galectin-3 Expression Is Associated with Tumor Progression and Pattern of Sun Exposure in Melanoma

Victor G. Prieto, Alexandra A. Mourad-Zeidan, Vladislava Melnikova, Marcella M. Johnson, Adriana Lopez, A. Hafeez Diwan, Alexander J.F. Lazar, Steven S. Shen, Peter S. Zhang, Jon A. Reed, Jeffrey E. Gershenwald, Avraham Raz, and Menashe Bar-Eli
Clin Cancer Res 2006 12: 6709-6715 doi: 10.1158/1078-0432.CCR-06-0758 [Abstract] [Full Text] [PDF]  

Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients

Catherine F. Poh, Lewei Zhang, Don W. Anderson, J. Scott Durham, P. Michele Williams, Robert W. Priddy, Ken W. Berean, Samson Ng, Olivia L. Tseng, Calum MacAulay, and Miriam P. Rosin
Clin Cancer Res 2006 12: 6716-6722 doi: 10.1158/1078-0432.CCR-06-1317 [Abstract] [Full Text] [PDF]  

Fragile Histidine Triad Expression in Oral Squamous Cell Carcinoma and Precursor Lesions

Omar Kujan, Richard Oliver, Luca Roz, Gabriella Sozzi, Noel Ribeiro, Robert Woodwards, Nalin Thakker, and Philip Sloan
Clin Cancer Res 2006 12: 6723-6729 doi: 10.1158/1078-0432.CCR-06-1475 [Abstract] [Full Text] [PDF]  

Computed Tomography–Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer

Kazuhiro Ueda, Mitsutaka Jinbo, Tao-Sheng Li, Takaharu Yagi, Kazuyoshi Suga, and Kimikazu Hamano
Clin Cancer Res 2006 12: 6730-6736 doi: 10.1158/1078-0432.CCR-06-1196 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Phase I Study of OncoVEX^GM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor

Jennifer C.C. Hu, Robert S. Coffin, Ceri J. Davis, Nicola J. Graham, Natasha Groves, Peter J. Guest, Kevin J. Harrington, Nicholas D. James, Colin A. Love, Iain McNeish, Louise C. Medley, Agnieszka Michael, Christopher M. Nutting, Hardev S. Pandha, Claire A. Shorrock, Julie Simpson, Jan Steiner, Neil M. Steven, Dennis Wright, and R. Charles Coombes
Clin Cancer Res 2006 12: 6737-6747 doi: 10.1158/1078-0432.CCR-06-0759 [Abstract] [Full Text] [PDF]  

Nitroglycerin Treatment May Enhance Chemosensitivity to Docetaxel and Carboplatin in Patients with Lung Adenocarcinoma

Hiroyasu Yasuda, Katsutoshi Nakayama, Mika Watanabe, Satoshi Suzuki, Hiromi Fuji, Shoji Okinaga, Akio Kanda, Kiyoshi Zayasu, Takahiko Sasaki, Masanori Asada, Tomoko Suzuki, Motoki Yoshida, Shinsuke Yamanda, Daisuke Inoue, Tomohiro Kaneta, Takashi Kondo, Yoshihiro Takai, Hidetada Sasaki, Kazuhiro Yanagihara, and Mutsuo Yamaya
Clin Cancer Res 2006 12: 6748-6757 doi: 10.1158/1078-0432.CCR-06-1124 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

James C. Cusack, Jr., Rong Liu, Lijun Xia, Ta-Hsiang Chao, Christine Pien, Wei Niu, Vito J. Palombella, Saskia T.C. Neuteboom, and Michael A. Palladino
Clin Cancer Res 2006 12: 6758-6764 doi: 10.1158/1078-0432.CCR-06-1151 [Abstract] [Full Text] [PDF]  

CXCR4 Inhibition Synergizes with Cytotoxic Chemotherapy in Gliomas

Navid Redjal, Jennifer A. Chan, Rosalind A. Segal, and Andrew L. Kung
Clin Cancer Res 2006 12: 6765-6771 doi: 10.1158/1078-0432.CCR-06-1372 [Abstract] [Full Text] [PDF]  

Down-Regulation of Insulin-Like Growth Factor I Receptor Activity by NVP-AEW541 Has an Antitumor Effect on Neuroblastoma Cells In vitro and In vivo

Barbara Tanno, Camillo Mancini, Roberta Vitali, Mariateresa Mancuso, Heather P. McDowell, Carlo Dominici, and Giuseppe Raschellà
Clin Cancer Res 2006 12: 6772-6780 doi: 10.1158/1078-0432.CCR-06-1479 [Abstract] [Full Text] [PDF]  

Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma

Silvia Mateo-Lozano, Prafulla C. Gokhale, Viatcheslav A. Soldatenkov, Anatoly Dritschilo, Oscar M. Tirado, and Vicente Notario
Clin Cancer Res 2006 12: 6781-6790 doi: 10.1158/1078-0432.CCR-06-0609 [Abstract] [Full Text] [PDF]  

Dominant-Negative Fibroblast Growth Factor Receptor Expression Enhances Antitumoral Potency of Oncolytic Herpes Simplex Virus in Neural Tumors

Ta-Chiang Liu, Tingguo Zhang, Hiroshi Fukuhara, Toshihiko Kuroda, Tomoki Todo, Xavier Canron, Andreas Bikfalvi, Robert L. Martuza, Andreas Kurtz, and Samuel D. Rabkin
Clin Cancer Res 2006 12: 6791-6799 doi: 10.1158/1078-0432.CCR-06-0263 [Abstract] [Full Text] [PDF]  

A Tracer Dose of Technetium-99m–Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation

Miriam M. Kleiter, Daohai Yu, Lenore A. Mohammadian, Nelsen Niehaus, Ivan Spasojevic, Linda Sanders, Benjamin L. Viglianti, Pavel S. Yarmolenko, Marlene Hauck, Neil A. Petry, Terence Z. Wong, Mark W. Dewhirst, and Donald E. Thrall
Clin Cancer Res 2006 12: 6800-6807 doi: 10.1158/1078-0432.CCR-06-0839 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy

Betty Li, Alshad S. Lalani, Thomas C. Harding, Bo Luan, Kathryn Koprivnikar, Guang Huan Tu, Rodney Prell, Melinda J. VanRoey, Andrew D. Simmons, and Karin Jooss
Clin Cancer Res 2006 12: 6808-6816 doi: 10.1158/1078-0432.CCR-06-1558 [Abstract] [Full Text] [PDF]  

Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation

Meir Wetzler, Michael T. Brady, Erin Tracy, Zhang-Rong Li, Kathleen A. Donohue, Kieran L. O'Loughlin, Yijun Cheng, Amir Mortazavi, Amy A. McDonald, Padmaja Kunapuli, Paul K. Wallace, Maria R. Baer, John K. Cowell, and Heinz Baumann
Clin Cancer Res 2006 12: 6817-6825 doi: 10.1158/1078-0432.CCR-06-1354 [Abstract] [Full Text] [PDF]  

Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma

Lanie K. Francis, Yazan Alsayed, Xavier Leleu, Xiaoying Jia, Ujjal K. Singha, Judith Anderson, Michael Timm, Hai Ngo, Ganwei Lu, Alissa Huston, Lori A. Ehrlich, Elizabeth Dimmock, Suzanne Lentzsch, Teru Hideshima, G. David Roodman, Kenneth C. Anderson, and Irene M. Ghobrial
Clin Cancer Res 2006 12: 6826-6835 doi: 10.1158/1078-0432.CCR-06-1331 [Abstract] [Full Text] [PDF]  

Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft In vivo in Association with Bax and Bak Induction

Dong Xiao, Karen L. Lew, Young-Ae Kim, Yan Zeng, Eun-Ryeong Hahm, Rajiv Dhir, and Shivendra V. Singh
Clin Cancer Res 2006 12: 6836-6843 doi: 10.1158/1078-0432.CCR-06-1273 [Abstract] [Full Text] [PDF]  

SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation

Zhenfeng Duan, James E. Bradner, Edward Greenberg, Ross Levine, Rosemary Foster, Jennifer Mahoney, and Michael V. Seiden
Clin Cancer Res 2006 12: 6844-6852 doi: 10.1158/1078-0432.CCR-06-1330 [Abstract] [Full Text] [PDF]  

A Novel HSV-1 Virus, JS1/34.5^–/47^–, Purges Contaminating Breast Cancer Cells From Bone Marrow

Jennifer C. Hu, Matthew J. Booth, Gopichand Tripuraneni, Derek Davies, Syed A.A. Zaidi, Manuela Tamburo de Bella, Martin J. Slade, Stephen B. Marley, Myrtle Y.A. Gordon, Robert S. Coffin, R. Charles Coombes, and Tahereh Kamalati
Clin Cancer Res 2006 12: 6853-6862 doi: 10.1158/1078-0432.CCR-06-1228 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Unexpected Immunohistochemical Localization of Deoxycytidine Kinase

Lorelei Johnson, Raymond Lai, Cheryl Santos, Laith Dabbagh, and John Mackey
Clin Cancer Res 2006 12: 6863 doi: 10.1158/1078-0432.CCR-06-1590 [Full Text] [PDF]  

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