Editorials:

Effective Strategies for Tumors Affecting Chemopreventive Metabolism

Jeroen T.M. Buters
Clin Cancer Res 2006 12: 7203-7204. [Full Text] [PDF]  

The Biology Behind:

Circulating Methylated DNA: A New Generation of Tumor Markers

Martin Widschwendter and Usha Menon
Clin Cancer Res 2006 12: 7205 -7208 doi: 10.1158/1078-0432.CCR-06-2531 [Full Text] [PDF]  

CCR Practice of Translational Oncology:

Chips to Bedside: Incorporation of Microarray Data into Clinical Practice

Lajos Pusztai
Clin Cancer Res 2006 12: 7209-7214. [Full Text] [PDF]  

Molecular Pathways:

Targeting von Hippel-Lindau Pathway in Renal Cell Carcinoma

Premal H. Patel, Rajendrakumar S.V. Chadalavada, R.S.K. Chaganti, and Robert J. Motzer
Clin Cancer Res 2006 12: 7215-7220. [Abstract] [Full Text] [PDF]  

CCR Focus:

Epidermal Growth Factor Receptor Activation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway

Rafael Rosell, Miquel Taron, Noemi Reguart, Dolores Isla, and Teresa Moran
Clin Cancer Res 2006 12: 7222-7231. [Abstract] [Full Text] [PDF]  

Update on Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer

Gregory J. Riely, Katerina A. Politi, Vincent A. Miller, and William Pao
Clin Cancer Res 2006 12: 7232-7241. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs

Mayumi Ono and Michihiko Kuwano
Clin Cancer Res 2006 12: 7242-7251. [Abstract] [Full Text] [PDF]  

Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response

Burkhard Brandt, Sönke Meyer-Staeckling, Hartmut Schmidt, Konstantin Agelopoulos, and Horst Buerger
Clin Cancer Res 2006 12: 7252-7260. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor–Mediated Signal Transduction in the Development and Therapy of Gliomas

M. Kelly Nicholas, Rimas V. Lukas, Nazia F. Jafri, Leonardo Faoro, and Ravi Salgia
Clin Cancer Res 2006 12: 7261-7270. [Abstract] [Full Text] [PDF]  

Report from FDA:

Sorafenib for the Treatment of Advanced Renal Cell Carcinoma

Robert C. Kane, Ann T. Farrell, Haleh Saber, Shenghui Tang, Gene Williams, Josephine M. Jee, Chengyi Liang, Brian Booth, Nallaperumal Chidambaram, David Morse, Rajeshwari Sridhara, Patricia Garvey, Robert Justice, and Richard Pazdur
Clin Cancer Res 2006 12: 7271-7278. [Abstract] [Full Text] [PDF]  

Perspective:

Maspin: The New Frontier

Zhila Khalkhali-Ellis
Clin Cancer Res 2006 12: 7279-7283. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors

Rachael Natrajan, Suzanne E. Little, Jorge S. Reis-Filho, Lara Hing, Boo Messahel, Paul E. Grundy, Jeffrey S. Dome, Toni Schneider, Gordan M. Vujanic, Kathy Pritchard-Jones, and Chris Jones
Clin Cancer Res 2006 12: 7284-7293. [Abstract] [Full Text] [PDF]  

ß₂-Microglobulin Promotes the Growth of Human Renal Cell Carcinoma through the Activation of the Protein Kinase A, Cyclic AMP–Responsive Element-Binding Protein, and Vascular Endothelial Growth Factor Axis

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Daqing Wu, Zhihui Xie, Hiromitsu Mimata, Majd Zayzafoon, Andrew N. Young, Fray F. Marshall, M. Neale Weitzmann, and Leland W.K. Chung
Clin Cancer Res 2006 12: 7294-7305. [Abstract] [Full Text] [PDF]  

Profiling of CD4⁺, CD8⁺, and CD4⁺CD25⁺CD45RO⁺FoxP3⁺ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers

Chris A. Learn, Peter E. Fecci, Robert J. Schmittling, Weihua Xie, Isaac Karikari, Duane A. Mitchell, Gary E. Archer, ZhengZheng Wei, Holly Dressman, and John H. Sampson
Clin Cancer Res 2006 12: 7306-7315. [Abstract] [Full Text] [PDF]  

The Coamplification Pattern of the MYCN Amplicon Is an Invariable Attribute of Most MYCN-Amplified Human Neuroblastomas

Axel Weber, Sven Starke, Eckhard Bergmann, and Holger Christiansen
Clin Cancer Res 2006 12: 7316-7321. [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients

Nobuyoshi Sugito, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Hiroki Kurehara, Takuya Ando, Ryota Mori, Nobuhiro Takashima, Ryo Ogawa, and Yoshitaka Fujii
Clin Cancer Res 2006 12: 7322-7328. [Abstract] [Full Text] [PDF]  

Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer

Jian Gu, David Berman, Charles Lu, Ignacio I. Wistuba, Jack A. Roth, Marsha Frazier, Margaret R. Spitz, and Xifeng Wu
Clin Cancer Res 2006 12: 7329-7338. [Abstract] [Full Text] [PDF]  

Vascular Cell Adhesion Molecule 1 Predicts Cancer-Free Survival in Clear Cell Renal Carcinoma Patients

Ko-ichi Shioi, Atsushi Komiya, Keiko Hattori, Ying Huang, Futoshi Sano, Takayuki Murakami, Noboru Nakaigawa, Takeshi Kishida, Yoshinobu Kubota, Yoji Nagashima, and Masahiro Yao
Clin Cancer Res 2006 12: 7339-7346. [Abstract] [Full Text] [PDF] Supplementary Data  

Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer

Maike Wallner, Andreas Herbst, Andrea Behrens, Alexander Crispin, Petra Stieber, Burkhard Göke, Rolf Lamerz, and Frank T. Kolligs
Clin Cancer Res 2006 12: 7347-7352. [Abstract] [Full Text] [PDF] Supplementary Data  

Implications of Methylation Patterns of Cancer Genes in Salivary Gland Tumors

Michelle D. Williams, Nitin Chakravarti, Merrill S. Kies, Shin-Ichiro Maruya, Jeffrey N. Myers, Joie C. Haviland, Randal S. Weber, Reuben Lotan, and Adel K. El-Naggar
Clin Cancer Res 2006 12: 7353-7358. [Abstract] [Full Text] [PDF]  

Molecular Profiling of ADAM12 in Human Bladder Cancer

Camilla Fröhlich, Reidar Albrechtsen, Lars Dyrskjøt, Lise Rudkjær, Torben F. Ørntoft, and Ulla M. Wewer
Clin Cancer Res 2006 12: 7359-7368. [Abstract] [Full Text] [PDF]  

Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease

Vitaly Margulis, Shahrokh F. Shariat, Raheela Ashfaq, Arthur I. Sagalowsky, and Yair Lotan
Clin Cancer Res 2006 12: 7369-7373. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Contribution of ABL Kinase Domain Mutations to Imatinib Resistance in Different Subsets of Philadelphia-Positive Patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia

Simona Soverini, Sabrina Colarossi, Alessandra Gnani, Gianantonio Rosti, Fausto Castagnetti, Angela Poerio, Ilaria Iacobucci, Marilina Amabile, Elisabetta Abruzzese, Ester Orlandi, Franca Radaelli, Fabrizio Ciccone, Mario Tiribelli, Roberto di Lorenzo, Clementina Caracciolo, Barbara Izzo, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Giovanni Martinelli on behalf of the GIMEMA Working Party on Chronic Myeloid Leukemia
Clin Cancer Res 2006 12: 7374-7379. [Abstract] [Full Text] [PDF]  

Immunologic and Clinical Effects of Injecting Mature Peptide-Loaded Dendritic Cells by Intralymphatic and Intranodal Routes in Metastatic Melanoma Patients

Thierry Lesimple, Eve-Marie Neidhard, Virginie Vignard, Claudia Lefeuvre, Henri Adamski, Nathalie Labarrière, André Carsin, Delphine Monnier, Brigitte Collet, Gilles Clapisson, Brigitte Birebent, Irène Philip, Louis Toujas, Mohamed Chokri, and Véronique Quillien
Clin Cancer Res 2006 12: 7380-7388. [Abstract] [Full Text] [PDF]  

A Neoadjuvant/Adjuvant Randomized Trial of Colorectal Cancer Patients Vaccinated with an Anti-Idiotypic Antibody, 105AD7, Mimicking CD55

Gustav J. Ullenhag, Ian Spendlove, Nicholas F.S. Watson, Adrian A. Indar, Mukul Dube, Richard A. Robins, Charles Maxwell-Armstrong, John H. Scholefield, and Lindy G. Durrant
Clin Cancer Res 2006 12: 7389-7396. [Abstract] [Full Text] [PDF]  

HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan

Shigehisa Kitano, Shinichi Kageyama, Yasuhiro Nagata, Yoshihiro Miyahara, Atsunori Hiasa, Hiroaki Naota, Satoshi Okumura, Hiroshi Imai, Taizo Shiraishi, Masahiro Masuya, Masakatsu Nishikawa, Junzo Sunamoto, Kazunari Akiyoshi, Takashi Kanematsu, Andrew M. Scott, Roger Murphy, Eric W. Hoffman, Lloyd J. Old, and Hiroshi Shiku
Clin Cancer Res 2006 12: 7397-7405. [Abstract] [Full Text] [PDF]  

Phase I, Pharmacokinetic, and Biological Study of Erlotinib in Combination with Paclitaxel and Carboplatin in Patients with Advanced Solid Tumors

Amita Patnaik, Debra Wood, Anthony W. Tolcher, Marta Hamilton, Jeffrey I. Kreisberg, Lisa A. Hammond, Garry Schwartz, Muralidhar Beeram, Manuel Hidalgo, Monica M. Mita, Julie Wolf, Paul Nadler, and Eric K. Rowinsky
Clin Cancer Res 2006 12: 7406-7413. [Abstract] [Full Text] [PDF]  

Rapid Androgen Cycling as Treatment for Patients with Prostate Cancer

David Feltquate, Luke Nordquist, Caitlin Eicher, Michael Morris, Oren Smaletz, Susan Slovin, Tracy Curley, Andrew Wilton, Martin Fleisher, Glenn Heller, and Howard I. Scher
Clin Cancer Res 2006 12: 7414-7421. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Active Antiviral T-Lymphocyte Response Can Be Redirected against Tumor Cells by Antitumor Antibody x MHC/Viral Peptide Conjugates

Valérie Cesson, Kathrin Stirnemann, Bruno Robert, Immanuel Luescher, Thomas Filleron, Giampietro Corradin, Jean-Pierre Mach, and Alena Donda
Clin Cancer Res 2006 12: 7422-7430. [Abstract] [Full Text] [PDF]  

Inhibitory Effects of Castration in an Orthotopic Model of Androgen-Independent Prostate Cancer Can Be Mimicked and Enhanced by Angiogenesis Inhibition

Peter Hammarsten, Sofia Halin, Pernilla Wikstöm, Roger Henriksson, Stina Häggström Rudolfsson, and Anders Bergh
Clin Cancer Res 2006 12: 7431-7436. [Abstract] [Full Text] [PDF]  

Systemic Anthrax Lethal Toxin Therapy Produces Regressions of Subcutaneous Human Melanoma Tumors in Athymic Nude Mice

Ralph J. Abi-Habib, Ravibhushan Singh, Stephen H. Leppla, John J. Greene, Yan Ding, Bree Berghuis, Nicholas S. Duesbery, and Arthur E. Frankel
Clin Cancer Res 2006 12: 7437-7443. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers

Anthony Rusk, Evelyn McKeegan, Fortuna Haviv, Sandra Majest, Jack Henkin, and Chand Khanna
Clin Cancer Res 2006 12: 7444-7455. [Abstract] [Full Text] [PDF]  

Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma

Anthony Rusk, Elizabeth Cozzi, Marty Stebbins, David Vail, Joanne Graham, Victor Valli, Jack Henkin, Rick Sharpee, and Chand Khanna
Clin Cancer Res 2006 12: 7456-7464. [Abstract] [Full Text] [PDF] Supplementary Data  

Enhancement of Immunologic Tumor Regression by Intratumoral Administration of Dendritic Cells in Combination with Cryoablative Tumor Pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation

Masaru Udagawa, Chie Kudo-Saito, Go Hasegawa, Kazuhito Yano, Aiko Yamamoto, Masae Yaguchi, Masahiro Toda, Ichiro Azuma, Takehisa Iwai, and Yutaka Kawakami
Clin Cancer Res 2006 12: 7465-7475. [Abstract] [Full Text] [PDF]  

Identification of a Highly Immunogenic HLA-A*01-Binding T Cell Epitope of WT1

Anne Marie Asemissen, Ulrich Keilholz, Stefan Tenzer, Margret Müller, Steffen Walter, Stefan Stevanovic, Hansjörg Schild, Anne Letsch, Eckhard Thiel, Hans-Georg Rammensee, and Carmen Scheibenbogen
Clin Cancer Res 2006 12: 7476-7482. [Abstract] [Full Text] [PDF]  

Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2'-Deoxycytidine in Mice

Jan H. Beumer, Julie L. Eiseman, Robert A. Parise, Erin Joseph, Julianne L. Holleran, Joseph M. Covey, and Merrill J. Egorin
Clin Cancer Res 2006 12: 7483-7491. [Abstract] [Full Text] [PDF]  

Transcriptional Repression of Hepatic Cytochrome P450 3A4 Gene in the Presence of Cancer

Kellie A. Charles, Laurent P. Rivory, Sandie L. Brown, Christopher Liddle, Stephen J. Clarke, and Graham R. Robertson
Clin Cancer Res 2006 12: 7492-7497. [Abstract] [Full Text] [PDF]  

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